SIMILAR PATTERNS OF AMINO ACIDS FOR 2YVL_D_SAMD603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  22
GLY A  20
ALA A  27
ASP A 474
VAL A 473
 FAD  A 510 (-3.9A)
FAD  A 510 (-3.4A)
None
FAD  A 510 (-4.7A)
None
 1.19A 2yvlD-1coyA:
3.1		 2yvlD-1coyA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLY O   4
ALA O 111
LEU O  82
VAL O   1
VAL O  93
 None
 1.05A 2yvlD-1dbvO:
4.7		 2yvlD-1dbvO:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 THR A 308
GLY A  38
ALA A  34
ALA A  41
ASP A  43
 None
 1.12A 2yvlD-1f2jA:
undetectable		 2yvlD-1f2jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 283
ILE A 296
GLY A 280
ALA A 297
LEU A 298
 None
None
FAD  A 448 (-3.1A)
FAD  A 448 (-4.6A)
FAD  A 448 (-3.7A)
 1.06A 2yvlD-1f8wA:
3.1		 2yvlD-1f8wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		5 THR A 298
GLY A  28
ALA A  24
ALA A  31
ASP A  33
 None
 1.13A 2yvlD-1fbaA:
undetectable		 2yvlD-1fbaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		7 ILE A  83
GLY A 107
GLY A 109
ALA A 112
LEU A 113
ASP A 161
ASP A 178
 SAM  A 301 (-4.0A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
 0.42A 2yvlD-1i9gA:
27.4		 2yvlD-1i9gA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		5 THR A  71
ILE A 135
GLY A  13
ALA A 137
VAL A  29
 None
 1.18A 2yvlD-1jaxA:
3.9		 2yvlD-1jaxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A  15
ALA A   5
ASP A 126
ASP A  28
VAL A  27
 None
 1.01A 2yvlD-1jmyA:
undetectable		 2yvlD-1jmyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5s FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanosarcina
barkeri) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 ALA A 111
ALA A 151
VAL A 104
PHE A 119
ASP A 115
 None
 0.98A 2yvlD-1m5sA:
undetectable		 2yvlD-1m5sA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 227
GLY A 225
ALA A 232
ASP A 721
VAL A 720
 6FA  A 801 (-4.1A)
6FA  A 801 (-3.3A)
None
6FA  A 801 (-4.3A)
None
 1.18A 2yvlD-1naaA:
2.5		 2yvlD-1naaA:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		5 GLY A 108
GLY A 110
ALA A 113
ASP A 176
VAL A 177
 None
None
CL  A 266 (-3.6A)
None
None
 0.43A 2yvlD-1o54A:
27.9		 2yvlD-1o54A:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata;
Torpedo
marmorata) 		PF02932
(Neur_chan_memb)
PF02932
(Neur_chan_memb) 		5 ILE B 231
ALA B 235
LEU B 234
VAL A 249
VAL B 261
 None
 1.04A 2yvlD-1oedB:
undetectable		 2yvlD-1oedB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 THR A 130
GLY A 378
GLY A 128
ALA A 149
VAL A  93
 None
 1.18A 2yvlD-1pxtA:
undetectable		 2yvlD-1pxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		5 THR A  21
ILE A 214
GLY A 160
ALA A  18
ALA A  40
 None
 1.18A 2yvlD-1vzyA:
undetectable		 2yvlD-1vzyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		5 THR A 132
ILE A 209
GLY A 138
VAL A 168
VAL A 153
 None
 1.15A 2yvlD-1x1qA:
2.1		 2yvlD-1x1qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		5 THR A 299
GLY A  29
ALA A  25
ALA A  32
ASP A  34
 None
 1.20A 2yvlD-1xfbA:
undetectable		 2yvlD-1xfbA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg5 ARPG836

(Homo sapiens) 		PF00106
(adh_short) 		5 ILE A 146
ALA A 193
ALA A 233
VAL A 232
VAL A  16
 None
 0.81A 2yvlD-1xg5A:
6.8		 2yvlD-1xg5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0k GTP-BINDING PROTEIN

(Homo sapiens) 		PF00071
(Ras) 		5 GLY A  66
GLY A  15
ALA A  98
VAL A  13
PHE A  70
 GTP  A1200 (-3.5A)
None
None
None
None
 1.18A 2yvlD-1z0kA:
undetectable		 2yvlD-1z0kA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		5 THR A  84
GLY A 111
GLY A 113
ASP A 173
ASP A 192
 SAM  A 601 (-3.8A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.46A 2yvlD-2b25A:
24.6		 2yvlD-2b25A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 THR A  88
GLY A 117
GLY A 119
ALA A 122
ASP A 167
 SAH  A 300 (-3.9A)
SAH  A 300 (-3.4A)
SAH  A 300 (-3.5A)
SAH  A 300 (-3.4A)
SAH  A 300 (-3.0A)
 0.81A 2yvlD-2b3tA:
17.1		 2yvlD-2b3tA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP A 398
 None
 1.10A 2yvlD-2e0wA:
undetectable		 2yvlD-2e0wA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli;
Escherichia
coli) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		5 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP B 398
 None
 1.09A 2yvlD-2e0xA:
undetectable		 2yvlD-2e0xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvz INOSITOL
MONOPHOSPHATASE 2

(Homo sapiens) 		PF00459
(Inositol_P) 		5 GLY A 105
ALA A 210
LEU A 209
PHE A 109
ASP A 104
 None
 1.04A 2yvlD-2fvzA:
undetectable		 2yvlD-2fvzA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		5 ILE A 196
GLY A 191
GLY A 159
ALA A 186
ASP A 185
 None
 1.15A 2yvlD-2gd2A:
3.6		 2yvlD-2gd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 GLY A 230
ALA A 232
ALA A 165
VAL A 188
VAL A  75
 None
None
PMS  A 601 ( 3.8A)
None
None
 1.16A 2yvlD-2gkoA:
2.2		 2yvlD-2gkoA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		5 THR A 162
ILE A 108
GLY A 159
ALA A 107
ALA A 134
 None
 1.07A 2yvlD-2hp3A:
undetectable		 2yvlD-2hp3A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 212
GLY A 392
ALA A 205
VAL A 206
ASP A 218
 None
6NA  A1462 ( 4.3A)
None
None
None
 1.17A 2yvlD-2ix4A:
undetectable		 2yvlD-2ix4A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0d COLICIN-E7 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		5 ILE X  54
GLY X  74
GLY X  71
ALA X  58
VAL X  76
 None
 1.14A 2yvlD-2k0dX:
undetectable		 2yvlD-2k0dX:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m3v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03162
(Y_phosphatase2) 		5 LEU A 188
ALA A 178
ASP A 175
ASP A 108
VAL A 107
 None
 0.91A 2yvlD-2m3vA:
undetectable		 2yvlD-2m3vA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfl INOSITOL-1-MONOPHOSP
HATASE

(Escherichia
coli) 		PF00459
(Inositol_P) 		5 GLY A  88
GLY A 186
LEU A 190
PHE A  92
ASP A  87
 ACT  A 375 (-3.7A)
EEE  A 376 (-4.2A)
None
None
EEE  A 376 (-2.7A)
 1.09A 2yvlD-2qflA:
undetectable		 2yvlD-2qflA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcy TRANS-2-ENOYL-COA
REDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 105
GLY A 136
ALA A  45
LEU A  46
ALA A 133
 None
 1.05A 2yvlD-2vcyA:
6.4		 2yvlD-2vcyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 151
GLY A 104
ALA A 147
ALA A  26
VAL A 131
 None
 1.04A 2yvlD-2vxyA:
3.6		 2yvlD-2vxyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p AQUAPORIN PIP2-7
7


(Komagataella
pastoris) 		PF00230
(MIP) 		5 ILE A 204
GLY A  95
GLY A  93
ALA A 207
VAL A  98
 None
 1.17A 2yvlD-2w1pA:
undetectable		 2yvlD-2w1pA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		5 THR A  82
ALA A  98
ALA A  63
VAL A  64
ASP A  34
 None
 1.08A 2yvlD-2wzmA:
undetectable		 2yvlD-2wzmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 332
GLY A 335
ALA A  88
LEU A  87
ASP A 531
 None
 1.11A 2yvlD-2x40A:
undetectable		 2yvlD-2x40A:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		6 THR A  72
ILE A  75
GLY A  99
ALA A 121
ASP A 148
PHE A 119
 SAM  A 601 (-3.9A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.9A)
SAM  A 601 (-3.1A)
None
 1.50A 2yvlD-2yvlA:
38.8		 2yvlD-2yvlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		12 THR A  72
ILE A  75
GLY A  99
GLY A 101
ALA A 104
LEU A 105
ALA A 121
VAL A 122
ASP A 148
PHE A 149
ASP A 165
VAL A 166
 SAM  A 601 (-3.9A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.9A)
SAM  A 601 ( 4.5A)
SAM  A 601 (-3.1A)
None
SAM  A 601 (-3.4A)
SAM  A 601 ( 4.3A)
 0.21A 2yvlD-2yvlA:
38.8		 2yvlD-2yvlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 THR B 338
ILE B 569
GLY B 549
ALA B 551
VAL B 587
 None
None
CDS  B 901 ( 3.4A)
CDS  B 901 ( 3.7A)
None
 1.09A 2yvlD-2z2mB:
undetectable		 2yvlD-2z2mB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 THR A 285
GLY A 514
GLY A 516
LEU A 279
PHE A 510
 None
 1.19A 2yvlD-2zciA:
undetectable		 2yvlD-2zciA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A 456
GLY A 454
LEU A 450
ALA A 223
VAL A 222
 None
 1.19A 2yvlD-2zxoA:
3.2		 2yvlD-2zxoA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE

(Humulus lupulus) 		PF01715
(IPPT) 		5 THR A  41
GLY A 128
ALA A 269
LEU A 268
PHE A 132
 PO4  A 900 (-4.6A)
ATP  A 800 (-4.6A)
None
ATP  A 800 (-3.9A)
None
 1.08A 2yvlD-3a8tA:
undetectable		 2yvlD-3a8tA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		5 THR A 298
GLY A  28
ALA A  24
ALA A  31
ASP A  33
 None
None
None
13P  A3371 ( 4.3A)
None
 1.11A 2yvlD-3bv4A:
undetectable		 2yvlD-3bv4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum) 		PF13472
(Lipase_GDSL_2) 		5 GLY A 175
ALA A 157
LEU A 156
ALA A 192
ASP A 189
 None
 1.19A 2yvlD-3dciA:
3.7		 2yvlD-3dciA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 ILE A 173
GLY A 131
GLY A 224
LEU A 154
ASP A 108
 None
 1.17A 2yvlD-3djcA:
undetectable		 2yvlD-3djcA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 GLY A  50
GLY A  52
ALA A  55
LEU A  56
ASP A 100
 SAM  A 220 (-3.5A)
SAM  A 220 (-3.2A)
SAM  A 220 ( 4.9A)
None
SAM  A 220 (-3.2A)
 0.38A 2yvlD-3dlcA:
14.6		 2yvlD-3dlcA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		5 GLY A  54
GLY A  56
ALA A  59
LEU A  60
ASP A  99
 None
 0.59A 2yvlD-3futA:
13.8		 2yvlD-3futA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 GLY A 257
GLY A 481
ALA A 484
LEU A 483
PHE A  48
 None
 1.14A 2yvlD-3ialA:
undetectable		 2yvlD-3ialA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 THR A  81
ILE A 125
GLY A  85
GLY A  88
ALA A 123
 None
None
MLI  A 341 ( 4.9A)
None
None
 0.87A 2yvlD-3l6cA:
2.1		 2yvlD-3l6cA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		5 THR A  81
ILE A 125
GLY A  85
GLY A  88
ALA A 123
 None
None
MLI  A 347 ( 4.8A)
None
None
 0.84A 2yvlD-3l6rA:
2.4		 2yvlD-3l6rA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 GLY A 101
GLY A 103
ALA A 106
LEU A 107
ASP A 153
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
 0.31A 2yvlD-3lgaA:
26.0		 2yvlD-3lgaA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 ILE A 226
GLY A  93
GLY A  97
ALA A 223
ALA A  81
 None
 1.06A 2yvlD-3o7qA:
undetectable		 2yvlD-3o7qA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0h INACTIVATION-NO-AFTE
R-POTENTIAL D
PROTEIN

(Drosophila
melanogaster) 		PF00595
(PDZ) 		5 THR A 518
GLY A 626
ALA A 609
VAL A 511
VAL A 660
 None
 1.01A 2yvlD-3r0hA:
undetectable		 2yvlD-3r0hA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 ILE A 211
GLY A 166
ALA A 207
VAL A 171
VAL A 190
 None
 1.20A 2yvlD-3uqzA:
undetectable		 2yvlD-3uqzA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		5 ILE A 467
GLY A  76
GLY A  48
ALA A 470
ASP A  72
 FAD  A1487 (-3.7A)
FAD  A1487 (-3.3A)
FAD  A1487 (-3.6A)
FAD  A1487 (-3.3A)
None
 1.07A 2yvlD-3zdnA:
2.3		 2yvlD-3zdnA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 GLY A 187
GLY A 189
ALA A 192
LEU A 193
VAL A 253
 SAM  A1349 (-3.6A)
SAM  A1349 ( 3.8A)
None
None
SAM  A1349 ( 4.7A)
 0.74A 2yvlD-4a6eA:
12.3		 2yvlD-4a6eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu9 BETA-GALACTOSIDASE

(Streptococcus
pneumoniae) 		no annotation 5 GLY A1958
ALA A1900
ASP A1905
PHE A1898
ASP A1959
 None
 1.08A 2yvlD-4cu9A:
undetectable		 2yvlD-4cu9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Synechococcus
elongatus) 		PF13561
(adh_short_C2) 		5 ILE A  20
GLY A  15
ALA A  23
ALA A  40
ASP A  66
 None
SO4  A 301 (-3.6A)
None
SO4  A 301 (-3.4A)
None
 1.04A 2yvlD-4dmmA:
7.2		 2yvlD-4dmmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 GLY A  13
GLY A  15
ALA A  20
LEU A  21
ALA A  37
 FAD  A 602 (-3.1A)
FAD  A 602 (-3.7A)
None
None
FAD  A 602 (-4.0A)
 0.87A 2yvlD-4eipA:
3.0		 2yvlD-4eipA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 ILE A 520
GLY A  76
GLY A  47
ALA A 523
ASP A  72
 FAD  A 601 (-4.2A)
FAD  A 601 (-3.1A)
FAD  A 601 (-3.6A)
FAD  A 601 (-3.1A)
None
 1.00A 2yvlD-4iv9A:
4.2		 2yvlD-4iv9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 200
GLY A 191
GLY A 194
ALA A 199
VAL A 259
 None
 0.93A 2yvlD-4j6fA:
9.1		 2yvlD-4j6fA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE

(Sulfurimonas
denitrificans) 		PF01048
(PNP_UDP_1) 		5 THR A 147
GLY A 178
GLY A 174
ALA A  92
ALA A  56
 None
 1.04A 2yvlD-4jwtA:
undetectable		 2yvlD-4jwtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		5 GLY A  29
GLY A 180
ALA A 209
ALA A  17
VAL A  37
 None
 1.12A 2yvlD-4m7gA:
undetectable		 2yvlD-4m7gA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 GLY A   8
GLY A 221
ALA A  39
VAL A   5
VAL A 225
 None
None
AMP  A 501 ( 4.6A)
None
None
 0.92A 2yvlD-4m9dA:
2.2		 2yvlD-4m9dA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntc GLIT

(Aspergillus
fumigatus) 		PF07992
(Pyr_redox_2) 		5 ILE A 275
GLY A 123
ALA A 296
VAL A  46
PHE A  42
 None
FAD  A 401 (-3.5A)
None
FAD  A 401 (-4.3A)
None
 1.15A 2yvlD-4ntcA:
4.6		 2yvlD-4ntcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcv BDCA (YJGI)

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 ILE A 130
GLY A  14
ALA A  55
VAL A  56
VAL A  23
 None
 1.03A 2yvlD-4pcvA:
8.0		 2yvlD-4pcvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcv BDCA (YJGI)

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 ILE A 130
GLY A  14
ALA A  83
ALA A  55
VAL A  23
 None
 1.15A 2yvlD-4pcvA:
8.0		 2yvlD-4pcvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 5 GLY B 179
GLY B 177
ALA B 118
ALA B 135
PHE B 139
 SF4  B 401 (-3.8A)
SF4  B 401 (-3.6A)
None
SF4  B 401 (-3.5A)
None
 1.17A 2yvlD-4pl2B:
undetectable		 2yvlD-4pl2B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 5 ILE A 146
GLY A  59
LEU A 136
ALA A  25
VAL A  56
 None
 1.03A 2yvlD-4rggA:
undetectable		 2yvlD-4rggA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A3345
GLY A3388
ALA A3506
LEU A3505
PHE A3268
 None
 0.94A 2yvlD-4tktA:
undetectable		 2yvlD-4tktA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE

(Brucella
abortus) 		PF01370
(Epimerase) 		5 GLY A 134
GLY A 132
ALA A 296
LEU A 297
ALA A 136
 None
 1.19A 2yvlD-4twrA:
5.7		 2yvlD-4twrA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN

(Zobellia
galactanivorans) 		no annotation 5 THR A 342
GLY A 347
GLY A 345
ALA A 296
VAL A 335
 EDO  A 511 (-4.1A)
None
None
None
None
 1.09A 2yvlD-4u6dA:
undetectable		 2yvlD-4u6dA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ILE A 382
GLY A 365
GLY A 369
PHE A  12
ASP A 366
 None
 1.19A 2yvlD-4uzuA:
undetectable		 2yvlD-4uzuA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0l HAPTOGLOBIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY C 353
GLY C 188
LEU C 375
VAL C 180
ASP C 354
 None
 0.94A 2yvlD-4x0lC:
undetectable		 2yvlD-4x0lC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  47
ALA A  18
ALA A  59
VAL A  58
ASP A 160
 None
 1.01A 2yvlD-4x0oA:
undetectable		 2yvlD-4x0oA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  47
GLY A 161
ALA A  18
VAL A  58
ASP A 160
 None
 1.15A 2yvlD-4x0oA:
undetectable		 2yvlD-4x0oA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 173
GLY A 131
LEU A 200
ALA A 160
VAL A 170
 None
 1.06A 2yvlD-4xgjA:
undetectable		 2yvlD-4xgjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 187
GLY A 103
ALA A 107
ALA A 185
VAL A 101
 None
 1.00A 2yvlD-4xoxA:
undetectable		 2yvlD-4xoxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yiv APICAL MEMBRANE
ANTIGEN AMA1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		5 GLY A 366
GLY A  94
ALA A 114
VAL A 334
ASP A 388
 None
 1.08A 2yvlD-4yivA:
undetectable		 2yvlD-4yivA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 GLY A 157
ALA A 165
LEU A 164
ALA A 105
ASP A 102
 None
 1.02A 2yvlD-4yweA:
undetectable		 2yvlD-4yweA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B

(Corynebacterium
sp.) 		PF13561
(adh_short_C2) 		5 ILE A  58
LEU A  12
ALA A 200
ASP A 199
VAL A 114
 None
 1.16A 2yvlD-4zd6A:
4.8		 2yvlD-4zd6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 ILE A 172
GLY A 165
GLY A 132
ALA A 171
ALA A 160
 None
None
None
None
RIP  A 301 (-3.3A)
 1.08A 2yvlD-4zjpA:
undetectable		 2yvlD-4zjpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 ILE A 777
GLY A 785
GLY A 783
ALA A 779
ALA A 314
 None
 1.04A 2yvlD-5a42A:
undetectable		 2yvlD-5a42A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 THR A  72
GLY A 131
ALA A  47
LEU A  46
VAL A 134
 None
 1.11A 2yvlD-5by7A:
undetectable		 2yvlD-5by7A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		5 THR A  84
GLY A 111
GLY A 113
ASP A 163
ASP A 181
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-2.7A)
SAH  A 301 (-2.4A)
 0.42A 2yvlD-5ccxA:
26.1		 2yvlD-5ccxA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 GLY A  17
GLY A  19
ALA A  24
LEU A  25
ALA A  49
 None
 0.80A 2yvlD-5cqfA:
3.2		 2yvlD-5cqfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		5 THR A  44
ILE A 250
GLY A 109
ASP A 158
VAL A 253
 None
 1.17A 2yvlD-5ebbA:
undetectable		 2yvlD-5ebbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		5 THR B 107
ILE B 184
GLY B 113
VAL B 143
VAL B 128
 None
 1.12A 2yvlD-5ey5B:
2.2		 2yvlD-5ey5B:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1p PTMO8

(Streptomyces
platensis) 		PF13561
(adh_short_C2) 		5 GLY A 123
ALA A 167
LEU A 168
ASP A  67
VAL A 126
 None
 1.19A 2yvlD-5f1pA:
7.6		 2yvlD-5f1pA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g10 HDAH

(Pseudomonas
aeruginosa) 		PF00850
(Hist_deacetyl) 		5 THR A 188
ILE A 201
LEU A 178
ALA A 162
VAL A 175
 None
 1.20A 2yvlD-5g10A:
3.5		 2yvlD-5g10A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ILE A 232
GLY A 192
ALA A 190
VAL A 195
ASP A  73
 None
 1.08A 2yvlD-5gndA:
undetectable		 2yvlD-5gndA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		5 ILE A  77
GLY A 347
GLY A 350
ALA A  73
ALA A 123
 None
 1.19A 2yvlD-5l25A:
undetectable		 2yvlD-5l25A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLY A 262
ALA A 314
ALA A 290
VAL A 291
ASP A 284
 None
None
None
None
MN  A 601 (-2.2A)
 0.97A 2yvlD-5lhkA:
undetectable		 2yvlD-5lhkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		5 GLY A 564
ALA A 593
VAL A 592
ASP A 565
VAL A 566
 None
 0.94A 2yvlD-5uqeA:
undetectable		 2yvlD-5uqeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		5 ILE A 232
GLY A 158
GLY A 156
ALA A 233
ALA A 152
 None
 1.18A 2yvlD-5vf3A:
undetectable		 2yvlD-5vf3A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 THR A 253
ILE A 301
GLY A 345
ALA A 305
ALA A 122
 None
 1.11A 2yvlD-5xnzA:
undetectable		 2yvlD-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		5 ILE A  77
GLY A  48
ALA A  80
ASP A  45
VAL A  43
 None
 1.11A 2yvlD-5xw3A:
3.4		 2yvlD-5xw3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 5 GLY A 208
GLY A 210
LEU A 214
ASP A 295
PHE A 296
 SAM  A 505 (-3.3A)
SAM  A 505 ( 3.9A)
None
SAM  A 505 (-3.6A)
None
 0.82A 2yvlD-5yf0A:
14.3		 2yvlD-5yf0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 ILE A 376
GLY A 368
ALA A 377
ALA A 392
VAL A 448
 None
 0.95A 2yvlD-5zqzA:
6.8		 2yvlD-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae;
Cyanidioschyzon
merolae) 		no annotation
no annotation 		5 ILE A 559
GLY A 573
GLY A 575
ASP B 558
ASP A 572
 None
SF4  A3001 ( 4.0A)
None
None
None
 0.98A 2yvlD-6fosA:
undetectable		 2yvlD-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ILE P 164
GLY P 213
ALA P 208
VAL P 207
VAL P 215
 None
 0.84A 2yvlD-6g2jP:
undetectable		 2yvlD-6g2jP:
undetectable