SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z0Y_A_SAMA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		6 ALA A 203
VAL A 192
GLY A 189
GLY A 273
LEU A 207
ALA A  84
 None
 1.44A 2z0yA-1ci9A:
undetectable		 2z0yA-1ci9A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		6 ALA A 203
VAL A 192
GLY A 189
GLY A 273
LEU A 207
ILE A  80
 None
 1.32A 2z0yA-1ci9A:
undetectable		 2z0yA-1ci9A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eun KDPG ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		5 ALA A  67
VAL A  64
LEU A  44
ILE A  57
ALA A  33
 None
 0.99A 2z0yA-1eunA:
3.0		 2z0yA-1eunA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		6 ALA A 120
VAL A  95
GLY A  96
GLY A 100
LEU A 223
LEU A 225
 None
 1.32A 2z0yA-1hkhA:
undetectable		 2z0yA-1hkhA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu2 DISABLED HOMOLOG 1

(Mus musculus) 		PF00640
(PID) 		5 VAL A  40
GLY A  39
GLY A  37
ILE A  32
LEU A  31
 None
 0.97A 2z0yA-1nu2A:
undetectable		 2z0yA-1nu2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 164
GLY A 158
GLY A 157
LEU A 166
ALA A 131
 None
NDP  A1325 (-3.4A)
NDP  A1325 (-3.1A)
None
None
 0.93A 2z0yA-1o8cA:
2.1		 2z0yA-1o8cA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ALA A 113
GLY A  20
GLY A  23
ILE A  41
LEU A  59
 None
GDP  A1318 (-3.5A)
None
None
None
 0.91A 2z0yA-1ofuA:
3.4		 2z0yA-1ofuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 VAL A 328
VAL A  45
GLY A  67
LEU A 326
ILE A  10
ALA A 336
 None
 1.38A 2z0yA-1q1nA:
2.9		 2z0yA-1q1nA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		5 VAL A 243
VAL A 268
GLY A 269
GLY A 270
ALA A 223
 None
 0.90A 2z0yA-1u0kA:
undetectable		 2z0yA-1u0kA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		6 ALA A 241
VAL A 290
GLY A 271
GLY A 325
ILE A 286
ALA A 237
 None
 1.16A 2z0yA-1u7gA:
undetectable		 2z0yA-1u7gA:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		7 ALA A 158
VAL A 160
GLY A 185
LEU A 204
ILE A 208
LEU A 209
ALA A 214
 None
 0.74A 2z0yA-1v6zA:
32.5		 2z0yA-1v6zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		8 ALA A 158
VAL A 180
GLY A 181
GLY A 185
LEU A 204
ILE A 208
LEU A 209
ALA A 214
 None
 0.59A 2z0yA-1v6zA:
32.5		 2z0yA-1v6zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		7 ALA A 173
GLY A 204
GLY A 208
LEU A 227
ILE A 231
LEU A 232
ALA A 237
 None
 0.67A 2z0yA-1vhkA:
23.1		 2z0yA-1vhkA:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		5 VAL A 150
GLY A 151
LEU A 218
ILE A 213
ALA A 140
 None
 0.95A 2z0yA-1vpbA:
undetectable		 2z0yA-1vpbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		6 ALA A  96
VAL A 115
GLY A 116
GLY A 118
LEU A 105
ALA A 102
 None
 1.35A 2z0yA-1wcxA:
undetectable		 2z0yA-1wcxA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 VAL A 318
GLY A 319
GLY A 323
ILE A 245
ALA A 269
 None
 0.93A 2z0yA-1z6rA:
2.6		 2z0yA-1z6rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjc AMINOPEPTIDASE AMPS

(Staphylococcus
aureus) 		PF02073
(Peptidase_M29) 		5 GLY A 352
GLY A 313
ILE A 371
LEU A 375
ALA A 354
 None
 0.99A 2z0yA-1zjcA:
undetectable		 2z0yA-1zjcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		5 ALA A  81
VAL A  89
GLY A  90
LEU A 154
ALA A 141
 None
 0.71A 2z0yA-2cw5A:
2.1		 2z0yA-2cw5A:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6;
Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase)
PF01593
(Amino_oxidase) 		5 ALA C 643
GLY A  70
GLY A  67
ILE C 654
ALA C 661
 None
None
FAD  A 801 (-3.4A)
FAD  A 801 (-3.9A)
None
 0.95A 2z0yA-2e1mC:
undetectable		 2z0yA-2e1mC:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		6 VAL A 184
GLY A 185
GLY A 189
LEU A 208
LEU A 213
ALA A 218
 SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 3.6A)
 0.64A 2z0yA-2egwA:
23.7		 2z0yA-2egwA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Sulfurisphaera
tokodaii) 		PF04321
(RmlD_sub_bind) 		5 ALA A 255
VAL A 207
GLY A 209
LEU A 259
ALA A 192
 None
 0.90A 2z0yA-2ggsA:
undetectable		 2z0yA-2ggsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		5 VAL A 148
GLY A 149
GLY A 150
ILE A  59
ALA A 118
 None
 0.92A 2z0yA-2gzxA:
undetectable		 2z0yA-2gzxA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		5 ALA A 179
GLY A 203
GLY A 208
LEU A 237
ALA A 242
 None
 0.86A 2z0yA-2i6dA:
12.5		 2z0yA-2i6dA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig8 HYPOTHETICAL PROTEIN
PA3499

(Pseudomonas
aeruginosa) 		PF01042
(Ribonuc_L-PSP) 		5 ALA A  11
LEU A  12
ILE A   7
LEU A  67
ALA A  66
 None
 0.89A 2z0yA-2ig8A:
undetectable		 2z0yA-2ig8A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ALA A  83
VAL A  40
VAL A  81
GLY A  35
ALA A  64
 None
 0.87A 2z0yA-2ipiA:
undetectable		 2z0yA-2ipiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		5 ALA A 137
VAL A 145
VAL A 124
GLY A 125
ALA A 239
 None
 0.90A 2z0yA-2ivpA:
undetectable		 2z0yA-2ivpA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 VAL A 559
GLY A 514
ILE A 510
LEU A 511
ALA A 535
 None
 0.97A 2z0yA-2o1xA:
2.7		 2z0yA-2o1xA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 376
GLY A 375
GLY A 373
ILE A 296
ALA A 326
 None
 0.91A 2z0yA-2ppgA:
2.5		 2z0yA-2ppgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		5 ALA A  48
GLY A  72
LEU A 373
LEU A  84
ALA A  87
 None
 0.93A 2z0yA-2qa2A:
undetectable		 2z0yA-2qa2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 231
GLY A 311
GLY A 241
ILE A 244
LEU A 324
 None
 0.91A 2z0yA-2rb9A:
undetectable		 2z0yA-2rb9A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		5 VAL A 146
GLY A 147
GLY A 152
ILE A 327
LEU A 326
 None
 0.94A 2z0yA-2vatA:
undetectable		 2z0yA-2vatA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwq GLUCOSE
DEHYDROGENASE

(Haloferax
mediterranei) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		6 ALA A   5
VAL A  60
GLY A 122
GLY A  62
ILE A 352
ALA A   3
 None
 1.26A 2z0yA-2vwqA:
3.5		 2z0yA-2vwqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		5 ALA A 155
VAL A 160
GLY A 159
LEU A   6
ALA A   4
 None
 0.91A 2z0yA-2wf7A:
undetectable		 2z0yA-2wf7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 501
GLY A 504
LEU A 499
ILE A 381
LEU A 390
 None
 0.98A 2z0yA-2wtzA:
3.9		 2z0yA-2wtzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		5 ALA A 282
VAL A 258
GLY A 255
LEU A 275
LEU A 249
 None
 0.84A 2z0yA-2zwvA:
2.3		 2z0yA-2zwvA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ALA A 245
GLY A 290
GLY A 270
LEU A 249
ALA A 295
 None
 0.99A 2z0yA-3b9yA:
undetectable		 2z0yA-3b9yA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8l FTSZ-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF09585
(Lin0512_fam) 		5 ALA A 112
VAL A  59
GLY A  89
ILE A  14
ALA A  25
 None
None
None
CL  A 124 (-4.4A)
None
 0.85A 2z0yA-3c8lA:
undetectable		 2z0yA-3c8lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		5 ALA A 189
VAL A 215
GLY A 218
LEU A 167
ALA A 161
 None
 0.99A 2z0yA-3cdkA:
undetectable		 2z0yA-3cdkA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		6 ALA A  88
VAL A 107
GLY A 108
GLY A 110
LEU A  97
ALA A  94
 None
 1.33A 2z0yA-3d8nA:
2.8		 2z0yA-3d8nA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		5 ALA A 285
VAL A 216
GLY A 217
GLY A 219
ALA A 252
 None
None
None
NAG  A 565 ( 4.1A)
NAG  A 565 ( 3.8A)
 0.90A 2z0yA-3edyA:
undetectable		 2z0yA-3edyA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE

(Pseudomonas
savastanoi) 		PF13561
(adh_short_C2) 		6 ALA A  51
VAL A  32
GLY A  29
LEU A  46
LEU A  23
ALA A  22
 None
 1.17A 2z0yA-3gemA:
2.1		 2z0yA-3gemA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 VAL A 557
VAL A 574
GLY A 599
ILE A 190
ALA A 564
 None
 0.87A 2z0yA-3i04A:
5.3		 2z0yA-3i04A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ALA B  39
VAL B 440
GLY B 439
LEU B 433
ALA B  35
 NA  B 601 (-4.4A)
None
None
None
None
 0.98A 2z0yA-3igzB:
4.0		 2z0yA-3igzB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih6 PUTATIVE ZINC
PROTEASE

(Bordetella
pertussis) 		PF05193
(Peptidase_M16_C) 		5 ALA A 343
VAL A 281
LEU A 317
LEU A 322
ALA A 354
 None
 0.79A 2z0yA-3ih6A:
undetectable		 2z0yA-3ih6A:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  85
VAL A  65
GLY A  66
LEU A 143
ALA A 148
 None
 0.83A 2z0yA-3jv7A:
3.2		 2z0yA-3jv7A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 ALA A 201
VAL A 199
VAL A 180
GLY A 184
GLY A 187
ALA A 212
 None
 1.08A 2z0yA-3jv7A:
3.2		 2z0yA-3jv7A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00106
(adh_short) 		5 ALA A 191
GLY A 188
ILE A 137
LEU A 140
ALA A 146
 None
 0.84A 2z0yA-3kvoA:
2.7		 2z0yA-3kvoA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw2 PROBABLE R-RNA
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		PF04452
(Methyltrans_RNA) 		6 ALA A 164
VAL A 166
GLY A 196
LEU A 219
LEU A 224
ALA A 229
 ADN  A 300 (-3.5A)
ADN  A 300 (-4.1A)
ADN  A 300 (-3.2A)
ADN  A 300 (-4.1A)
ADN  A 300 (-3.8A)
ADN  A 300 (-3.4A)
 0.84A 2z0yA-3kw2A:
21.9		 2z0yA-3kw2A:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A  56
VAL A  63
GLY A  80
GLY A  81
ALA A 106
 None
 0.96A 2z0yA-3l01A:
4.1		 2z0yA-3l01A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis) 		PF01965
(DJ-1_PfpI) 		5 ALA A 193
VAL A 136
GLY A  94
GLY A  95
LEU A  25
 None
 0.99A 2z0yA-3l3bA:
2.7		 2z0yA-3l3bA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		5 ALA A 283
GLY A  19
GLY A  16
ILE A 296
ALA A 303
 None
None
FAD  A1000 (-3.4A)
FAD  A1000 (-3.7A)
None
 0.95A 2z0yA-3lzxA:
2.9		 2z0yA-3lzxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 ALA B 302
VAL B 299
LEU B 366
LEU B 311
ALA B 364
 None
 0.75A 2z0yA-3mcaB:
undetectable		 2z0yA-3mcaB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvg RIBOSOME
INACTIVATING TYPE 1
PROTEIN

(Iris x
hollandica) 		PF00161
(RIP) 		6 ALA A 115
VAL A 114
GLY A 109
ILE A 156
LEU A 152
ALA A 149
 None
None
GOL  A 281 (-3.6A)
None
None
None
 1.34A 2z0yA-3mvgA:
undetectable		 2z0yA-3mvgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083

(Pyrococcus
furiosus) 		PF01593
(Amino_oxidase) 		5 GLY A 311
GLY A 278
ILE A 315
LEU A 314
ALA A 308
 None
 0.99A 2z0yA-3nrnA:
undetectable		 2z0yA-3nrnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 164
GLY A 158
GLY A 157
LEU A 166
ALA A 131
 None
NAP  A 330 (-3.4A)
NAP  A 330 (-3.2A)
None
None
 0.93A 2z0yA-3nx4A:
2.5		 2z0yA-3nx4A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 ALA A 240
VAL A 376
GLY A 377
LEU A 466
ALA A 236
 None
 0.98A 2z0yA-3nz4A:
undetectable		 2z0yA-3nz4A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 ALA A 240
VAL A 376
ILE A 467
LEU A 466
ALA A 236
 None
 0.97A 2z0yA-3nz4A:
undetectable		 2z0yA-3nz4A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 ALA A 280
GLY A 271
LEU A 281
ILE A 274
LEU A 418
 None
FAD  A 690 (-3.3A)
None
FAD  A 690 (-4.8A)
None
 0.98A 2z0yA-3pvcA:
undetectable		 2z0yA-3pvcA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		5 VAL A 823
GLY A 649
GLY A 653
ILE A 634
ALA A 647
 None
 0.99A 2z0yA-4ammA:
undetectable		 2z0yA-4ammA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		5 GLY A 252
LEU A 278
ILE A 170
LEU A 174
ALA A 175
 None
 0.94A 2z0yA-4djiA:
undetectable		 2z0yA-4djiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Borreliella
burgdorferi) 		PF00300
(His_Phos_1) 		5 ALA A 186
VAL A  12
GLY A  15
ILE A  73
LEU A  70
 None
 0.94A 2z0yA-4embA:
undetectable		 2z0yA-4embA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqy ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ALA A 173
VAL A 156
GLY A 151
ILE A 162
ALA A 189
 None
 0.99A 2z0yA-4eqyA:
undetectable		 2z0yA-4eqyA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 ALA A 185
GLY A 180
GLY A 213
LEU A  72
ILE A  46
 None
None
None
None
GOL  A 402 (-4.3A)
 0.90A 2z0yA-4f62A:
undetectable		 2z0yA-4f62A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 GLY A 223
GLY A 220
LEU A 348
LEU A 226
ALA A 330
 None
 0.98A 2z0yA-4g9iA:
undetectable		 2z0yA-4g9iA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 VAL A 486
GLY A 476
GLY A 648
ILE A 571
LEU A 479
 None
 0.93A 2z0yA-4igdA:
undetectable		 2z0yA-4igdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		5 VAL A 309
GLY A 240
GLY A 243
ILE A 297
ALA A 312
 None
 0.94A 2z0yA-4infA:
undetectable		 2z0yA-4infA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A  18
GLY A 139
LEU A 182
LEU A 179
ALA A 145
 None
 0.88A 2z0yA-4iv5A:
4.4		 2z0yA-4iv5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 ALA A 509
GLY A  50
GLY A  47
ILE A 520
ALA A 527
 None
None
FAD  A 601 (-3.6A)
FAD  A 601 (-4.2A)
None
 0.99A 2z0yA-4iv9A:
2.8		 2z0yA-4iv9A:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Sinorhizobium
meliloti) 		PF04452
(Methyltrans_RNA) 		6 GLY A 195
GLY A 199
LEU A 219
ILE A 223
LEU A 224
ALA A 229
 None
 0.72A 2z0yA-4j3cA:
16.5		 2z0yA-4j3cA:
33.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 166
GLY A 160
GLY A 159
LEU A 168
ALA A 133
 None
EDO  A 402 (-3.6A)
None
None
None
 0.97A 2z0yA-4jxkA:
2.9		 2z0yA-4jxkA:
26.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 198
GLY A 199
GLY A 203
LEU A 222
ALA A 232
 None
 0.76A 2z0yA-4l69A:
19.3		 2z0yA-4l69A:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 ALA A 232
VAL A 235
GLY A 229
GLY A 313
ILE A 213
 None
 0.90A 2z0yA-4rbnA:
2.1		 2z0yA-4rbnA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		6 ALA A3271
VAL A3316
VAL A3347
GLY A3346
GLY A3345
LEU A3296
 None
 1.05A 2z0yA-4tktA:
undetectable		 2z0yA-4tktA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur2 TETRACHLOROETHENE
REDUCTIVE
DEHALOGENASE
CATALYTIC SUBUNIT
PCEA

(Sulfurospirillum
multivorans) 		PF13484
(Fer4_16)
PF13486
(Dehalogenase) 		5 ALA A 221
VAL A 309
VAL A 159
ILE A 260
ALA A 151
 None
None
IOD  A1465 (-4.8A)
None
None
 0.93A 2z0yA-4ur2A:
undetectable		 2z0yA-4ur2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt5 RUBISCO ACCUMULATION
FACTOR 1, ISOFORM 2

(Arabidopsis
thaliana) 		no annotation 5 ALA A 385
VAL A 361
GLY A 360
LEU A 400
LEU A 424
 None
 0.99A 2z0yA-4wt5A:
undetectable		 2z0yA-4wt5A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 VAL A 813
GLY A 771
GLY A 768
ILE A 789
ALA A 820
 None
 0.90A 2z0yA-4xriA:
undetectable		 2z0yA-4xriA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A  28
GLY A   8
GLY A  31
LEU A   4
ILE A 121
 None
FAD  A 501 (-2.8A)
FAD  A 501 (-3.5A)
None
None
 0.98A 2z0yA-4ywoA:
3.2		 2z0yA-4ywoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE

(Moraxella sp.
TAE123) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 234
GLY A 230
LEU A 257
LEU A 248
ALA A 247
 None
 0.96A 2z0yA-4z6kA:
2.4		 2z0yA-4z6kA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 GLY A 418
GLY A 415
LEU A  87
LEU A  84
ALA A 423
 None
 0.99A 2z0yA-5a4jA:
undetectable		 2z0yA-5a4jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aid MEP2

(Candida
albicans) 		PF00909
(Ammonium_transp) 		5 ALA A 317
VAL A 315
GLY A 293
GLY A 296
ILE A 311
 None
 0.98A 2z0yA-5aidA:
undetectable		 2z0yA-5aidA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		5 ALA A 279
VAL A 293
GLY A 294
GLY A 295
ALA A 134
 None
 0.87A 2z0yA-5d95A:
undetectable		 2z0yA-5d95A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 VAL A 171
GLY A 165
GLY A 164
LEU A 173
ALA A 141
 None
NAP  A 401 (-3.5A)
NAP  A 401 (-3.2A)
None
None
 0.97A 2z0yA-5dp2A:
3.4		 2z0yA-5dp2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		5 GLY A  78
LEU A 264
ILE A  32
LEU A  81
ALA A 336
 None
 0.89A 2z0yA-5gneA:
undetectable		 2z0yA-5gneA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 5 ALA E 184
GLY E 180
GLY E 178
LEU E 100
ALA E 104
 None
 0.98A 2z0yA-5h36E:
undetectable		 2z0yA-5h36E:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 ALA A   8
VAL A  88
VAL A  33
GLY A  13
ILE A 225
 None
 0.97A 2z0yA-5ilgA:
2.9		 2z0yA-5ilgA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		5 ALA A 361
GLY A 427
LEU A 372
ILE A 386
ALA A 417
 None
 0.96A 2z0yA-5iryA:
undetectable		 2z0yA-5iryA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		5 ALA T 235
VAL T 246
GLY T 247
GLY T 248
ALA T 212
 None
 0.94A 2z0yA-5k0yT:
undetectable		 2z0yA-5k0yT:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus;
Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		5 GLY A  67
GLY A 102
LEU B 561
ILE B 555
ALA B 562
 None
 0.97A 2z0yA-5kenA:
undetectable		 2z0yA-5kenA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 245
VAL A 242
GLY A 241
GLY A 263
ILE A 169
 None
 0.94A 2z0yA-5kiaA:
3.8		 2z0yA-5kiaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf7 PROTEASOME SUBUNIT
BETA TYPE-1

(Homo sapiens) 		PF00227
(Proteasome) 		5 ALA L 141
GLY L  10
LEU L 145
ILE L 109
LEU L  13
 None
 0.88A 2z0yA-5lf7L:
undetectable		 2z0yA-5lf7L:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 ALA A 108
LEU A  44
ILE A  54
LEU A  53
ALA A 102
 None
 0.95A 2z0yA-5lkdA:
undetectable		 2z0yA-5lkdA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 5 GLY A 196
GLY A 200
LEU A 219
LEU A 224
ALA A 229
 SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
 0.66A 2z0yA-5o96A:
21.1		 2z0yA-5o96A:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocp -

(-) 		no annotation 5 ALA A  59
VAL A  84
VAL A   3
GLY A   4
ILE A  86
 None
 0.87A 2z0yA-5ocpA:
3.8		 2z0yA-5ocpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ALA A  69
GLY A 134
GLY A 135
LEU A  71
ALA A 124
 None
 0.91A 2z0yA-5opjA:
undetectable		 2z0yA-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		6 ALA A 521
VAL A 529
VAL A 494
GLY A 495
GLY A 496
ALA A 556
 None
 1.13A 2z0yA-5uy7A:
undetectable		 2z0yA-5uy7A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		5 VAL A 331
LEU A 251
ILE A 345
LEU A 349
ALA A 350
 97Y  A1201 (-4.6A)
None
None
None
None
 0.96A 2z0yA-5vewA:
undetectable		 2z0yA-5vewA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 5 ALA C 182
VAL C 180
VAL C 142
GLY C 157
ALA C 131
 None
 0.95A 2z0yA-5w4tC:
undetectable		 2z0yA-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli) 		no annotation 6 GLY A 251
GLY A 252
LEU A  17
ILE A 171
LEU A 175
ALA A  89
 None
 1.44A 2z0yA-5ya1A:
undetectable		 2z0yA-5ya1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-10

(Homo sapiens) 		no annotation 6 ALA B 158
VAL B 159
GLY B 162
GLY B 165
LEU B 138
LEU B 135
 None
 1.16A 2z0yA-6avoB:
undetectable		 2z0yA-6avoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 5 ALA A  46
VAL A  44
VAL A 116
GLY A  65
ALA A 137
 None
 0.96A 2z0yA-6f9mA:
3.0		 2z0yA-6f9mA:
undetectable