SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z0A_A_GLYA74

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ail NONSTRUCTURAL
PROTEIN NS1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		4 LYS A  20
LEU A  36
ARG A  37
GLN A  40
 None
 1.18A 2z0aA-1ailA:
14.1		 2z0aA-1ailA:
84.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 LYS A1036
LEU A1069
ARG A1071
GLN A1072
 None
 1.35A 2z0aA-1jl5A:
0.2		 2z0aA-1jl5A:
10.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zko NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		4 LYS A  20
LEU A  36
ARG A  37
GLN A  40
 None
 1.14A 2z0aA-2zkoA:
14.1		 2z0aA-2zkoA:
89.61