SIMILAR PATTERNS OF AMINO ACIDS FOR 2YVL_C_SAMC604_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 GLY A  39
GLU A  40
ASP A  42
TYR A 296
 PO4  A 414 (-3.2A)
None
None
None
 1.37A 2yvlC-1bjwA:
4.0		 2yvlC-1bjwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 GLY A 293
GLU A 288
ASP A 300
TYR A 180
 None
 0.87A 2yvlC-1k0fA:
undetectable		 2yvlC-1k0fA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxq ANTIBODY VHH
FRAGMENT CABAMD9

(Camelus
dromedarius) 		PF07686
(V-set) 		4 GLY E  44
GLU E  43
ASP E  59
TYR E  56
 None
 1.45A 2yvlC-1kxqE:
undetectable		 2yvlC-1kxqE:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvg GUANYLATE KINASE

(Mus musculus) 		PF00625
(Guanylate_kin) 		4 GLY A  82
GLU A  72
ASP A 101
TYR A  53
 5GP  A1202 (-3.2A)
5GP  A1202 (-2.9A)
5GP  A1202 ( 3.4A)
5GP  A1202 (-4.5A)
 1.06A 2yvlC-1lvgA:
undetectable		 2yvlC-1lvgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6d CATHEPSIN F

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 GLY A 167
GLU A   4
ASP A   6
TYR A 188
 None
 1.23A 2yvlC-1m6dA:
undetectable		 2yvlC-1m6dA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 GLY A 108
GLU A 132
ASP A 160
TYR A 183
 None
 0.71A 2yvlC-1o54A:
23.8		 2yvlC-1o54A:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY A 657
GLU A 646
ASP A 649
TYR A 661
 None
 1.47A 2yvlC-1ogyA:
2.2		 2yvlC-1ogyA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 GLY A 486
GLU A 485
ASP A 220
TYR A 639
 None
 1.37A 2yvlC-1r5nA:
undetectable		 2yvlC-1r5nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Methanoculleus
thermophilus) 		PF00296
(Bac_luciferase) 		4 GLY A 107
GLU A 108
ASP A  38
TYR A  80
 F42  A 351 (-3.2A)
ACN  A 352 ( 2.9A)
None
None
 1.27A 2yvlC-1rhcA:
1.3		 2yvlC-1rhcA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 GLY A 293
GLU A 288
ASP A 300
TYR A 180
 None
 0.81A 2yvlC-1toaA:
undetectable		 2yvlC-1toaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 GLY A 153
GLU A 151
ASP A  79
TYR A  53
 SO4  A 610 (-3.0A)
SO4  A 610 (-4.4A)
SO4  A 610 ( 4.7A)
None
 1.47A 2yvlC-1vcnA:
1.6		 2yvlC-1vcnA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		4 GLY A 147
GLU A 148
ASP A 170
TYR A 118
 None
LYS  A 601 (-3.5A)
None
None
 1.44A 2yvlC-2cdqA:
undetectable		 2yvlC-2cdqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		4 GLY A  62
GLU A  61
ASP A 103
TYR A  88
 None
 1.35A 2yvlC-2cw5A:
undetectable		 2yvlC-2cw5A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 GLY X 362
GLU X 130
ASP X 127
TYR X 217
 None
CA  X1016 (-3.3A)
None
None
 1.37A 2yvlC-2hi8X:
undetectable		 2yvlC-2hi8X:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 GLY X 362
GLU X 300
ASP X 127
TYR X 217
 None
CA  X1016 (-3.3A)
None
None
 1.49A 2yvlC-2hi8X:
undetectable		 2yvlC-2hi8X:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri;
Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF02332
(Phenol_Hydrox) 		4 GLY A 138
GLU A 104
ASP A 230
TYR B  83
 None
FE  A 501 (-2.6A)
None
None
 1.37A 2yvlC-2incA:
undetectable		 2yvlC-2incA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		4 GLY A 314
GLU A 190
ASP A 309
TYR A 349
 None
 1.35A 2yvlC-2nxxA:
undetectable		 2yvlC-2nxxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptg ENOYL-ACYL CARRIER
REDUCTASE

(Eimeria tenella) 		PF13561
(adh_short_C2) 		4 GLY A 208
GLU A 213
ASP A 184
TYR A 203
 None
 1.41A 2yvlC-2ptgA:
6.8		 2yvlC-2ptgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qki COMPLEMENT C3

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		4 GLY C1591
GLU C1592
ASP C1552
TYR C1598
 None
 1.36A 2yvlC-2qkiC:
undetectable		 2yvlC-2qkiC:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		4 GLY A  99
GLU A 120
ASP A 148
TYR A 172
 SAM  A 601 (-3.2A)
SAM  A 601 (-2.7A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.0A)
 0.09A 2yvlC-2yvlA:
38.8		 2yvlC-2yvlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		4 GLY A 141
GLU A 144
ASP A 146
TYR A 213
 ACE  A 368 (-3.3A)
ACE  A 368 (-3.1A)
None
None
 1.03A 2yvlC-3h4xA:
undetectable		 2yvlC-3h4xA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		4 GLY A 188
GLU A 189
ASP A 258
TYR A 179
 None
 1.45A 2yvlC-3onqA:
undetectable		 2yvlC-3onqA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 GLY B1074
GLU B1036
ASP B1080
TYR B 834
 None
 1.34A 2yvlC-4f92B:
2.8		 2yvlC-4f92B:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		4 GLY A 104
GLU A 109
ASP A  80
TYR A  99
 None
None
NAD  A 401 (-3.6A)
None
 1.47A 2yvlC-4o1mA:
6.2		 2yvlC-4o1mA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A
TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN E

(Pseudomonas
mendocina;
Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox)
PF02332
(Phenol_Hydrox) 		4 GLY A 138
GLU A 104
ASP A 230
TYR B  80
 None
FE  A 501 ( 2.4A)
None
None
 1.34A 2yvlC-4p1cA:
undetectable		 2yvlC-4p1cA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbn NUCLEASE

(Salmonella
virus SETP3) 		PF08774
(VRR_NUC) 		4 GLY A  81
GLU A  55
ASP A  87
TYR A  11
 None
 1.43A 2yvlC-4qbnA:
undetectable		 2yvlC-4qbnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 GLY A 398
GLU A 507
ASP A 299
TYR A 344
 None
 1.42A 2yvlC-5by3A:
undetectable		 2yvlC-5by3A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A 448
GLU A 447
ASP A 184
TYR A 708
 None
None
None
EDO  A1006 (-4.2A)
 1.30A 2yvlC-5chcA:
1.8		 2yvlC-5chcA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME COMPONENT
C8, PUTATIVE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 GLY G 149
GLU G  41
ASP G  44
TYR G 227
 None
 1.43A 2yvlC-5fmgG:
undetectable		 2yvlC-5fmgG:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 4 GLY A 323
GLU A 292
ASP A 303
TYR A 300
 None
 1.35A 2yvlC-5fzpA:
undetectable		 2yvlC-5fzpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvi UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Danio rerio) 		PF00443
(UCH) 		4 GLY A 441
GLU A 155
ASP A 157
TYR A 485
 None
 1.36A 2yvlC-5gviA:
undetectable		 2yvlC-5gviA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 GLY A 339
GLU A 338
ASP A 333
TYR A 237
 None
 1.22A 2yvlC-5kojA:
2.3		 2yvlC-5kojA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A 451
GLU A 159
ASP A 161
TYR A 495
 AYE  A 602 (-4.7A)
AYE  A 602 (-3.5A)
None
None
 1.29A 2yvlC-5ohkA:
undetectable		 2yvlC-5ohkA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 GLY A 683
GLU A 622
ASP A 615
TYR A 559
 None
 1.34A 2yvlC-5ue8A:
2.9		 2yvlC-5ue8A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 4 GLY A 106
GLU A 107
ASP A 495
TYR A  96
 None
 1.49A 2yvlC-5whsA:
undetectable		 2yvlC-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 4 GLY A 208
GLU A 229
ASP A 295
TYR A 324
 SAM  A 505 (-3.3A)
SAM  A 505 (-2.9A)
SAM  A 505 (-3.6A)
None
 0.83A 2yvlC-5yf0A:
14.6		 2yvlC-5yf0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE

(Arabidopsis
thaliana) 		no annotation 4 GLY A 303
GLU A 441
ASP A 408
TYR A 326
 AMP  A 600 ( 4.2A)
None
AMP  A 600 (-2.8A)
AMP  A 600 (-4.8A)
 1.20A 2yvlC-6avhA:
undetectable		 2yvlC-6avhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfs PHOSPHOMANNOMUTASE 1

(Homo sapiens) 		no annotation 4 GLY A  88
GLU A  71
ASP A  67
TYR A  56
 None
 1.47A 2yvlC-6cfsA:
undetectable		 2yvlC-6cfsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 473
GLU A 475
ASP A 477
TYR A 419
 None
 1.11A 2yvlC-6f91A:
undetectable		 2yvlC-6f91A:
undetectable