SIMILAR PATTERNS OF AMINO ACIDS FOR 2YVL_B_SAMB602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 ILE A 268
GLY A 264
GLY A 266
ALA A 200
PHE A 261
 None
 1.16A 2yvlB-1c3lA:
2.6		 2yvlB-1c3lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLY O   4
ALA O 111
LEU O  82
VAL O   1
VAL O  93
 None
 1.07A 2yvlB-1dbvO:
4.3		 2yvlB-1dbvO:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 145
ILE A 144
GLY A 316
ALA A 314
VAL A  20
 None
None
FAD  A 480 ( 4.0A)
None
None
 1.00A 2yvlB-1dxlA:
4.1		 2yvlB-1dxlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 145
ILE A 144
GLY A 316
ALA A 325
VAL A  20
 None
None
FAD  A 480 ( 4.0A)
FAD  A 480 (-3.5A)
None
 1.08A 2yvlB-1dxlA:
4.1		 2yvlB-1dxlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 108
ILE A 109
GLY A  11
LEU A   6
ALA A 299
 None
None
FAD  A 448 (-3.7A)
FAD  A 448 (-4.4A)
FAD  A 448 (-3.4A)
 1.03A 2yvlB-1f8wA:
3.3		 2yvlB-1f8wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 GLY A 409
GLY A 411
ALA A  88
ALA A 150
ASP A 408
 None
 1.13A 2yvlB-1fc9A:
undetectable		 2yvlB-1fc9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftg APOFLAVODOXIN

(Nostoc sp. PCC
7119) 		PF00258
(Flavodoxin_1) 		5 GLY A  53
GLY A  87
ALA A  19
VAL A  18
PHE A   7
 None
 0.94A 2yvlB-1ftgA:
undetectable		 2yvlB-1ftgA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 ILE A  83
GLY A 107
GLY A 109
ALA A 112
LEU A 113
ASP A 178
 SAM  A 301 (-4.0A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
 0.37A 2yvlB-1i9gA:
27.7		 2yvlB-1i9gA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		5 ILE A  60
ILE A  56
ALA A 200
VAL A 201
PHE A 198
 None
 1.15A 2yvlB-1ka0A:
undetectable		 2yvlB-1ka0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5s FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanosarcina
barkeri) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 ALA A 111
ALA A 151
VAL A 104
PHE A 119
ASP A 115
 None
 1.00A 2yvlB-1m5sA:
undetectable		 2yvlB-1m5sA:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		6 ILE A  83
GLY A 108
GLY A 110
ALA A 113
ASP A 176
VAL A 177
 CL  A 266 ( 4.7A)
None
None
CL  A 266 (-3.6A)
None
None
 0.39A 2yvlB-1o54A:
27.7		 2yvlB-1o54A:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata;
Torpedo
marmorata) 		PF02932
(Neur_chan_memb)
PF02932
(Neur_chan_memb) 		5 ILE B 231
ALA B 235
LEU B 234
VAL A 249
VAL B 261
 None
 1.05A 2yvlB-1oedB:
undetectable		 2yvlB-1oedB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major) 		PF01212
(Beta_elim_lyase) 		5 ILE A 212
GLY A  74
GLY A 222
ALA A 224
LEU A 225
 None
 0.96A 2yvlB-1svvA:
2.2		 2yvlB-1svvA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		5 ILE A 262
ILE A 263
ALA A 243
VAL A 244
PHE A 238
 None
 0.89A 2yvlB-1tdjA:
2.6		 2yvlB-1tdjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		5 ILE A 107
GLY A  60
ALA A   7
LEU A   6
VAL A  55
 None
 1.15A 2yvlB-1vh0A:
undetectable		 2yvlB-1vh0A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		5 THR A 132
ILE A 209
GLY A 138
VAL A 168
VAL A 153
 None
 1.15A 2yvlB-1x1qA:
2.4		 2yvlB-1x1qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 252
GLY A 268
GLY A 255
ALA A 271
VAL A 266
 None
 0.95A 2yvlB-1xdiA:
4.2		 2yvlB-1xdiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg5 ARPG836

(Homo sapiens) 		PF00106
(adh_short) 		5 ILE A 146
ALA A 193
ALA A 233
VAL A 232
VAL A  16
 None
 0.88A 2yvlB-1xg5A:
6.8		 2yvlB-1xg5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 ILE A  36
GLY A  28
GLY A  30
ALA A  35
VAL A 111
 None
 1.01A 2yvlB-1yj8A:
5.9		 2yvlB-1yj8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		5 ILE A 292
LEU A 222
ALA A 260
VAL A 265
ASP A 223
 None
 1.16A 2yvlB-2as0A:
17.1		 2yvlB-2as0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjr MFP2B

(Ascaris suum) 		PF12150
(MFP2b) 		5 ILE A 244
GLY A 326
GLY A 242
ALA A 253
ALA A 328
 None
 1.08A 2yvlB-2bjrA:
undetectable		 2yvlB-2bjrA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP A 398
 None
 1.08A 2yvlB-2e0wA:
undetectable		 2yvlB-2e0wA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli;
Escherichia
coli) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		5 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP B 398
 None
 1.08A 2yvlB-2e0xA:
undetectable		 2yvlB-2e0xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		5 THR A 882
ILE A 884
ILE A 885
LEU A 914
ALA A 785
 None
 1.14A 2yvlB-2eyqA:
4.9		 2yvlB-2eyqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 THR A  75
ILE A  73
ALA A 110
VAL A 109
ASP A 117
 None
 1.08A 2yvlB-2fjaA:
2.5		 2yvlB-2fjaA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 ALA A 344
ALA A 290
VAL A 377
ASP A 341
VAL A 340
 None
 0.90A 2yvlB-2gahA:
4.2		 2yvlB-2gahA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 ILE A 162
GLY A 193
GLY A 282
VAL A 190
VAL A 197
 NDP  A 400 (-3.8A)
NDP  A 400 (-3.5A)
NDP  A 400 ( 3.8A)
None
None
 0.90A 2yvlB-2hxvA:
undetectable		 2yvlB-2hxvA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 142
ILE A 141
GLY A 313
ALA A 311
VAL A  16
 None
None
FAD  A 480 (-3.4A)
None
None
 1.00A 2yvlB-2qaeA:
3.1		 2yvlB-2qaeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  77
GLY A 138
ALA A 118
LEU A 119
VAL A   8
 None
 1.09A 2yvlB-2qnyA:
undetectable		 2yvlB-2qnyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		5 THR A  15
ILE A  13
ILE A  12
GLY A 231
LEU A  68
 None
 0.82A 2yvlB-2qpqA:
undetectable		 2yvlB-2qpqA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE

(Lactobacillus
plantarum) 		PF03807
(F420_oxidored) 		5 ILE A  15
GLY A   7
GLY A   9
ALA A  14
VAL A  46
 None
NAP  A 200 ( 3.5A)
NAP  A 200 ( 3.2A)
None
NAP  A 200 ( 4.1A)
 1.06A 2yvlB-2rafA:
3.5		 2yvlB-2rafA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcy TRANS-2-ENOYL-COA
REDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 105
GLY A 136
ALA A  45
LEU A  46
ALA A 133
 None
 1.05A 2yvlB-2vcyA:
6.5		 2yvlB-2vcyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 151
GLY A 104
ALA A 147
ALA A  26
VAL A 131
 None
 1.04A 2yvlB-2vxyA:
3.3		 2yvlB-2vxyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  46
GLY A 159
ALA A  17
ALA A  59
ASP A 158
 None
 0.98A 2yvlB-2x3eA:
undetectable		 2yvlB-2x3eA:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		5 ILE A  75
GLY A  99
ALA A 121
PHE A 119
ASP A 165
 SAM  A 601 (-4.1A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.9A)
None
SAM  A 601 (-3.4A)
 0.95A 2yvlB-2yvlA:
38.9		 2yvlB-2yvlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		6 THR A  72
ILE A  74
GLY A 101
ALA A 104
VAL A 122
PHE A 145
 SAM  A 601 (-3.9A)
SAM  A 601 ( 4.6A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.2A)
SAM  A 601 ( 4.5A)
None
 1.35A 2yvlB-2yvlA:
38.9		 2yvlB-2yvlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		12 THR A  72
ILE A  74
ILE A  75
GLY A  99
GLY A 101
ALA A 104
LEU A 105
ALA A 121
VAL A 122
PHE A 149
ASP A 165
VAL A 166
 SAM  A 601 (-3.9A)
SAM  A 601 ( 4.6A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.9A)
SAM  A 601 ( 4.5A)
None
SAM  A 601 (-3.4A)
SAM  A 601 ( 4.3A)
 0.11A 2yvlB-2yvlA:
38.9		 2yvlB-2yvlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		6 ILE A 285
ILE A 171
GLY A 191
ALA A 172
ALA A  24
VAL A  23
 FMN  A 401 ( 4.9A)
None
FMN  A 401 (-3.2A)
None
None
None
 1.24A 2yvlB-2z6iA:
undetectable		 2yvlB-2z6iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		5 ILE A 172
ILE A 696
GLY A 693
VAL A 690
ASP A 695
 None
 1.07A 2yvlB-3abzA:
undetectable		 2yvlB-3abzA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		5 GLY A  39
ALA A  44
LEU A  45
ALA A  61
VAL A 101
 None
 0.90A 2yvlB-3cc8A:
12.2		 2yvlB-3cc8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjp PREDICTED
AMIDOHYDROLASE,
DIHYDROOROTASE
FAMILY

(Clostridium
acetobutylicum) 		PF04909
(Amidohydro_2) 		5 ILE A   5
ILE A   4
GLY A 225
LEU A 254
ALA A 204
 None
 0.97A 2yvlB-3cjpA:
undetectable		 2yvlB-3cjpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cty THIOREDOXIN
REDUCTASE

(Thermoplasma
acidophilum) 		PF07992
(Pyr_redox_2) 		5 THR A 160
ILE A 172
GLY A 164
GLY A 167
VAL A 248
 None
 1.05A 2yvlB-3ctyA:
4.6		 2yvlB-3ctyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00857
(Isochorismatase) 		5 THR A  99
GLY A  95
ALA A  92
VAL A  46
ASP A 130
 None
 1.00A 2yvlB-3eefA:
3.5		 2yvlB-3eefA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A 214
ILE A 213
GLY A 200
ALA A 197
VAL A 208
 None
 0.98A 2yvlB-3fhlA:
4.6		 2yvlB-3fhlA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd8 AQUAPORIN-4

(Homo sapiens) 		PF00230
(MIP) 		5 ILE A 189
GLY A  93
GLY A  89
ALA A 190
ALA A  37
 GOL  A   4 (-3.7A)
None
GOL  A   4 ( 3.8A)
GOL  A   4 (-3.4A)
None
 1.07A 2yvlB-3gd8A:
undetectable		 2yvlB-3gd8A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 ILE A 166
GLY A 168
ALA A 123
LEU A 126
PHE A   6
 None
 1.08A 2yvlB-3gl1A:
undetectable		 2yvlB-3gl1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima) 		PF00154
(RecA) 		5 THR A  53
ILE A  49
GLY A  56
LEU A  47
VAL A  39
 None
 0.97A 2yvlB-3hr8A:
3.2		 2yvlB-3hr8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 THR A  81
ILE A 125
GLY A  85
GLY A  88
ALA A 123
 None
None
MLI  A 341 ( 4.9A)
None
None
 0.90A 2yvlB-3l6cA:
2.3		 2yvlB-3l6cA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		5 THR A  81
ILE A 125
GLY A  85
GLY A  88
ALA A 123
 None
None
MLI  A 347 ( 4.8A)
None
None
 0.88A 2yvlB-3l6rA:
2.4		 2yvlB-3l6rA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 ILE A  76
GLY A 101
GLY A 103
ALA A 106
LEU A 107
ASP A 169
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.6A)
 0.36A 2yvlB-3lgaA:
25.9		 2yvlB-3lgaA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		5 ILE A 828
GLY A 865
LEU A 826
ALA A 906
VAL A 861
 None
 1.10A 2yvlB-3nowA:
undetectable		 2yvlB-3nowA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		5 ILE A 139
GLY A 362
ALA A 108
ALA A 387
VAL A 386
 None
 1.01A 2yvlB-3penA:
2.6		 2yvlB-3penA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		6 ILE A  15
GLY A   7
GLY A   9
ALA A  14
ALA A  33
VAL A  67
 None
 1.24A 2yvlB-3qsgA:
6.1		 2yvlB-3qsgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		5 GLY A 147
GLY A 152
ALA A 157
LEU A 158
VAL A  49
 None
 1.16A 2yvlB-3vvlA:
2.1		 2yvlB-3vvlA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 GLY A 265
ALA A 304
VAL A 269
ASP A 262
VAL A 259
 None
 1.00A 2yvlB-3x1lA:
undetectable		 2yvlB-3x1lA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 GLY A 187
GLY A 189
ALA A 192
LEU A 193
VAL A 253
 SAM  A1349 (-3.6A)
SAM  A1349 ( 3.8A)
None
None
SAM  A1349 ( 4.7A)
 0.71A 2yvlB-4a6eA:
12.2		 2yvlB-4a6eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bko PUTATIVE REDUCTASE
BURPS305_1051

(Burkholderia
pseudomallei) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 THR A 250
ILE A 205
GLY A 198
ALA A 194
VAL A 193
 None
 1.09A 2yvlB-4bkoA:
5.6		 2yvlB-4bkoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 GLY A  13
GLY A  15
ALA A  20
LEU A  21
ALA A  37
 FAD  A 602 (-3.1A)
FAD  A 602 (-3.7A)
None
None
FAD  A 602 (-4.0A)
 0.87A 2yvlB-4eipA:
3.0		 2yvlB-4eipA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4w NUCLEOCAPSID

(Punta Toro
phlebovirus) 		PF05733
(Tenui_N) 		5 ILE A 135
GLY A 129
ALA A 134
ALA A 118
PHE A 148
 None
 1.10A 2yvlB-4j4wA:
undetectable		 2yvlB-4j4wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 200
GLY A 191
GLY A 194
ALA A 199
VAL A 259
 None
 0.98A 2yvlB-4j6fA:
9.6		 2yvlB-4j6fA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE

(Staphylococcus
aureus) 		PF01656
(CbiA) 		5 THR A1114
ILE A1112
ILE A1111
LEU A1122
VAL A1064
 None
 1.00A 2yvlB-4jmpA:
3.1		 2yvlB-4jmpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnq THIOREDOXIN
REDUCTASE

(Brucella
melitensis) 		PF07992
(Pyr_redox_2) 		5 ILE A 111
ILE A 110
GLY A 285
ALA A 283
ALA A 295
 None
None
FDA  A 401 (-3.4A)
None
FDA  A 401 (-3.4A)
 0.99A 2yvlB-4jnqA:
3.3		 2yvlB-4jnqA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE

(Sulfurimonas
denitrificans) 		PF01048
(PNP_UDP_1) 		5 THR A 147
GLY A 178
GLY A 174
ALA A  92
ALA A  56
 None
 1.09A 2yvlB-4jwtA:
undetectable		 2yvlB-4jwtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		5 GLY A  71
GLY A 135
ALA A 131
ALA A 138
VAL A 139
 None
 1.09A 2yvlB-4kqkA:
undetectable		 2yvlB-4kqkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		5 GLY A  29
GLY A 180
ALA A 209
ALA A  17
VAL A  37
 None
 1.16A 2yvlB-4m7gA:
undetectable		 2yvlB-4m7gA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcv BDCA (YJGI)

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 ILE A 130
GLY A  14
ALA A  55
VAL A  56
VAL A  23
 None
 1.07A 2yvlB-4pcvA:
8.3		 2yvlB-4pcvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		5 ILE A  95
GLY A  92
ALA A 113
ASP A  88
VAL A  89
 SAH  A1000 (-4.8A)
SAH  A1000 ( 3.7A)
SAH  A1000 (-3.6A)
SAH  A1000 ( 4.2A)
None
 0.99A 2yvlB-4qppA:
9.1		 2yvlB-4qppA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 5 ILE A 146
GLY A  59
LEU A 136
ALA A  25
VAL A  56
 None
 1.09A 2yvlB-4rggA:
undetectable		 2yvlB-4rggA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 5 ILE A 545
ILE A 546
GLY A 519
ALA A 516
LEU A 517
 None
 1.11A 2yvlB-4ru5A:
undetectable		 2yvlB-4ru5A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A3345
GLY A3388
ALA A3506
LEU A3505
PHE A3268
 None
 0.93A 2yvlB-4tktA:
undetectable		 2yvlB-4tktA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up3 THIOREDOXIN
REDUCTASE

(Entamoeba
histolytica) 		PF07992
(Pyr_redox_2) 		5 ILE A 115
ILE A 114
GLY A 283
ALA A 281
ALA A 293
 None
None
FAD  A1315 (-3.3A)
None
FAD  A1315 (-3.5A)
 0.92A 2yvlB-4up3A:
4.7		 2yvlB-4up3A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 5 GLY C 349
GLY C 184
LEU C 371
VAL C 176
ASP C 350
 None
 0.95A 2yvlB-4wjgC:
undetectable		 2yvlB-4wjgC:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0l HAPTOGLOBIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY C 353
GLY C 188
LEU C 375
VAL C 180
ASP C 354
 None
 0.91A 2yvlB-4x0lC:
undetectable		 2yvlB-4x0lC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  47
ALA A  18
ALA A  59
VAL A  58
ASP A 160
 None
 0.98A 2yvlB-4x0oA:
undetectable		 2yvlB-4x0oA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  47
GLY A 161
ALA A  18
VAL A  58
ASP A 160
 None
 1.11A 2yvlB-4x0oA:
undetectable		 2yvlB-4x0oA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus) 		PF00840
(Glyco_hydro_7) 		5 ILE A 180
GLY A 150
GLY A 167
ALA A 205
VAL A 152
 None
 1.10A 2yvlB-4xebA:
undetectable		 2yvlB-4xebA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 187
GLY A 103
ALA A 107
ALA A 185
VAL A 101
 None
 0.99A 2yvlB-4xoxA:
undetectable		 2yvlB-4xoxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		5 ILE A  56
ILE A  57
GLY A 211
LEU A  62
VAL A 215
 None
 1.10A 2yvlB-4z7lA:
undetectable		 2yvlB-4z7lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 ILE A 777
GLY A 785
GLY A 783
ALA A 779
ALA A 314
 None
 1.05A 2yvlB-5a42A:
undetectable		 2yvlB-5a42A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Enterovirus D;
Enterovirus D) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 THR C 164
ILE C 166
ILE C 167
LEU C 113
VAL A  29
 None
 1.08A 2yvlB-5bnnC:
undetectable		 2yvlB-5bnnC:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		5 THR A  84
ILE A  86
GLY A 111
GLY A 113
ASP A 181
 SAH  A 301 (-3.4A)
SAH  A 301 ( 4.2A)
SAH  A 301 (-3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-2.4A)
 0.24A 2yvlB-5ccxA:
26.0		 2yvlB-5ccxA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 GLY A  17
GLY A  19
ALA A  24
LEU A  25
ALA A  49
 None
 0.80A 2yvlB-5cqfA:
2.2		 2yvlB-5cqfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp)
PF01740
(STAS) 		5 ILE A  59
GLY A 281
ALA A 269
ALA A  82
VAL A  52
 None
 1.13A 2yvlB-5da0A:
undetectable		 2yvlB-5da0A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		5 ILE A 346
ILE A 349
GLY A 558
ALA A 313
PHE A 214
 None
 0.79A 2yvlB-5e26A:
undetectable		 2yvlB-5e26A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		5 THR B 107
ILE B 184
GLY B 113
VAL B 143
VAL B 128
 None
 1.12A 2yvlB-5ey5B:
2.0		 2yvlB-5ey5B:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 ILE A 544
ILE A 545
ALA A 350
LEU A 349
ALA A 315
 None
 0.96A 2yvlB-5ez3A:
undetectable		 2yvlB-5ez3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1p PTMO8

(Streptomyces
platensis) 		PF13561
(adh_short_C2) 		5 ILE A  61
GLY A  13
ALA A  34
LEU A  35
ALA A  92
 None
 1.15A 2yvlB-5f1pA:
7.6		 2yvlB-5f1pA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp) 		5 ILE A  59
GLY A 281
ALA A 269
ALA A  82
VAL A  52
 None
 1.13A 2yvlB-5iofA:
undetectable		 2yvlB-5iofA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		5 ILE A 486
ILE A 702
ALA A 701
VAL A 727
VAL A 769
 None
 1.08A 2yvlB-5iw7A:
undetectable		 2yvlB-5iw7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltv CHEMOTACTIC
TRANSDUCER PCTC

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		5 THR A 144
ILE A 142
GLY A 175
ALA A 135
LEU A 161
 None
 1.07A 2yvlB-5ltvA:
undetectable		 2yvlB-5ltvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 5 THR E 114
ILE E 112
GLY E  52
LEU E  49
ALA E  84
 CLF  E 501 (-4.2A)
None
None
None
None
 1.15A 2yvlB-5n6yE:
5.0		 2yvlB-5n6yE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 5 THR E 114
ILE E 112
ILE E 111
GLY E  52
ALA E  84
 CLF  E 501 (-4.2A)
None
None
None
None
 0.89A 2yvlB-5n6yE:
5.0		 2yvlB-5n6yE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 105
GLY A  49
GLY A  76
ALA A  97
PHE A 328
 None
 1.14A 2yvlB-5tf0A:
undetectable		 2yvlB-5tf0A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		5 ILE A 111
ILE A 110
GLY A 285
ALA A 283
ALA A 295
 None
None
FAD  A 401 (-3.1A)
None
FAD  A 401 (-3.4A)
 0.95A 2yvlB-5u63A:
4.6		 2yvlB-5u63A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		5 GLY A 564
ALA A 593
VAL A 592
ASP A 565
VAL A 566
 None
 0.92A 2yvlB-5uqeA:
undetectable		 2yvlB-5uqeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE

(Sinorhizobium
meliloti) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 157
GLY A 149
GLY A 151
ALA A 156
VAL A 201
 None
 1.14A 2yvlB-5v72A:
5.3		 2yvlB-5v72A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwn TRIOSEPHOSPHATE
ISOMERASE

(Trichomonas
vaginalis) 		no annotation 5 ILE A 162
GLY A 168
GLY A 166
LEU A 124
VAL A 170
 None
 0.97A 2yvlB-5vwnA:
undetectable		 2yvlB-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		5 ILE A  77
GLY A  48
ALA A  80
ASP A  45
VAL A  43
 None
 1.14A 2yvlB-5xw3A:
undetectable		 2yvlB-5xw3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwt THIOREDOXIN
REDUCTASE

(Francisella
tularensis) 		no annotation 5 ILE A 109
ILE A 108
GLY A 283
ALA A 281
ALA A 293
 None
None
SO4  A 402 (-3.5A)
None
None
 0.97A 2yvlB-6bwtA:
5.0		 2yvlB-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ILE P 164
GLY P 213
ALA P 208
VAL P 207
VAL P 215
 None
 0.88A 2yvlB-6g2jP:
undetectable		 2yvlB-6g2jP:
undetectable