SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZB7_A_NCAA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqz PROTEIN (ANTIGEN
85-C)

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 TYR A 242
ILE A 195
LEU A 151
LEU A 131
 None
 1.15A 2zb7A-1dqzA:
2.6		 2zb7A-1dqzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g29 MALTOSE TRANSPORT
PROTEIN MALK

(Thermococcus
litoralis) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 ILE 1 194
MET 1 213
LEU 1   6
LEU 1  24
 None
 0.85A 2zb7A-1g291:
undetectable		 2zb7A-1g291:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 TYR A 977
MET A 627
LEU A 957
LEU A 997
 None
 1.02A 2zb7A-1hwwA:
undetectable		 2zb7A-1hwwA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 TYR A 475
ILE A 484
LEU A 369
LEU A   5
 None
 1.16A 2zb7A-1i5pA:
undetectable		 2zb7A-1i5pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij9 VASCULAR CELL
ADHESION PROTEIN 1

(Homo sapiens) 		PF05790
(C2-set)
PF07679
(I-set) 		4 ILE A 109
MET A 135
LEU A 193
LEU A 169
 None
 1.14A 2zb7A-1ij9A:
undetectable		 2zb7A-1ij9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TYR A 157
ILE A 148
LEU A 226
LEU A  95
 None
 1.16A 2zb7A-1jd0A:
undetectable		 2zb7A-1jd0A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		4 ILE A 151
MET A 168
LEU A 211
LEU A 208
 None
 1.16A 2zb7A-1jqeA:
3.3		 2zb7A-1jqeA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqp DIPEPTIDYL PEPTIDASE
I

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 TYR A 285
ILE A 281
LEU A 242
LEU A 239
 None
 1.13A 2zb7A-1jqpA:
undetectable		 2zb7A-1jqpA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		4 TYR A 163
ILE A 247
LEU A 226
LEU A 230
 None
 0.94A 2zb7A-1jv1A:
2.0		 2zb7A-1jv1A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  54
MET A 272
LEU A 321
LEU A 298
 None
None
None
APG  A 361 ( 4.9A)
 1.15A 2zb7A-1mnsA:
undetectable		 2zb7A-1mnsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 TYR A 578
ILE A 585
LEU A 412
LEU A 607
 None
 1.13A 2zb7A-1ndfA:
undetectable		 2zb7A-1ndfA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ILE A 605
MET A 729
LEU A 620
LEU A 623
 None
 1.17A 2zb7A-1qf7A:
3.4		 2zb7A-1qf7A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu5 PROTEIN KINASE SPK1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 TYR A 649
ILE A 625
LEU A 578
LEU A 580
 None
 1.09A 2zb7A-1qu5A:
undetectable		 2zb7A-1qu5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		4 TYR A  13
ILE A   5
LEU A  57
LEU A 135
 None
 1.07A 2zb7A-1r4pA:
undetectable		 2zb7A-1r4pA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major) 		PF01212
(Beta_elim_lyase) 		4 ILE A 109
MET A 209
LEU A  87
LEU A 148
 None
 1.15A 2zb7A-1svvA:
2.1		 2zb7A-1svvA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2k INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF00605
(IRF) 		4 TYR A 107
ILE A  36
LEU A  16
LEU A  12
 None
 1.12A 2zb7A-1t2kA:
undetectable		 2zb7A-1t2kA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		4 TYR A 203
ILE A 190
LEU A 131
LEU A 186
 None
 1.18A 2zb7A-1ue8A:
undetectable		 2zb7A-1ue8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 ILE A 197
MET A 216
LEU A  15
LEU A  33
 None
 0.96A 2zb7A-1v43A:
undetectable		 2zb7A-1v43A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo8 METHYLGLYOXAL
SYNTHASE

(Thermus
thermophilus) 		PF02142
(MGS) 		4 ILE A 120
MET A  16
LEU A  32
LEU A  27
 None
 1.02A 2zb7A-1wo8A:
undetectable		 2zb7A-1wo8A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm7 HYPOTHETICAL PROTEIN
AQ_1665

(Aquifex
aeolicus) 		PF12850
(Metallophos_2) 		4 TYR A  94
ILE A  73
LEU A  48
LEU A 109
 None
 1.15A 2zb7A-1xm7A:
undetectable		 2zb7A-1xm7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3r PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
3-KINASE C2
DOMAIN-CONTAINING
ALPHA POLYPEPTIDE

(Mus musculus) 		PF00168
(C2) 		4 TYR A1452
ILE A1399
LEU A1493
LEU A1488
 None
None
SO4  A 303 (-4.0A)
None
 1.11A 2zb7A-2b3rA:
undetectable		 2zb7A-2b3rA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		4 TYR A 144
ILE A 170
LEU A 212
LEU A 213
 None
 1.12A 2zb7A-2bi3A:
undetectable		 2zb7A-2bi3A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 ILE A 197
MET A 216
LEU A   9
LEU A  27
 None
 0.88A 2zb7A-2d62A:
undetectable		 2zb7A-2d62A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edp SHROOM FAMILY MEMBER
4

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  79
MET A  54
LEU A  27
LEU A  60
 None
 1.05A 2zb7A-2edpA:
undetectable		 2zb7A-2edpA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		4 TYR A 352
ILE A 365
LEU A 432
LEU A 428
 None
 1.08A 2zb7A-2epjA:
undetectable		 2zb7A-2epjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		4 TYR A  49
ILE A  40
LEU A  87
LEU A 239
 None
 1.18A 2zb7A-2jfnA:
undetectable		 2zb7A-2jfnA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus;
Mus musculus) 		PF13867
(SAP30_Sin3_bdg)
PF02671
(PAH) 		4 TYR A 161
ILE B 490
LEU A 153
LEU A 150
 None
 1.02A 2zb7A-2ld7A:
undetectable		 2zb7A-2ld7A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		4 TYR A  48
ILE A  11
LEU A  23
LEU A  20
 None
 1.17A 2zb7A-2myiA:
undetectable		 2zb7A-2myiA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 TYR A 287
ILE A 125
LEU A 309
LEU A 313
 None
 1.15A 2zb7A-2nrjA:
undetectable		 2zb7A-2nrjA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF00605
(IRF)
PF16179
(RHD_dimer) 		4 TYR A2107
ILE A2036
LEU A2016
LEU A2012
 None
 1.07A 2zb7A-2o61A:
undetectable		 2zb7A-2o61A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  67
ILE A  47
LEU A 343
LEU A 340
 None
 0.94A 2zb7A-2og9A:
undetectable		 2zb7A-2og9A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 TYR A 426
ILE A 408
LEU A 443
LEU A 434
 None
 1.05A 2zb7A-2pkgA:
undetectable		 2zb7A-2pkgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 TYR A  88
ILE A 152
LEU A 414
LEU A 168
 None
 0.94A 2zb7A-2pokA:
undetectable		 2zb7A-2pokA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 TYR A 406
ILE A 409
LEU A 385
LEU A 383
 None
 1.07A 2zb7A-2qvwA:
undetectable		 2zb7A-2qvwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 TYR A 271
ILE A 303
LEU A  15
LEU A  22
 None
 1.00A 2zb7A-2r14A:
undetectable		 2zb7A-2r14A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		4 TYR A 195
ILE A 191
LEU A 171
LEU A 144
 None
 1.16A 2zb7A-2vugA:
undetectable		 2zb7A-2vugA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2i 2-OXOGLUTARATE
OXYGENASE

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ILE A 169
MET A 318
LEU A 158
LEU A 161
 None
 1.07A 2zb7A-2w2iA:
undetectable		 2zb7A-2w2iA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 TYR A 189
ILE A 165
LEU A 207
LEU A 205
 None
 1.06A 2zb7A-2z81A:
undetectable		 2zb7A-2z81A:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zb4 PROSTAGLANDIN
REDUCTASE 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 TYR A  51
ILE A  65
MET A 135
LEU A 288
LEU A 290
 5OP  A 600 (-3.4A)
5OP  A 600 ( 4.6A)
5OP  A 600 ( 2.7A)
NAP  A 500 (-4.7A)
5OP  A 600 (-3.7A)
 0.45A 2zb7A-2zb4A:
60.2		 2zb7A-2zb4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE

(Trypanosoma
cruzi) 		PF00724
(Oxidored_FMN) 		4 TYR A 282
ILE A 311
LEU A  11
LEU A  18
 None
 1.06A 2zb7A-3atyA:
undetectable		 2zb7A-3atyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bby UNCHARACTERIZED
GST-LIKE PROTEIN
YFCF

(Escherichia
coli) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		4 TYR A  78
ILE A  64
LEU A  26
LEU A  31
 None
 1.16A 2zb7A-3bbyA:
undetectable		 2zb7A-3bbyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A A SUBUNIT

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 TYR A 426
ILE A 408
LEU A 446
LEU A 443
 None
 1.09A 2zb7A-3c5wA:
undetectable		 2zb7A-3c5wA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnr TYPE IV FIMBRIAE
ASSEMBLY PROTEIN

(Xanthomonas
citri) 		PF07238
(PilZ) 		4 TYR A  25
ILE A  34
LEU A  15
LEU A  54
 None
 1.16A 2zb7A-3cnrA:
undetectable		 2zb7A-3cnrA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxm URACIL-DNA
GLYCOSYLASE

(Leishmania
naiffi) 		PF03167
(UDG) 		4 ILE A 234
MET A 261
LEU A 366
LEU A 253
 None
 1.08A 2zb7A-3cxmA:
undetectable		 2zb7A-3cxmA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 TYR B  36
ILE B 376
LEU B 171
LEU B 167
 None
 1.15A 2zb7A-3draB:
undetectable		 2zb7A-3draB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsg TYPE IV FIMBRIAE
ASSEMBLY PROTEIN

(Xanthomonas
campestris) 		PF07238
(PilZ) 		4 TYR A  25
ILE A  34
LEU A  15
LEU A  54
 None
 1.12A 2zb7A-3dsgA:
undetectable		 2zb7A-3dsgA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0z PROTEIN OF UNKNOWN
FUNCTION

([Eubacterium]
rectale) 		PF12939
(DUF3837) 		4 TYR A  29
ILE A  10
LEU A  76
LEU A  72
 None
 1.10A 2zb7A-3e0zA:
undetectable		 2zb7A-3e0zA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebc TYPE-2 RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		4 ILE A 143
MET A 155
LEU A 125
LEU A  88
 None
 1.06A 2zb7A-3ebcA:
undetectable		 2zb7A-3ebcA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		4 TYR A 122
ILE A   9
LEU A 117
LEU A 105
 None
 1.18A 2zb7A-3gl5A:
undetectable		 2zb7A-3gl5A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY

(Pseudomonas
putida) 		PF01965
(DJ-1_PfpI) 		4 ILE A  35
MET A 126
LEU A 117
LEU A 118
 None
 1.15A 2zb7A-3graA:
undetectable		 2zb7A-3graA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		4 TYR A 178
ILE A 343
LEU A 196
LEU A 253
 None
 1.00A 2zb7A-3gxoA:
8.3		 2zb7A-3gxoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ILE B 222
MET B  46
LEU B 172
LEU B  25
 None
 1.05A 2zb7A-3l7zB:
undetectable		 2zb7A-3l7zB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 TYR A 112
ILE A 401
LEU A 438
LEU A 421
 None
 1.13A 2zb7A-3pihA:
undetectable		 2zb7A-3pihA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfq LARGE T ANTIGEN

(Human
polyomavirus 5) 		PF02217
(T_Ag_DNA_bind) 		4 TYR A 339
ILE A 370
LEU A 323
LEU A 319
 None
 0.90A 2zb7A-3qfqA:
undetectable		 2zb7A-3qfqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2

(Homo sapiens) 		PF04495
(GRASP55_65) 		4 TYR A  17
ILE A  40
LEU A  96
LEU A  59
 None
 1.16A 2zb7A-3rleA:
undetectable		 2zb7A-3rleA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4k PUTATIVE ESTERASE
RV1847/MT1895

(Mycobacterium
tuberculosis) 		PF03061
(4HBT) 		4 TYR A  55
ILE A 118
LEU A  23
LEU A  37
 None
 1.06A 2zb7A-3s4kA:
undetectable		 2zb7A-3s4kA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vml 3-ISOPROPYLMALATE
DEHYDROGENASE

(Shewanella
benthica;
Shewanella
oneidensis) 		PF00180
(Iso_dh) 		4 TYR A   3
ILE A  36
LEU A 306
LEU A 307
 None
 1.13A 2zb7A-3vmlA:
undetectable		 2zb7A-3vmlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 TYR A  82
ILE A 190
LEU A 171
LEU A 174
 None
 1.08A 2zb7A-3w1gA:
undetectable		 2zb7A-3w1gA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 TYR A 104
ILE A 101
LEU A 156
LEU A 128
 None
 1.14A 2zb7A-3zx2A:
undetectable		 2zb7A-3zx2A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 TYR A 415
ILE A 393
MET A 358
LEU A 407
 None
 1.05A 2zb7A-4aoaA:
3.1		 2zb7A-4aoaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 TYR A 229
ILE A 140
LEU A  81
LEU A  95
 None
 1.14A 2zb7A-4b7gA:
undetectable		 2zb7A-4b7gA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 TYR A 698
ILE A 692
LEU A 684
LEU A 681
 None
 1.05A 2zb7A-4fnqA:
undetectable		 2zb7A-4fnqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hva CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A 157
MET A  39
LEU A 282
LEU A 286
 None
 1.16A 2zb7A-4hvaA:
3.8		 2zb7A-4hvaA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1p NHEA

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 TYR A  88
ILE A 130
LEU A  21
LEU A 307
 None
 1.09A 2zb7A-4k1pA:
undetectable		 2zb7A-4k1pA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 ILE A 428
MET A 568
LEU A 352
LEU A 353
 None
 1.17A 2zb7A-4k90A:
undetectable		 2zb7A-4k90A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 TYR A 426
ILE A 408
LEU A 446
LEU A 443
 None
 1.05A 2zb7A-4lacA:
undetectable		 2zb7A-4lacA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1

(Archaeoglobus
fulgidus) 		PF01867
(Cas_Cas1) 		4 TYR A 175
ILE A 179
LEU A 135
LEU A 120
 None
 1.14A 2zb7A-4n06A:
undetectable		 2zb7A-4n06A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		4 ILE A  52
MET A 251
LEU A 267
LEU A 263
 None
 1.07A 2zb7A-4n2xA:
undetectable		 2zb7A-4n2xA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN

(Pseudomonas
putida) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 TYR A  96
ILE A  74
LEU A  38
LEU A  43
 None
 1.18A 2zb7A-4naxA:
undetectable		 2zb7A-4naxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 ILE E 273
MET E 408
LEU E 282
LEU E 291
 None
 1.18A 2zb7A-4obuE:
undetectable		 2zb7A-4obuE:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5f GLUTATHIONE
S-TRANSFERASE 1

(Ascaris suum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A  68
ILE A  21
LEU A  54
LEU A   6
 None
 1.04A 2zb7A-4q5fA:
undetectable		 2zb7A-4q5fA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5r GLUTATHIONE
S-TRANSFERASE

(Blattella
germanica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A 156
ILE A  96
LEU A 161
LEU A 164
 None
 1.05A 2zb7A-4q5rA:
undetectable		 2zb7A-4q5rA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		4 TYR A 347
ILE A 191
LEU A 251
LEU A 215
 None
 0.94A 2zb7A-4qb7A:
undetectable		 2zb7A-4qb7A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus) 		PF13416
(SBP_bac_8) 		4 ILE A 325
MET A 123
LEU A 107
LEU A 103
 None
 1.05A 2zb7A-4r9gA:
undetectable		 2zb7A-4r9gA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roj GUANINE NUCLEOTIDE
EXCHANGE FACTOR VAV2

(Homo sapiens) 		PF00017
(SH2) 		4 TYR A 695
ILE A 709
LEU A 759
LEU A 752
 None
 1.13A 2zb7A-4rojA:
undetectable		 2zb7A-4rojA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TYR A  41
ILE A  32
LEU A  82
LEU A 126
 None
 1.18A 2zb7A-4up7A:
undetectable		 2zb7A-4up7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x57 MEMBRANE-ANCHORED
UBIQUITIN-FOLD
PROTEIN 3

(Arabidopsis
thaliana) 		PF13881
(Rad60-SLD_2) 		4 TYR B  24
ILE B   9
LEU B  64
LEU B  57
 None
 1.15A 2zb7A-4x57B:
undetectable		 2zb7A-4x57B:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		4 ILE A 346
MET A 247
LEU A 238
LEU A 255
 None
 0.76A 2zb7A-4xkqA:
undetectable		 2zb7A-4xkqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru PNKP1

(Capnocytophaga
gingivalis) 		PF13671
(AAA_33) 		4 ILE A 276
MET A 295
LEU A 285
LEU A 302
 None
 1.18A 2zb7A-4xruA:
4.1		 2zb7A-4xruA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN

(Methanosarcina
acetivorans) 		PF04446
(Thg1)
PF14413
(Thg1C) 		4 TYR A  65
ILE A 224
LEU A 239
LEU A 236
 None
 1.06A 2zb7A-5axkA:
undetectable		 2zb7A-5axkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		4 TYR A  87
ILE A  92
LEU A 113
LEU A 110
 None
 1.12A 2zb7A-5cdhA:
undetectable		 2zb7A-5cdhA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 ILE B 561
MET B 493
LEU B 608
LEU B 550
 None
 1.14A 2zb7A-5dlqB:
undetectable		 2zb7A-5dlqB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsy POLY [ADP-RIBOSE]
POLYMERASE 2

(Homo sapiens) 		PF00644
(PARP) 		4 ILE A 232
MET A 556
LEU A 356
LEU A 559
 None
 1.16A 2zb7A-5dsyA:
undetectable		 2zb7A-5dsyA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		4 TYR A 340
ILE A 324
LEU A 204
LEU A 308
 None
 1.15A 2zb7A-5fa1A:
2.4		 2zb7A-5fa1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuz 645 FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  32
ILE H  27
LEU H   4
LEU H 110
 None
 1.18A 2zb7A-5fuzH:
undetectable		 2zb7A-5fuzH:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h65 PROTECTION OF
TELOMERES PROTEIN 1

(Homo sapiens) 		no annotation 4 ILE A 624
MET A 587
LEU A 548
LEU A 603
 None
 1.11A 2zb7A-5h65A:
undetectable		 2zb7A-5h65A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnm D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Enterococcus
faecalis) 		PF02557
(VanY) 		4 TYR A 242
ILE A 196
LEU A 125
LEU A 128
 None
 0.95A 2zb7A-5hnmA:
undetectable		 2zb7A-5hnmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ILE A 745
MET A 615
LEU A 765
LEU A 577
 None
 1.15A 2zb7A-5ikpA:
2.6		 2zb7A-5ikpA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		4 TYR A1385
ILE A1418
MET A1208
LEU A1412
 None
 1.10A 2zb7A-5jbeA:
2.1		 2zb7A-5jbeA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbl PROHEAD CORE PROTEIN
PROTEASE

(Escherichia
virus T4) 		PF03420
(Peptidase_S77) 		4 TYR A  69
MET A 103
LEU A  62
LEU A  45
 None
 0.98A 2zb7A-5jblA:
undetectable		 2zb7A-5jblA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA

(Chaetomium
thermophilum) 		PF01602
(Adaptin_N) 		4 TYR A  81
ILE A 104
LEU A 126
LEU A 131
 None
 1.14A 2zb7A-5mu7A:
undetectable		 2zb7A-5mu7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suj UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A 293
ILE A 248
LEU A 122
LEU A 118
 None
 1.01A 2zb7A-5sujA:
undetectable		 2zb7A-5sujA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsc UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A 280
ILE A 235
LEU A 113
LEU A 109
 None
 1.04A 2zb7A-5tscA:
undetectable		 2zb7A-5tscA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 TYR A 397
ILE A 156
LEU A 341
LEU A 345
 None
 1.15A 2zb7A-5u09A:
3.3		 2zb7A-5u09A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urb METHIONINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 TYR A 344
ILE A 339
LEU A 324
LEU A 370
 None
 1.18A 2zb7A-5urbA:
2.3		 2zb7A-5urbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 TYR E 322
ILE E 458
LEU E 332
LEU E 432
 None
 1.14A 2zb7A-5v8fE:
undetectable		 2zb7A-5v8fE:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdr RAS PROTEIN

(Choanoflagellida) 		PF00071
(Ras) 		4 TYR A 158
ILE A  46
LEU A   6
LEU A  53
 None
 1.15A 2zb7A-5wdrA:
2.5		 2zb7A-5wdrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 4 ILE A 466
MET A 715
LEU A 745
LEU A 718
 None
 1.15A 2zb7A-5xipA:
undetectable		 2zb7A-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 28

(Homo sapiens) 		no annotation 4 TYR C1124
ILE C1061
LEU C1115
LEU C1108
 None
 1.17A 2zb7A-6bc1C:
undetectable		 2zb7A-6bc1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL

(endosymbiont of
Tevnia
jerichonana) 		no annotation 4 TYR A 104
ILE A  94
LEU A  68
LEU A  65
 None
 1.04A 2zb7A-6fvsA:
undetectable		 2zb7A-6fvsA:
undetectable