SIMILAR PATTERNS OF AMINO ACIDS FOR 2YVL_C_SAMC604_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 ILE A 145
ILE A 144
GLY A 316
ALA A 314
ALA A 325
VAL A  20
 None
None
FAD  A 480 ( 4.0A)
None
FAD  A 480 (-3.5A)
None
 1.12A 2yvlC-1dxlA:
3.8		 2yvlC-1dxlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		5 ILE A 569
GLY A 363
SER A 364
LEU A 475
ASP A 573
 None
 0.93A 2yvlC-1e3hA:
undetectable		 2yvlC-1e3hA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		5 THR A  16
GLY A 101
SER A 102
VAL A 296
VAL A   9
 None
 1.25A 2yvlC-1escA:
2.0		 2yvlC-1escA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 283
ILE A 296
GLY A 280
ALA A 297
LEU A 298
 None
None
FAD  A 448 (-3.1A)
FAD  A 448 (-4.6A)
FAD  A 448 (-3.7A)
 1.05A 2yvlC-1f8wA:
3.3		 2yvlC-1f8wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		5 ILE A 129
GLY A 126
ALA A  96
VAL A 158
ASP A  62
 None
CO3  A 700 (-3.6A)
None
None
FE  A 702 ( 3.1A)
 0.90A 2yvlC-1h76A:
undetectable		 2yvlC-1h76A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 ILE A  83
GLY A 109
SER A 110
ALA A 112
LEU A 113
ASP A 178
 SAM  A 301 (-4.0A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
 0.38A 2yvlC-1i9gA:
27.5		 2yvlC-1i9gA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		5 THR A  71
ILE A 135
GLY A  13
ALA A 137
VAL A  29
 None
 1.18A 2yvlC-1jaxA:
4.0		 2yvlC-1jaxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		5 ILE A  60
ILE A  56
ALA A 200
VAL A 201
PHE A 198
 None
 1.18A 2yvlC-1ka0A:
undetectable		 2yvlC-1ka0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		5 ILE A 205
ILE A 163
GLY A 292
ALA A 164
ALA A  37
 None
 1.00A 2yvlC-1l0qA:
undetectable		 2yvlC-1l0qA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF13847
(Methyltransf_31) 		5 THR A  71
ALA A  52
LEU A  51
ASP A  39
VAL A  40
 None
 1.24A 2yvlC-1l3iA:
21.7		 2yvlC-1l3iA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5s FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanosarcina
barkeri) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 ALA A 111
ALA A 151
VAL A 104
PHE A 119
ASP A 115
 None
 0.97A 2yvlC-1m5sA:
undetectable		 2yvlC-1m5sA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		5 GLY A 661
ALA A 775
LEU A 777
ALA A 667
VAL A 784
 None
 1.24A 2yvlC-1nd7A:
undetectable		 2yvlC-1nd7A:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		5 ILE A  83
GLY A 110
ALA A 113
ASP A 176
VAL A 177
 CL  A 266 ( 4.7A)
None
CL  A 266 (-3.6A)
None
None
 0.35A 2yvlC-1o54A:
23.8		 2yvlC-1o54A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		5 ILE A  83
GLY A 110
SER A 111
ASP A 176
VAL A 177
 CL  A 266 ( 4.7A)
None
CL  A 266 ( 4.4A)
None
None
 0.89A 2yvlC-1o54A:
23.8		 2yvlC-1o54A:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata;
Torpedo
marmorata) 		PF02932
(Neur_chan_memb)
PF02932
(Neur_chan_memb) 		5 ILE B 231
ALA B 235
LEU B 234
VAL A 249
VAL B 261
 None
 1.12A 2yvlC-1oedB:
undetectable		 2yvlC-1oedB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		5 ILE A 110
ILE A 109
GLY A 285
ALA A 283
ALA A 295
 None
None
FAD  A 500 (-3.1A)
None
FAD  A 500 (-3.6A)
 0.96A 2yvlC-1tdfA:
4.7		 2yvlC-1tdfA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY B 336
SER B 335
LEU B 165
ALA B  12
VAL B 343
 None
 1.16A 2yvlC-1tqyB:
undetectable		 2yvlC-1tqyB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		5 ILE A  90
ALA A  89
ALA A  29
VAL A  30
VAL A   9
 None
 1.08A 2yvlC-1u9cA:
undetectable		 2yvlC-1u9cA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 ILE A 130
ALA A 154
LEU A 155
ALA A 142
VAL A 133
 None
 1.19A 2yvlC-1v9cA:
undetectable		 2yvlC-1v9cA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiu TWITCHIN 18TH IGSF
MODULE

(Caenorhabditis
elegans) 		PF07679
(I-set) 		5 ILE A  91
ILE A  12
GLY A  71
SER A  70
ALA A  43
 None
 1.18A 2yvlC-1wiuA:
undetectable		 2yvlC-1wiuA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A 159
ALA A 314
LEU A 315
PHE A  60
VAL A  44
 None
 1.29A 2yvlC-1wz9A:
undetectable		 2yvlC-1wz9A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		5 THR A 132
ILE A 209
GLY A 138
VAL A 168
VAL A 153
 None
 1.16A 2yvlC-1x1qA:
2.3		 2yvlC-1x1qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg5 ARPG836

(Homo sapiens) 		PF00106
(adh_short) 		5 ILE A 146
ALA A 193
ALA A 233
VAL A 232
VAL A  16
 None
 0.89A 2yvlC-1xg5A:
7.0		 2yvlC-1xg5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 306
GLY A  68
ALA A 132
LEU A 110
ALA A  65
 None
FAD  A 501 (-3.1A)
None
None
FAD  A 501 (-3.8A)
 1.04A 2yvlC-1zr6A:
undetectable		 2yvlC-1zr6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		5 GLY A 241
SER A 242
ALA A 246
ALA A 277
VAL A 238
 None
 1.02A 2yvlC-2aa4A:
undetectable		 2yvlC-2aa4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		5 ILE A 292
LEU A 222
ALA A 260
VAL A 265
ASP A 223
 None
 1.20A 2yvlC-2as0A:
16.4		 2yvlC-2as0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 THR A 602
SER A 543
ALA A 474
ALA A 551
VAL A 597
 None
 1.23A 2yvlC-2cvtA:
undetectable		 2yvlC-2cvtA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 ILE A 127
GLY A 124
ALA A  94
VAL A 161
ASP A  60
 None
BCT  A 688 (-3.8A)
None
None
AL  A 687 ( 2.9A)
 0.93A 2yvlC-2d3iA:
undetectable		 2yvlC-2d3iA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP A 398
 None
 1.10A 2yvlC-2e0wA:
undetectable		 2yvlC-2e0wA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli;
Escherichia
coli) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		5 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP B 398
 None
 1.10A 2yvlC-2e0xA:
undetectable		 2yvlC-2e0xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		5 THR A 882
ILE A 884
ILE A 885
LEU A 914
ALA A 785
 None
 1.16A 2yvlC-2eyqA:
3.0		 2yvlC-2eyqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 ALA A 344
ALA A 290
VAL A 377
ASP A 341
VAL A 340
 None
 0.86A 2yvlC-2gahA:
4.1		 2yvlC-2gahA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		5 THR A 162
ILE A 108
GLY A 159
ALA A 107
ALA A 134
 None
 1.13A 2yvlC-2hp3A:
undetectable		 2yvlC-2hp3A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huo INOSITOL OXYGENASE

(Mus musculus) 		PF05153
(MIOX) 		5 ILE A 217
GLY A 120
LEU A 125
PHE A  97
ASP A 124
 None
None
None
None
FE  A 302 ( 2.5A)
 1.21A 2yvlC-2huoA:
undetectable		 2yvlC-2huoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 142
ILE A 141
GLY A 313
ALA A 311
VAL A  16
 None
None
FAD  A 480 (-3.4A)
None
None
 0.96A 2yvlC-2qaeA:
2.8		 2yvlC-2qaeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3u PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		5 ILE A 236
GLY A 202
SER A 201
VAL A  61
VAL A 129
 None
 1.27A 2yvlC-2r3uA:
undetectable		 2yvlC-2r3uA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		5 SER A 433
ALA A  37
LEU A  38
ALA A  96
VAL A 437
 None
 1.26A 2yvlC-2vf8A:
undetectable		 2yvlC-2vf8A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vm6 BCL-2-RELATED
PROTEIN A1

(Homo sapiens) 		PF00452
(Bcl-2) 		5 ILE A  84
GLY A  87
ALA A  41
VAL A  40
PHE A  95
 None
 1.09A 2yvlC-2vm6A:
undetectable		 2yvlC-2vm6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vof BCL-2-RELATED
PROTEIN A1

(Mus musculus) 		PF00452
(Bcl-2) 		5 ILE A  84
GLY A  87
ALA A  41
VAL A  40
PHE A  95
 None
 1.29A 2yvlC-2vofA:
undetectable		 2yvlC-2vofA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A 470
GLY A 472
SER A 473
ALA A 477
VAL A 389
 None
 1.03A 2yvlC-2vosA:
3.1		 2yvlC-2vosA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ILE A 545
GLY A 548
ALA A 537
VAL A 553
ASP A 574
 None
 1.16A 2yvlC-2xf2A:
2.9		 2yvlC-2xf2A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhz ARABINOSE
5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		5 ILE A  63
ILE A 103
GLY A 171
ALA A 177
VAL A 176
 None
 1.20A 2yvlC-2xhzA:
undetectable		 2yvlC-2xhzA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		12 THR A  72
ILE A  74
ILE A  75
GLY A 101
SER A 102
ALA A 104
LEU A 105
ALA A 121
VAL A 122
PHE A 149
ASP A 165
VAL A 166
 SAM  A 601 (-3.9A)
SAM  A 601 ( 4.6A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.9A)
SAM  A 601 ( 4.5A)
None
SAM  A 601 (-3.4A)
SAM  A 601 ( 4.3A)
 0.21A 2yvlC-2yvlA:
38.8		 2yvlC-2yvlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		6 ILE A 285
ILE A 171
GLY A 191
ALA A 172
ALA A  24
VAL A  23
 FMN  A 401 ( 4.9A)
None
FMN  A 401 (-3.2A)
None
None
None
 1.22A 2yvlC-2z6iA:
undetectable		 2yvlC-2z6iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsf AT4G34840

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 ILE A  93
SER A  89
ALA A  92
ALA A 194
VAL A 193
 None
 1.07A 2yvlC-3bsfA:
undetectable		 2yvlC-3bsfA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjp PREDICTED
AMIDOHYDROLASE,
DIHYDROOROTASE
FAMILY

(Clostridium
acetobutylicum) 		PF04909
(Amidohydro_2) 		5 ILE A   5
ILE A   4
GLY A 225
LEU A 254
ALA A 204
 None
 0.95A 2yvlC-3cjpA:
undetectable		 2yvlC-3cjpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 ILE A 166
GLY A 168
ALA A 123
LEU A 126
PHE A   6
 None
 1.08A 2yvlC-3gl1A:
undetectable		 2yvlC-3gl1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 ILE A  30
ILE A 105
GLY A  28
ALA A 186
VAL A 122
 None
 1.20A 2yvlC-3h7tA:
undetectable		 2yvlC-3h7tA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hps 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF08502
(LeuA_dimer) 		5 ILE A 383
GLY A 377
SER A 378
ALA A 382
VAL A 425
 None
 1.18A 2yvlC-3hpsA:
2.3		 2yvlC-3hpsA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpx 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like) 		5 ILE A 383
GLY A 377
SER A 378
ALA A 382
VAL A 425
 None
 1.17A 2yvlC-3hpxA:
undetectable		 2yvlC-3hpxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		5 THR A1331
ILE A1333
ALA A1342
LEU A1341
ASP A1337
 None
 1.26A 2yvlC-3hrrA:
undetectable		 2yvlC-3hrrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y MS30

(Homo sapiens) 		PF00829
(Ribosomal_L21p) 		5 ILE s 241
SER s 182
ALA s 146
VAL s 145
VAL s 422
 None
 1.28A 2yvlC-3j7ys:
undetectable		 2yvlC-3j7ys:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 ILE A  76
GLY A 103
SER A 104
ALA A 106
LEU A 107
ASP A 169
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.6A)
 0.41A 2yvlC-3lgaA:
25.5		 2yvlC-3lgaA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 ILE A 296
GLY A 291
SER A 292
ALA A  79
ALA A 344
 None
 1.26A 2yvlC-3nd0A:
undetectable		 2yvlC-3nd0A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyw S-LAYER PROTEIN SAP

(Bacillus
anthracis) 		PF00395
(SLH) 		5 SER A 104
ALA A 106
LEU A 109
ALA A  44
VAL A  81
 None
 1.25A 2yvlC-3pywA:
undetectable		 2yvlC-3pywA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ILE A  15
GLY A   9
ALA A  14
ALA A  33
VAL A  67
 None
 1.18A 2yvlC-3qsgA:
5.8		 2yvlC-3qsgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sil SIALIDASE

(Salmonella
enterica) 		PF13859
(BNR_3) 		5 ILE A 285
ILE A 235
SER A 283
VAL A 280
PHE A 228
 None
 1.19A 2yvlC-3silA:
undetectable		 2yvlC-3silA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 THR A 391
GLY A 481
PHE A 545
ASP A 532
VAL A 509
 None
CIT  A   1 (-3.6A)
None
None
None
 1.17A 2yvlC-3u1kA:
undetectable		 2yvlC-3u1kA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae) 		PF13561
(adh_short_C2) 		5 ILE A  21
ILE A  25
GLY A  16
ALA A  64
VAL A  13
 NAP  A 274 (-3.7A)
None
NAP  A 274 (-3.8A)
None
None
 1.21A 2yvlC-3uf0A:
7.1		 2yvlC-3uf0A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 THR A 142
ILE A 139
GLY A 116
ALA A 150
VAL A 151
 GOL  A 487 (-3.6A)
None
GOL  A 487 (-3.9A)
None
None
 1.23A 2yvlC-3uhjA:
undetectable		 2yvlC-3uhjA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 ILE A 211
GLY A 166
ALA A 207
VAL A 171
VAL A 190
 None
 1.25A 2yvlC-3uqzA:
undetectable		 2yvlC-3uqzA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 GLY A 547
SER A 548
ALA A 552
LEU A 553
ALA A 345
 None
 1.22A 2yvlC-3vfdA:
undetectable		 2yvlC-3vfdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bem F1FO ATPASE C1
SUBUNIT

(Acetobacterium
woodii) 		PF00137
(ATP-synt_C) 		5 GLY J 116
ALA J 112
ALA J  38
VAL J  37
PHE J  84
 None
None
None
None
HTG  J1187 ( 4.7A)
 1.27A 2yvlC-4bemJ:
undetectable		 2yvlC-4bemJ:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 ILE A 212
ALA A 215
ALA A 348
VAL A 347
VAL A 206
 None
 0.93A 2yvlC-4dioA:
6.4		 2yvlC-4dioA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ds3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		5 GLY A  14
SER A  15
ALA A  19
LEU A  20
PHE A  37
 GOL  A 305 (-3.7A)
GOL  A 305 (-4.7A)
None
None
None
 1.06A 2yvlC-4ds3A:
3.9		 2yvlC-4ds3A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4w NUCLEOCAPSID

(Punta Toro
phlebovirus) 		PF05733
(Tenui_N) 		5 ILE A 135
GLY A 129
ALA A 134
ALA A 118
PHE A 148
 None
 1.15A 2yvlC-4j4wA:
undetectable		 2yvlC-4j4wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnq THIOREDOXIN
REDUCTASE

(Brucella
melitensis) 		PF07992
(Pyr_redox_2) 		5 ILE A 111
ILE A 110
GLY A 285
ALA A 283
ALA A 295
 None
None
FDA  A 401 (-3.4A)
None
FDA  A 401 (-3.4A)
 1.01A 2yvlC-4jnqA:
4.6		 2yvlC-4jnqA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4neg TRYPTOPHAN SYNTHASE
BETA CHAIN

(Bacillus
anthracis) 		PF00291
(PALP) 		5 THR A 114
ILE A 191
GLY A 120
VAL A 150
VAL A 135
 SO4  A 401 (-3.3A)
None
None
None
None
 1.22A 2yvlC-4negA:
3.1		 2yvlC-4negA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 ILE A 234
ILE A 261
GLY A 297
ALA A 263
VAL A 321
 None
 0.96A 2yvlC-4qq1A:
undetectable		 2yvlC-4qq1A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1p UNCHARACTERIZED
PROTEIN

(Slackia
heliotrinireducens) 		PF13472
(Lipase_GDSL_2) 		5 GLY A 169
SER A 170
ALA A 174
LEU A 175
ALA A 154
 None
 1.15A 2yvlC-4s1pA:
3.8		 2yvlC-4s1pA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up3 THIOREDOXIN
REDUCTASE

(Entamoeba
histolytica) 		PF07992
(Pyr_redox_2) 		5 ILE A 115
ILE A 114
GLY A 283
ALA A 281
ALA A 293
 None
None
FAD  A1315 (-3.3A)
None
FAD  A1315 (-3.5A)
 0.93A 2yvlC-4up3A:
4.5		 2yvlC-4up3A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 133
SER A 185
LEU A 199
ALA A 370
VAL A 217
 None
 1.23A 2yvlC-4wkyA:
2.0		 2yvlC-4wkyA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  47
ALA A  18
ALA A  59
VAL A  58
ASP A 160
 None
 1.00A 2yvlC-4x0oA:
undetectable		 2yvlC-4x0oA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 173
GLY A 131
LEU A 200
ALA A 160
VAL A 170
 None
 1.12A 2yvlC-4xgjA:
undetectable		 2yvlC-4xgjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		5 ILE A  56
ILE A  57
GLY A 211
LEU A  62
VAL A 215
 None
 1.04A 2yvlC-4z7lA:
undetectable		 2yvlC-4z7lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 ILE A  97
ILE A  96
GLY A  27
LEU A  24
PHE A  82
 None
 1.28A 2yvlC-4z8yA:
undetectable		 2yvlC-4z8yA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Enterovirus D;
Enterovirus D) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 THR C 164
ILE C 166
ILE C 167
LEU C 113
VAL A  29
 None
 1.11A 2yvlC-5bnnC:
undetectable		 2yvlC-5bnnC:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		5 ILE A 121
GLY A 115
SER A 116
ALA A 120
VAL A 159
 None
SAH  A 301 (-3.9A)
SAH  A 301 (-4.3A)
None
None
 1.29A 2yvlC-5ccxA:
24.9		 2yvlC-5ccxA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		5 THR A  84
ILE A  86
GLY A 113
SER A 114
ASP A 181
 SAH  A 301 (-3.4A)
SAH  A 301 ( 4.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-4.4A)
SAH  A 301 (-2.4A)
 0.35A 2yvlC-5ccxA:
24.9		 2yvlC-5ccxA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp)
PF01740
(STAS) 		5 ILE A  59
GLY A 281
ALA A 269
ALA A  82
VAL A  52
 None
 1.11A 2yvlC-5da0A:
undetectable		 2yvlC-5da0A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 GLY A 231
SER A 236
ALA A 212
LEU A 216
VAL A 168
 None
 1.15A 2yvlC-5dkvA:
2.9		 2yvlC-5dkvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		5 ILE A 346
ILE A 349
GLY A 558
ALA A 313
PHE A 214
 None
 0.78A 2yvlC-5e26A:
undetectable		 2yvlC-5e26A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		5 THR B 107
ILE B 184
GLY B 113
VAL B 143
VAL B 128
 None
 1.12A 2yvlC-5ey5B:
2.3		 2yvlC-5ey5B:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 ILE A 544
ILE A 545
ALA A 350
LEU A 349
ALA A 315
 None
 0.97A 2yvlC-5ez3A:
undetectable		 2yvlC-5ez3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE B 135
SER B 138
ALA B 221
VAL B 224
VAL B 163
 None
 1.20A 2yvlC-5g06B:
undetectable		 2yvlC-5g06B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02771
(Acyl-CoA_dh_N) 		5 ILE D  91
GLY D  85
SER D  86
ALA D  90
VAL D  79
 None
 1.19A 2yvlC-5gj8D:
undetectable		 2yvlC-5gj8D:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6i PROTEIN B

(Streptococcus
agalactiae) 		no annotation 5 GLY A 105
SER A 106
ALA A 110
LEU A 111
ALA A  47
 None
 1.08A 2yvlC-5h6iA:
undetectable		 2yvlC-5h6iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb1 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF03177
(Nucleoporin_C) 		5 ILE A 611
SER A 671
ALA A 675
LEU A 676
ALA A 749
 None
 0.91A 2yvlC-5hb1A:
undetectable		 2yvlC-5hb1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp) 		5 ILE A  59
GLY A 281
ALA A 269
ALA A  82
VAL A  52
 None
 1.11A 2yvlC-5iofA:
undetectable		 2yvlC-5iofA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		5 ILE A 486
ILE A 702
ALA A 701
VAL A 727
VAL A 769
 None
 1.12A 2yvlC-5iw7A:
2.1		 2yvlC-5iw7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 ILE A 233
GLY A  19
ALA A  46
VAL A  49
PHE A  38
 None
None
None
None
ADP  A 300 (-3.5A)
 1.26A 2yvlC-5iz4A:
6.6		 2yvlC-5iz4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 5 THR E 114
ILE E 112
ILE E 111
GLY E  52
ALA E  84
 CLF  E 501 (-4.2A)
None
None
None
None
 0.92A 2yvlC-5n6yE:
4.7		 2yvlC-5n6yE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 258
LEU A 183
ALA A 166
PHE A 163
VAL A 228
 None
 1.28A 2yvlC-5neuA:
undetectable		 2yvlC-5neuA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 THR A 466
GLY A 274
SER A 273
ALA A 281
ALA A 528
 None
 1.15A 2yvlC-5oltA:
undetectable		 2yvlC-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		5 ILE A 111
ILE A 110
GLY A 285
ALA A 283
ALA A 295
 None
None
FAD  A 401 (-3.1A)
None
FAD  A 401 (-3.4A)
 0.95A 2yvlC-5u63A:
4.3		 2yvlC-5u63A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A  25
ALA A  29
VAL A   9
ASP A 155
VAL A 152
 None
 1.19A 2yvlC-5wyrA:
undetectable		 2yvlC-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		5 ILE A  77
GLY A  48
ALA A  80
ASP A  45
VAL A  43
 None
 1.23A 2yvlC-5xw3A:
3.2		 2yvlC-5xw3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bt4 S-LAYER PROTEIN SAP

(Bacillus
anthracis) 		no annotation 5 SER A 133
ALA A 135
LEU A 138
ALA A  73
VAL A 110
 KPM  A 301 (-3.5A)
None
None
None
None
 1.28A 2yvlC-6bt4A:
undetectable		 2yvlC-6bt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwt THIOREDOXIN
REDUCTASE

(Francisella
tularensis) 		no annotation 5 ILE A 109
ILE A 108
GLY A 283
ALA A 281
ALA A 293
 None
None
SO4  A 402 (-3.5A)
None
None
 0.98A 2yvlC-6bwtA:
4.7		 2yvlC-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 5 GLY F 237
SER F 238
ALA F 242
LEU F 243
ALA F 286
 None
 1.25A 2yvlC-6f0kF:
undetectable		 2yvlC-6f0kF:
undetectable