SIMILAR PATTERNS OF AMINO ACIDS FOR 2YQZ_B_SAMB401_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1atg | PERIPLASMICMOLYBDATE-BINDINGPROTEIN (Azotobactervinelandii) |
PF13531(SBP_bac_11) | 6 | GLY A 162ILE A 169ASP A 160VAL A 84HIS A 180LEU A 85 | NoneNoneACT A 301 (-3.5A)NoneNoneNone | 1.37A | 2yqzB-1atgA:undetectable | 2yqzB-1atgA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c1d | L-PHENYLALANINEDEHYDROGENASE (Rhodococcus sp.) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 187GLY A 182LEU A 190ALA A 260ALA A 154 | NoneNAI A 360 (-3.6A)NoneNAI A 360 (-3.7A)None | 0.92A | 2yqzB-1c1dA:7.3 | 2yqzB-1c1dA:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cbf | COBALT-PRECORRIN-4TRANSMETHYLASE (Bacillusmegaterium) |
PF00590(TP_methylase) | 6 | GLY A 29GLY A 129ILE A 26LEU A 35ALA A 135HIS A 100 | NoneNoneNoneNoneNonePO4 A 401 (-3.5A) | 1.05A | 2yqzB-1cbfA:3.4 | 2yqzB-1cbfA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d5f | E6AP HECT CATALYTICDOMAIN, E3 LIGASE (Homo sapiens) |
PF00632(HECT) | 5 | ASP A 507ALA A 513VAL A 547LEU A 554VAL A 555 | None | 0.94A | 2yqzB-1d5fA:undetectable | 2yqzB-1d5fA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e0c | SULFURTRANSFERASE (Azotobactervinelandii) |
PF00581(Rhodanese) | 5 | GLY A 115GLY A 91ILE A 207ASP A 89LEU A 113 | NoneNoneNone MG A 378 ( 4.7A)None | 0.95A | 2yqzB-1e0cA:undetectable | 2yqzB-1e0cA:26.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e7s | GDP-FUCOSESYNTHETASE (Escherichiacoli) |
PF01370(Epimerase) | 5 | GLY A 246GLY A 248LEU A 290ALA A 220LEU A 212 | None | 0.94A | 2yqzB-1e7sA:4.6 | 2yqzB-1e7sA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ea9 | CYCLOMALTODEXTRINASE (Bacillus sp.(in: Bacteria)) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 6 | ILE C 136ALA C 239ASP C 325VAL C 189LEU C 236LEU C 352 | None | 1.27A | 2yqzB-1ea9C:undetectable | 2yqzB-1ea9C:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eye | DIHYDROPTEROATESYNTHASE I (Mycobacteriumtuberculosis) |
PF00809(Pterin_bind) | 6 | GLY A 110LEU A 120ALA A 164ASP A 163VAL A 107LEU A 157 | None | 1.48A | 2yqzB-1eyeA:undetectable | 2yqzB-1eyeA:25.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gey | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 6 | ILE A 180LEU A 174ASP A 145VAL A 149LEU A 104VAL A 127 | None | 1.35A | 2yqzB-1geyA:3.3 | 2yqzB-1geyA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htj | KIAA0380 (Homo sapiens) |
PF09128(RGS-like) | 5 | GLY F 361ALA F 346ALA F 404LEU F 369VAL F 377 | None | 0.78A | 2yqzB-1htjF:undetectable | 2yqzB-1htjF:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyq | CELL DIVISIONINHIBITOR (MIND-1) (Archaeoglobusfulgidus) |
PF01656(CbiA) | 5 | GLY A 194ALA A 190VAL A 139LEU A 165VAL A 164 | None | 0.93A | 2yqzB-1hyqA:undetectable | 2yqzB-1hyqA:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ja9 | 1,3,6,8-TETRAHYDROXYNAPHTHALENEREDUCTASE (Magnaporthegrisea) |
PF13561(adh_short_C2) | 5 | GLY A 50GLY A 53ALA A 32ALA A 46LEU A 74 | None | 0.87A | 2yqzB-1ja9A:6.8 | 2yqzB-1ja9A:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jj7 | PEPTIDE TRANSPORTERTAP1 (Homo sapiens) |
PF00005(ABC_tran) | 5 | GLY A 585LEU A 653ASP A 668LEU A 697VAL A 696 | None | 0.95A | 2yqzB-1jj7A:undetectable | 2yqzB-1jj7A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m6e | S-ADENOSYL-L-METHIONINE:SALICYLIC ACIDCARBOXYLMETHYLTRANSFERASE (Clarkia breweri) |
PF03492(Methyltransf_7) | 6 | GLY X 203LEU X 140ALA X 54ALA X 56LEU X 73VAL X 70 | None | 1.41A | 2yqzB-1m6eX:10.6 | 2yqzB-1m6eX:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mjf | SPERMIDINE SYNTHASE (Pyrococcusfuriosus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 86GLY A 84ILE A 117LEU A 123VAL A 65 | None | 0.95A | 2yqzB-1mjfA:11.5 | 2yqzB-1mjfA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nxj | PROBABLES-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE METHYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF03737(RraA-like) | 6 | GLY A 92GLY A 62ILE A 39VAL A 65LEU A 93VAL A 77 | NoneNoneNoneNoneNoneTLA A 391 ( 4.8A) | 1.45A | 2yqzB-1nxjA:undetectable | 2yqzB-1nxjA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ose | PORCINEALPHA-AMYLASE (Sus scrofa) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 6 | GLY A 193LEU A 186ALA A 97LEU A 214LEU A 211VAL A 210 | None | 1.10A | 2yqzB-1oseA:undetectable | 2yqzB-1oseA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r3d | CONSERVEDHYPOTHETICAL PROTEINVC1974 (Vibrio cholerae) |
PF12697(Abhydrolase_6) | 5 | ILE A 86ALA A 77VAL A 18LEU A 46LEU A 6 | None | 0.94A | 2yqzB-1r3dA:undetectable | 2yqzB-1r3dA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8q | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE,PERIPLASMIC (Escherichiacoli) |
PF03009(GDPD) | 5 | GLY A 339ALA A 333HIS A 311LEU A 343VAL A 315 | None | 0.93A | 2yqzB-1t8qA:undetectable | 2yqzB-1t8qA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tc5 | PROBABLE EUKARYOTICD-AMINO ACID TRNADEACYLASE,LMAJ005534AAA (Leishmaniamajor) |
PF02580(Tyr_Deacylase) | 5 | ILE A 194ALA A 136VAL A 64LEU A 66LEU A 86 | None | 0.93A | 2yqzB-1tc5A:undetectable | 2yqzB-1tc5A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1thg | LIPASE 2 (Galactomycescandidus) |
PF00135(COesterase) | 5 | GLY A 476ILE A 516LEU A 452LEU A 455VAL A 456 | None | 0.90A | 2yqzB-1thgA:3.0 | 2yqzB-1thgA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqj | RIBULOSE-PHOSPHATE3-EPIMERASE (Synechocystissp.) |
PF00834(Ribul_P_3_epim) | 5 | ALA A 115ALA A 117HIS A 100LEU A 101VAL A 131 | None | 0.78A | 2yqzB-1tqjA:undetectable | 2yqzB-1tqjA:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 2 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 6 | GLY B 169ILE B 175ALA B 280ALA B 284VAL B 3LEU B 400 | None | 1.15A | 2yqzB-1tqyB:undetectable | 2yqzB-1tqyB:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2x | ADP-SPECIFICPHOSPHOFRUCTOKINASE (Pyrococcushorikoshii) |
PF04587(ADP_PFK_GK) | 5 | GLY A 341LEU A 340ASP A 347LEU A 317LEU A 320 | None | 0.96A | 2yqzB-1u2xA:4.7 | 2yqzB-1u2xA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulv | GLUCODEXTRANASE (Arthrobacterglobiformis) |
PF00723(Glyco_hydro_15)PF09136(Glucodextran_B)PF09137(Glucodextran_N)PF09985(Glucodextran_C) | 5 | GLY A 828ASP A 807ALA A 824HIS A 841VAL A 844 | None CA A2005 (-3.3A)NoneNoneNone | 0.96A | 2yqzB-1ulvA:undetectable | 2yqzB-1ulvA:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urj | MAJOR DNA-BINDINGPROTEIN (Humanalphaherpesvirus1) |
PF00747(Viral_DNA_bp) | 5 | GLY A 537GLY A 673LEU A 656LEU A 771VAL A 773 | None | 0.80A | 2yqzB-1urjA:undetectable | 2yqzB-1urjA:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uzn | 3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | GLY A 23ILE A 27ALA A 43LEU A 85VAL A 84 | NoneNAP A1249 (-4.1A)NoneNoneNone | 0.92A | 2yqzB-1uznA:6.1 | 2yqzB-1uznA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v19 | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermusthermophilus) |
PF00294(PfkB) | 6 | GLY A 256GLY A 260LEU A 43ALA A 42LEU A 277LEU A 276 | None | 1.46A | 2yqzB-1v19A:5.1 | 2yqzB-1v19A:26.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9s | URACILPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF14681(UPRTase) | 6 | GLY A 80ALA A 36VAL A 74LEU A 73LEU A 88VAL A 91 | None | 1.31A | 2yqzB-1v9sA:3.4 | 2yqzB-1v9sA:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9s | URACILPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF14681(UPRTase) | 6 | GLY A 80ILE A 99ALA A 36VAL A 74LEU A 73LEU A 88 | None | 1.38A | 2yqzB-1v9sA:3.4 | 2yqzB-1v9sA:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve5 | THREONINE DEAMINASE (Thermusthermophilus) |
PF00291(PALP) | 5 | GLY A 153GLY A 156ALA A 187LEU A 7LEU A 4 | None | 0.96A | 2yqzB-1ve5A:2.0 | 2yqzB-1ve5A:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | GLY A 289ALA A 153ALA A 157LEU A 299VAL A 243 | None | 0.95A | 2yqzB-1vknA:2.9 | 2yqzB-1vknA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vli | SPORE COATPOLYSACCHARIDEBIOSYNTHESIS PROTEINSPSE (Bacillussubtilis) |
PF03102(NeuB)PF08666(SAF) | 5 | GLY A 229ILE A 209ALA A 221LEU A 194LEU A 284 | None | 0.96A | 2yqzB-1vliA:undetectable | 2yqzB-1vliA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w0m | TRIOSEPHOSPHATEISOMERASE (Thermoproteustenax) |
PF00121(TIM)PF05690(ThiG) | 5 | GLY A 181GLY A 147ALA A 204LEU A 200VAL A 199 | PO4 A1226 (-3.6A)PO4 A1226 (-3.7A)NoneNoneNone | 0.82A | 2yqzB-1w0mA:undetectable | 2yqzB-1w0mA:25.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wa3 | 2-KETO-3-DEOXY-6-PHOSPHOGLUCONATEALDOLASE (Thermotogamaritima) |
PF01081(Aldolase) | 6 | GLY A 66ILE A 64LEU A 16ALA A 48ALA A 24LEU A 55 | None | 1.43A | 2yqzB-1wa3A:undetectable | 2yqzB-1wa3A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wuu | GALACTOKINASE (Homo sapiens) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C)PF10509(GalKase_gal_bdg) | 5 | GLY A 36ILE A 222ALA A 34ALA A 143VAL A 38 | None | 0.94A | 2yqzB-1wuuA:undetectable | 2yqzB-1wuuA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wv2 | THIAZOLEBIOSYNTHESIS PROTEINTHIG (Pseudomonasaeruginosa) |
PF05690(ThiG) | 5 | GLY A1195GLY A1168ALA A1218LEU A1214VAL A1213 | None | 0.91A | 2yqzB-1wv2A:undetectable | 2yqzB-1wv2A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdi | RV3303C-LPDA (Mycobacteriumtuberculosis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 14GLY A 11ALA A 329LEU A 19VAL A 20 | NoneFAD A 999 (-3.3A)NoneNoneNone | 0.91A | 2yqzB-1xdiA:4.0 | 2yqzB-1xdiA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b7n | PROBABLENICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Helicobacterpylori) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 6 | GLY A 45ILE A 103ALA A 49LEU A 97LEU A 76VAL A 35 | None | 1.14A | 2yqzB-2b7nA:undetectable | 2yqzB-2b7nA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cbf | COBALT-PRECORRIN-4TRANSMETHYLASE (Bacillusmegaterium) |
PF00590(TP_methylase) | 6 | GLY A 29GLY A 129ILE A 26LEU A 35ALA A 135HIS A 100 | None | 1.05A | 2yqzB-2cbfA:3.3 | 2yqzB-2cbfA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy8 | D-PHENYLGLYCINEAMINOTRANSFERASE (Pseudomonasstutzeri) |
PF00202(Aminotran_3) | 6 | GLY A 360ILE A 330ALA A 354ALA A 340HIS A 416LEU A 424 | None | 1.26A | 2yqzB-2cy8A:undetectable | 2yqzB-2cy8A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy8 | D-PHENYLGLYCINEAMINOTRANSFERASE (Pseudomonasstutzeri) |
PF00202(Aminotran_3) | 6 | GLY A 360ILE A 330ALA A 354HIS A 416LEU A 424VAL A 425 | None | 1.02A | 2yqzB-2cy8A:undetectable | 2yqzB-2cy8A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1y | HYPOTHETICAL PROTEINTT0321 (Thermusthermophilus) |
PF13561(adh_short_C2) | 6 | GLY A 13ILE A 22ALA A 71VAL A 82LEU A 10LEU A 115 | NAD A1001 (-3.5A)NoneNoneNoneNoneNone | 1.39A | 2yqzB-2d1yA:6.4 | 2yqzB-2d1yA:27.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dht | 409AA LONGHYPOTHETICALNADP-DEPENDENTISOCITRATEDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00180(Iso_dh) | 6 | GLY A 32GLY A 34ILE A 39ALA A 68LEU A 99VAL A 110 | None | 1.26A | 2yqzB-2dhtA:undetectable | 2yqzB-2dhtA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | GLY A 78ILE A 76LEU A 179VAL A 189LEU A 198 | GOL A2003 ( 4.8A)NoneNoneNoneNone | 0.89A | 2yqzB-2elcA:2.4 | 2yqzB-2elcA:28.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ewo | PUTATIVE AGMATINEDEIMINASE (Streptococcusmutans) |
PF04371(PAD_porph) | 6 | GLY A 233ALA A 227VAL A 167LEU A 174LEU A 208VAL A 210 | None | 1.20A | 2yqzB-2ewoA:undetectable | 2yqzB-2ewoA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fgy | CARBOXYSOME SHELLPOLYPEPTIDE (Halothiobacillusneapolitanus) |
PF08936(CsoSCA) | 6 | ILE A 302ALA A 263ASP A 260ALA A 267VAL A 304LEU A 292 | None | 1.35A | 2yqzB-2fgyA:undetectable | 2yqzB-2fgyA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftp | HYDROXYMETHYLGLUTARYL-COA LYASE (Pseudomonasaeruginosa) |
PF00682(HMGL-like) | 5 | GLY A 267ILE A 264ASP A 269VAL A 7LEU A 42 | None | 0.95A | 2yqzB-2ftpA:undetectable | 2yqzB-2ftpA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2geb | HYPOXANTHINE-GUANINEPHOSPHORIBOSYLTRANSFERASE (Caldanaerobactersubterraneus) |
PF00156(Pribosyltran) | 6 | ILE A 99LEU A 62ASP A 32LEU A 54LEU A 25VAL A 22 | None | 1.50A | 2yqzB-2gebA:3.9 | 2yqzB-2gebA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gqw | FERREDOXIN REDUCTASE (Pseudomonas sp.KKS102) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 5 | GLY A 153ILE A 235VAL A 151LEU A 173VAL A 202 | None | 0.90A | 2yqzB-2gqwA:3.4 | 2yqzB-2gqwA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hcf | HYDROLASE, HALOACIDDEHALOGENASE-LIKEFAMILY (Chlorobaculumtepidum) |
PF13419(HAD_2) | 6 | ILE A 227LEU A 111ALA A 159VAL A 173LEU A 7LEU A 115 | None | 1.50A | 2yqzB-2hcfA:2.7 | 2yqzB-2hcfA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2htm | THIAZOLEBIOSYNTHESIS PROTEINTHIG (Thermusthermophilus) |
PF05690(ThiG) | 5 | GLY A 186GLY A 157ALA A 209LEU A 205VAL A 204 | None | 0.94A | 2yqzB-2htmA:undetectable | 2yqzB-2htmA:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ihf | SINGLE-STRANDEDDNA-BINDING PROTEIN (Thermusaquaticus) |
PF00436(SSB) | 5 | GLY A 135GLY A 4LEU A 157LEU A 174VAL A 176 | None | 0.91A | 2yqzB-2ihfA:undetectable | 2yqzB-2ihfA:25.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwz | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Homo sapiens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 234GLY A 212ALA A 280HIS A 203VAL A 192 | None | 0.84A | 2yqzB-2iwzA:undetectable | 2yqzB-2iwzA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ix4 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Arabidopsisthaliana) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 6 | GLY A 212GLY A 234ILE A 400ALA A 205ALA A 210VAL A 397 | None | 1.47A | 2yqzB-2ix4A:undetectable | 2yqzB-2ix4A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jpo | PHEROMONE-BINDINGPROTEIN (Antheraeapolyphemus) |
PF01395(PBP_GOBP) | 5 | GLY A 13ASP A 17ALA A 51LEU A 33VAL A 29 | None | 0.95A | 2yqzB-2jpoA:undetectable | 2yqzB-2jpoA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nlx | XYLULOSE KINASE (Escherichiacoli) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | GLY A 205ILE A 208ASP A 170LEU A 431VAL A 239 | None | 0.95A | 2yqzB-2nlxA:undetectable | 2yqzB-2nlxA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ns9 | HYPOTHETICAL PROTEINAPE2225 (Aeropyrumpernix) |
PF06240(COXG) | 5 | LEU A 62ALA A 138ASP A 135LEU A 10VAL A 122 | None | 0.96A | 2yqzB-2ns9A:undetectable | 2yqzB-2ns9A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ob5 | HYPOTHETICAL PROTEINATU2016 (Agrobacteriumfabrum) |
PF05025(RbsD_FucU) | 6 | ILE A 146LEU A 63ALA A 61LEU A 17LEU A 14VAL A 13 | None | 1.27A | 2yqzB-2ob5A:undetectable | 2yqzB-2ob5A:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2opj | O-SUCCINYLBENZOATE-COA SYNTHASE (Thermobifidafusca) |
PF13378(MR_MLE_C) | 6 | GLY A 239GLY A 235LEU A 242ALA A 243LEU A 255LEU A 277 | None | 1.43A | 2yqzB-2opjA:undetectable | 2yqzB-2opjA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ov9 | HYPOTHETICAL PROTEIN (Rhodococcusjostii) |
PF03061(4HBT) | 5 | GLY A 131LEU A 136LEU A 118LEU A 172VAL A 116 | None | 0.94A | 2yqzB-2ov9A:undetectable | 2yqzB-2ov9A:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph3 | 3-OXOACYL-[ACYLCARRIER PROTEIN]REDUCTASE (Thermusthermophilus) |
PF13561(adh_short_C2) | 6 | GLY A 8ILE A 17ALA A 59VAL A 85LEU A 5VAL A 71 | None | 1.49A | 2yqzB-2ph3A:6.3 | 2yqzB-2ph3A:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2plj | LYSINE/ORNITHINEDECARBOXYLASE (Vibriovulnificus) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | GLY A 336ALA A 284ASP A 302VAL A 333LEU A 320 | None | 0.85A | 2yqzB-2pljA:undetectable | 2yqzB-2pljA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 124GLY A 126ILE A 130ASP A 149ALA A 179 | S4M A 501 (-3.4A)S4M A 501 ( 4.4A)NoneNoneS4M A 501 (-3.5A) | 0.80A | 2yqzB-2pt6A:12.0 | 2yqzB-2pt6A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qny | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Mycobacteriumtuberculosis) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 6 | GLY A 167ALA A 131ASP A 74ALA A 122LEU A 135VAL A 136 | None | 1.45A | 2yqzB-2qnyA:undetectable | 2yqzB-2qnyA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4j | AEROBICGLYCEROL-3-PHOSPHATEDEHYDROGENASE (Escherichiacoli) |
PF01266(DAO)PF16901(DAO_C) | 6 | GLY A 10GLY A 11ILE A 18ALA A 34ALA A 172VAL A 203 | FAD A 600 ( 3.7A)FAD A 600 ( 4.6A)NoneFAD A 600 ( 3.3A)FAD A 600 (-3.7A)None | 1.42A | 2yqzB-2r4jA:3.9 | 2yqzB-2r4jA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4j | AEROBICGLYCEROL-3-PHOSPHATEDEHYDROGENASE (Escherichiacoli) |
PF01266(DAO)PF16901(DAO_C) | 6 | GLY A 10GLY A 11ILE A 18LEU A 32ALA A 34ALA A 172 | FAD A 600 ( 3.7A)FAD A 600 ( 4.6A)NoneNoneFAD A 600 ( 3.3A)FAD A 600 (-3.7A) | 1.14A | 2yqzB-2r4jA:3.9 | 2yqzB-2r4jA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rau | PUTATIVE ESTERASE (Sulfolobussolfataricus) |
PF12146(Hydrolase_4) | 5 | GLY A 149GLY A 153LEU A 175LEU A 53VAL A 52 | None | 0.75A | 2yqzB-2rauA:undetectable | 2yqzB-2rauA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rng | BIG DEFENSIN (Tachypleustridentatus) |
PF14862(Defensin_big) | 5 | ALA A 33VAL A 17LEU A 21LEU A 24VAL A 25 | None | 0.89A | 2yqzB-2rngA:undetectable | 2yqzB-2rngA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vx4 | CELLVIBRIO JAPONICUSMANNANASE CJMAN26C (Cellvibriojaponicus) |
PF02156(Glyco_hydro_26) | 5 | LEU A 320ALA A 335HIS A 79LEU A 80LEU A 81 | None | 0.92A | 2yqzB-2vx4A:undetectable | 2yqzB-2vx4A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vxy | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 110ILE A 117ALA A 147VAL A 101VAL A 163 | CIT A 401 (-4.0A)NoneNoneNoneNone | 0.93A | 2yqzB-2vxyA:4.2 | 2yqzB-2vxyA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4g | NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE (Pseudomonasaeruginosa) |
PF01370(Epimerase) | 6 | GLY A 178GLY A 124LEU A 121ALA A 228LEU A 240LEU A 239 | None | 1.27A | 2yqzB-2x4gA:5.4 | 2yqzB-2x4gA:24.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yr0 | HYPOTHETICAL PROTEINTTHA0223 (Thermusthermophilus) |
PF08241(Methyltransf_11) | 12 | GLY A 47GLY A 49ILE A 53LEU A 67ALA A 69ASP A 70ALA A 95VAL A 111HIS A 112LEU A 113LEU A 116VAL A 117 | None | 0.42A | 2yqzB-2yr0A:36.8 | 2yqzB-2yr0A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yr0 | HYPOTHETICAL PROTEINTTHA0223 (Thermusthermophilus) |
PF08241(Methyltransf_11) | 7 | GLY A 47ILE A 109ALA A 69ASP A 70LEU A 113LEU A 116VAL A 117 | None | 1.29A | 2yqzB-2yr0A:36.8 | 2yqzB-2yr0A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzr | PYRIDOXALBIOSYNTHESIS LYASEPDXS (Methanocaldococcusjannaschii) |
PF01680(SOR_SNZ)PF05690(ThiG) | 5 | GLY A 149ILE A 156ALA A 128VAL A 160LEU A 165 | None | 0.94A | 2yqzB-2yzrA:undetectable | 2yqzB-2yzrA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a8k | AMINOMETHYLTRANSFERASE (Escherichiacoli) |
PF01571(GCV_T)PF08669(GCV_T_C) | 6 | GLY A 282LEU A 280ALA A 327VAL A 284LEU A 283VAL A 297 | None | 1.35A | 2yqzB-3a8kA:undetectable | 2yqzB-3a8kA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3anx | SPERMIDINE SYNTHASE (Thermusthermophilus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 85GLY A 87ASP A 110ALA A 141LEU A 159 | MTA A 315 (-3.2A)MTA A 315 (-4.0A)NoneMTA A 315 (-3.5A)None | 0.66A | 2yqzB-3anxA:11.1 | 2yqzB-3anxA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6m | SPERMINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 198GLY A 200ILE A 204ASP A 222LEU A 277 | MTA A 401 (-3.3A)MTA A 401 (-3.7A)NoneNoneMTA A 401 ( 4.4A) | 0.89A | 2yqzB-3c6mA:12.5 | 2yqzB-3c6mA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dip | ENOLASE (unidentified) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 331ALA A 338HIS A 320LEU A 292VAL A 290 | NoneNoneSIC A 321 ( 3.1A)NoneNone | 0.90A | 2yqzB-3dipA:undetectable | 2yqzB-3dipA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 5 | GLY A 475ILE A 469ALA A 380LEU A 478VAL A 504 | None | 0.95A | 2yqzB-3dlaA:5.1 | 2yqzB-3dlaA:17.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecd | SERINEHYDROXYMETHYLTRANSFERASE 2 (Burkholderiapseudomallei) |
PF00464(SHMT) | 5 | GLY A 364GLY A 351ILE A 361LEU A 326VAL A 310 | None | 0.87A | 2yqzB-3ecdA:undetectable | 2yqzB-3ecdA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ekg | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Azotobactervinelandii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 79ILE A 86ALA A 21ASP A 22VAL A 294 | None | 0.94A | 2yqzB-3ekgA:undetectable | 2yqzB-3ekgA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fy4 | 6-4 PHOTOLYASE (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 6 | GLY A 342ILE A 352ALA A 337VAL A 370LEU A 374LEU A 379 | None | 1.14A | 2yqzB-3fy4A:3.3 | 2yqzB-3fy4A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gsi | N,N-DIMETHYLGLYCINEOXIDASE (Arthrobacterglobiformis) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 6 | GLY A 16GLY A 11LEU A 19ALA A 357ALA A 369VAL A 154 | NoneFAD A 902 (-3.2A)NoneNoneNoneNone | 1.17A | 2yqzB-3gsiA:undetectable | 2yqzB-3gsiA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2b | SAM-DEPENDENTMETHYLTRANSFERASE (Corynebacteriumglutamicum) |
PF13649(Methyltransf_25) | 6 | GLY A 108GLY A 106LEU A 77ALA A 73VAL A 133LEU A 132 | SAH A 301 (-3.4A)SAH A 301 (-3.4A)SAH A 301 (-3.7A)NoneNoneSAH A 301 ( 4.9A) | 1.48A | 2yqzB-3h2bA:15.1 | 2yqzB-3h2bA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdy | UDP-GALACTOPYRANOSEMUTASE (Deinococcusradiodurans) |
PF03275(GLF)PF13450(NAD_binding_8) | 5 | GLY A 41GLY A 36ILE A 64LEU A 44ALA A 380 | NoneFAD A 450 (-3.4A)NoneNoneNone | 0.91A | 2yqzB-3hdyA:undetectable | 2yqzB-3hdyA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hea | ARYLESTERASE (Pseudomonasfluorescens) |
PF00561(Abhydrolase_1) | 5 | GLY A 92GLY A 96LEU A 118LEU A 23VAL A 22 | None | 0.67A | 2yqzB-3heaA:2.4 | 2yqzB-3heaA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hi0 | PUTATIVEEXOPOLYPHOSPHATASE (Agrobacteriumfabrum) |
PF02541(Ppx-GppA) | 5 | GLY A 22LEU A 50ALA A 95LEU A 90VAL A 89 | None | 0.85A | 2yqzB-3hi0A:undetectable | 2yqzB-3hi0A:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpd | HYDROXYETHYLTHIAZOLEKINASE (Pyrococcushorikoshii) |
PF02110(HK) | 5 | GLY A 119ALA A 96VAL A 90LEU A 91LEU A 110 | None | 0.90A | 2yqzB-3hpdA:4.5 | 2yqzB-3hpdA:24.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvu | HYPOXANTHINEPHOSPHORIBOSYLTRANSFERASE (Bacillusanthracis) |
PF00156(Pribosyltran) | 6 | ILE A 97LEU A 60ALA A 28ASP A 30LEU A 52LEU A 23 | None | 1.30A | 2yqzB-3hvuA:3.3 | 2yqzB-3hvuA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvu | HYPOXANTHINEPHOSPHORIBOSYLTRANSFERASE (Bacillusanthracis) |
PF00156(Pribosyltran) | 6 | ILE A 97LEU A 60ASP A 30LEU A 52LEU A 23VAL A 20 | None | 1.47A | 2yqzB-3hvuA:3.3 | 2yqzB-3hvuA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iah | SHORT CHAINDEHYDROGENASE YCIK (Salmonellaenterica) |
PF00106(adh_short) | 5 | GLY A 25LEU A 30ASP A 22LEU A 41LEU A 49 | NoneNoneNAP A 254 (-4.4A)NoneNone | 0.96A | 2yqzB-3iahA:7.6 | 2yqzB-3iahA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9q | SHEATH (Pseudomonasaeruginosa) |
PF04984(Phage_sheath_1)PF17482(Phage_sheath_1C) | 5 | GLY A 145ALA A 140ALA A 130LEU A 111VAL A 98 | None | 0.96A | 2yqzB-3j9qA:undetectable | 2yqzB-3j9qA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzu | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE II (Brucellamelitensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 6 | GLY A 178ILE A 184ALA A 294ALA A 298VAL A 4LEU A 415 | None | 1.27A | 2yqzB-3kzuA:undetectable | 2yqzB-3kzuA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm2 | PUTATIVE KINASE (Agrobacteriumfabrum) |
PF00480(ROK) | 5 | GLY A 117GLY A 189VAL A 186LEU A 116VAL A 172 | EDO A 227 (-3.6A)EDO A 227 (-3.1A)NoneNoneNone | 0.89A | 2yqzB-3lm2A:undetectable | 2yqzB-3lm2A:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmk | FUSION OFLIM/HOMEOBOX PROTEINLHX4, LINKER,INSULIN GENEENHANCER PROTEINISL-2 (Mus musculus) |
PF00412(LIM) | 5 | LEU A 275ALA A 277ASP A 128ALA A 105LEU A 138 | None | 0.94A | 2yqzB-3mmkA:undetectable | 2yqzB-3mmkA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq2 | 16S RRNAMETHYLTRANSFERASE (Streptoalloteichustenebrarius) |
PF02390(Methyltransf_4) | 6 | GLY A 32GLY A 34LEU A 54ALA A 56ASP A 57ALA A 87 | SAH A 216 (-3.5A)SAH A 216 (-3.4A)NoneSAH A 216 (-3.8A)NoneSAH A 216 (-3.5A) | 0.70A | 2yqzB-3mq2A:10.9 | 2yqzB-3mq2A:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq2 | 16S RRNAMETHYLTRANSFERASE (Streptoalloteichustenebrarius) |
PF02390(Methyltransf_4) | 6 | GLY A 32GLY A 34LEU A 54ALA A 56ASP A 57LEU A 108 | SAH A 216 (-3.5A)SAH A 216 (-3.4A)NoneSAH A 216 (-3.8A)NoneSAH A 216 (-4.0A) | 0.99A | 2yqzB-3mq2A:10.9 | 2yqzB-3mq2A:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntd | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE (Shewanellaloihica) |
PF00581(Rhodanese)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 160ILE A 263VAL A 157LEU A 209VAL A 207 | None | 0.96A | 2yqzB-3ntdA:undetectable | 2yqzB-3ntdA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfr | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Actinobacillussuccinogenes) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 313ASP A 314ALA A 327HIS A 354LEU A 320 | None | 0.82A | 2yqzB-3pfrA:undetectable | 2yqzB-3pfrA:20.26 |