SIMILAR PATTERNS OF AMINO ACIDS FOR 2YZQ_A_SAMA6075_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ILE A 213
ASP A 212
THR A 214
VAL A 261
PRO A 185
 None
 1.23A 2yzqA-1biiA:
undetectable		 2yzqA-1biiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvw PROTEIN
(CELLOBIOHYDROLASE
II)

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 ASP A 175
ARG A 140
THR A 143
ILE A 171
GLU A 224
 None
 1.21A 2yzqA-1bvwA:
undetectable		 2yzqA-1bvwA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ILE A 213
ASP A 212
THR A 214
VAL A 261
PRO A 185
 None
 1.22A 2yzqA-1ed3A:
undetectable		 2yzqA-1ed3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 MET A 382
ILE A 436
THR A 440
ILE A 512
GLU A 452
 None
 1.29A 2yzqA-1h54A:
undetectable		 2yzqA-1h54A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfr LIPASE

(Streptomyces
exfoliatus) 		PF03403
(PAF-AH_p_II) 		5 ILE A  87
ASP A  88
VAL A  58
ILE A  59
ILE A  70
 None
 1.26A 2yzqA-1jfrA:
undetectable		 2yzqA-1jfrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		5 ASP A 589
THR A 321
ILE A 330
GLU A 338
PRO A 332
 None
 1.05A 2yzqA-1jnfA:
0.0		 2yzqA-1jnfA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001

(Methanothermobacter
thermautotrophicus) 		PF02598
(Methyltrn_RNA_3) 		6 ILE A  57
ASP A  12
THR A  15
VAL A  28
ILE A  31
ILE A  10
 None
 1.24A 2yzqA-1k3rA:
0.0		 2yzqA-1k3rA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjv MATURE ALPHA CHAIN
OF MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
ANTIGEN (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ILE A 213
ASP A 212
THR A 214
VAL A 261
PRO A 185
 None
 1.23A 2yzqA-1kjvA:
undetectable		 2yzqA-1kjvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 ILE A  89
ASP A  37
THR A 114
VAL A 112
ILE A 111
 None
 1.28A 2yzqA-1kq3A:
undetectable		 2yzqA-1kq3A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9y FEZ-1 B-LACTAMASE

(Fluoribacter
gormanii) 		PF00753
(Lactamase_B) 		5 MET A 139
ILE A 146
ASP A 142
THR A 197
ILE A 114
 None
 1.15A 2yzqA-1l9yA:
undetectable		 2yzqA-1l9yA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhc MHC CLASS I ANTIGEN
H2-M3

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ILE A 213
ASP A 212
THR A 214
VAL A 261
PRO A 185
 None
 1.21A 2yzqA-1mhcA:
undetectable		 2yzqA-1mhcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o50 CBS
DOMAIN-CONTAINING
PREDICTED PROTEIN
TM0935

(Thermotoga
maritima) 		PF00571
(CBS) 		5 ILE A  30
THR A  36
VAL A  53
ILE A  51
ILE A  26
 None
 1.31A 2yzqA-1o50A:
14.9		 2yzqA-1o50A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7s H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-B ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ILE A 213
ASP A 212
THR A 214
VAL A 261
PRO A 185
 None
 1.24A 2yzqA-1s7sA:
undetectable		 2yzqA-1s7sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ILE B 150
ASP B 154
THR B 182
VAL B 178
PRO B 355
 None
 1.31A 2yzqA-1skyB:
undetectable		 2yzqA-1skyB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 ILE A 146
ILE A 240
ILE A 290
GLU A 248
PRO A 242
 None
 1.25A 2yzqA-1ybiA:
undetectable		 2yzqA-1ybiA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv7 P-30 PROTEIN

(Rana pipiens) 		PF00074
(RnaseA) 		5 ILE A  47
THR A  59
VAL A  88
ILE A  37
PRO A  95
 None
 1.20A 2yzqA-1yv7A:
undetectable		 2yzqA-1yv7A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 ASP A 599
VAL A 559
ILE A 590
GLN A 593
PRO A 561
 None
 1.29A 2yzqA-1z26A:
undetectable		 2yzqA-1z26A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 980
THR A 982
VAL A1118
GLU A 999
PRO A1116
 None
 1.30A 2yzqA-2bzlA:
undetectable		 2yzqA-2bzlA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 THR B 300
VAL B 302
ILE B 342
GLU B 481
GLN B 344
 None
 1.22A 2yzqA-2c6wB:
undetectable		 2yzqA-2c6wB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7i COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		5 ILE A1120
ASP A1119
VAL A1134
ILE A1150
PRO A1112
 None
 1.28A 2yzqA-2g7iA:
undetectable		 2yzqA-2g7iA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7i COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		5 ILE A1120
THR A1121
VAL A1134
ILE A1150
PRO A1112
 None
 1.29A 2yzqA-2g7iA:
undetectable		 2yzqA-2g7iA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00121
(TIM) 		5 ILE A 135
VAL A 116
ILE A 115
GLU A 194
PRO A 132
 None
 1.30A 2yzqA-2h6rA:
undetectable		 2yzqA-2h6rA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi6 UPF0107 PROTEIN
AF0055

(Archaeoglobus
fulgidus) 		PF01989
(DUF126) 		5 ILE A   8
THR A   9
ILE A  81
ILE A  90
GLU A  87
 None
 1.30A 2yzqA-2hi6A:
undetectable		 2yzqA-2hi6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqq CONSERVED OLIGOMERIC
GOLGI COMPLEX
SUBUNIT 2

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 125
ASP A 128
THR A 132
ILE A 186
GLU A 185
 None
 1.20A 2yzqA-2jqqA:
undetectable		 2yzqA-2jqqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT

(Lactobacillus
plantarum) 		PF00890
(FAD_binding_2) 		5 THR A 115
VAL A  53
ILE A  46
ILE A  32
GLN A  49
 None
 1.23A 2yzqA-2lfcA:
undetectable		 2yzqA-2lfcA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Aquifex
aeolicus) 		PF00793
(DAHP_synth_1) 		5 ILE A1180
THR A1184
THR A1152
ILE A1097
ILE A1007
 None
 1.26A 2yzqA-2nxgA:
undetectable		 2yzqA-2nxgA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Mus musculus;
Mus musculus) 		PF02404
(SCF)
no annotation 		5 ILE A  50
ASP A  47
VAL A  87
GLU X  74
PRO X 124
 None
 1.28A 2yzqA-2o26A:
undetectable		 2yzqA-2o26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 VAL A  83
ILE A  87
ILE A  90
GLU A  27
GLN A  36
 None
 1.31A 2yzqA-2obvA:
undetectable		 2yzqA-2obvA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohd PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C

(Sulfurisphaera
tokodaii) 		PF01967
(MoaC) 		5 ILE A 115
THR A 114
VAL A  45
ILE A  46
ILE A  79
 None
 1.19A 2yzqA-2ohdA:
undetectable		 2yzqA-2ohdA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9m HYPOTHETICAL PROTEIN
MJ0922

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		5 ILE A  54
ILE A  84
ILE A 109
GLN A 111
PRO A 113
 None
 0.87A 2yzqA-2p9mA:
13.6		 2yzqA-2p9mA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9m HYPOTHETICAL PROTEIN
MJ0922

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		6 ILE A  54
THR A  58
VAL A  83
ILE A  84
ILE A 109
PRO A 113
 None
 0.95A 2yzqA-2p9mA:
13.6		 2yzqA-2p9mA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9m HYPOTHETICAL PROTEIN
MJ0922

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		5 ILE A 124
THR A  15
VAL A  18
GLN A 111
PRO A  43
 None
 1.12A 2yzqA-2p9mA:
13.6		 2yzqA-2p9mA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9m HYPOTHETICAL PROTEIN
MJ0922

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		6 ILE A 124
THR A  15
VAL A  18
ILE A  19
ILE A  39
PRO A  43
 None
 1.00A 2yzqA-2p9mA:
13.6		 2yzqA-2p9mA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9m HYPOTHETICAL PROTEIN
MJ0922

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		5 THR A  80
VAL A  83
ILE A  84
ILE A 109
PRO A 113
 None
 0.54A 2yzqA-2p9mA:
13.6		 2yzqA-2p9mA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9

(Homo sapiens) 		PF00102
(Y_phosphatase) 		6 ILE A 373
THR A 375
VAL A 512
GLU A 392
GLN A 393
PRO A 510
 None
 1.39A 2yzqA-2pa5A:
undetectable		 2yzqA-2pa5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 THR F 300
VAL F 302
ILE F 342
GLU F 481
GLN F 344
 None
 1.20A 2yzqA-2v2fF:
undetectable		 2yzqA-2v2fF:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wng TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE
SUBSTRATE 1

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ILE A 149
ASP A 148
THR A 150
VAL A 199
PRO A 117
 None
 1.25A 2yzqA-2wngA:
undetectable		 2yzqA-2wngA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 ASP A 738
THR A 696
ARG A 690
ILE A 387
PRO A 389
 None
 1.22A 2yzqA-2xt6A:
undetectable		 2yzqA-2xt6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		5 ILE A  97
ASP A 101
ARG A 142
VAL A 114
PRO A  69
 None
 1.31A 2yzqA-2xu2A:
undetectable		 2yzqA-2xu2A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Candida
albicans) 		PF01704
(UDPGP) 		5 ILE A 296
THR A 281
VAL A 283
ILE A 336
GLU A 309
 None
None
None
None
GN1  A1001 (-3.0A)
 1.31A 2yzqA-2yqhA:
undetectable		 2yzqA-2yqhA:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780

(Pyrococcus
horikoshii) 		PF00571
(CBS) 		12 MET A 158
ILE A 172
ASP A 174
THR A 176
ARG A 180
THR A 228
VAL A 231
ILE A 232
ILE A 252
GLU A 253
GLN A 254
PRO A 256
 SAM  A6075 (-4.2A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.4A)
SAM  A6075 (-3.7A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
SAM  A6075 (-3.0A)
SAM  A6075 (-4.1A)
SAM  A6075 (-4.6A)
 0.01A 2yzqA-2yzqA:
38.0		 2yzqA-2yzqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		5 ILE A  69
ASP A  71
VAL A 104
ILE A 103
PRO A  50
 None
 0.84A 2yzqA-3dhuA:
undetectable		 2yzqA-3dhuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		5 ILE A 148
THR A 187
ARG A 100
THR A 146
PRO A 150
 None
 1.27A 2yzqA-3dqpA:
undetectable		 2yzqA-3dqpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		5 ARG A  12
VAL A  98
ILE A  48
GLU A  39
GLN A  80
 None
 1.31A 2yzqA-3e3pA:
undetectable		 2yzqA-3e3pA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggn UNCHARACTERIZED
PROTEIN DR_A0006

(Deinococcus
radiodurans) 		PF03364
(Polyketide_cyc) 		5 ILE A  11
ARG A  99
THR A 101
VAL A 103
GLN A 143
 None
 1.19A 2yzqA-3ggnA:
undetectable		 2yzqA-3ggnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A  98
ARG A   5
THR A  91
ILE A  96
GLU A  97
 None
 1.31A 2yzqA-3gp0A:
undetectable		 2yzqA-3gp0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 ILE A  86
VAL A  44
ILE A  45
ILE A 114
PRO A  88
 None
 1.21A 2yzqA-3h4hA:
undetectable		 2yzqA-3h4hA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		5 ILE A 256
ARG A 288
ILE A 243
ILE A   7
GLN A 248
 None
 1.31A 2yzqA-3hxwA:
undetectable		 2yzqA-3hxwA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		6 ILE A 193
THR A 197
VAL A 233
ILE A 234
ILE A 254
PRO A 258
 AMP  A 282 ( 4.3A)
AMP  A 282 (-3.9A)
AMP  A 282 (-3.8A)
AMP  A 282 (-3.9A)
AMP  A 282 (-4.1A)
None
 0.56A 2yzqA-3kh5A:
21.0		 2yzqA-3kh5A:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		5 ILE A 269
THR A 155
VAL A 158
ILE A 159
PRO A 183
 ADP  A 284 ( 4.3A)
ADP  A 284 (-3.2A)
ADP  A 284 (-3.9A)
ADP  A 284 (-4.2A)
None
 0.34A 2yzqA-3kh5A:
21.0		 2yzqA-3kh5A:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		5 VAL A 233
ILE A 234
ILE A 254
GLU A 272
PRO A 258
 AMP  A 282 (-3.8A)
AMP  A 282 (-3.9A)
AMP  A 282 (-4.1A)
None
None
 1.03A 2yzqA-3kh5A:
21.0		 2yzqA-3kh5A:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpb UNCHARACTERIZED
PROTEIN MJ0100

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		5 ILE A 434
ASP A 439
VAL A 459
ILE A 460
PRO A 484
 SAM  A1000 ( 4.2A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
 1.12A 2yzqA-3kpbA:
13.5		 2yzqA-3kpbA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpb UNCHARACTERIZED
PROTEIN MJ0100

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		6 ILE A 434
THR A 456
VAL A 459
ILE A 460
ILE A 480
PRO A 484
 SAM  A1000 ( 4.2A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
SAM  A1000 (-4.0A)
None
 0.54A 2yzqA-3kpbA:
13.5		 2yzqA-3kpbA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lot UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF05853
(BKACE) 		5 MET A  47
ILE A  74
VAL A  34
ILE A  33
ILE A  50
 None
 1.24A 2yzqA-3lotA:
undetectable		 2yzqA-3lotA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 ILE A 225
THR A 228
VAL A 424
GLU A 394
PRO A 390
 None
 1.29A 2yzqA-3m1lA:
undetectable		 2yzqA-3m1lA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A 382
THR A 325
THR A 353
VAL A 215
ILE A 216
 None
 1.17A 2yzqA-3mogA:
undetectable		 2yzqA-3mogA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Entamoeba
histolytica) 		PF01791
(DeoC) 		5 THR A 161
THR A 157
VAL A  94
ILE A  95
ILE A  97
 None
 1.31A 2yzqA-3ngjA:
undetectable		 2yzqA-3ngjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwm PEPTIDE/BETA-2MICROG
LOBULIN/MHC CLASS I
H-2KD CHIMERIC
PROTEIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ILE A 213
ASP A 212
THR A 214
VAL A 261
PRO A 185
 None
 1.21A 2yzqA-3nwmA:
undetectable		 2yzqA-3nwmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		5 THR A 366
VAL A 134
ILE A 126
GLU A 154
GLN A 130
 None
 1.24A 2yzqA-3nzqA:
undetectable		 2yzqA-3nzqA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		5 THR A 366
VAL A 134
ILE A 135
ILE A 126
GLN A 130
 None
 1.30A 2yzqA-3nzqA:
undetectable		 2yzqA-3nzqA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		5 ILE A  87
THR A  10
THR A 121
VAL A 119
ILE A 118
 None
 1.30A 2yzqA-3pl5A:
undetectable		 2yzqA-3pl5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A

(Salmonella
enterica) 		PF02826
(2-Hacid_dh_C) 		5 ILE A   3
ASP A  40
ILE A 289
ILE A 293
GLU A 297
 None
 1.30A 2yzqA-3pp8A:
undetectable		 2yzqA-3pp8A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjz COATOMER SUBUNIT
GAMMA

(Bos taurus) 		PF01602
(Adaptin_N) 		5 ILE B 131
ASP B 133
THR B 135
VAL B 105
ILE B 104
 None
 0.94A 2yzqA-3tjzB:
undetectable		 2yzqA-3tjzB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty9 POLYNUCLEOTIDE
2',3'-CYCLIC
PHOSPHATE
PHOSPHODIESTERASE /
POLYNUCLEOTIDE
5'-HYDROXYL-KINASE /
POLYNUCLEOTIDE
3'-PHOSPHATASE

(Ruminiclostridium
thermocellum) 		PF16536
(PNKP-ligase_C)
PF16542
(PNKP_ligase) 		5 MET A 574
ILE A 581
VAL A 541
ILE A 540
ILE A 561
 None
 1.11A 2yzqA-3ty9A:
undetectable		 2yzqA-3ty9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdd PROTEIN VP1

(Rhinovirus A) 		PF00073
(Rhv) 		5 MET A 232
THR A  95
ILE A 123
ILE A 235
PRO A 178
 None
None
BT8  A 301 (-4.2A)
BT8  A 301 ( 4.9A)
None
 1.13A 2yzqA-3vddA:
undetectable		 2yzqA-3vddA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm8 PROBABLE DNA
DC->DU-EDITING
ENZYME APOBEC-3C

(Homo sapiens) 		PF08210
(APOBEC_N) 		5 ILE A 118
THR A  38
THR A 117
VAL A 145
PRO A  96
 None
 1.31A 2yzqA-3vm8A:
undetectable		 2yzqA-3vm8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu9 CHROMOSOME
SEGREGATION IN
MEIOSIS PROTEIN 2

(Saccharomyces
cerevisiae) 		PF16834
(CSM2) 		5 ILE B   9
THR B 142
THR B 161
ILE B  11
ILE B 203
 None
 1.25A 2yzqA-3vu9B:
undetectable		 2yzqA-3vu9B:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 ASP A 738
THR A 696
ARG A 690
ILE A 387
PRO A 389
 None
 1.24A 2yzqA-3zhrA:
undetectable		 2yzqA-3zhrA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7

(Homo sapiens) 		PF04548
(AIG1) 		5 THR A  77
THR A  64
VAL A  12
ILE A  95
ILE A 115
 None
 1.27A 2yzqA-3zjcA:
undetectable		 2yzqA-3zjcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A 358
VAL A 308
ILE A 356
GLU A 355
PRO A 301
 None
None
None
None
ANP  A1489 ( 4.4A)
 1.23A 2yzqA-4d4gA:
undetectable		 2yzqA-4d4gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A 256
ASP A   4
VAL A 205
ILE A 206
GLU A 251
 ILE  A 256 ( 0.7A)
ASP  A   4 ( 0.6A)
VAL  A 205 ( 0.5A)
ILE  A 206 ( 0.7A)
GLU  A 251 ( 0.6A)
 1.16A 2yzqA-4flxA:
undetectable		 2yzqA-4flxA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqj HEMAGGLUTININ

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 ILE A 104
THR A 102
VAL A 245
ILE A 243
GLU A 233
 None
 1.26A 2yzqA-4fqjA:
undetectable		 2yzqA-4fqjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR

(Homo sapiens) 		PF14598
(PAS_11) 		5 ILE B 457
THR B 445
VAL B 415
ILE B 369
GLU B 370
 None
 1.27A 2yzqA-4h6jB:
undetectable		 2yzqA-4h6jB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		5 ASP A 264
THR A 231
VAL A 235
ILE A 261
GLN A 276
 None
CL  A 713 ( 4.5A)
None
None
None
 1.10A 2yzqA-4hhrA:
undetectable		 2yzqA-4hhrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		5 ILE B  17
ASP B 476
THR B  11
VAL B   6
ILE B 189
 None
 1.23A 2yzqA-4hstB:
undetectable		 2yzqA-4hstB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 MET A 259
ILE A 150
THR A 233
ILE A 191
GLU A 252
 None
 1.28A 2yzqA-4n54A:
undetectable		 2yzqA-4n54A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9k ARABINOSE
5-PHOSPHATE
ISOMERASE

(Methylococcus
capsulatus) 		PF00571
(CBS) 		5 MET A 321
THR A 256
VAL A 254
ILE A 304
PRO A 308
 None
CMK  A 401 (-3.4A)
None
CMK  A 401 (-3.5A)
CMK  A 401 (-4.5A)
 1.17A 2yzqA-4o9kA:
16.3		 2yzqA-4o9kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r81 NADH DEHYDROGENASE

(Methanothermobacter
marburgensis) 		PF02525
(Flavodoxin_2) 		5 ILE A 122
ASP A 123
THR A 120
VAL A 161
GLU A 125
 None
 1.03A 2yzqA-4r81A:
undetectable		 2yzqA-4r81A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		5 ILE A 250
THR A 262
THR A 251
VAL A 257
ILE A   5
 None
 1.27A 2yzqA-4repA:
undetectable		 2yzqA-4repA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ASP A 152
THR A 154
ILE A 147
ILE A 208
PRO A 206
 None
 1.28A 2yzqA-4rybA:
undetectable		 2yzqA-4rybA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF03734
(YkuD) 		5 THR A 173
VAL A 100
ILE A 177
GLU A 180
PRO A  78
 CSO  A 176 ( 2.7A)
CSO  A 176 ( 4.3A)
CSO  A 176 ( 4.1A)
None
None
 1.19A 2yzqA-4y4vA:
undetectable		 2yzqA-4y4vA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		6 ILE A  59
ASP A  61
THR A  17
THR A  24
ILE A 164
ILE A  83
 None
MG  A2002 ( 4.0A)
MG  A2002 ( 3.2A)
None
None
None
 1.48A 2yzqA-4zu9A:
undetectable		 2yzqA-4zu9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 ILE A 195
ASP A 197
VAL A 232
ILE A 231
PRO A 182
 None
 0.79A 2yzqA-5d0fA:
undetectable		 2yzqA-5d0fA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 ILE A 921
THR A 898
VAL A 940
ILE A 941
GLN A 947
 None
 1.20A 2yzqA-5eawA:
2.4		 2yzqA-5eawA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 ILE C 356
THR C 359
VAL C 306
ILE C 268
ILE C 248
 None
EDO  C 502 (-3.8A)
None
None
None
 1.20A 2yzqA-5eg6C:
undetectable		 2yzqA-5eg6C:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 5 ARG A  11
VAL A 373
ILE A 112
ILE A  38
PRO A  28
 None
 1.16A 2yzqA-5gheA:
undetectable		 2yzqA-5gheA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 5 ILE A  18
ARG A  11
VAL A 373
ILE A  38
PRO A  28
 None
 1.22A 2yzqA-5gheA:
undetectable		 2yzqA-5gheA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ILE A 213
ASP A 212
THR A 214
VAL A 261
PRO A 185
 None
 1.27A 2yzqA-5gsbA:
undetectable		 2yzqA-5gsbA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 ILE A 220
ASP A 161
THR A 165
VAL A 264
ILE A 265
 None
None
ANP  A 602 ( 4.5A)
None
None
 1.32A 2yzqA-5h1cA:
undetectable		 2yzqA-5h1cA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hci GPN-LOOP GTPASE 1

(Saccharomyces
cerevisiae) 		PF03029
(ATP_bind_1) 		5 THR A   5
VAL A 134
ILE A 135
GLU A 125
PRO A 167
 None
 1.22A 2yzqA-5hciA:
undetectable		 2yzqA-5hciA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF00225
(Kinesin) 		5 ILE K 127
THR K 110
VAL K  86
ILE K  85
ILE K  97
 None
 1.11A 2yzqA-5hnzK:
undetectable		 2yzqA-5hnzK:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt1 KINESIN-LIKE PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		5 ILE A 111
THR A  94
VAL A  70
ILE A  69
ILE A  81
 None
 1.19A 2yzqA-5lt1A:
undetectable		 2yzqA-5lt1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjr PROTEIN THF1

(Thermosynechococcus
elongatus) 		PF11264
(ThylakoidFormat) 		5 THR A 157
ILE A 165
ILE A 169
GLU A 170
PRO A 163
 None
 1.26A 2yzqA-5mjrA:
undetectable		 2yzqA-5mjrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H

(Homo sapiens) 		PF00084
(Sushi) 		5 ILE C1120
THR C1121
VAL C1134
ILE C1150
PRO C1112
 None
 1.29A 2yzqA-5o32C:
undetectable		 2yzqA-5o32C:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ILE A 163
THR A 184
VAL A 187
ILE A 188
PRO A 212
 ATP  A 601 ( 4.6A)
ATP  A 601 (-2.8A)
ATP  A 601 (-4.0A)
ATP  A 601 (-4.2A)
ATP  A 601 ( 4.9A)
 0.52A 2yzqA-5tc3A:
9.6		 2yzqA-5tc3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 5 ILE A 146
THR A 371
THR A 144
VAL A 317
ILE A 357
 None
 1.30A 2yzqA-5u81A:
undetectable		 2yzqA-5u81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbj FLAGELLAR
HOOK-ASSOCIATED
PROTEIN FLGK

(Campylobacter
jejuni) 		no annotation 5 ILE A 272
ARG A 302
VAL A 169
ILE A 172
ILE A 245
 None
 1.13A 2yzqA-5xbjA:
undetectable		 2yzqA-5xbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A   5
ASP A  77
ARG A 119
ILE A  84
GLU A  83
 None
 1.22A 2yzqA-5xd7A:
undetectable		 2yzqA-5xd7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 5 ILE A 223
THR A  74
ILE A 231
GLU A 167
PRO A 187
 None
 1.06A 2yzqA-5zb8A:
undetectable		 2yzqA-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 ILE A 460
ILE A 387
ILE A 468
GLU A 467
PRO A 384
 None
 1.24A 2yzqA-6fn1A:
undetectable		 2yzqA-6fn1A:
undetectable