SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z2P_B_DOLB2003

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 ASN A 615
GLU A 613
GLY A 572
SER A 609
GLU A 608
 None
 1.21A 2z2pA-2b0tA:
0.0
2z2pB-2b0tA:
0.0		 2z2pA-2b0tA:
15.50
2z2pB-2b0tA:
15.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2n VIRGINIAMYCIN B
LYASE

(Staphylococcus
aureus) 		no annotation 5 LYS A  34
TRP A 243
GLY A 244
SER A 266
GLU A 268
 None
 0.98A 2z2pA-2z2nA:
51.3
2z2pB-2z2nA:
51.3		 2z2pA-2z2nA:
98.33
2z2pB-2z2nA:
98.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8z E3 SUMO-PROTEIN
LIGASE CBX4

(Homo sapiens) 		PF00385
(Chromo) 		5 PRO A  37
ASN A  40
GLU A  17
SER A  15
GLU A  14
 None
 1.47A 2z2pA-3i8zA:
undetectable
2z2pB-3i8zA:
undetectable		 2z2pA-3i8zA:
9.40
2z2pB-3i8zA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 ASN A1067
THR A 810
GLU A 809
GLY A1066
GLU A 793
 None
 1.42A 2z2pA-5f7uA:
0.0
2z2pB-5f7uA:
1.7		 2z2pA-5f7uA:
14.37
2z2pB-5f7uA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 PRO A  65
ASN A  63
ASN A  66
GLY A  36
SER A  95
 None
 1.13A 2z2pA-5fbzA:
0.0
2z2pB-5fbzA:
0.0		 2z2pA-5fbzA:
21.87
2z2pB-5fbzA:
21.87