SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z77_D_NCAD200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylococcus
capsulatus) 		PF02461
(AMO) 		5 ASP B  49
LEU B  97
LEU B  68
LEU B 124
MET B  45
 None
 1.46A 2z77D-1yewB:
0.0		 2z77D-1yewB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE SMALL
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00866
(Ring_hydroxyl_B) 		5 ASP B 534
LEU B 626
LEU B 677
LEU B 628
TYR B 538
 None
 1.32A 2z77D-2b24B:
11.4		 2z77D-2b24B:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		5 ASP A 204
LEU A 186
LEU A 362
LEU A 379
MET A 208
 None
 1.41A 2z77D-2i58A:
0.0		 2z77D-2i58A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of3 ZYG-9

(Caenorhabditis
elegans) 		no annotation 5 SER A 761
LEU A 738
LEU A 773
LEU A 739
TYR A 795
 None
 1.39A 2z77D-2of3A:
undetectable		 2z77D-2of3A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqm CELL INHIBITING
FACTOR (CIFBP)

(Burkholderia
pseudomallei) 		PF16374
(CIF) 		5 SER A 200
LEU A 143
LEU A 214
LEU A 215
MET A 206
 None
 1.38A 2z77D-3gqmA:
0.0		 2z77D-3gqmA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ier OHP9

(synthetic
construct) 		PF02136
(NTF2) 		5 TRP A  13
TRP A  24
LEU A  69
LEU A  89
TYR A 109
 None
3QZ  A 201 ( 4.5A)
3QZ  A 201 (-4.0A)
3QZ  A 201 ( 4.5A)
None
 0.85A 2z77D-5ierA:
26.0		 2z77D-5ierA:
95.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z3r STEROID
DELTA-ISOMERASE

(Mycolicibacterium
neoaurum) 		no annotation 8 SER A  20
TRP A  21
TRP A  32
ASP A  44
LEU A  77
LEU A  97
LEU A  99
TYR A 117
 None
 0.79A 2z77D-5z3rA:
25.1		 2z77D-5z3rA:
undetectable