SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z0Y_B_SAMB400_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		5 ALA A  97
VAL A  99
VAL A  87
GLY A  56
ALA A 280
 None
 0.97A 2z0yB-1c3xA:
undetectable		 2z0yB-1c3xA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		5 ALA A 340
VAL A 337
GLY A 195
ILE A 318
ALA A 324
 None
 0.94A 2z0yB-1gr0A:
2.7		 2z0yB-1gr0A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 216
VAL A 214
VAL A 195
GLY A 199
ALA A 227
 None
 0.89A 2z0yB-1h2bA:
undetectable		 2z0yB-1h2bA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 203
GLY A 197
GLY A 196
LEU A 205
ALA A 173
 None
NAJ  A1361 (-3.5A)
NAJ  A1361 (-3.2A)
None
None
 0.90A 2z0yB-1h2bA:
undetectable		 2z0yB-1h2bA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E

(Chondrostereum
purpureum) 		PF00295
(Glyco_hydro_28) 		5 ALA A 273
GLY A 270
GLY A 301
ILE A 258
ALA A 229
 None
 0.91A 2z0yB-1k5cA:
undetectable		 2z0yB-1k5cA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 ALA A  46
VAL A  50
GLY A 226
GLY A 225
ILE A   4
 None
 0.76A 2z0yB-1li7A:
undetectable		 2z0yB-1li7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  38
GLY A  77
LEU A 111
ILE A 104
ALA A  80
 None
 0.91A 2z0yB-1nu5A:
2.4		 2z0yB-1nu5A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 164
GLY A 158
GLY A 157
LEU A 166
ALA A 131
 None
NDP  A1325 (-3.4A)
NDP  A1325 (-3.1A)
None
None
 0.95A 2z0yB-1o8cA:
2.3		 2z0yB-1o8cA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ALA A 273
VAL A 441
GLY A 439
LEU A 249
ALA A 424
 None
 0.94A 2z0yB-1pl0A:
undetectable		 2z0yB-1pl0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 VAL A 328
VAL A  45
GLY A  67
LEU A 326
ILE A  10
ALA A 336
 None
 1.41A 2z0yB-1q1nA:
3.2		 2z0yB-1q1nA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 ALA A 295
VAL A 299
GLY A 249
GLY A 246
ALA A 338
 None
 0.96A 2z0yB-1q5nA:
undetectable		 2z0yB-1q5nA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A  64
GLY A  65
LEU A 296
LEU A 138
ALA A 143
 None
 0.84A 2z0yB-1rjwA:
undetectable		 2z0yB-1rjwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		6 ALA A 311
VAL A 262
VAL A 351
GLY A 352
GLY A 323
ALA A 269
 None
 1.42A 2z0yB-1uqwA:
undetectable		 2z0yB-1uqwA:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		9 ALA A 158
VAL A 160
VAL A 180
GLY A 181
GLY A 185
LEU A 204
ILE A 208
LEU A 209
ALA A 214
 None
 0.63A 2z0yB-1v6zA:
30.8		 2z0yB-1v6zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		7 ALA A 173
GLY A 204
GLY A 208
LEU A 227
ILE A 231
LEU A 232
ALA A 237
 None
 0.65A 2z0yB-1vhkA:
22.7		 2z0yB-1vhkA:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		6 ALA A  96
VAL A 115
GLY A 116
GLY A 118
LEU A 105
ALA A 102
 None
 1.25A 2z0yB-1wcxA:
undetectable		 2z0yB-1wcxA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 VAL A 318
GLY A 319
GLY A 323
ILE A 245
ALA A 269
 None
 0.84A 2z0yB-1z6rA:
2.4		 2z0yB-1z6rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP

(Lobophyllia
hemprichii) 		PF01353
(GFP) 		5 ALA A 103
VAL A 118
GLY A  16
ILE A  56
ALA A  60
 None
None
None
None
NFA  A  61 ( 3.4A)
 0.96A 2z0yB-2btjA:
undetectable		 2z0yB-2btjA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9i GREEN FLUORESCENT
PROTEIN ASFP499

(Anemonia
sulcata) 		PF01353
(GFP) 		5 ALA A 104
VAL A 119
GLY A  17
ILE A  57
ALA A  61
 None
 0.94A 2z0yB-2c9iA:
undetectable		 2z0yB-2c9iA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		5 ALA A  81
VAL A  89
GLY A  90
LEU A 154
ALA A 141
 None
 0.77A 2z0yB-2cw5A:
3.2		 2z0yB-2cw5A:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 ALA A 305
GLY A 300
LEU A 242
LEU A 245
ALA A 334
 None
 0.93A 2z0yB-2e9fA:
undetectable		 2z0yB-2e9fA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		6 VAL A 184
GLY A 185
GLY A 189
LEU A 208
LEU A 213
ALA A 218
 SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 3.6A)
 0.54A 2z0yB-2egwA:
23.2		 2z0yB-2egwA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanopyrus
kandleri) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 ALA A 196
VAL A 193
GLY A 192
ILE A 246
ALA A 259
 K  A 701 (-4.8A)
K  A 701 (-4.9A)
None
None
None
 0.84A 2z0yB-2fhkA:
undetectable		 2z0yB-2fhkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		5 ALA A 103
VAL A 118
GLY A  16
ILE A  56
ALA A  60
 None
 0.91A 2z0yB-2gw3A:
undetectable		 2z0yB-2gw3A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw4 KAEDE
KAEDE

(Trachyphyllia
geoffroyi;
Trachyphyllia
geoffroyi) 		PF01353
(GFP)
PF01353
(GFP) 		5 ALA B 103
VAL B 118
GLY A  16
ILE A  56
ALA A  60
 None
None
None
None
NFA  A  61 ( 3.4A)
 0.91A 2z0yB-2gw4B:
undetectable		 2z0yB-2gw4B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		5 VAL A 148
GLY A 149
GLY A 150
ILE A  59
ALA A 118
 None
 0.90A 2z0yB-2gzxA:
undetectable		 2z0yB-2gzxA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 VAL A 131
GLY A 135
GLY A 289
ILE A 122
ALA A 151
 None
None
PCP  A 392 (-3.3A)
None
None
 0.93A 2z0yB-2i14A:
undetectable		 2z0yB-2i14A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		5 ALA A 179
GLY A 203
GLY A 208
LEU A 237
ALA A 242
 None
 0.75A 2z0yB-2i6dA:
11.8		 2z0yB-2i6dA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig8 HYPOTHETICAL PROTEIN
PA3499

(Pseudomonas
aeruginosa) 		PF01042
(Ribonuc_L-PSP) 		5 ALA A  11
LEU A  12
ILE A   7
LEU A  67
ALA A  66
 None
 0.91A 2z0yB-2ig8A:
undetectable		 2z0yB-2ig8A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 375
GLY A 374
GLY A 372
ILE A 295
ALA A 325
 None
 0.82A 2z0yB-2nqlA:
undetectable		 2z0yB-2nqlA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 376
GLY A 375
GLY A 373
ILE A 296
ALA A 326
 None
 0.82A 2z0yB-2ppgA:
undetectable		 2z0yB-2ppgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 259
VAL A 235
GLY A 237
LEU A 284
ALA A 309
 None
 0.95A 2z0yB-2vosA:
2.7		 2z0yB-2vosA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwq GLUCOSE
DEHYDROGENASE

(Haloferax
mediterranei) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		6 ALA A   5
VAL A  60
GLY A 122
GLY A  62
ILE A 352
ALA A   3
 None
 1.21A 2z0yB-2vwqA:
2.3		 2z0yB-2vwqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqp POLYSIALIC ACID
CAPSULE BIOSYNTHESIS
PROTEIN SIAC

(Neisseria
meningitidis) 		PF03102
(NeuB)
PF08666
(SAF) 		5 VAL A 226
GLY A 230
GLY A 211
LEU A 260
ILE A  23
 None
ACT  A1352 (-4.0A)
None
None
None
 0.89A 2z0yB-2wqpA:
undetectable		 2z0yB-2wqpA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ALA A  14
GLY A  10
GLY A   9
LEU A 288
ALA A 293
 None
 0.91A 2z0yB-2yw2A:
undetectable		 2z0yB-2yw2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		5 ALA A 282
VAL A 258
GLY A 255
LEU A 275
LEU A 249
 None
 0.79A 2z0yB-2zwvA:
undetectable		 2z0yB-2zwvA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ALA A 245
GLY A 290
GLY A 270
LEU A 249
ALA A 295
 None
 0.89A 2z0yB-3b9yA:
undetectable		 2z0yB-3b9yA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8l FTSZ-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF09585
(Lin0512_fam) 		5 ALA A 112
VAL A  59
GLY A  89
ILE A  14
ALA A  25
 None
None
None
CL  A 124 (-4.4A)
None
 0.93A 2z0yB-3c8lA:
undetectable		 2z0yB-3c8lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 5 ALA A 272
VAL A 276
GLY A 267
GLY A 210
ALA A 296
 None
 0.93A 2z0yB-3d0kA:
2.6		 2z0yB-3d0kA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		6 ALA A  88
VAL A 107
GLY A 108
GLY A 110
LEU A  97
ALA A  94
 None
 1.23A 2z0yB-3d8nA:
undetectable		 2z0yB-3d8nA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS

(Trichormus
variabilis) 		PF01965
(DJ-1_PfpI)
PF09537
(DUF2383) 		5 ALA A 128
GLY A 125
GLY A 142
ILE A 118
LEU A 117
 None
 0.96A 2z0yB-3fseA:
2.8		 2z0yB-3fseA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE

(Pseudomonas
savastanoi) 		PF13561
(adh_short_C2) 		6 ALA A  51
VAL A  32
GLY A  29
LEU A  46
LEU A  23
ALA A  22
 None
 1.31A 2z0yB-3gemA:
undetectable		 2z0yB-3gemA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		5 VAL A 291
GLY A  58
GLY A  60
LEU A 288
ALA A  34
 None
 0.93A 2z0yB-3hdjA:
2.2		 2z0yB-3hdjA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 VAL A 557
VAL A 574
GLY A 599
ILE A 190
ALA A 564
 None
 0.77A 2z0yB-3i04A:
4.4		 2z0yB-3i04A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih6 PUTATIVE ZINC
PROTEASE

(Bordetella
pertussis) 		PF05193
(Peptidase_M16_C) 		5 ALA A 343
VAL A 281
LEU A 317
LEU A 322
ALA A 354
 None
 0.71A 2z0yB-3ih6A:
undetectable		 2z0yB-3ih6A:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  85
VAL A  65
GLY A  66
LEU A 143
ALA A 148
 None
 0.89A 2z0yB-3jv7A:
2.7		 2z0yB-3jv7A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 ALA A 201
VAL A 199
VAL A 180
GLY A 184
GLY A 187
ALA A 212
 None
 0.92A 2z0yB-3jv7A:
2.7		 2z0yB-3jv7A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00106
(adh_short) 		5 ALA A 191
GLY A 188
ILE A 137
LEU A 140
ALA A 146
 None
 0.82A 2z0yB-3kvoA:
2.6		 2z0yB-3kvoA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw2 PROBABLE R-RNA
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		PF04452
(Methyltrans_RNA) 		6 ALA A 164
VAL A 166
GLY A 196
LEU A 219
LEU A 224
ALA A 229
 ADN  A 300 (-3.5A)
ADN  A 300 (-4.1A)
ADN  A 300 (-3.2A)
ADN  A 300 (-4.1A)
ADN  A 300 (-3.8A)
ADN  A 300 (-3.4A)
 0.97A 2z0yB-3kw2A:
21.9		 2z0yB-3kw2A:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kws PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		5 ALA A 151
GLY A 154
LEU A 117
ILE A 123
ALA A 158
 None
 0.89A 2z0yB-3kwsA:
3.6		 2z0yB-3kwsA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A  56
VAL A  63
GLY A  80
GLY A  81
ALA A 106
 None
 0.92A 2z0yB-3l01A:
3.9		 2z0yB-3l01A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		5 VAL A 399
GLY A 400
GLY A 367
LEU A 358
ALA A 355
 None
 0.95A 2z0yB-3m8uA:
undetectable		 2z0yB-3m8uA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 ALA B 302
VAL B 299
LEU B 366
LEU B 311
ALA B 364
 None
 0.80A 2z0yB-3mcaB:
undetectable		 2z0yB-3mcaB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 164
GLY A 158
GLY A 157
LEU A 166
ALA A 131
 None
NAP  A 330 (-3.4A)
NAP  A 330 (-3.2A)
None
None
 0.94A 2z0yB-3nx4A:
2.8		 2z0yB-3nx4A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Yersinia pestis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 200
VAL A 191
GLY A 190
ILE A 169
ALA A  55
 None
 0.88A 2z0yB-3pyzA:
2.3		 2z0yB-3pyzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		6 ALA A  62
VAL A  57
GLY A  58
GLY A 365
ILE A  36
LEU A  35
 None
 1.04A 2z0yB-3t8lA:
undetectable		 2z0yB-3t8lA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty9 POLYNUCLEOTIDE
2',3'-CYCLIC
PHOSPHATE
PHOSPHODIESTERASE /
POLYNUCLEOTIDE
5'-HYDROXYL-KINASE /
POLYNUCLEOTIDE
3'-PHOSPHATASE

(Ruminiclostridium
thermocellum) 		PF16536
(PNKP-ligase_C)
PF16542
(PNKP_ligase) 		5 VAL A 602
VAL A 843
GLY A 711
ILE A 706
LEU A 707
 None
 0.95A 2z0yB-3ty9A:
undetectable		 2z0yB-3ty9A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6x MPR1 PROTEIN

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 211
VAL A 196
GLY A 194
LEU A 173
ILE A 170
 None
None
None
HZP  A 301 (-4.9A)
None
 0.95A 2z0yB-3w6xA:
undetectable		 2z0yB-3w6xA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A  40
GLY A 258
GLY A 117
ILE A 262
ALA A  12
 None
 0.94A 2z0yB-4c2kA:
undetectable		 2z0yB-4c2kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 ALA A 454
GLY A 426
GLY A 425
LEU A 463
ALA A 432
 None
 0.93A 2z0yB-4cjaA:
undetectable		 2z0yB-4cjaA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 ALA A 553
GLY A 525
GLY A 524
LEU A 562
ALA A 531
 None
 0.90A 2z0yB-4cjaA:
undetectable		 2z0yB-4cjaA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqy ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 VAL A 156
GLY A 170
GLY A 151
ILE A 162
ALA A 189
 None
 0.92A 2z0yB-4eqyA:
undetectable		 2z0yB-4eqyA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 GLY A 223
GLY A 220
LEU A 348
LEU A 226
ALA A 330
 None
 0.82A 2z0yB-4g9iA:
undetectable		 2z0yB-4g9iA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD/NADP
TRANSHYDROGENASE
ALPHA SUBUNIT 1

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 ALA A 195
VAL A 193
VAL A 175
GLY A 179
ALA A 206
 None
None
NAD  A 500 (-4.7A)
None
None
 0.91A 2z0yB-4j16A:
3.5		 2z0yB-4j16A:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Sinorhizobium
meliloti) 		PF04452
(Methyltrans_RNA) 		6 GLY A 195
GLY A 199
LEU A 219
ILE A 223
LEU A 224
ALA A 229
 None
 0.64A 2z0yB-4j3cA:
16.6		 2z0yB-4j3cA:
33.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 198
GLY A 199
GLY A 203
LEU A 222
ALA A 232
 None
 0.76A 2z0yB-4l69A:
18.4		 2z0yB-4l69A:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4og1 ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		5 ALA A 112
VAL A 114
GLY A  60
ILE A  40
ALA A 126
 None
 0.92A 2z0yB-4og1A:
undetectable		 2z0yB-4og1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 ALA A 343
VAL A 358
GLY A 256
ILE A 296
ALA A 300
 None
 0.93A 2z0yB-4oy4A:
undetectable		 2z0yB-4oy4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 VAL A  90
GLY A  89
GLY A 137
LEU A 153
ALA A 105
 None
 0.94A 2z0yB-4rt6A:
undetectable		 2z0yB-4rt6A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 VAL A 158
VAL A  90
GLY A  89
GLY A 137
ALA A 105
 None
 0.97A 2z0yB-4rt6A:
undetectable		 2z0yB-4rt6A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A3271
VAL A3316
VAL A3347
GLY A3345
LEU A3296
 None
 0.82A 2z0yB-4tktA:
undetectable		 2z0yB-4tktA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sviceus) 		PF00977
(His_biosynth) 		5 ALA A 228
VAL A 203
GLY A 202
GLY A 176
LEU A 229
 None
None
PO4  A 301 (-3.7A)
PO4  A 301 (-3.4A)
None
 0.95A 2z0yB-4u28A:
3.5		 2z0yB-4u28A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur2 TETRACHLOROETHENE
REDUCTIVE
DEHALOGENASE
CATALYTIC SUBUNIT
PCEA

(Sulfurospirillum
multivorans) 		PF13484
(Fer4_16)
PF13486
(Dehalogenase) 		6 ALA A 221
VAL A 309
VAL A 159
GLY A 160
ILE A 260
ALA A 151
 None
None
IOD  A1465 (-4.8A)
None
None
None
 1.09A 2z0yB-4ur2A:
undetectable		 2z0yB-4ur2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB

(Burkholderia
cenocepacia) 		PF00155
(Aminotran_1_2) 		5 VAL A 255
GLY A 256
GLY A 257
LEU A  71
ALA A 291
 None
 0.82A 2z0yB-4wd2A:
undetectable		 2z0yB-4wd2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt5 RUBISCO ACCUMULATION
FACTOR 1, ISOFORM 2

(Arabidopsis
thaliana) 		no annotation 5 ALA A 385
VAL A 361
GLY A 359
LEU A 400
LEU A 424
 None
 0.92A 2z0yB-4wt5A:
undetectable		 2z0yB-4wt5A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE

(Moraxella sp.
TAE123) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 ALA A 234
VAL A 169
GLY A 230
LEU A 257
LEU A 248
ALA A 247
 None
 1.23A 2z0yB-4z6kA:
2.3		 2z0yB-4z6kA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		5 VAL A 237
GLY A 238
GLY A 242
LEU A  88
ALA A 218
 None
 0.94A 2z0yB-4zaaA:
undetectable		 2z0yB-4zaaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 GLY A 418
GLY A 415
LEU A  87
LEU A  84
ALA A 423
 None
 0.95A 2z0yB-5a4jA:
undetectable		 2z0yB-5a4jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdf ATP SYNTHASE SUBUNIT
BETA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		6 ALA E 179
VAL E 181
GLY E 216
ILE E 111
LEU E 230
ALA E 229
 None
 1.36A 2z0yB-5cdfE:
undetectable		 2z0yB-5cdfE:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		5 ALA A 279
VAL A 293
GLY A 294
GLY A 295
ALA A 134
 None
 0.92A 2z0yB-5d95A:
undetectable		 2z0yB-5d95A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		6 ALA A 169
VAL A 171
GLY A 165
GLY A 164
LEU A 173
ALA A 141
 None
None
NAP  A 401 (-3.5A)
NAP  A 401 (-3.2A)
None
None
 1.23A 2z0yB-5dp2A:
2.9		 2z0yB-5dp2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA B 353
GLY B 113
ILE B  27
LEU B  29
ALA B 254
 None
None
EDO  B 405 ( 4.2A)
None
None
 0.92A 2z0yB-5f38B:
undetectable		 2z0yB-5f38B:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		6 VAL B 111
GLY B  54
GLY B 114
ILE B  34
LEU B  70
ALA B  66
 None
 1.39A 2z0yB-5f38B:
undetectable		 2z0yB-5f38B:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		5 ALA A  78
VAL A 230
GLY A 175
ILE A 232
ALA A  74
 None
 0.96A 2z0yB-5fhzA:
3.4		 2z0yB-5fhzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		5 GLY A  78
LEU A 264
ILE A  32
LEU A  81
ALA A 336
 None
 0.83A 2z0yB-5gneA:
undetectable		 2z0yB-5gneA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		5 VAL A 219
GLY A 216
GLY A 174
ILE A  15
ALA A  10
 None
 0.92A 2z0yB-5h05A:
2.3		 2z0yB-5h05A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		5 ALA A 361
GLY A 427
LEU A 372
ILE A 386
ALA A 417
 None
 0.91A 2z0yB-5iryA:
undetectable		 2z0yB-5iryA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 245
VAL A 242
GLY A 241
GLY A 263
ILE A 169
 None
 0.97A 2z0yB-5kiaA:
3.4		 2z0yB-5kiaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf7 PROTEASOME SUBUNIT
BETA TYPE-1

(Homo sapiens) 		PF00227
(Proteasome) 		5 ALA L 141
GLY L  10
LEU L 145
ILE L 109
LEU L  13
 None
 0.95A 2z0yB-5lf7L:
undetectable		 2z0yB-5lf7L:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 ALA A 108
LEU A  44
ILE A  54
LEU A  53
ALA A 102
 None
 0.95A 2z0yB-5lkdA:
undetectable		 2z0yB-5lkdA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 5 GLY A 196
GLY A 200
LEU A 219
LEU A 224
ALA A 229
 SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
 0.62A 2z0yB-5o96A:
20.6		 2z0yB-5o96A:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ALA A  69
GLY A 134
GLY A 135
LEU A  71
ALA A 124
 None
 0.88A 2z0yB-5opjA:
undetectable		 2z0yB-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		6 ALA A 521
VAL A 529
VAL A 494
GLY A 495
GLY A 496
ALA A 556
 None
 1.14A 2z0yB-5uy7A:
undetectable		 2z0yB-5uy7A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w35 DNA PRIMASE

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 186
GLY A 112
LEU A 188
LEU A 173
ALA A 120
 None
 0.92A 2z0yB-5w35A:
undetectable		 2z0yB-5w35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w35 DNA PRIMASE

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 186
GLY A 112
LEU A 188
LEU A 173
ALA A 120
 None
 0.95A 2z0yB-5w35A:
undetectable		 2z0yB-5w35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 5 ALA C 182
VAL C 180
VAL C 142
GLY C 157
ALA C 131
 None
 0.81A 2z0yB-5w4tC:
undetectable		 2z0yB-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 ALA A 304
VAL A 308
GLY A 258
GLY A 255
ALA A 347
 None
 0.90A 2z0yB-5xnzA:
undetectable		 2z0yB-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6f FLAGELLAR BRAKE
PROTEIN YCGR

(Escherichia
coli) 		no annotation 5 ALA A 153
GLY A 150
LEU A 209
ILE A 189
LEU A 188
 None
C2E  A 302 (-2.7A)
None
C2E  A 303 ( 4.1A)
None
 0.95A 2z0yB-5y6fA:
undetectable		 2z0yB-5y6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli) 		no annotation 6 GLY A 251
GLY A 252
LEU A  17
ILE A 171
LEU A 175
ALA A  89
 None
 1.46A 2z0yB-5ya1A:
undetectable		 2z0yB-5ya1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 5 ALA A  46
VAL A  44
VAL A 116
GLY A  65
ALA A 137
 None
 0.85A 2z0yB-6f9mA:
undetectable		 2z0yB-6f9mA:
undetectable