SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z9W_B_PXLB1197_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m32 2-AMINOETHYLPHOSPHON
ATE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 TYR A  91
THR A 142
ASP A 167
SER A 170
LYS A 193
 PLP  A4401 ( 3.6A)
PLP  A4401 (-3.2A)
PLP  A4401 (-2.9A)
PLP  A4401 ( 3.8A)
PLP  A4401 ( 4.2A)
 0.70A 2z9wB-1m32A:
42.4		 2z9wB-1m32A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m32 2-AMINOETHYLPHOSPHON
ATE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 TYR A  91
THR A 142
SER A 170
ASN A 192
LYS A 193
 PLP  A4401 ( 3.6A)
PLP  A4401 (-3.2A)
PLP  A4401 ( 3.8A)
None
PLP  A4401 ( 4.2A)
 0.84A 2z9wB-1m32A:
42.4		 2z9wB-1m32A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		5 PRO 3  54
LEU 2 177
VAL 1 279
ASN 3  57
LYS 1 281
 None
 1.20A 2z9wB-1rhi3:
undetectable		 2z9wB-1rhi3:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 104
TYR A 125
ASP A 202
VAL A 204
LYS A 236
 None
PLP  A 400 (-3.6A)
PLP  A 400 (-2.9A)
PLP  A 400 (-4.6A)
PLP  A 400 (-2.7A)
 0.92A 2z9wB-1u08A:
22.7		 2z9wB-1u08A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		5 PRO A 277
LEU A 397
THR A 293
VAL A 285
SER A 288
 None
 1.35A 2z9wB-1yxaA:
undetectable		 2z9wB-1yxaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		5 THR A 157
ASP A 182
VAL A 184
SER A 185
LYS A 208
 PLP  A1001 (-2.8A)
PLP  A1001 (-2.8A)
PLP  A1001 (-4.2A)
PLP  A1001 (-3.6A)
PLP  A1001 (-1.4A)
 0.33A 2z9wB-2dr1A:
47.9		 2z9wB-2dr1A:
28.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		10 GLU A  68
PRO A  69
LEU A  73
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
ASN A 196
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
None
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
None
 0.38A 2z9wB-2z9vA:
69.7		 2z9wB-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		8 GLU A  68
PRO A  69
TYR A  95
CYH A 142
THR A 146
SER A 174
ASN A 196
LYS A 197
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 ( 3.7A)
None
SO4  A1601 (-2.7A)
 0.71A 2z9wB-2z9vA:
69.7		 2z9wB-2z9vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		5 GLU A 154
PRO A 149
THR A  29
SER A 293
ASN A 223
 None
 1.25A 2z9wB-3dcdA:
undetectable		 2z9wB-3dcdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlt ESTERASE D

(Lactobacillus
rhamnosus) 		PF12146
(Hydrolase_4) 		5 GLU A  57
PRO A  58
LEU A  62
SER A 148
ASN A 139
 None
 1.26A 2z9wB-3dltA:
undetectable		 2z9wB-3dltA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 CYH A 152
THR A 156
ASP A 176
SER A 179
LYS A 200
 PLP  A 400 ( 3.9A)
PLP  A 400 (-2.9A)
PLP  A 400 (-2.9A)
PLP  A 400 (-3.3A)
PLP  A 400 (-1.4A)
 0.50A 2z9wB-3e77A:
34.1		 2z9wB-3e77A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5u PHOSPHOSERINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00266
(Aminotran_5) 		5 CYH A 144
THR A 148
ASP A 167
SER A 170
LYS A 191
 MES  A 362 ( 4.9A)
MES  A 362 (-3.9A)
MES  A 362 (-3.1A)
MES  A 362 ( 4.6A)
MES  A 362 (-2.8A)
 0.45A 2z9wB-3m5uA:
7.1		 2z9wB-3m5uA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		5 CYH A 149
THR A 153
ASP A 173
SER A 176
LYS A 197
 PLP  A 501 (-3.6A)
PLP  A 501 (-2.9A)
PLP  A 501 (-2.8A)
PLP  A 501 ( 3.9A)
PLP  A 501 (-1.3A)
 0.61A 2z9wB-3qboA:
34.4		 2z9wB-3qboA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 CYH A 149
THR A 153
ASP A 174
SER A 177
LYS A 198
 None
 0.68A 2z9wB-3qm2A:
32.4		 2z9wB-3qm2A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 GLU A 227
LEU A 267
THR A 102
VAL A 242
SER A  99
 None
 1.48A 2z9wB-3rc0A:
undetectable		 2z9wB-3rc0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 THR A 138
ASP A 163
VAL A 165
SER A 166
LYS A 189
 PLP  A1189 (-2.9A)
PLP  A1189 (-2.8A)
PLP  A1189 (-4.2A)
PLP  A1189 (-3.5A)
PLP  A1189 (-1.3A)
 0.49A 2z9wB-3zrpA:
47.5		 2z9wB-3zrpA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		5 GLU A 238
TYR A 234
THR A  33
VAL A 218
ASN A 214
 None
 1.25A 2z9wB-4ql6A:
undetectable		 2z9wB-4ql6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDD

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 PRO B 186
LEU B 201
ASP B 206
SER B 259
ASN D   6
 MGD  B 504 (-4.4A)
None
MGD  B 504 (-2.9A)
MGD  B 504 (-3.7A)
MGD  B 504 (-3.3A)
 1.23A 2z9wB-5t5iB:
undetectable		 2z9wB-5t5iB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 5 LEU A 139
TYR A 160
ASP A 247
VAL A 249
LYS A 281
 None
PLP  A 701 (-4.0A)
PLP  A 701 (-3.0A)
None
PLP  A 701 (-1.5A)
 1.02A 2z9wB-5verA:
21.3		 2z9wB-5verA:
20.59