SIMILAR PATTERNS OF AMINO ACIDS FOR 2YVL_A_SAMA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLU A 122
ASP A 129
ASP A 168
TYR A 177
 None
 1.27A 2yvlA-1j0nA:
0.0		 2yvlA-1j0nA:
15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 GLU A 132
ASP A 160
ASP A 176
TYR A 183
 None
 0.68A 2yvlA-1o54A:
27.7		 2yvlA-1o54A:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN

(Halobacterium
salinarum) 		PF00210
(Ferritin) 		4 GLU A  69
ASP A  62
ASP A 161
TYR A 169
 None
 1.46A 2yvlA-1tkpA:
undetectable		 2yvlA-1tkpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9x UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09138
(Urm1) 		4 GLU A  94
ASP A  91
ASP A  76
TYR A  85
 None
 0.96A 2yvlA-2k9xA:
0.0		 2yvlA-2k9xA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		4 GLU A 120
ASP A 148
ASP A 165
TYR A 172
 SAM  A 601 (-2.7A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.4A)
SAM  A 601 (-4.0A)
 0.00A 2yvlA-2yvlA:
40.6		 2yvlA-2yvlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S27,
MITOCHONDRIAL

(Bos taurus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 GLU e 174
ASP e 372
ASP e 140
TYR e 142
 None
 1.40A 2yvlA-3jd5e:
0.0		 2yvlA-3jd5e:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nat UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF11217
(DUF3013) 		4 GLU A  83
ASP A  81
ASP A  28
TYR A  72
 None
CIT  A 162 ( 3.3A)
None
ZN  A 165 ( 4.9A)
 1.16A 2yvlA-3natA:
0.0		 2yvlA-3natA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdu DCN1-LIKE PROTEIN 1

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 GLU A 135
ASP A  92
ASP A 132
TYR A  72
 None
 1.48A 2yvlA-3tduA:
0.0		 2yvlA-3tduA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		4 GLU A  73
ASP A  66
ASP A  36
TYR A  95
 None
None
ZN  A 902 ( 2.5A)
None
 1.37A 2yvlA-3wx7A:
1.3		 2yvlA-3wx7A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		4 GLU A  77
ASP A  70
ASP A  40
TYR A  99
 None
None
CD  A 502 ( 2.6A)
None
 1.39A 2yvlA-4nz5A:
0.0		 2yvlA-4nz5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqa POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00645
(zf-PARP)
PF08063
(PADR1) 		4 GLU A  76
ASP A 285
ASP A 307
TYR A 309
 None
 1.50A 2yvlA-4oqaA:
undetectable		 2yvlA-4oqaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 GLU A 156
ASP A  75
ASP A  17
TYR A 160
 None
 0.85A 2yvlA-4p5yA:
undetectable		 2yvlA-4p5yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN

(Bacillus
thuringiensis) 		PF13424
(TPR_12) 		4 GLU A  70
ASP A  77
ASP A 107
TYR A 113
 None
 1.06A 2yvlA-5dbkA:
undetectable		 2yvlA-5dbkA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR

(Yersinia
enterocolitica) 		PF03472
(Autoind_bind) 		4 GLU A   9
ASP A   7
ASP A  14
TYR A 162
 None
 1.44A 2yvlA-5l09A:
undetectable		 2yvlA-5l09A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nur ABC TRANSPORTER
PERMEASE

(Klebsiella
pneumoniae) 		no annotation 4 GLU D 200
ASP D 207
ASP D  15
TYR D 129
 None
 1.44A 2yvlA-5nurD:
undetectable		 2yvlA-5nurD:
20.15