SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z9X_B_PXLB2503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzn FISSION PROTEIN
FIS1P

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		5 GLU A  10
VAL A  14
LEU A  17
TYR A  50
ASP A  53
 None
None
None
GOL  A 301 (-4.9A)
None
 1.41A 2z9xB-1nznA:
undetectable		 2z9xB-1nznA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 104
TYR A 125
ASP A 202
VAL A 204
LYS A 236
 None
PLP  A 400 (-3.6A)
PLP  A 400 (-2.9A)
PLP  A 400 (-4.6A)
PLP  A 400 (-2.7A)
 1.32A 2z9xB-1u08A:
22.8		 2z9xB-1u08A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		5 PRO A 277
LEU A 397
THR A 293
VAL A 285
SER A 288
 None
 1.37A 2z9xB-1yxaA:
undetectable		 2z9xB-1yxaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE

(Bacillus
anthracis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A  26
LEU A 134
THR A 139
ASP A 104
VAL A 120
 None
 1.19A 2z9xB-2btuA:
undetectable		 2z9xB-2btuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLU A 115
PRO A  75
LEU A  78
ASP A 296
LYS A 185
 None
 1.50A 2z9xB-2c7zA:
0.5		 2z9xB-2c7zA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A  26
LEU A 134
THR A 139
ASP A 104
VAL A 120
 None
 1.07A 2z9xB-2z01A:
undetectable		 2z9xB-2z01A:
23.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		10 GLU A  68
PRO A  69
VAL A  70
LEU A  73
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
PXM  A1501 (-4.1A)
None
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
 0.31A 2z9xB-2z9vA:
69.1		 2z9xB-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		5 TYR A  95
CYH A 142
ASP A 171
SER A 174
LYS A 197
 PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 3.7A)
SO4  A1601 (-2.7A)
 1.02A 2z9xB-2z9vA:
69.1		 2z9xB-2z9vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		5 VAL A  95
TYR A 119
CYH A 167
ASP A 199
LYS A 234
 0JO  A 401 ( 3.8A)
0JO  A 401 ( 3.7A)
0JO  A 401 (-3.3A)
0JO  A 401 (-2.8A)
0JO  A 401 (-2.8A)
 1.14A 2z9xB-3b1eA:
23.1		 2z9xB-3b1eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		5 PRO A 243
VAL A 244
LEU A 247
VAL A 320
SER A 319
 None
 0.84A 2z9xB-3glgA:
1.3		 2z9xB-3glgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		5 PRO A 243
VAL A 244
THR A 311
VAL A 320
SER A 319
 None
 1.34A 2z9xB-3glgA:
1.3		 2z9xB-3glgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT

(Vibrio
parahaemolyticus) 		PF00532
(Peripla_BP_1) 		5 VAL B  53
LEU B  63
THR B 118
VAL B 282
SER B 281
 None
 1.05A 2z9xB-3o1hB:
4.3		 2z9xB-3o1hB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc5 TOXIN COREGULATED
PILUS BIOSYNTHESIS
PROTEIN F

(Vibrio cholerae) 		PF06340
(TcpF) 		5 PRO A 184
VAL A 151
THR A 176
VAL A 179
SER A 178
 None
 1.42A 2z9xB-3oc5A:
undetectable		 2z9xB-3oc5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		5 VAL A  92
LEU A  95
TYR A 116
CYH A 163
ASP A 195
 LLP  A 230 ( 3.8A)
None
LLP  A 230 ( 3.8A)
LLP  A 230 ( 3.5A)
LLP  A 230 ( 3.0A)
 0.84A 2z9xB-3t32A:
22.6		 2z9xB-3t32A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaj DE NOVO DESIGNED
PROTEIN OR258

(synthetic
construct) 		no annotation 5 PRO A  53
VAL A 126
LEU A 127
ASP A  26
VAL A  29
 None
 1.48A 2z9xB-5gajA:
2.1		 2z9xB-5gajA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 5 LEU A 139
TYR A 160
ASP A 247
VAL A 249
LYS A 281
 None
PLP  A 701 (-4.0A)
PLP  A 701 (-3.0A)
None
PLP  A 701 (-1.5A)
 1.18A 2z9xB-5verA:
21.9		 2z9xB-5verA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 5 GLU B 226
CYH B 199
VAL B 182
SER B 181
LYS B 179
 None
 1.39A 2z9xB-6ckcB:
undetectable		 2z9xB-6ckcB:
11.53