SIMILAR PATTERNS OF AMINO ACIDS FOR 2Z0A_A_GLYA73

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		4 GLN A  73
ALA A  54
GLN A  53
ILE A  52
 None
 1.48A 2z0aA-1agxA:
undetectable		 2z0aA-1agxA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 140
GLN A 141
ILE A 142
ARG A 145
 None
 1.48A 2z0aA-1biiA:
undetectable		 2z0aA-1biiA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzy UBIQUITIN-CONJUGATIN
G ENZYME E2-24 KDA

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 GLN A 122
ALA A  86
GLN A  70
ILE A  87
 None
 1.06A 2z0aA-1fzyA:
undetectable		 2z0aA-1fzyA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgy TRIACYLGLYCEROL
LIPASE

(Rhizopus niveus) 		PF01764
(Lipase_3) 		4 GLN A  15
ALA A  12
GLN A  13
ILE A  14
 None
 1.49A 2z0aA-1lgyA:
undetectable		 2z0aA-1lgyA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 GLN A 156
ALA A 149
GLN A 148
ILE A 147
 None
 1.43A 2z0aA-1mc8A:
undetectable		 2z0aA-1mc8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxs KDPG ALDOLASE

(Pseudomonas
putida) 		PF01081
(Aldolase) 		4 ALA A 100
GLN A 101
ILE A 121
ARG A  19
 None
 1.44A 2z0aA-1mxsA:
undetectable		 2z0aA-1mxsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmy PSEUDOAZURIN

(Methylobacterium
extorquens) 		PF00127
(Copper-bind) 		4 ALA A 120
GLN A 121
ILE A 122
ARG A  24
 None
 1.41A 2z0aA-1pmyA:
undetectable		 2z0aA-1pmyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		4 GLN A  59
ALA A  56
GLN A  53
ILE A  55
 None
 1.38A 2z0aA-1q6hA:
undetectable		 2z0aA-1q6hA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcj POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		4 GLN A 139
ALA A 194
GLN A 143
ILE A 144
 None
 1.21A 2z0aA-1qcjA:
undetectable		 2z0aA-1qcjA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7u H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, D-B ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 140
GLN A 141
ILE A 142
ARG A 145
 None
 1.44A 2z0aA-1s7uA:
undetectable		 2z0aA-1s7uA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Shewanella
oneidensis) 		PF02542
(YgbB) 		4 ALA A 119
GLN A 116
ILE A 129
ARG A 115
 None
 1.38A 2z0aA-1t0aA:
undetectable		 2z0aA-1t0aA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 GLN A 431
ALA A 523
ILE A 524
ARG A 490
 None
 1.27A 2z0aA-1w07A:
0.3		 2z0aA-1w07A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		4 GLN A 174
ALA A 112
ILE A 113
ARG A 131
 None
 1.47A 2z0aA-1x77A:
undetectable		 2z0aA-1x77A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLN A 305
ALA A 302
GLN A 298
ILE A 301
 None
 1.24A 2z0aA-1xtjA:
undetectable		 2z0aA-1xtjA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbt PEPTIDE CHAIN
RELEASE FACTOR 1

(Streptococcus
mutans) 		PF00472
(RF-1)
PF03462
(PCRF) 		4 GLN A  64
ALA A  61
GLN A  58
ILE A  60
 None
 1.23A 2z0aA-1zbtA:
4.2		 2z0aA-1zbtA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgd CHALCONE REDUCTASE

(Medicago sativa) 		PF00248
(Aldo_ket_red) 		4 GLN A 196
ALA A 290
GLN A 291
ILE A 292
 None
 1.49A 2z0aA-1zgdA:
undetectable		 2z0aA-1zgdA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 214
GLN A 299
ILE A 209
ARG A 303
 None
 1.10A 2z0aA-2a2aA:
1.2		 2z0aA-2a2aA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2f EXOCYST COMPLEX
COMPONENT SEC15

(Drosophila
melanogaster) 		PF04091
(Sec15) 		4 GLN X 284
ALA X 217
GLN X 277
ILE X 221
 None
 1.40A 2z0aA-2a2fX:
2.5		 2z0aA-2a2fX:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA

(Escherichia
coli) 		PF00282
(Pyridoxal_deC) 		4 GLN A 327
ALA A 280
GLN A  65
ARG A 427
 None
 1.44A 2z0aA-2dgkA:
undetectable		 2z0aA-2dgkA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iic ALPHA-11 GIARDIN

(Giardia
intestinalis) 		no annotation 4 ALA A 239
GLN A 251
ILE A 255
ARG A 254
 None
 1.40A 2z0aA-2iicA:
0.5		 2z0aA-2iicA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrj STAPHYLOXANTHIN
BIOSYNTHESIS
PROTEIN, PUTATIVE

(Staphylococcus
aureus) 		PF05257
(CHAP) 		4 GLN A  60
ALA A  39
GLN A  43
ILE A 111
 None
 1.42A 2z0aA-2lrjA:
undetectable		 2z0aA-2lrjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mh9 BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF09382
(RQC) 		4 ALA A  58
GLN A  61
ILE A  60
ARG A  32
 None
 1.33A 2z0aA-2mh9A:
undetectable		 2z0aA-2mh9A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4x STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00567
(TUDOR) 		4 ALA B 768
GLN B 767
ILE B 739
ARG B 722
 None
 1.47A 2z0aA-2o4xB:
undetectable		 2z0aA-2o4xB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfz TBC1 DOMAIN FAMILY
MEMBER 22A

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 GLN A 320
GLN A 279
ILE A 282
ARG A 278
 UNX  A1012 (-3.1A)
None
None
None
 1.34A 2z0aA-2qfzA:
undetectable		 2z0aA-2qfzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		4 GLN A 367
ALA A 387
GLN A 390
ARG A 391
 None
 1.43A 2z0aA-2wu0A:
undetectable		 2z0aA-2wu0A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 GLN A 235
ALA A 370
GLN A  26
ILE A  29
 None
 1.26A 2z0aA-2y4fA:
undetectable		 2z0aA-2y4fA:
11.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zko NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		4 GLN A  10
ALA A  60
GLN A  63
ILE A  64
 None
 0.55A 2z0aA-2zkoA:
14.1		 2z0aA-2zkoA:
89.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		4 GLN A 253
ALA A 274
GLN A 277
ARG A 281
 None
None
A  C  26 ( 3.4A)
A  C  38 ( 3.7A)
 1.31A 2z0aA-2zm5A:
undetectable		 2z0aA-2zm5A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE

(Photobacterium
phosphoreum) 		PF11477
(PM0188) 		4 GLN A 325
ALA A 285
GLN A 288
ILE A 289
 None
 1.32A 2z0aA-2zwiA:
undetectable		 2z0aA-2zwiA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 GLN A 163
ALA A 178
GLN A 177
ILE A 183
 None
 1.15A 2z0aA-3a8kA:
undetectable		 2z0aA-3a8kA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 2

(Mus musculus) 		PF00169
(PH) 		4 GLN A 674
ALA A 655
GLN A 658
ILE A 671
 None
 1.33A 2z0aA-3a8pA:
3.4		 2z0aA-3a8pA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 ALA A 768
GLN A 767
ILE A 739
ARG A 722
 None
 1.43A 2z0aA-3bdlA:
undetectable		 2z0aA-3bdlA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 GLN A 580
ALA A 193
ILE A 191
ARG A 713
 None
 1.33A 2z0aA-3egwA:
undetectable		 2z0aA-3egwA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 GLN A1084
ALA A1101
GLN A1104
ILE A1105
 None
 1.46A 2z0aA-3eh1A:
undetectable		 2z0aA-3eh1A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803) 		PF03575
(Peptidase_S51) 		4 ALA A 136
GLN A 173
ILE A 143
ARG A 183
 None
SO4  A 272 (-3.5A)
None
SO4  A 272 (-3.0A)
 1.24A 2z0aA-3en0A:
undetectable		 2z0aA-3en0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE

(Azospirillum
brasilense) 		PF00701
(DHDPS) 		4 GLN A 111
ALA A 148
GLN A 177
ILE A 147
 None
 1.47A 2z0aA-3fkrA:
undetectable		 2z0aA-3fkrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 GLN A  30
ALA A  33
GLN A  36
ILE A  34
 None
 1.49A 2z0aA-3gehA:
2.7		 2z0aA-3gehA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		4 GLN A 308
ALA A 269
ILE A 273
ARG A 243
 None
 1.50A 2z0aA-3hjlA:
undetectable		 2z0aA-3hjlA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ALA B 289
GLN B 290
ILE B 293
ARG B 308
 None
 1.41A 2z0aA-3hkzB:
undetectable		 2z0aA-3hkzB:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 248
ALA A 307
GLN A 348
ILE A 344
 None
 1.30A 2z0aA-3ho8A:
undetectable		 2z0aA-3ho8A:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhr ZINC FINGER PROTEIN
24

(Homo sapiens) 		PF02023
(SCAN) 		4 GLN A  56
ALA A  59
GLN A  66
ILE A  60
 None
 1.17A 2z0aA-3lhrA:
undetectable		 2z0aA-3lhrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n89 DEFECTIVE IN GERM
LINE DEVELOPMENT
PROTEIN 3, ISOFORM A

(Caenorhabditis
elegans) 		no annotation 4 GLN A 417
ALA A 428
GLN A 430
ILE A 427
 None
 1.50A 2z0aA-3n89A:
undetectable		 2z0aA-3n89A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 140
GLN A 141
ILE A 142
ARG A 145
 None
 1.43A 2z0aA-3rl2A:
undetectable		 2z0aA-3rl2A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wap AUTOPHAGY-RELATED
PROTEIN 13,
MICROTUBULE-ASSOCIAT
ED PROTEINS 1A/1B
LIGHT CHAIN 3C

(Homo sapiens) 		PF02991
(Atg8) 		4 ALA A 111
GLN A  71
ILE A  46
ARG A  39
 None
 1.17A 2z0aA-3wapA:
undetectable		 2z0aA-3wapA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00334
(NDK) 		4 ALA A 108
GLN A 109
ILE A 106
ARG A  26
 None
 1.46A 2z0aA-3ztoA:
undetectable		 2z0aA-3ztoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4afr METACASPASE

(Trypanosoma
brucei) 		PF00656
(Peptidase_C14) 		4 ALA A 233
GLN A 232
ILE A 305
ARG A 308
 None
 1.35A 2z0aA-4afrA:
undetectable		 2z0aA-4afrA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 GLN A 140
ALA A 310
ILE A 301
ARG A 110
 CL  A1011 ( 4.0A)
CL  A1011 ( 4.2A)
None
None
 1.32A 2z0aA-4bl3A:
undetectable		 2z0aA-4bl3A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 GLN A 257
ALA A 295
ILE A 278
ARG A 304
 None
 1.32A 2z0aA-4dfeA:
undetectable		 2z0aA-4dfeA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eay MANNONATE
DEHYDRATASE

(Escherichia
coli) 		PF03786
(UxuA) 		4 GLN A  80
ALA A  83
GLN A  86
ARG A  90
 None
 1.26A 2z0aA-4eayA:
undetectable		 2z0aA-4eayA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eay MANNONATE
DEHYDRATASE

(Escherichia
coli) 		PF03786
(UxuA) 		4 GLN A  86
ALA A  83
GLN A  80
ILE A  82
 None
 1.24A 2z0aA-4eayA:
undetectable		 2z0aA-4eayA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 GLN A 799
ALA A 802
GLN A 805
ILE A 803
 None
 1.39A 2z0aA-4f9oA:
undetectable		 2z0aA-4f9oA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 GLN A 799
ALA A 802
GLN A 806
ILE A 803
 None
 1.24A 2z0aA-4f9oA:
undetectable		 2z0aA-4f9oA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqt HEAT SHOCK PROTEIN
90

(Caenorhabditis
elegans) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 GLN A  11
ALA A  12
GLN A  16
ILE A  14
 None
 1.07A 2z0aA-4gqtA:
undetectable		 2z0aA-4gqtA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjc ENVELOPE
GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF07245
(Phlebovirus_G2) 		4 ALA A 914
GLN A 983
ILE A 915
ARG A 985
 None
 1.41A 2z0aA-4hjcA:
undetectable		 2z0aA-4hjcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 GLN A 151
ALA A 149
GLN A  42
ILE A 150
 None
 1.36A 2z0aA-4hqnA:
undetectable		 2z0aA-4hqnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		4 GLN A 432
ALA A 112
ILE A 116
ARG A 122
 None
 1.49A 2z0aA-4i5uA:
undetectable		 2z0aA-4i5uA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		4 ALA A 181
GLN A 185
ILE A 186
ARG A 237
 FMT  A 406 (-3.8A)
FMT  A 406 ( 3.8A)
None
None
 1.38A 2z0aA-4isaA:
undetectable		 2z0aA-4isaA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbr GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF08718
(GLTP) 		4 ALA A  59
GLN A  62
ILE A  63
ARG A  66
 None
 0.53A 2z0aA-4kbrA:
2.3		 2z0aA-4kbrA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I) 		4 ALA E 140
GLN E 141
ILE E 142
ARG E 145
 None
 1.45A 2z0aA-4nhuE:
undetectable		 2z0aA-4nhuE:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4opa NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		no annotation 4 GLN B  10
ALA B  60
GLN B  63
ILE B  64
 None
 0.57A 2z0aA-4opaB:
12.8		 2z0aA-4opaB:
93.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC

(Human
immunodeficiency
virus 1) 		no annotation 4 ALA A  39
GLN A  38
ILE A  41
ARG A 151
 None
 1.41A 2z0aA-4r61A:
4.1		 2z0aA-4r61A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC

(Human
immunodeficiency
virus 1) 		no annotation 4 ALA A  73
GLN A  74
ILE A  71
ARG A  40
 None
 1.23A 2z0aA-4r61A:
4.1		 2z0aA-4r61A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC

(Human
immunodeficiency
virus 1) 		no annotation 4 ALA A 150
GLN A 149
ILE A 152
ARG A  72
 None
 1.30A 2z0aA-4r61A:
4.1		 2z0aA-4r61A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 ALA A 373
GLN A 376
ILE A 378
ARG A 321
 CSO  A 349 ( 3.9A)
None
None
None
 1.26A 2z0aA-4rvhA:
undetectable		 2z0aA-4rvhA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 ALA A 239
GLN A 242
ILE A 243
ARG A 246
 None
 0.49A 2z0aA-4rxlA:
undetectable		 2z0aA-4rxlA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		4 GLN A 236
ALA A 207
GLN A 206
ILE A 233
 None
 1.34A 2z0aA-4rxtA:
undetectable		 2z0aA-4rxtA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 GLN L 397
ALA L 394
GLN L 390
ILE L 393
 None
 1.33A 2z0aA-4u9iL:
1.8		 2z0aA-4u9iL:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLN A 189
ALA A 225
GLN A 222
ILE A 224
 None
 1.48A 2z0aA-4uuoA:
undetectable		 2z0aA-4uuoA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1
HYDRATASE CHSH2

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N)
no annotation 		4 GLN B  60
ALA A  67
GLN A 109
ILE B  76
 None
 1.32A 2z0aA-4w78B:
undetectable		 2z0aA-4w78B:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 GLN A 260
ALA A 259
GLN A 262
ILE A 263
 None
 1.41A 2z0aA-4xgjA:
undetectable		 2z0aA-4xgjA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 GLN A 294
ALA A 153
GLN A 307
ILE A 308
 None
 0.88A 2z0aA-4xxhA:
undetectable		 2z0aA-4xxhA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ALA A 140
GLN A 192
ILE A 196
ARG A 195
 None
 1.42A 2z0aA-4zgsA:
undetectable		 2z0aA-4zgsA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zut CLASSICAL MHC CLASS
I ANTIGEN

(Equus caballus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 138
GLN A 141
ILE A 142
ARG A 145
 None
 0.94A 2z0aA-4zutA:
undetectable		 2z0aA-4zutA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 GLN A 117
ALA A  10
GLN A  11
ILE A   9
 None
 1.34A 2z0aA-5a4jA:
undetectable		 2z0aA-5a4jA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1r B-CELL
DIFFERENTIATION
ANTIGEN CD72

(Mus musculus) 		no annotation 4 ALA A 268
GLN A 299
ILE A 298
ARG A 327
 None
GOL  A 402 ( 4.7A)
None
None
 1.12A 2z0aA-5b1rA:
undetectable		 2z0aA-5b1rA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1z IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B

(Staphylococcus
aureus) 		PF05031
(NEAT) 		4 ALA I 257
GLN I 258
ILE I 151
ARG I 149
 None
 1.10A 2z0aA-5d1zI:
undetectable		 2z0aA-5d1zI:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L6

(Deinococcus
radiodurans) 		PF00347
(Ribosomal_L6) 		4 GLN E  49
ALA E  10
ILE E   9
ARG E  69
 None
 1.29A 2z0aA-5dm6E:
undetectable		 2z0aA-5dm6E:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpw MICROTUBULE-ASSOCIAT
ED PROTEINS 1A/1B
LIGHT CHAIN 3C

(Homo sapiens) 		PF02991
(Atg8) 		4 ALA A  92
GLN A  52
ILE A  27
ARG A  20
 None
 1.22A 2z0aA-5dpwA:
undetectable		 2z0aA-5dpwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5n MONOOXYGENASE

(Micromonospora
sp. TP-A0468) 		PF05368
(NmrA) 		4 GLN A 180
ALA A 209
ILE A 268
ARG A 272
 None
 1.39A 2z0aA-5f5nA:
undetectable		 2z0aA-5f5nA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjy MHC CLASS I ANTIGEN

(Anas
platyrhynchos) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 137
GLN A 140
ILE A 141
ARG A 144
 None
 0.90A 2z0aA-5gjyA:
undetectable		 2z0aA-5gjyA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjy MHC CLASS I ANTIGEN

(Anas
platyrhynchos) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 139
GLN A 140
ILE A 141
ARG A 144
 None
 1.49A 2z0aA-5gjyA:
undetectable		 2z0aA-5gjyA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		4 GLN A 406
ALA A 387
GLN A 374
ILE A 389
 None
 1.35A 2z0aA-5gkqA:
undetectable		 2z0aA-5gkqA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhx CAT-2000 FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN L  53
ALA L  50
GLN L  34
ILE L  48
 None
 1.29A 2z0aA-5hhxL:
undetectable		 2z0aA-5hhxL:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjw SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 4 ALA A 315
GLN A 314
ILE A 317
ARG A 349
 None
EDO  A 601 ( 4.6A)
None
EDO  A 601 (-4.2A)
 1.32A 2z0aA-5jjwA:
3.6		 2z0aA-5jjwA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 211
ALA A 270
GLN A 311
ILE A 307
 None
 1.32A 2z0aA-5ks8A:
undetectable		 2z0aA-5ks8A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj4 ALPHABODY MA12

(synthetic
construct) 		no annotation 4 GLN C  98
ALA C 101
GLN C 105
ILE C 102
 None
 1.31A 2z0aA-5mj4C:
4.3		 2z0aA-5mj4C:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE
ARSENITE OXIDASE
SMALL SUBUNIT AIOB
RIESKE [2FE-2S]
CLUSTER

(Rhizobium sp.
NT-26;
Rhizobium sp.
NT-26) 		no annotation
no annotation 		4 GLN B 136
ALA B 141
GLN B 143
ARG A   5
 None
 1.48A 2z0aA-5nqdB:
undetectable		 2z0aA-5nqdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDF

(Methanothermobacter
wolfeii) 		PF00037
(Fer4)
PF12838
(Fer4_7) 		4 GLN F  27
GLN F  89
ILE F  25
ARG F  23
 None
 1.38A 2z0aA-5t5iF:
undetectable		 2z0aA-5t5iF:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN

(Ruminiclostridium
thermocellum) 		PF11969
(DcpS_C) 		4 ALA A  58
GLN A  59
ILE A  60
ARG A  24
 None
 1.18A 2z0aA-5uvmA:
undetectable		 2z0aA-5uvmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 GLN A 298
ALA A 117
ILE A 118
ARG A 439
 None
None
HEM  A 601 (-4.1A)
HEM  A 601 (-3.9A)
 1.31A 2z0aA-5veuA:
undetectable		 2z0aA-5veuA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpr CYSTEINE DESULFURASE

(Elizabethkingia
anophelis) 		PF00266
(Aminotran_5) 		4 GLN A 170
ALA A 203
ILE A 209
ARG A 297
 None
 1.31A 2z0aA-5vprA:
undetectable		 2z0aA-5vprA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 211
ALA A 270
GLN A 310
ILE A 306
 None
 1.29A 2z0aA-5vywA:
undetectable		 2z0aA-5vywA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsg PRE-MRNA-SPLICING
FACTOR
CEF1,PRE-MRNA-SPLICI
NG FACTOR
CEF1,CEF1,PRE-MRNA-S
PLICING FACTOR CEF1

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 GLN c 163
ALA c 167
ILE c 171
ARG c 174
 None
C  E  85 ( 3.3A)
None
G  E  86 ( 4.0A)
 1.06A 2z0aA-5wsgc:
undetectable		 2z0aA-5wsgc:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 4 GLN A 420
ALA A 434
GLN A 436
ILE A 538
 None
 1.48A 2z0aA-5xnrA:
undetectable		 2z0aA-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9s VV2_1132

(Vibrio
vulnificus) 		no annotation 4 ALA A  42
GLN A  41
ILE A  40
ARG A  54
 None
 1.33A 2z0aA-5y9sA:
2.7		 2z0aA-5y9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ylz PRE-MRNA-SPLICING
FACTOR CEF1

(Saccharomyces
cerevisiae) 		no annotation 4 GLN J 163
ALA J 167
ILE J 171
ARG J 174
 None
C  D  85 ( 3.4A)
None
G  D  86 ( 4.1A)
 1.03A 2z0aA-5ylzJ:
undetectable		 2z0aA-5ylzJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 4 ALA B 362
GLN B 364
ILE B 365
ARG B 404
 MG  B 901 (-4.0A)
None
None
None
 1.48A 2z0aA-6bywB:
undetectable		 2z0aA-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwo RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 4 GLN A 167
ALA A  62
GLN A  65
ILE A  63
 None
 1.21A 2z0aA-6cwoA:
undetectable		 2z0aA-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwp RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 4 GLN A 167
ALA A  62
GLN A  65
ILE A  63
 None
 1.17A 2z0aA-6cwpA:
1.5		 2z0aA-6cwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8fab IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN A  30
ALA A  89
GLN A  88
ILE A  96
 None
 1.08A 2z0aA-8fabA:
undetectable		 2z0aA-8fabA:
13.68