SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z0A_C_GLYC73_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ail NONSTRUCTURAL
PROTEIN NS1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		4 ASP A  12
ASP A  39
SER A  42
ARG A  46
 None
 0.21A 2z0aC-1ailA:
14.2		 2z0aC-1ailA:
84.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojl TRANSCRIPTIONAL
REGULATORY PROTEIN
ZRAR

(Salmonella
enterica) 		PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		4 ASP A 274
ASP A 162
SER A 161
ARG A 188
 None
 1.43A 2z0aC-1ojlA:
undetectable		 2z0aC-1ojlA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		4 ASP A  16
ASP A  11
SER A   7
ARG A   2
 None
 1.13A 2z0aC-1sa3A:
undetectable		 2z0aC-1sa3A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 ASP A 843
ASP A 832
SER A1013
ARG A1016
 CA  A2010 (-3.1A)
CA  A2012 ( 2.8A)
None
None
 1.45A 2z0aC-1ux6A:
undetectable		 2z0aC-1ux6A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ASP A 863
ASP A 852
SER A1033
ARG A1036
 CA  A  10 (-3.1A)
CA  A  12 ( 2.6A)
None
NAG  A   4 ( 3.8A)
 1.49A 2z0aC-2rhpA:
undetectable		 2z0aC-2rhpA:
8.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zko NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		4 ASP A  12
ASP A  39
SER A  42
ARG A  46
 GOL  A  71 ( 3.8A)
GOL  A  71 (-3.5A)
GOL  A  71 (-2.4A)
GOL  A  71 (-3.8A)
 0.20A 2z0aC-2zkoA:
14.2		 2z0aC-2zkoA:
89.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ASP A 798
ASP A 797
SER A 802
ARG A 803
 None
 1.40A 2z0aC-3h0gA:
2.4		 2z0aC-3h0gA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		4 ASP A 357
ASP A 355
SER A 354
ARG A 360
 None
 1.49A 2z0aC-3m6cA:
1.0		 2z0aC-3m6cA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whj PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P27

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A  40
ASP A  16
SER A  18
ARG A  22
 None
 1.00A 2z0aC-3whjA:
3.7		 2z0aC-3whjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		4 ASP A 431
ASP A 453
SER A 456
ARG A 460
 None
 1.42A 2z0aC-4bmaA:
0.0		 2z0aC-4bmaA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7w SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 ASP A 162
ASP A 160
SER A 159
ARG A 150
 None
 1.26A 2z0aC-4d7wA:
undetectable		 2z0aC-4d7wA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		4 ASP A 378
ASP A 451
SER A 452
ARG A 391
 None
 1.32A 2z0aC-4gxpA:
0.0		 2z0aC-4gxpA:
10.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4opa NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		no annotation 4 ASP B  12
ASP B  39
SER B  42
ARG B  46
 None
 0.35A 2z0aC-4opaB:
12.7		 2z0aC-4opaB:
93.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		4 ASP A 179
ASP A 176
SER A 175
ARG A 213
 None
 1.47A 2z0aC-5kh0A:
0.0		 2z0aC-5kh0A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 4 ASP A  10
ASP A 161
SER A 163
ARG A 126
 None
 1.47A 2z0aC-5m86A:
undetectable		 2z0aC-5m86A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 ASP A 530
ASP A 466
SER A 459
ARG A 463
 BGC  A 801 (-3.5A)
BGC  A 801 ( 2.7A)
BGC  A 802 ( 4.6A)
BGC  A 802 (-3.5A)
 1.40A 2z0aC-5v1wA:
3.5		 2z0aC-5v1wA:
7.40