SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z9X_A_PXLA1503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		9 GLU A  68
PRO A  69
VAL A  70
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
PXM  A1501 (-4.1A)
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
 0.24A 2z9xA-2z9vA:
70.2		 2z9xA-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		5 TYR A  95
CYH A 142
ASP A 171
SER A 174
LYS A 197
 PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 3.7A)
SO4  A1601 (-2.7A)
 1.01A 2z9xA-2z9vA:
70.2		 2z9xA-2z9vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		5 VAL A  95
TYR A 119
CYH A 167
ASP A 199
LYS A 234
 0JO  A 401 ( 3.8A)
0JO  A 401 ( 3.7A)
0JO  A 401 (-3.3A)
0JO  A 401 (-2.8A)
0JO  A 401 (-2.8A)
 1.14A 2z9xA-3b1eA:
22.8		 2z9xA-3b1eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		5 PRO A 243
VAL A 244
THR A 311
VAL A 320
SER A 319
 None
 1.36A 2z9xA-3glgA:
1.3		 2z9xA-3glgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 5 GLU B 226
CYH B 199
VAL B 182
SER B 181
LYS B 179
 None
 1.41A 2z9xA-6ckcB:
0.0		 2z9xA-6ckcB:
11.53