SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z54_A_AB1A200_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

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	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1fk8	3ALPHA-HYDROXYSTEROI D DEHYDROGENASE/CARBON YL REDUCTASE (Comamonas testosteroni)	PF00106 (adh_short) PF13561 (adh_short_C2)	5	ALA A 40 ASP A 41 GLY A 89 VAL A 5 ILE A 31	None NAD A 800 (-3.3A) None None None	1.08A	2z54A-1fk8A: undetectable	2z54A-1fk8A: 17.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ALA A 28 ASP A 29 GLY A 48 PRO A 81 ILE A 84	A79 A 800 (-3.2A) A79 A 800 (-2.7A) A79 A 800 (-4.1A) A79 A 800 ( 3.4A) A79 A 800 (-3.8A)	0.74A	2z54A-1hvcA: 14.1	2z54A-1hvcA: 97.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ALA A 28 ASP A 29 VAL A 32 GLY A 48 ILE A 84	A79 A 800 (-3.1A) A79 A 800 (-2.8A) A79 A 800 ( 4.4A) A79 A 800 (-3.6A) A79 A 800 (-3.6A)	0.70A	2z54A-1hvcA: 14.1	2z54A-1hvcA: 97.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	11	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 32 GLY A 49 ILE A 50 PRO A 81 VAL A 82 ILE A 84	A79 A 800 (-2.7A) A79 A 800 (-3.0A) A79 A 800 (-3.1A) A79 A 800 (-2.8A) A79 A 800 ( 4.9A) A79 A 800 ( 4.4A) A79 A 800 ( 3.7A) A79 A 800 (-3.8A) A79 A 800 ( 3.9A) A79 A 800 (-4.5A) A79 A 800 (-3.6A)	0.46A	2z54A-1hvcA: 14.1	2z54A-1hvcA: 97.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	11	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 32 GLY A 49 ILE A 50 PRO A 81 VAL A 82 ILE A 84	A79 A 800 (-2.8A) A79 A 800 (-3.0A) A79 A 800 (-3.2A) A79 A 800 (-2.7A) A79 A 800 ( 4.7A) A79 A 800 ( 4.3A) A79 A 800 (-3.4A) A79 A 800 ( 4.0A) A79 A 800 ( 3.4A) A79 A 800 (-4.5A) A79 A 800 (-3.8A)	0.37A	2z54A-1hvcA: 14.1	2z54A-1hvcA: 97.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1j9l	STATIONARY PHASE SURVIVAL PROTEIN (Thermotoga maritima)	PF01975 (SurE)	5	GLY A 138 ALA A 139 GLY A 15 VAL A 91 ILE A 126	None	1.02A	2z54A-1j9lA: undetectable	2z54A-1j9lA: 16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1kae	HISTIDINOL DEHYDROGENASE (Escherichia coli)	PF00815 (Histidinol_dh)	5	GLY A 227 ALA A 228 ASP A 204 GLY A 196 ILE A 206	None	0.90A	2z54A-1kaeA: undetectable	2z54A-1kaeA: 13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1lk5	D-RIBOSE-5-PHOSPHATE ISOMERASE (Pyrococcus horikoshii)	PF06026 (Rib_5-P_isom_A)	5	GLY A 101 ALA A 102 GLY A 207 ILE A 97 ILE A 179	CL A1001 (-3.4A) None None None None	0.84A	2z54A-1lk5A: undetectable	2z54A-1lk5A: 18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1lrt	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Tritrichomonas suis)	PF00478 (IMPDH)	5	GLY A 288 ASP A 261 GLY A 235 VAL A 247 ILE A 238	None TAD A 901 (-2.3A) None None None	0.89A	2z54A-1lrtA: undetectable	2z54A-1lrtA: 15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1mew	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Tritrichomonas suis)	PF00478 (IMPDH) PF00571 (CBS)	5	GLY A 288 ASP A 261 GLY A 235 VAL A 247 ILE A 238	None NAD A 987 (-2.5A) None None None	0.81A	2z54A-1mewA: undetectable	2z54A-1mewA: 12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1naa	CELLOBIOSE DEHYDROGENASE (Phanerochaete chrysosporium)	PF00732 (GMC_oxred_N) PF05199 (GMC_oxred_C)	5	GLY A 223 ALA A 224 VAL A 407 GLY A 305 ILE A 229	6FA A 801 (-3.0A) 6FA A 801 ( 4.9A) None 6FA A 801 (-3.5A) None	1.01A	2z54A-1naaA: undetectable	2z54A-1naaA: 11.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1q9p	HIV-1 PROTEASE (Homo sapiens)	PF00077 (RVP)	5	ALA A 28 ASP A 30 VAL A 32 PRO A 81 ILE A 84	None	0.72A	2z54A-1q9pA: 10.0	2z54A-1q9pA: 92.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1q9p	HIV-1 PROTEASE (Homo sapiens)	PF00077 (RVP)	7	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 32 ILE A 84	None	0.54A	2z54A-1q9pA: 10.0	2z54A-1q9pA: 92.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	10	ARG A 8 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None	0.49A	2z54A-1sivA: 18.4	2z54A-1sivA: 49.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1tjr	BX1 (Zea mays)	PF00290 (Trp_syntA)	5	GLY A 307 ALA A 308 ASP A 309 VAL A 269 ILE A 303	None	0.83A	2z54A-1tjrA: undetectable	2z54A-1tjrA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1to3	PUTATIVE ALDOLASE YIHT (Salmonella enterica)	PF01791 (DeoC)	5	GLY A 188 ALA A 189 ASP A 190 VAL A 127 ILE A 158	None	0.66A	2z54A-1to3A: undetectable	2z54A-1to3A: 15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1uww	ENDOGLUCANASE (Bacillus akibai)	PF03424 (CBM_17_28)	5	ALA A 122 VAL A 89 ILE A 169 VAL A 147 ILE A 149	None	0.92A	2z54A-1uwwA: undetectable	2z54A-1uwwA: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1v5f	PYRUVATE OXIDASE (Aerococcus viridans)	PF00205 (TPP_enzyme_M) PF02775 (TPP_enzyme_C) PF02776 (TPP_enzyme_N)	5	ASP A 388 ALA A 444 ASP A 442 VAL A 466 ILE A 440	None TPP A1602 (-3.7A) MG A1603 ( 2.8A) None None	0.88A	2z54A-1v5fA: undetectable	2z54A-1v5fA: 10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1v5j	KIAA1355 PROTEIN (Homo sapiens)	PF00041 (fn3)	5	GLY A 85 ALA A 84 VAL A 33 GLY A 60 PRO A 11	None	0.97A	2z54A-1v5jA: undetectable	2z54A-1v5jA: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1w3f	HEMOLYTIC LECTIN FROM LAETIPORUS SULPHUREUS (Laetiporus sulphureus)	PF03318 (ETX_MTX2)	5	GLY A 241 GLY A 296 ILE A 297 PRO A 221 VAL A 220	None	0.97A	2z54A-1w3fA: undetectable	2z54A-1w3fA: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xtz	RIBOSE-5-PHOSPHATE ISOMERASE (Saccharomyces cerevisiae)	PF06026 (Rib_5-P_isom_A)	5	GLY A 123 ALA A 124 GLY A 235 ILE A 119 ILE A 207	None	0.87A	2z54A-1xtzA: undetectable	2z54A-1xtzA: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yg0	COP ASSOCIATED PROTEIN (Helicobacter pylori)	PF00403 (HMA)	5	GLY A 62 ALA A 61 ASP A 60 VAL A 23 ILE A 19	None	0.98A	2z54A-1yg0A: undetectable	2z54A-1yg0A: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yr2	PROLYL OLIGOPEPTIDASE (Novosphingobium capsulatum)	PF00326 (Peptidase_S9) PF02897 (Peptidase_S9_N)	5	ALA A 538 ASP A 537 GLY A 529 PRO A 475 VAL A 474	None	1.07A	2z54A-1yr2A: undetectable	2z54A-1yr2A: 8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yr2	PROLYL OLIGOPEPTIDASE (Novosphingobium capsulatum)	PF00326 (Peptidase_S9) PF02897 (Peptidase_S9_N)	5	GLY A 539 ALA A 538 ASP A 537 GLY A 529 PRO A 475	None	1.07A	2z54A-1yr2A: undetectable	2z54A-1yr2A: 8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zno	HYPOTHETICAL UPF0244 PROTEIN VC0702 (Vibrio cholerae)	PF01931 (NTPase_I-T)	5	ARG A 74 GLY A 77 ALA A 78 VAL A 44 ILE A 14	None	0.82A	2z54A-1znoA: undetectable	2z54A-1znoA: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2bc0	NADH OXIDASE (Streptococcus pyogenes)	PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	GLY A 453 ALA A 454 ASP A 456 ILE A 387 ILE A 426	None	0.68A	2z54A-2bc0A: undetectable	2z54A-2bc0A: 12.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2fmb	EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE (Equine infectious anemia virus)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 VAL A 32 GLY A 55 PRO A 86 VAL A 87 ILE A 89	LP1 A 201 (-2.3A) LP1 A 201 (-3.8A) LP1 A 201 (-3.5A) LP1 A 201 (-3.6A) None LP1 A 201 (-3.4A) LP1 A 201 (-3.9A) LP1 A 201 ( 4.9A) LP1 A 201 (-4.2A)	0.49A	2z54A-2fmbA: 15.1	2z54A-2fmbA: 30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2isq	CYSTEINE SYNTHASE (Arabidopsis thaliana)	PF00291 (PALP)	5	GLY A 190 ALA A 189 GLY A 183 ILE A 180 PRO A 296	None None PLP A 400 (-3.4A) PLP A 400 (-4.9A) PLP A 400 (-4.0A)	0.82A	2z54A-2isqA: undetectable	2z54A-2isqA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2iwz	3-OXOACYL-[ACYL-CARR IER-PROTEIN] SYNTHASE (Homo sapiens)	PF00109 (ketoacyl-synt) PF02801 (Ketoacyl-synt_C)	5	GLY A 234 ALA A 233 GLY A 48 ILE A 49 VAL A 302	None	0.90A	2z54A-2iwzA: undetectable	2z54A-2iwzA: 14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ARG A 8 GLY A 27 GLY A 49 ILE A 50 PRO A 81 ILE A 84	AB1 A 501 ( 4.7A) AB1 A 501 (-3.9A) AB1 A 501 (-3.5A) AB1 A 501 (-3.8A) AB1 A 501 (-4.2A) AB1 A 501 ( 4.2A)	0.57A	2z54A-2rkfA: 21.1	2z54A-2rkfA: 87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 PRO A 81 ILE A 84	AB1 A 501 (-2.4A) AB1 A 501 (-3.9A) AB1 A 501 (-3.5A) AB1 A 501 ( 3.3A) AB1 A 501 (-3.8A) AB1 A 501 (-3.5A) AB1 A 501 (-3.8A) AB1 A 501 (-4.2A) AB1 A 501 ( 4.2A)	0.30A	2z54A-2rkfA: 21.1	2z54A-2rkfA: 87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rsp	RSV PROTEASE (Rous sarcoma virus)	PF00077 (RVP)	5	ARG A 10 ASP A 37 ALA A 40 ASP A 41 ILE A 108	None	0.93A	2z54A-2rspA: 12.9	2z54A-2rspA: 30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rsp	RSV PROTEASE (Rous sarcoma virus)	PF00077 (RVP)	5	ASP A 37 GLY A 39 ALA A 40 ASP A 41 ILE A 108	None	0.39A	2z54A-2rspA: 12.9	2z54A-2rspA: 30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2w45	ALKALINE EXONUCLEASE (Human gammaherpesvirus 4)	PF01771 (Herpes_alk_exo)	5	GLY A 442 ALA A 441 GLY A 461 PRO A 42 ILE A 197	None	1.03A	2z54A-2w45A: undetectable	2z54A-2w45A: 14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2z2i	PEPTIDYL-TRNA HYDROLASE (Mycobacterium tuberculosis)	PF01195 (Pept_tRNA_hydro)	5	GLY A 47 ALA A 48 VAL A 8 GLY A 77 VAL A 61	None	0.94A	2z54A-2z2iA: undetectable	2z54A-2z2iA: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zc0	ALANINE GLYOXYLATE TRANSAMINASE (Thermococcus litoralis)	PF00155 (Aminotran_1_2)	5	GLY A 243 ALA A 242 ASP A 214 ILE A 105 VAL A 268	None None PMP A 409 (-2.7A) None None	1.00A	2z54A-2zc0A: undetectable	2z54A-2zc0A: 13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3abi	PUTATIVE UNCHARACTERIZED PROTEIN PH1688 (Pyrococcus horikoshii)	PF03435 (Sacchrp_dh_NADP) PF16653 (Sacchrp_dh_C)	5	GLY A 117 ALA A 116 ASP A 115 GLY A 67 ILE A 306	NAD A1001 (-3.6A) None None None None	0.97A	2z54A-3abiA: undetectable	2z54A-3abiA: 14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3b1s	FLAGELLAR BIOSYNTHETIC PROTEIN FLHB (Aquifex aeolicus)	PF01312 (Bac_export_2)	5	ALA B 270 VAL B 322 GLY B 287 ILE B 267 VAL B 320	None	0.99A	2z54A-3b1sB: undetectable	2z54A-3b1sB: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cgg	SAM-DEPENDENT METHYLTRANSFERASE (Corynebacterium glutamicum)	PF13649 (Methyltransf_25)	5	ASP A 51 GLY A 53 GLY A 145 ILE A 144 ILE A 59	None NHE A 195 (-3.2A) None NHE A 195 ( 4.5A) None	1.05A	2z54A-3cggA: undetectable	2z54A-3cggA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dbg	PUTATIVE CYTOCHROME P450 (Streptomyces coelicolor)	PF00067 (p450)	5	GLY A 359 ALA A 360 ASP A 361 PRO A 24 ILE A 356	None	0.94A	2z54A-3dbgA: undetectable	2z54A-3dbgA: 11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3f6m	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Yersinia pestis)	PF02542 (YgbB)	5	GLY A 39 ASP A 8 GLY A 147 PRO A 105 ILE A 22	None	1.07A	2z54A-3f6mA: undetectable	2z54A-3f6mA: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gve	YFKN PROTEIN (Bacillus subtilis)	PF00149 (Metallophos)	5	GLY A 121 ALA A 122 ASP A 123 ILE A 89 ILE A 126	None	0.76A	2z54A-3gveA: undetectable	2z54A-3gveA: 14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hdf	LYSOZYME (Escherichia virus Lambda)	PF00959 (Phage_lysozyme)	5	ALA A 131 ASP A 127 GLY A 163 PRO A 95 ILE A 123	None	0.99A	2z54A-3hdfA: undetectable	2z54A-3hdfA: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hdy	UDP-GALACTOPYRANOSE MUTASE (Deinococcus radiodurans)	PF03275 (GLF) PF13450 (NAD_binding_8)	5	GLY A 38 ALA A 37 VAL A 237 VAL A 55 ILE A 57	FAD A 450 (-3.3A) None None None None	0.85A	2z54A-3hdyA: undetectable	2z54A-3hdyA: 11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i5g	MYOSIN HEAVY CHAIN ISOFORM A (Doryteuthis pealeii)	PF00063 (Myosin_head) PF00612 (IQ) PF02736 (Myosin_N)	5	ALA A 265 ASP A 266 GLY A 460 ILE A 459 ILE A 224	None	0.93A	2z54A-3i5gA: undetectable	2z54A-3i5gA: 8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i5g	MYOSIN HEAVY CHAIN ISOFORM A (Doryteuthis pealeii)	PF00063 (Myosin_head) PF00612 (IQ) PF02736 (Myosin_N)	5	GLY A 264 ALA A 265 ASP A 266 GLY A 460 ILE A 459	None	0.81A	2z54A-3i5gA: undetectable	2z54A-3i5gA: 8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3l2z	BIRA BIFUNCTIONAL PROTEIN (Mycobacterium tuberculosis)	PF02237 (BPL_C) PF03099 (BPL_LplA_LipB)	5	GLY A 50 ALA A 51 VAL A 56 VAL A 152 ILE A 53	None	1.06A	2z54A-3l2zA: undetectable	2z54A-3l2zA: 18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lun	ULILYSIN (Methanosarcina acetivorans)	PF05572 (Peptidase_M43)	5	ALA A 209 ASP A 207 VAL A 175 ILE A 93 ILE A 205	None	0.96A	2z54A-3lunA: undetectable	2z54A-3lunA: 20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ALA A 28 ASP A 29 ASP A 30 VAL A 32 GLY A 48 PRO A 81	None	0.81A	2z54A-3mwsA: 20.0	2z54A-3mwsA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	10	ARG A 8 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 32 PRO A 81 VAL A 82 ILE A 84	None	0.53A	2z54A-3mwsA: 20.0	2z54A-3mwsA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	11	ARG A 8 ASP A 25 GLY A 27 ALA A 28 ASP A 29 VAL A 32 GLY A 49 ILE A 50 PRO A 81 VAL A 82 ILE A 84	None	0.49A	2z54A-3mwsA: 20.0	2z54A-3mwsA: 76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o8l	6-PHOSPHOFRUCTOKINAS E, MUSCLE TYPE (Oryctolagus cuniculus)	PF00365 (PFK)	5	GLY A 224 ALA A 225 ASP A 226 ILE A 192 VAL A 207	PO4 A 767 ( 4.6A) None None None None	1.04A	2z54A-3o8lA: undetectable	2z54A-3o8lA: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	PF00365 (PFK)	5	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.93A	2z54A-3o8oA: undetectable	2z54A-3o8oA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3opy	6-PHOSPHOFRUCTO-1-KI NASE ALPHA-SUBUNIT (Komagataella pastoris)	PF00365 (PFK)	5	GLY A 419 ALA A 420 ASP A 421 VAL A 402 ILE A 457	None	0.79A	2z54A-3opyA: undetectable	2z54A-3opyA: 8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3p4g	ANTIFREEZE PROTEIN (Marinomonas primoryensis)	no annotation	5	ASP A 103 GLY A 99 ALA A 98 VAL A 124 GLY A 137	CA A 403 ( 2.4A) CA A 403 (-4.1A) CA A 404 (-4.5A) None CA A 405 (-4.1A)	1.01A	2z54A-3p4gA: undetectable	2z54A-3p4gA: 14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3pgy	SERINE HYDROXYMETHYLTRANSFE RASE (Staphylococcus aureus)	PF00464 (SHMT)	5	GLY A 208 ALA A 207 ILE A 201 PRO A 362 VAL A 285	None	1.05A	2z54A-3pgyA: undetectable	2z54A-3pgyA: 12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rcm	TATD FAMILY HYDROLASE (Pseudomonas putida)	PF01026 (TatD_DNase)	5	ASP A 5 GLY A 7 ASP A 209 VAL A 235 GLY A 178	None None CIT A 289 (-3.3A) None None	1.07A	2z54A-3rcmA: undetectable	2z54A-3rcmA: 19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3slz	GAG-PRO-POL POLYPROTEIN (Murine leukemia virus)	PF00077 (RVP)	5	ASP A 32 GLY A 34 ALA A 35 VAL A 39 GLY A 56	3TL A 126 (-2.4A) 3TL A 126 (-3.1A) 3TL A 126 ( 4.0A) None 3TL A 126 (-3.4A)	0.58A	2z54A-3slzA: 11.1	2z54A-3slzA: 28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3slz	GAG-PRO-POL POLYPROTEIN (Murine leukemia virus)	PF00077 (RVP)	5	ASP A 32 GLY A 34 ALA A 35 VAL A 39 PRO A 89	3TL A 126 (-2.4A) 3TL A 126 (-3.1A) 3TL A 126 ( 4.0A) None 3TL A 126 (-4.0A)	0.58A	2z54A-3slzA: 11.1	2z54A-3slzA: 28.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	ARG A 8 ASP A 25 GLY A 27 ALA A 28 ASP A 29 VAL A 32 GLY A 49 ILE A 50	SO4 A 101 (-3.8A) 017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-3.5A) 017 A 201 (-3.5A) None 017 A 201 (-4.0A) 017 A 201 (-3.3A)	0.56A	2z54A-3t3cA: 18.7	2z54A-3t3cA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 32 GLY A 49 ILE A 50	017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-3.5A) 017 A 201 (-3.5A) 017 A 201 (-4.2A) None 017 A 201 (-4.0A) 017 A 201 (-3.3A)	0.40A	2z54A-3t3cA: 18.7	2z54A-3t3cA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 32 GLY A 49 PRO A 81	017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-3.5A) 017 A 201 (-3.5A) 017 A 201 (-4.2A) None 017 A 201 (-4.0A) None	0.55A	2z54A-3t3cA: 18.7	2z54A-3t3cA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	10	ARG A 8 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 PRO A 81 ILE A 84	017 A 201 ( 4.8A) 017 A 201 (-2.6A) 017 A 201 (-3.6A) 017 A 201 (-3.4A) 017 A 201 (-3.3A) 017 A 201 (-4.6A) 017 A 201 (-3.0A) 017 A 201 (-3.3A) 017 A 201 (-4.1A) 017 A 201 (-4.7A)	0.44A	2z54A-3ttpA: 19.8	2z54A-3ttpA: 79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	8	ARG A 8 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ILE A 50 PRO A 81	None 017 A 202 ( 2.5A) 017 A 201 ( 3.5A) 017 A 201 (-3.4A) 017 A 201 (-3.2A) 017 A 201 ( 4.0A) 017 A 201 ( 3.5A) 017 A 202 (-4.0A)	0.50A	2z54A-3u7sA: 19.9	2z54A-3u7sA: 78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 PRO A 81	017 A 202 ( 2.5A) 017 A 201 ( 3.5A) 017 A 201 (-3.4A) 017 A 201 (-3.2A) 017 A 201 ( 4.0A) 017 A 202 (-2.9A) 017 A 201 ( 3.5A) 017 A 202 (-4.0A)	0.40A	2z54A-3u7sA: 19.9	2z54A-3u7sA: 78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3uhl	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 ASP A 29 PRO A 81 VAL A 82	None	0.54A	2z54A-3uhlA: 16.2	2z54A-3uhlA: 77.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wn6	ALPHA-AMYLASE (Oryza sativa)	PF00128 (Alpha-amylase) PF07821 (Alpha-amyl_C2)	5	GLY A 58 ASP A 52 VAL A 51 GLY A 106 ILE A 54	None	1.04A	2z54A-3wn6A: undetectable	2z54A-3wn6A: 13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ao7	ESTERASE (unidentified)	PF12146 (Hydrolase_4)	5	ALA A 125 VAL A 31 ILE A 119 PRO A 82 ILE A 79	None	0.81A	2z54A-4ao7A: undetectable	2z54A-4ao7A: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4b2o	YMDB PHOSPHODIESTERASE (Bacillus subtilis)	PF13277 (YmdB)	5	GLY A 59 ALA A 60 ASP A 61 VAL A 9 ILE A 36	None	0.87A	2z54A-4b2oA: undetectable	2z54A-4b2oA: 16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4dpp	DIHYDRODIPICOLINATE SYNTHASE 2, CHLOROPLASTIC (Arabidopsis thaliana)	PF00701 (DHDPS)	5	ASP A 83 ALA A 86 ASP A 89 GLY A 312 VAL A 317	None	1.06A	2z54A-4dppA: undetectable	2z54A-4dppA: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4fxg	MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN (Homo sapiens)	PF00089 (Trypsin)	5	GLY H 667 ALA H 619 GLY H 651 VAL H 588 ILE H 590	None	1.05A	2z54A-4fxgH: undetectable	2z54A-4fxgH: 17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4k5u	VARIABLE LYMPHOCYTE RECEPTOR (Petromyzon marinus)	no annotation	5	GLY B 63 GLY B 18 PRO B 25 VAL B 24 ILE B 42	None	0.94A	2z54A-4k5uB: undetectable	2z54A-4k5uB: 17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ALA A 28 ASP A 29 ASP A 30 VAL A 32 GLY A 48	RIT A 500 (-3.6A) RIT A 500 (-3.2A) RIT A 500 (-4.8A) None RIT A 500 (-4.8A)	0.64A	2z54A-4njvA: 20.5	2z54A-4njvA: 87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 32 PRO A 81 ILE A 84	RIT A 500 (-2.4A) RIT A 500 (-3.9A) RIT A 500 (-3.6A) RIT A 500 (-3.2A) RIT A 500 (-4.8A) None RIT A 500 (-3.9A) RIT A 500 (-4.3A)	0.38A	2z54A-4njvA: 20.5	2z54A-4njvA: 87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 VAL A 32 GLY A 49 ILE A 50 PRO A 81 ILE A 84	RIT A 500 (-2.4A) RIT A 500 (-3.9A) RIT A 500 (-3.6A) RIT A 500 (-3.2A) None RIT A 500 (-3.4A) RIT A 500 (-4.3A) RIT A 500 (-3.9A) RIT A 500 (-4.3A)	0.41A	2z54A-4njvA: 20.5	2z54A-4njvA: 87.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4r1u	CINNAMOYL COA REDUCTASE (Medicago truncatula)	PF01370 (Epimerase)	5	GLY A 97 ASP A 59 GLY A 8 VAL A 70 ILE A 66	None	0.87A	2z54A-4r1uA: undetectable	2z54A-4r1uA: 13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rwe	SUGAR-BINDING TRANSPORT PROTEIN (Yersinia pestis)	PF13407 (Peripla_BP_4)	5	GLY A 196 ALA A 190 ILE A 223 VAL A 214 ILE A 156	None None GOL A 401 ( 4.2A) None None	0.99A	2z54A-4rweA: undetectable	2z54A-4rweA: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4u1r	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINAS E, PLATELET TYPE (Homo sapiens)	PF00365 (PFK)	5	GLY A 233 ALA A 234 ASP A 235 VAL A 216 ILE A 270	PO4 A 802 (-4.0A) None PO4 A 802 ( 4.6A) None None	0.90A	2z54A-4u1rA: undetectable	2z54A-4u1rA: 10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4us4	TRANSPORTER (Bacillus halodurans)	PF00209 (SNF)	5	GLY A 396 ALA A 93 VAL A 78 PRO A 332 VAL A 331	None	0.93A	2z54A-4us4A: undetectable	2z54A-4us4A: 12.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ydf	HTLV-1 PROTEASE (Primate T-lymphotropic virus 1)	PF00077 (RVP)	5	ASP A 32 GLY A 34 ALA A 35 ASP A 36 GLY A 58	4B1 A 201 (-2.9A) 4B1 A 201 ( 4.6A) 4B1 A 201 (-3.6A) 4B1 A 201 (-4.4A) 4B1 A 201 (-3.4A)	0.38A	2z54A-4ydfA: 12.9	2z54A-4ydfA: 31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ydf	HTLV-1 PROTEASE (Primate T-lymphotropic virus 1)	PF00077 (RVP)	6	ASP A 32 GLY A 34 ALA A 35 ASP A 36 VAL A 39 ILE A 100	4B1 A 201 (-2.9A) 4B1 A 201 ( 4.6A) 4B1 A 201 (-3.6A) 4B1 A 201 (-4.4A) None 4B1 A 201 (-4.8A)	0.35A	2z54A-4ydfA: 12.9	2z54A-4ydfA: 31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zox	RIBOSOME ASSEMBLY PROTEIN SQT1 (Saccharomyces cerevisiae)	no annotation	5	GLY A 419 ALA A 418 GLY A 84 VAL A 80 ILE A 71	None	1.10A	2z54A-4zoxA: undetectable	2z54A-4zoxA: 13.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5b18	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	GLY A 27 ALA A 28 ASP A 29 ASP A 30 ILE A 84	None	0.13A	2z54A-5b18A: 18.0	2z54A-5b18A: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5b18	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	GLY A 27 ALA A 28 ASP A 29 GLY A 49 ILE A 84	None	0.63A	2z54A-5b18A: 18.0	2z54A-5b18A: 77.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fmg	PROTEASOME, PUTATIVE (Plasmodium falciparum)	PF00227 (Proteasome)	5	ASP H 157 VAL H 12 ILE H 37 VAL H 231 ILE H 233	None	0.86A	2z54A-5fmgH: undetectable	2z54A-5fmgH: 14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5g5g	PUTATIVE XANTHINE DEHYDROGENASE YAGT IRON-SULFUR-BINDING SUBUNIT (Escherichia coli)	PF00111 (Fer2) PF01799 (Fer2_2)	5	GLY A 211 ALA A 212 ASP A 154 GLY A 159 ILE A 216	None None None FES A 230 (-4.2A) None	0.88A	2z54A-5g5gA: undetectable	2z54A-5g5gA: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ilg	PHOTORECEPTOR DEHYDROGENASE, ISOFORM C (Drosophila melanogaster)	PF00106 (adh_short)	5	ASP A 232 ASP A 85 GLY A 174 VAL A 178 ILE A 131	None	1.01A	2z54A-5ilgA: undetectable	2z54A-5ilgA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5j1k	TOXR-ACTIVATED GENE (TAGE) (Helicobacter pylori)	PF01551 (Peptidase_M23)	5	GLY A 230 ALA A 180 VAL A 186 GLY A 234 ILE A 227	None	1.00A	2z54A-5j1kA: undetectable	2z54A-5j1kA: 21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	10	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 32 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None	0.41A	2z54A-5t2zA: 20.2	2z54A-5t2zA: 80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u1w	P2X PURINOCEPTOR (Ailuropoda melanoleuca)	PF00864 (P2X_receptor)	5	ASP A 240 GLY A 253 ILE A 254 VAL A 104 ILE A 315	None	1.02A	2z54A-5u1wA: undetectable	2z54A-5u1wA: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5uib	OXIDOREDUCTASE PROTEIN (Agrobacterium tumefaciens)	PF01408 (GFO_IDH_MocA)	5	GLY A 250 VAL A 265 GLY A 143 VAL A 136 ILE A 255	None	1.02A	2z54A-5uibA: undetectable	2z54A-5uibA: 16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ve3	BPPRF (Paraburkholderia phytofirmans)	no annotation	5	GLY B 88 ALA B 89 ASP B 90 VAL B 59 ILE B 80	None	0.76A	2z54A-5ve3B: undetectable	2z54A-5ve3B: 13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5xj1	UNCHARACTERIZED RNA METHYLTRANSFERASE SP_1029 (Streptococcus pneumoniae)	no annotation	5	GLY A 399 ALA A 400 ASP A 401 ILE A 373 ILE A 378	None	0.98A	2z54A-5xj1A: undetectable	2z54A-5xj1A: 13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5z73	ALR0819 PROTEIN (Nostoc sp. PCC 7120)	no annotation	5	ASP A 183 GLY A 193 VAL A 181 PRO A 128 VAL A 126	None	1.05A	2z54A-5z73A: undetectable	2z54A-5z73A: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6cy1	SIGNAL RECOGNITION PARTICLE RECEPTOR FTSY (Elizabethkingia anophelis)	no annotation	5	GLY A 306 VAL A 266 GLY A 276 VAL A 294 ILE A 292	None	0.92A	2z54A-6cy1A: undetectable	2z54A-6cy1A: 24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6fiv	RETROPEPSIN (Feline immunodeficiency virus)	PF00077 (RVP)	5	ASP A 30 GLY A 32 ALA A 33 ASP A 34 GLY A 58	3TL A 201 (-3.5A) 3TL A 201 (-3.4A) 3TL A 201 (-4.0A) 3TL A 201 (-3.9A) 3TL A 201 (-3.4A)	0.21A	2z54A-6fivA: 15.4	2z54A-6fivA: 27.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	7	ARG A 8 ASP A 25 GLY A 27 ASP A 29 ASP A 30 GLY A 49 ILE A 84	None NIU A 100 (-2.8A) NIU A 100 (-4.5A) None None NIU A 100 ( 3.8A) None	0.63A	2z54A-6upjA: 17.9	2z54A-6upjA: 47.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	7	ARG A 8 GLY A 27 ASP A 29 ASP A 30 GLY A 49 ILE A 50 ILE A 84	None NIU A 100 (-4.5A) None None NIU A 100 ( 3.8A) NIU A 100 (-3.9A) None	0.73A	2z54A-6upjA: 17.9	2z54A-6upjA: 47.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 PRO A 81 ILE A 84	NIU A 100 (-2.8A) NIU A 100 (-4.5A) NIU A 100 (-3.6A) None None NIU A 100 ( 3.8A) None None	0.61A	2z54A-6upjA: 17.9	2z54A-6upjA: 47.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	7	GLY A 27 ASP A 29 ASP A 30 GLY A 49 ILE A 50 PRO A 81 ILE A 84	NIU A 100 (-4.5A) None None NIU A 100 ( 3.8A) NIU A 100 (-3.9A) None None	0.76A	2z54A-6upjA: 17.9	2z54A-6upjA: 47.47

[["2Z54_A_AB1A200_1","1fk8","Comamonas testosteroni","3ALPHA-HYDROXYSTEROID DEHYDROGENASE\/CARBONYL REDUCTASE","PF00106(adh_short);PF13561(adh_short_C2)",5,"ALA A  40;ASP A  41;GLY A  89;VAL A   5;ILE A  31","None;NAD A 800 (-3.3A);None;None;None","1.08A","2z54A-1fk8A:undetectable","2z54A-1fk8A:17.12"],["2Z54_A_AB1A200_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  29;GLY A  48;PRO A  81;ILE A  84","A79 A 800 (-3.2A);A79 A 800 (-2.7A);A79 A 800 (-4.1A);A79 A 800 ( 3.4A);A79 A 800 (-3.8A)","0.74A","2z54A-1hvcA:14.1","2z54A-1hvcA:97.98"],["2Z54_A_AB1A200_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  29;VAL A  32;GLY A  48;ILE A  84","A79 A 800 (-3.1A);A79 A 800 (-2.8A);A79 A 800 ( 4.4A);A79 A 800 (-3.6A);A79 A 800 (-3.6A)","0.70A","2z54A-1hvcA:14.1","2z54A-1hvcA:97.98"],["2Z54_A_AB1A200_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",11,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  32;GLY A  49;ILE A  50;PRO A  81;VAL A  82;ILE A  84","A79 A 800 (-2.7A);A79 A 800 (-3.0A);A79 A 800 (-3.1A);A79 A 800 (-2.8A);A79 A 800 ( 4.9A);A79 A 800 ( 4.4A);A79 A 800 ( 3.7A);A79 A 800 (-3.8A);A79 A 800 ( 3.9A);A79 A 800 (-4.5A);A79 A 800 (-3.6A)","0.46A","2z54A-1hvcA:14.1","2z54A-1hvcA:97.98"],["2Z54_A_AB1A200_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",11,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  32;GLY A  49;ILE A  50;PRO A  81;VAL A  82;ILE A  84","A79 A 800 (-2.8A);A79 A 800 (-3.0A);A79 A 800 (-3.2A);A79 A 800 (-2.7A);A79 A 800 ( 4.7A);A79 A 800 ( 4.3A);A79 A 800 (-3.4A);A79 A 800 ( 4.0A);A79 A 800 ( 3.4A);A79 A 800 (-4.5A);A79 A 800 (-3.8A)","0.37A","2z54A-1hvcA:14.1","2z54A-1hvcA:97.98"],["2Z54_A_AB1A200_1","1j9l","Thermotoga maritima","STATIONARY PHASE SURVIVAL PROTEIN","PF01975(SurE)",5,"GLY A 138;ALA A 139;GLY A  15;VAL A  91;ILE A 126","None","1.02A","2z54A-1j9lA:undetectable","2z54A-1j9lA:16.80"],["2Z54_A_AB1A200_1","1kae","Escherichia coli","HISTIDINOL DEHYDROGENASE","PF00815(Histidinol_dh)",5,"GLY A 227;ALA A 228;ASP A 204;GLY A 196;ILE A 206","None","0.90A","2z54A-1kaeA:undetectable","2z54A-1kaeA:13.23"],["2Z54_A_AB1A200_1","1lk5","Pyrococcus horikoshii","D-RIBOSE-5-PHOSPHATE ISOMERASE","PF06026(Rib_5-P_isom_A)",5,"GLY A 101;ALA A 102;GLY A 207;ILE A  97;ILE A 179"," CL A1001 (-3.4A);None;None;None;None","0.84A","2z54A-1lk5A:undetectable","2z54A-1lk5A:18.33"],["2Z54_A_AB1A200_1","1lrt","Tritrichomonas suis","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","PF00478(IMPDH)",5,"GLY A 288;ASP A 261;GLY A 235;VAL A 247;ILE A 238","None;TAD A 901 (-2.3A);None;None;None","0.89A","2z54A-1lrtA:undetectable","2z54A-1lrtA:15.22"],["2Z54_A_AB1A200_1","1mew","Tritrichomonas suis","INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE","PF00478(IMPDH);PF00571(CBS)",5,"GLY A 288;ASP A 261;GLY A 235;VAL A 247;ILE A 238","None;NAD A 987 (-2.5A);None;None;None","0.81A","2z54A-1mewA:undetectable","2z54A-1mewA:12.40"],["2Z54_A_AB1A200_1","1naa","Phanerochaete chrysosporium","CELLOBIOSE DEHYDROGENASE","PF00732(GMC_oxred_N);PF05199(GMC_oxred_C)",5,"GLY A 223;ALA A 224;VAL A 407;GLY A 305;ILE A 229","6FA A 801 (-3.0A);6FA A 801 ( 4.9A);None;6FA A 801 (-3.5A);None","1.01A","2z54A-1naaA:undetectable","2z54A-1naaA:11.31"],["2Z54_A_AB1A200_1","1q9p","Homo sapiens","HIV-1 PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  30;VAL A  32;PRO A  81;ILE A  84","None","0.72A","2z54A-1q9pA:10.0","2z54A-1q9pA:92.63"],["2Z54_A_AB1A200_1","1q9p","Homo sapiens","HIV-1 PROTEASE","PF00077(RVP)",7,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  32;ILE A  84","None","0.54A","2z54A-1q9pA:10.0","2z54A-1q9pA:92.63"],["2Z54_A_AB1A200_1","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",10,"ARG A   8;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None","0.49A","2z54A-1sivA:18.4","2z54A-1sivA:49.49"],["2Z54_A_AB1A200_1","1tjr","Zea mays","BX1","PF00290(Trp_syntA)",5,"GLY A 307;ALA A 308;ASP A 309;VAL A 269;ILE A 303","None","0.83A","2z54A-1tjrA:undetectable","2z54A-1tjrA:20.00"],["2Z54_A_AB1A200_1","1to3","Salmonella enterica","PUTATIVE ALDOLASE YIHT","PF01791(DeoC)",5,"GLY A 188;ALA A 189;ASP A 190;VAL A 127;ILE A 158","None","0.66A","2z54A-1to3A:undetectable","2z54A-1to3A:15.13"],["2Z54_A_AB1A200_1","1uww","Bacillus akibai","ENDOGLUCANASE","PF03424(CBM_17_28)",5,"ALA A 122;VAL A  89;ILE A 169;VAL A 147;ILE A 149","None","0.92A","2z54A-1uwwA:undetectable","2z54A-1uwwA:21.65"],["2Z54_A_AB1A200_1","1v5f","Aerococcus viridans","PYRUVATE OXIDASE","PF00205(TPP_enzyme_M);PF02775(TPP_enzyme_C);PF02776(TPP_enzyme_N)",5,"ASP A 388;ALA A 444;ASP A 442;VAL A 466;ILE A 440","None;TPP A1602 (-3.7A); MG A1603 ( 2.8A);None;None","0.88A","2z54A-1v5fA:undetectable","2z54A-1v5fA:10.45"],["2Z54_A_AB1A200_1","1v5j","Homo sapiens","KIAA1355 PROTEIN","PF00041(fn3)",5,"GLY A  85;ALA A  84;VAL A  33;GLY A  60;PRO A  11","None","0.97A","2z54A-1v5jA:undetectable","2z54A-1v5jA:21.93"],["2Z54_A_AB1A200_1","1w3f","Laetiporus sulphureus","HEMOLYTIC LECTIN FROM LAETIPORUS SULPHUREUS","PF03318(ETX_MTX2)",5,"GLY A 241;GLY A 296;ILE A 297;PRO A 221;VAL A 220","None","0.97A","2z54A-1w3fA:undetectable","2z54A-1w3fA:16.34"],["2Z54_A_AB1A200_1","1xtz","Saccharomyces cerevisiae","RIBOSE-5-PHOSPHATE ISOMERASE","PF06026(Rib_5-P_isom_A)",5,"GLY A 123;ALA A 124;GLY A 235;ILE A 119;ILE A 207","None","0.87A","2z54A-1xtzA:undetectable","2z54A-1xtzA:21.55"],["2Z54_A_AB1A200_1","1yg0","Helicobacter pylori","COP ASSOCIATED PROTEIN","PF00403(HMA)",5,"GLY A  62;ALA A  61;ASP A  60;VAL A  23;ILE A  19","None","0.98A","2z54A-1yg0A:undetectable","2z54A-1yg0A:18.37"],["2Z54_A_AB1A200_1","1yr2","Novosphingobium capsulatum","PROLYL OLIGOPEPTIDASE","PF00326(Peptidase_S9);PF02897(Peptidase_S9_N)",5,"ALA A 538;ASP A 537;GLY A 529;PRO A 475;VAL A 474","None","1.07A","2z54A-1yr2A:undetectable","2z54A-1yr2A:8.20"],["2Z54_A_AB1A200_1","1yr2","Novosphingobium capsulatum","PROLYL OLIGOPEPTIDASE","PF00326(Peptidase_S9);PF02897(Peptidase_S9_N)",5,"GLY A 539;ALA A 538;ASP A 537;GLY A 529;PRO A 475","None","1.07A","2z54A-1yr2A:undetectable","2z54A-1yr2A:8.20"],["2Z54_A_AB1A200_1","1zno","Vibrio cholerae","HYPOTHETICAL UPF0244 PROTEIN VC0702","PF01931(NTPase_I-T)",5,"ARG A  74;GLY A  77;ALA A  78;VAL A  44;ILE A  14","None","0.82A","2z54A-1znoA:undetectable","2z54A-1znoA:19.54"],["2Z54_A_AB1A200_1","2bc0","Streptococcus pyogenes","NADH OXIDASE","PF02852(Pyr_redox_dim);PF07992(Pyr_redox_2)",5,"GLY A 453;ALA A 454;ASP A 456;ILE A 387;ILE A 426","None","0.68A","2z54A-2bc0A:undetectable","2z54A-2bc0A:12.66"],["2Z54_A_AB1A200_1","2fmb","Equine infectious anemia virus","EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;VAL A  32;GLY A  55;PRO A  86;VAL A  87;ILE A  89","LP1 A 201 (-2.3A);LP1 A 201 (-3.8A);LP1 A 201 (-3.5A);LP1 A 201 (-3.6A);None;LP1 A 201 (-3.4A);LP1 A 201 (-3.9A);LP1 A 201 ( 4.9A);LP1 A 201 (-4.2A)","0.49A","2z54A-2fmbA:15.1","2z54A-2fmbA:30.77"],["2Z54_A_AB1A200_1","2isq","Arabidopsis thaliana","CYSTEINE SYNTHASE","PF00291(PALP)",5,"GLY A 190;ALA A 189;GLY A 183;ILE A 180;PRO A 296","None;None;PLP A 400 (-3.4A);PLP A 400 (-4.9A);PLP A 400 (-4.0A)","0.82A","2z54A-2isqA:undetectable","2z54A-2isqA:15.94"],["2Z54_A_AB1A200_1","2iwz","Homo sapiens","3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE","PF00109(ketoacyl-synt);PF02801(Ketoacyl-synt_C)",5,"GLY A 234;ALA A 233;GLY A  48;ILE A  49;VAL A 302","None","0.90A","2z54A-2iwzA:undetectable","2z54A-2iwzA:14.04"],["2Z54_A_AB1A200_1","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",6,"ARG A   8;GLY A  27;GLY A  49;ILE A  50;PRO A  81;ILE A  84","AB1 A 501 ( 4.7A);AB1 A 501 (-3.9A);AB1 A 501 (-3.5A);AB1 A 501 (-3.8A);AB1 A 501 (-4.2A);AB1 A 501 ( 4.2A)","0.57A","2z54A-2rkfA:21.1","2z54A-2rkfA:87.88"],["2Z54_A_AB1A200_1","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;PRO A  81;ILE A  84","AB1 A 501 (-2.4A);AB1 A 501 (-3.9A);AB1 A 501 (-3.5A);AB1 A 501 ( 3.3A);AB1 A 501 (-3.8A);AB1 A 501 (-3.5A);AB1 A 501 (-3.8A);AB1 A 501 (-4.2A);AB1 A 501 ( 4.2A)","0.30A","2z54A-2rkfA:21.1","2z54A-2rkfA:87.88"],["2Z54_A_AB1A200_1","2rsp","Rous sarcoma virus","RSV PROTEASE","PF00077(RVP)",5,"ARG A  10;ASP A  37;ALA A  40;ASP A  41;ILE A 108","None","0.93A","2z54A-2rspA:12.9","2z54A-2rspA:30.65"],["2Z54_A_AB1A200_1","2rsp","Rous sarcoma virus","RSV PROTEASE","PF00077(RVP)",5,"ASP A  37;GLY A  39;ALA A  40;ASP A  41;ILE A 108","None","0.39A","2z54A-2rspA:12.9","2z54A-2rspA:30.65"],["2Z54_A_AB1A200_1","2w45","Human gammaherpesvirus 4","ALKALINE EXONUCLEASE","PF01771(Herpes_alk_exo)",5,"GLY A 442;ALA A 441;GLY A 461;PRO A  42;ILE A 197","None","1.03A","2z54A-2w45A:undetectable","2z54A-2w45A:14.13"],["2Z54_A_AB1A200_1","2z2i","Mycobacterium tuberculosis","PEPTIDYL-TRNA HYDROLASE","PF01195(Pept_tRNA_hydro)",5,"GLY A  47;ALA A  48;VAL A   8;GLY A  77;VAL A  61","None","0.94A","2z54A-2z2iA:undetectable","2z54A-2z2iA:19.37"],["2Z54_A_AB1A200_1","2zc0","Thermococcus litoralis","ALANINE GLYOXYLATE TRANSAMINASE","PF00155(Aminotran_1_2)",5,"GLY A 243;ALA A 242;ASP A 214;ILE A 105;VAL A 268","None;None;PMP A 409 (-2.7A);None;None","1.00A","2z54A-2zc0A:undetectable","2z54A-2zc0A:13.80"],["2Z54_A_AB1A200_1","3abi","Pyrococcus horikoshii","PUTATIVE UNCHARACTERIZED PROTEIN PH1688","PF03435(Sacchrp_dh_NADP);PF16653(Sacchrp_dh_C)",5,"GLY A 117;ALA A 116;ASP A 115;GLY A  67;ILE A 306","NAD A1001 (-3.6A);None;None;None;None","0.97A","2z54A-3abiA:undetectable","2z54A-3abiA:14.57"],["2Z54_A_AB1A200_1","3b1s","Aquifex aeolicus","FLAGELLAR BIOSYNTHETIC PROTEIN FLHB","PF01312(Bac_export_2)",5,"ALA B 270;VAL B 322;GLY B 287;ILE B 267;VAL B 320","None","0.99A","2z54A-3b1sB:undetectable","2z54A-3b1sB:21.05"],["2Z54_A_AB1A200_1","3cgg","Corynebacterium glutamicum","SAM-DEPENDENT METHYLTRANSFERASE","PF13649(Methyltransf_25)",5,"ASP A  51;GLY A  53;GLY A 145;ILE A 144;ILE A  59","None;NHE A 195 (-3.2A);None;NHE A 195 ( 4.5A);None","1.05A","2z54A-3cggA:undetectable","2z54A-3cggA:18.75"],["2Z54_A_AB1A200_1","3dbg","Streptomyces coelicolor","PUTATIVE CYTOCHROME P450","PF00067(p450)",5,"GLY A 359;ALA A 360;ASP A 361;PRO A  24;ILE A 356","None","0.94A","2z54A-3dbgA:undetectable","2z54A-3dbgA:11.56"],["2Z54_A_AB1A200_1","3f6m","Yersinia pestis","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","PF02542(YgbB)",5,"GLY A  39;ASP A   8;GLY A 147;PRO A 105;ILE A  22","None","1.07A","2z54A-3f6mA:undetectable","2z54A-3f6mA:21.89"],["2Z54_A_AB1A200_1","3gve","Bacillus subtilis","YFKN PROTEIN","PF00149(Metallophos)",5,"GLY A 121;ALA A 122;ASP A 123;ILE A  89;ILE A 126","None","0.76A","2z54A-3gveA:undetectable","2z54A-3gveA:14.80"],["2Z54_A_AB1A200_1","3hdf","Escherichia virus Lambda","LYSOZYME","PF00959(Phage_lysozyme)",5,"ALA A 131;ASP A 127;GLY A 163;PRO A  95;ILE A 123","None","0.99A","2z54A-3hdfA:undetectable","2z54A-3hdfA:18.84"],["2Z54_A_AB1A200_1","3hdy","Deinococcus radiodurans","UDP-GALACTOPYRANOSE MUTASE","PF03275(GLF);PF13450(NAD_binding_8)",5,"GLY A  38;ALA A  37;VAL A 237;VAL A  55;ILE A  57","FAD A 450 (-3.3A);None;None;None;None","0.85A","2z54A-3hdyA:undetectable","2z54A-3hdyA:11.84"],["2Z54_A_AB1A200_1","3i5g","Doryteuthis pealeii","MYOSIN HEAVY CHAIN ISOFORM A","PF00063(Myosin_head);PF00612(IQ);PF02736(Myosin_N)",5,"ALA A 265;ASP A 266;GLY A 460;ILE A 459;ILE A 224","None","0.93A","2z54A-3i5gA:undetectable","2z54A-3i5gA:8.12"],["2Z54_A_AB1A200_1","3i5g","Doryteuthis pealeii","MYOSIN HEAVY CHAIN ISOFORM A","PF00063(Myosin_head);PF00612(IQ);PF02736(Myosin_N)",5,"GLY A 264;ALA A 265;ASP A 266;GLY A 460;ILE A 459","None","0.81A","2z54A-3i5gA:undetectable","2z54A-3i5gA:8.12"],["2Z54_A_AB1A200_1","3l2z","Mycobacterium tuberculosis","BIRA BIFUNCTIONAL PROTEIN","PF02237(BPL_C);PF03099(BPL_LplA_LipB)",5,"GLY A  50;ALA A  51;VAL A  56;VAL A 152;ILE A  53","None","1.06A","2z54A-3l2zA:undetectable","2z54A-3l2zA:18.29"],["2Z54_A_AB1A200_1","3lun","Methanosarcina acetivorans","ULILYSIN","PF05572(Peptidase_M43)",5,"ALA A 209;ASP A 207;VAL A 175;ILE A  93;ILE A 205","None","0.96A","2z54A-3lunA:undetectable","2z54A-3lunA:20.40"],["2Z54_A_AB1A200_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"ALA A  28;ASP A  29;ASP A  30;VAL A  32;GLY A  48;PRO A  81","None","0.81A","2z54A-3mwsA:20.0","2z54A-3mwsA:76.77"],["2Z54_A_AB1A200_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",10,"ARG A   8;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  32;PRO A  81;VAL A  82;ILE A  84","None","0.53A","2z54A-3mwsA:20.0","2z54A-3mwsA:76.77"],["2Z54_A_AB1A200_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",11,"ARG A   8;ASP A  25;GLY A  27;ALA A  28;ASP A  29;VAL A  32;GLY A  49;ILE A  50;PRO A  81;VAL A  82;ILE A  84","None","0.49A","2z54A-3mwsA:20.0","2z54A-3mwsA:76.77"],["2Z54_A_AB1A200_1","3o8l","Oryctolagus cuniculus","6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE","PF00365(PFK)",5,"GLY A 224;ALA A 225;ASP A 226;ILE A 192;VAL A 207","PO4 A 767 ( 4.6A);None;None;None;None","1.04A","2z54A-3o8lA:undetectable","2z54A-3o8lA:9.39"],["2Z54_A_AB1A200_1","3o8o","Saccharomyces cerevisiae","6-PHOSPHOFRUCTOKINASE SUBUNIT ALPHA","PF00365(PFK)",5,"GLY A 414;ALA A 415;ASP A 416;VAL A 397;ILE A 452","None","0.93A","2z54A-3o8oA:undetectable","2z54A-3o8oA:8.31"],["2Z54_A_AB1A200_1","3opy","Komagataella pastoris","6-PHOSPHOFRUCTO-1-KINASE ALPHA-SUBUNIT","PF00365(PFK)",5,"GLY A 419;ALA A 420;ASP A 421;VAL A 402;ILE A 457","None","0.79A","2z54A-3opyA:undetectable","2z54A-3opyA:8.35"],["2Z54_A_AB1A200_1","3p4g","Marinomonas primoryensis","ANTIFREEZE PROTEIN","no annotation",5,"ASP A 103;GLY A  99;ALA A  98;VAL A 124;GLY A 137"," CA A 403 ( 2.4A); CA A 403 (-4.1A); CA A 404 (-4.5A);None; CA A 405 (-4.1A)","1.01A","2z54A-3p4gA:undetectable","2z54A-3p4gA:14.06"],["2Z54_A_AB1A200_1","3pgy","Staphylococcus aureus","SERINE HYDROXYMETHYLTRANSFERASE","PF00464(SHMT)",5,"GLY A 208;ALA A 207;ILE A 201;PRO A 362;VAL A 285","None","1.05A","2z54A-3pgyA:undetectable","2z54A-3pgyA:12.53"],["2Z54_A_AB1A200_1","3rcm","Pseudomonas putida","TATD FAMILY HYDROLASE","PF01026(TatD_DNase)",5,"ASP A   5;GLY A   7;ASP A 209;VAL A 235;GLY A 178","None;None;CIT A 289 (-3.3A);None;None","1.07A","2z54A-3rcmA:undetectable","2z54A-3rcmA:19.19"],["2Z54_A_AB1A200_1","3slz","Murine leukemia virus","GAG-PRO-POL POLYPROTEIN","PF00077(RVP)",5,"ASP A  32;GLY A  34;ALA A  35;VAL A  39;GLY A  56","3TL A 126 (-2.4A);3TL A 126 (-3.1A);3TL A 126 ( 4.0A);None;3TL A 126 (-3.4A)","0.58A","2z54A-3slzA:11.1","2z54A-3slzA:28.99"],["2Z54_A_AB1A200_1","3slz","Murine leukemia virus","GAG-PRO-POL POLYPROTEIN","PF00077(RVP)",5,"ASP A  32;GLY A  34;ALA A  35;VAL A  39;PRO A  89","3TL A 126 (-2.4A);3TL A 126 (-3.1A);3TL A 126 ( 4.0A);None;3TL A 126 (-4.0A)","0.58A","2z54A-3slzA:11.1","2z54A-3slzA:28.99"],["2Z54_A_AB1A200_1","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",8,"ARG A   8;ASP A  25;GLY A  27;ALA A  28;ASP A  29;VAL A  32;GLY A  49;ILE A  50","SO4 A 101 (-3.8A);017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-3.5A);017 A 201 (-3.5A);None;017 A 201 (-4.0A);017 A 201 (-3.3A)","0.56A","2z54A-3t3cA:18.7","2z54A-3t3cA:77.78"],["2Z54_A_AB1A200_1","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  32;GLY A  49;ILE A  50","017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-3.5A);017 A 201 (-3.5A);017 A 201 (-4.2A);None;017 A 201 (-4.0A);017 A 201 (-3.3A)","0.40A","2z54A-3t3cA:18.7","2z54A-3t3cA:77.78"],["2Z54_A_AB1A200_1","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  32;GLY A  49;PRO A  81","017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-3.5A);017 A 201 (-3.5A);017 A 201 (-4.2A);None;017 A 201 (-4.0A);None","0.55A","2z54A-3t3cA:18.7","2z54A-3t3cA:77.78"],["2Z54_A_AB1A200_1","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",10,"ARG A   8;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;PRO A  81;ILE A  84","017 A 201 ( 4.8A);017 A 201 (-2.6A);017 A 201 (-3.6A);017 A 201 (-3.4A);017 A 201 (-3.3A);017 A 201 (-4.6A);017 A 201 (-3.0A);017 A 201 (-3.3A);017 A 201 (-4.1A);017 A 201 (-4.7A)","0.44A","2z54A-3ttpA:19.8","2z54A-3ttpA:79.80"],["2Z54_A_AB1A200_1","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",8,"ARG A   8;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ILE A  50;PRO A  81","None;017 A 202 ( 2.5A);017 A 201 ( 3.5A);017 A 201 (-3.4A);017 A 201 (-3.2A);017 A 201 ( 4.0A);017 A 201 ( 3.5A);017 A 202 (-4.0A)","0.50A","2z54A-3u7sA:19.9","2z54A-3u7sA:78.79"],["2Z54_A_AB1A200_1","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;PRO A  81","017 A 202 ( 2.5A);017 A 201 ( 3.5A);017 A 201 (-3.4A);017 A 201 (-3.2A);017 A 201 ( 4.0A);017 A 202 (-2.9A);017 A 201 ( 3.5A);017 A 202 (-4.0A)","0.40A","2z54A-3u7sA:19.9","2z54A-3u7sA:78.79"],["2Z54_A_AB1A200_1","3uhl","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;PRO A  81;VAL A  82","None","0.54A","2z54A-3uhlA:16.2","2z54A-3uhlA:77.78"],["2Z54_A_AB1A200_1","3wn6","Oryza sativa","ALPHA-AMYLASE","PF00128(Alpha-amylase);PF07821(Alpha-amyl_C2)",5,"GLY A  58;ASP A  52;VAL A  51;GLY A 106;ILE A  54","None","1.04A","2z54A-3wn6A:undetectable","2z54A-3wn6A:13.88"],["2Z54_A_AB1A200_1","4ao7","unidentified","ESTERASE","PF12146(Hydrolase_4)",5,"ALA A 125;VAL A  31;ILE A 119;PRO A  82;ILE A  79","None","0.81A","2z54A-4ao7A:undetectable","2z54A-4ao7A:21.11"],["2Z54_A_AB1A200_1","4b2o","Bacillus subtilis","YMDB PHOSPHODIESTERASE","PF13277(YmdB)",5,"GLY A  59;ALA A  60;ASP A  61;VAL A   9;ILE A  36","None","0.87A","2z54A-4b2oA:undetectable","2z54A-4b2oA:16.98"],["2Z54_A_AB1A200_1","4dpp","Arabidopsis thaliana","DIHYDRODIPICOLINATE SYNTHASE 2, CHLOROPLASTIC","PF00701(DHDPS)",5,"ASP A  83;ALA A  86;ASP A  89;GLY A 312;VAL A 317","None","1.06A","2z54A-4dppA:undetectable","2z54A-4dppA:14.42"],["2Z54_A_AB1A200_1","4fxg","Homo sapiens","MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN","PF00089(Trypsin)",5,"GLY H 667;ALA H 619;GLY H 651;VAL H 588;ILE H 590","None","1.05A","2z54A-4fxgH:undetectable","2z54A-4fxgH:17.72"],["2Z54_A_AB1A200_1","4k5u","Petromyzon marinus","VARIABLE LYMPHOCYTE RECEPTOR","no annotation",5,"GLY B  63;GLY B  18;PRO B  25;VAL B  24;ILE B  42","None","0.94A","2z54A-4k5uB:undetectable","2z54A-4k5uB:17.51"],["2Z54_A_AB1A200_1","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  29;ASP A  30;VAL A  32;GLY A  48","RIT A 500 (-3.6A);RIT A 500 (-3.2A);RIT A 500 (-4.8A);None;RIT A 500 (-4.8A)","0.64A","2z54A-4njvA:20.5","2z54A-4njvA:87.88"],["2Z54_A_AB1A200_1","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  32;PRO A  81;ILE A  84","RIT A 500 (-2.4A);RIT A 500 (-3.9A);RIT A 500 (-3.6A);RIT A 500 (-3.2A);RIT A 500 (-4.8A);None;RIT A 500 (-3.9A);RIT A 500 (-4.3A)","0.38A","2z54A-4njvA:20.5","2z54A-4njvA:87.88"],["2Z54_A_AB1A200_1","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;VAL A  32;GLY A  49;ILE A  50;PRO A  81;ILE A  84","RIT A 500 (-2.4A);RIT A 500 (-3.9A);RIT A 500 (-3.6A);RIT A 500 (-3.2A);None;RIT A 500 (-3.4A);RIT A 500 (-4.3A);RIT A 500 (-3.9A);RIT A 500 (-4.3A)","0.41A","2z54A-4njvA:20.5","2z54A-4njvA:87.88"],["2Z54_A_AB1A200_1","4r1u","Medicago truncatula","CINNAMOYL COA REDUCTASE","PF01370(Epimerase)",5,"GLY A  97;ASP A  59;GLY A   8;VAL A  70;ILE A  66","None","0.87A","2z54A-4r1uA:undetectable","2z54A-4r1uA:13.79"],["2Z54_A_AB1A200_1","4rwe","Yersinia pestis","SUGAR-BINDING TRANSPORT PROTEIN","PF13407(Peripla_BP_4)",5,"GLY A 196;ALA A 190;ILE A 223;VAL A 214;ILE A 156","None;None;GOL A 401 ( 4.2A);None;None","0.99A","2z54A-4rweA:undetectable","2z54A-4rweA:18.18"],["2Z54_A_AB1A200_1","4u1r","Homo sapiens","ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, PLATELET TYPE","PF00365(PFK)",5,"GLY A 233;ALA A 234;ASP A 235;VAL A 216;ILE A 270","PO4 A 802 (-4.0A);None;PO4 A 802 ( 4.6A);None;None","0.90A","2z54A-4u1rA:undetectable","2z54A-4u1rA:10.08"],["2Z54_A_AB1A200_1","4us4","Bacillus halodurans","TRANSPORTER","PF00209(SNF)",5,"GLY A 396;ALA A  93;VAL A  78;PRO A 332;VAL A 331","None","0.93A","2z54A-4us4A:undetectable","2z54A-4us4A:12.61"],["2Z54_A_AB1A200_1","4ydf","Primate T-lymphotropic virus 1","HTLV-1 PROTEASE","PF00077(RVP)",5,"ASP A  32;GLY A  34;ALA A  35;ASP A  36;GLY A  58","4B1 A 201 (-2.9A);4B1 A 201 ( 4.6A);4B1 A 201 (-3.6A);4B1 A 201 (-4.4A);4B1 A 201 (-3.4A)","0.38A","2z54A-4ydfA:12.9","2z54A-4ydfA:31.30"],["2Z54_A_AB1A200_1","4ydf","Primate T-lymphotropic virus 1","HTLV-1 PROTEASE","PF00077(RVP)",6,"ASP A  32;GLY A  34;ALA A  35;ASP A  36;VAL A  39;ILE A 100","4B1 A 201 (-2.9A);4B1 A 201 ( 4.6A);4B1 A 201 (-3.6A);4B1 A 201 (-4.4A);None;4B1 A 201 (-4.8A)","0.35A","2z54A-4ydfA:12.9","2z54A-4ydfA:31.30"],["2Z54_A_AB1A200_1","4zox","Saccharomyces cerevisiae","RIBOSOME ASSEMBLY PROTEIN SQT1","no annotation",5,"GLY A 419;ALA A 418;GLY A  84;VAL A  80;ILE A  71","None","1.10A","2z54A-4zoxA:undetectable","2z54A-4zoxA:13.53"],["2Z54_A_AB1A200_1","5b18","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",5,"GLY A  27;ALA A  28;ASP A  29;ASP A  30;ILE A  84","None","0.13A","2z54A-5b18A:18.0","2z54A-5b18A:77.78"],["2Z54_A_AB1A200_1","5b18","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",5,"GLY A  27;ALA A  28;ASP A  29;GLY A  49;ILE A  84","None","0.63A","2z54A-5b18A:18.0","2z54A-5b18A:77.78"],["2Z54_A_AB1A200_1","5fmg","Plasmodium falciparum","PROTEASOME, PUTATIVE","PF00227(Proteasome)",5,"ASP H 157;VAL H  12;ILE H  37;VAL H 231;ILE H 233","None","0.86A","2z54A-5fmgH:undetectable","2z54A-5fmgH:14.00"],["2Z54_A_AB1A200_1","5g5g","Escherichia coli","PUTATIVE XANTHINE DEHYDROGENASE YAGT IRON-SULFUR-BINDING SUBUNIT","PF00111(Fer2);PF01799(Fer2_2)",5,"GLY A 211;ALA A 212;ASP A 154;GLY A 159;ILE A 216","None;None;None;FES A 230 (-4.2A);None","0.88A","2z54A-5g5gA:undetectable","2z54A-5g5gA:23.78"],["2Z54_A_AB1A200_1","5ilg","Drosophila melanogaster","PHOTORECEPTOR DEHYDROGENASE, ISOFORM C","PF00106(adh_short)",5,"ASP A 232;ASP A  85;GLY A 174;VAL A 178;ILE A 131","None","1.01A","2z54A-5ilgA:undetectable","2z54A-5ilgA:17.65"],["2Z54_A_AB1A200_1","5j1k","Helicobacter pylori","TOXR-ACTIVATED GENE (TAGE)","PF01551(Peptidase_M23)",5,"GLY A 230;ALA A 180;VAL A 186;GLY A 234;ILE A 227","None","1.00A","2z54A-5j1kA:undetectable","2z54A-5j1kA:21.62"],["2Z54_A_AB1A200_1","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",10,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  32;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None","0.41A","2z54A-5t2zA:20.2","2z54A-5t2zA:80.81"],["2Z54_A_AB1A200_1","5u1w","Ailuropoda melanoleuca","P2X PURINOCEPTOR","PF00864(P2X_receptor)",5,"ASP A 240;GLY A 253;ILE A 254;VAL A 104;ILE A 315","None","1.02A","2z54A-5u1wA:undetectable","2z54A-5u1wA:16.12"],["2Z54_A_AB1A200_1","5uib","Agrobacterium tumefaciens","OXIDOREDUCTASE PROTEIN","PF01408(GFO_IDH_MocA)",5,"GLY A 250;VAL A 265;GLY A 143;VAL A 136;ILE A 255","None","1.02A","2z54A-5uibA:undetectable","2z54A-5uibA:16.23"],["2Z54_A_AB1A200_1","5ve3","Paraburkholderia phytofirmans","BPPRF","no annotation",5,"GLY B  88;ALA B  89;ASP B  90;VAL B  59;ILE B  80","None","0.76A","2z54A-5ve3B:undetectable","2z54A-5ve3B:13.69"],["2Z54_A_AB1A200_1","5xj1","Streptococcus pneumoniae","UNCHARACTERIZED RNA METHYLTRANSFERASE SP_1029","no annotation",5,"GLY A 399;ALA A 400;ASP A 401;ILE A 373;ILE A 378","None","0.98A","2z54A-5xj1A:undetectable","2z54A-5xj1A:13.72"],["2Z54_A_AB1A200_1","5z73","Nostoc sp. PCC 7120","ALR0819 PROTEIN","no annotation",5,"ASP A 183;GLY A 193;VAL A 181;PRO A 128;VAL A 126","None","1.05A","2z54A-5z73A:undetectable","2z54A-5z73A:23.23"],["2Z54_A_AB1A200_1","6cy1","Elizabethkingia anophelis","SIGNAL RECOGNITION PARTICLE RECEPTOR FTSY","no annotation",5,"GLY A 306;VAL A 266;GLY A 276;VAL A 294;ILE A 292","None","0.92A","2z54A-6cy1A:undetectable","2z54A-6cy1A:24.21"],["2Z54_A_AB1A200_1","6fiv","Feline immunodeficiency virus","RETROPEPSIN","PF00077(RVP)",5,"ASP A  30;GLY A  32;ALA A  33;ASP A  34;GLY A  58","3TL A 201 (-3.5A);3TL A 201 (-3.4A);3TL A 201 (-4.0A);3TL A 201 (-3.9A);3TL A 201 (-3.4A)","0.21A","2z54A-6fivA:15.4","2z54A-6fivA:27.43"],["2Z54_A_AB1A200_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",7,"ARG A   8;ASP A  25;GLY A  27;ASP A  29;ASP A  30;GLY A  49;ILE A  84","None;NIU A 100 (-2.8A);NIU A 100 (-4.5A);None;None;NIU A 100 ( 3.8A);None","0.63A","2z54A-6upjA:17.9","2z54A-6upjA:47.47"],["2Z54_A_AB1A200_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",7,"ARG A   8;GLY A  27;ASP A  29;ASP A  30;GLY A  49;ILE A  50;ILE A  84","None;NIU A 100 (-4.5A);None;None;NIU A 100 ( 3.8A);NIU A 100 (-3.9A);None","0.73A","2z54A-6upjA:17.9","2z54A-6upjA:47.47"],["2Z54_A_AB1A200_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;PRO A  81;ILE A  84","NIU A 100 (-2.8A);NIU A 100 (-4.5A);NIU A 100 (-3.6A);None;None;NIU A 100 ( 3.8A);None;None","0.61A","2z54A-6upjA:17.9","2z54A-6upjA:47.47"],["2Z54_A_AB1A200_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",7,"GLY A  27;ASP A  29;ASP A  30;GLY A  49;ILE A  50;PRO A  81;ILE A  84","NIU A 100 (-4.5A);None;None;NIU A 100 ( 3.8A);NIU A 100 (-3.9A);None;None","0.76A","2z54A-6upjA:17.9","2z54A-6upjA:47.47"]]