SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z0A_D_GLYD73

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ARG A 421
ASP A 407
SER A 414
ARG A 415
 GCU  A2002 (-2.7A)
CA  A3000 ( 2.2A)
None
GCU  A2002 (-2.8A)
 1.35A 2z0aC-1cb8A:
2.8
2z0aD-1cb8A:
2.8		 2z0aC-1cb8A:
9.69
2z0aD-1cb8A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfc TRANSCRIPTION-REPAIR
-COUPLING FACTOR
UVRABC SYSTEM
PROTEIN A

(Escherichia
coli;
Escherichia
coli) 		PF14814
(UB2H)
no annotation 		4 ARG B 216
ASP A 139
SER A 137
ARG A 138
 None
 1.28A 2z0aC-4dfcB:
undetectable
2z0aD-4dfcB:
undetectable		 2z0aC-4dfcB:
24.60
2z0aD-4dfcB:
24.60