SIMILAR PATTERNS OF AMINO ACIDS FOR 2YQZ_B_SAMB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		6 GLY A 162
ILE A 169
ASP A 160
VAL A  84
HIS A 180
LEU A  85
 None
None
ACT  A 301 (-3.5A)
None
None
None
 1.37A 2yqzB-1atgA:
undetectable		 2yqzB-1atgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE

(Rhodococcus sp.) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 187
GLY A 182
LEU A 190
ALA A 260
ALA A 154
 None
NAI  A 360 (-3.6A)
None
NAI  A 360 (-3.7A)
None
 0.92A 2yqzB-1c1dA:
7.3		 2yqzB-1c1dA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		6 GLY A  29
GLY A 129
ILE A  26
LEU A  35
ALA A 135
HIS A 100
 None
None
None
None
None
PO4  A 401 (-3.5A)
 1.05A 2yqzB-1cbfA:
3.4		 2yqzB-1cbfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		5 ASP A 507
ALA A 513
VAL A 547
LEU A 554
VAL A 555
 None
 0.94A 2yqzB-1d5fA:
undetectable		 2yqzB-1d5fA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		5 GLY A 115
GLY A  91
ILE A 207
ASP A  89
LEU A 113
 None
None
None
MG  A 378 ( 4.7A)
None
 0.95A 2yqzB-1e0cA:
undetectable		 2yqzB-1e0cA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		5 GLY A 246
GLY A 248
LEU A 290
ALA A 220
LEU A 212
 None
 0.94A 2yqzB-1e7sA:
4.6		 2yqzB-1e7sA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		6 ILE C 136
ALA C 239
ASP C 325
VAL C 189
LEU C 236
LEU C 352
 None
 1.27A 2yqzB-1ea9C:
undetectable		 2yqzB-1ea9C:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		6 GLY A 110
LEU A 120
ALA A 164
ASP A 163
VAL A 107
LEU A 157
 None
 1.48A 2yqzB-1eyeA:
undetectable		 2yqzB-1eyeA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		6 ILE A 180
LEU A 174
ASP A 145
VAL A 149
LEU A 104
VAL A 127
 None
 1.35A 2yqzB-1geyA:
3.3		 2yqzB-1geyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		5 GLY F 361
ALA F 346
ALA F 404
LEU F 369
VAL F 377
 None
 0.78A 2yqzB-1htjF:
undetectable		 2yqzB-1htjF:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		5 GLY A 194
ALA A 190
VAL A 139
LEU A 165
VAL A 164
 None
 0.93A 2yqzB-1hyqA:
undetectable		 2yqzB-1hyqA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ja9 1,3,6,8-TETRAHYDROXY
NAPHTHALENE
REDUCTASE

(Magnaporthe
grisea) 		PF13561
(adh_short_C2) 		5 GLY A  50
GLY A  53
ALA A  32
ALA A  46
LEU A  74
 None
 0.87A 2yqzB-1ja9A:
6.8		 2yqzB-1ja9A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj7 PEPTIDE TRANSPORTER
TAP1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 GLY A 585
LEU A 653
ASP A 668
LEU A 697
VAL A 696
 None
 0.95A 2yqzB-1jj7A:
undetectable		 2yqzB-1jj7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE

(Clarkia breweri) 		PF03492
(Methyltransf_7) 		6 GLY X 203
LEU X 140
ALA X  54
ALA X  56
LEU X  73
VAL X  70
 None
 1.41A 2yqzB-1m6eX:
10.6		 2yqzB-1m6eX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  86
GLY A  84
ILE A 117
LEU A 123
VAL A  65
 None
 0.95A 2yqzB-1mjfA:
11.5		 2yqzB-1mjfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03737
(RraA-like) 		6 GLY A  92
GLY A  62
ILE A  39
VAL A  65
LEU A  93
VAL A  77
 None
None
None
None
None
TLA  A 391 ( 4.8A)
 1.45A 2yqzB-1nxjA:
undetectable		 2yqzB-1nxjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 GLY A 193
LEU A 186
ALA A  97
LEU A 214
LEU A 211
VAL A 210
 None
 1.10A 2yqzB-1oseA:
undetectable		 2yqzB-1oseA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3d CONSERVED
HYPOTHETICAL PROTEIN
VC1974

(Vibrio cholerae) 		PF12697
(Abhydrolase_6) 		5 ILE A  86
ALA A  77
VAL A  18
LEU A  46
LEU A   6
 None
 0.94A 2yqzB-1r3dA:
undetectable		 2yqzB-1r3dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		5 GLY A 339
ALA A 333
HIS A 311
LEU A 343
VAL A 315
 None
 0.93A 2yqzB-1t8qA:
undetectable		 2yqzB-1t8qA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA

(Leishmania
major) 		PF02580
(Tyr_Deacylase) 		5 ILE A 194
ALA A 136
VAL A  64
LEU A  66
LEU A  86
 None
 0.93A 2yqzB-1tc5A:
undetectable		 2yqzB-1tc5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 GLY A 476
ILE A 516
LEU A 452
LEU A 455
VAL A 456
 None
 0.90A 2yqzB-1thgA:
3.0		 2yqzB-1thgA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqj RIBULOSE-PHOSPHATE
3-EPIMERASE

(Synechocystis
sp.) 		PF00834
(Ribul_P_3_epim) 		5 ALA A 115
ALA A 117
HIS A 100
LEU A 101
VAL A 131
 None
 0.78A 2yqzB-1tqjA:
undetectable		 2yqzB-1tqjA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 GLY B 169
ILE B 175
ALA B 280
ALA B 284
VAL B   3
LEU B 400
 None
 1.15A 2yqzB-1tqyB:
undetectable		 2yqzB-1tqyB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		5 GLY A 341
LEU A 340
ASP A 347
LEU A 317
LEU A 320
 None
 0.96A 2yqzB-1u2xA:
4.7		 2yqzB-1u2xA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		5 GLY A 828
ASP A 807
ALA A 824
HIS A 841
VAL A 844
 None
CA  A2005 (-3.3A)
None
None
None
 0.96A 2yqzB-1ulvA:
undetectable		 2yqzB-1ulvA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 GLY A 537
GLY A 673
LEU A 656
LEU A 771
VAL A 773
 None
 0.80A 2yqzB-1urjA:
undetectable		 2yqzB-1urjA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLY A  23
ILE A  27
ALA A  43
LEU A  85
VAL A  84
 None
NAP  A1249 (-4.1A)
None
None
None
 0.92A 2yqzB-1uznA:
6.1		 2yqzB-1uznA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		6 GLY A 256
GLY A 260
LEU A  43
ALA A  42
LEU A 277
LEU A 276
 None
 1.46A 2yqzB-1v19A:
5.1		 2yqzB-1v19A:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF14681
(UPRTase) 		6 GLY A  80
ALA A  36
VAL A  74
LEU A  73
LEU A  88
VAL A  91
 None
 1.31A 2yqzB-1v9sA:
3.4		 2yqzB-1v9sA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF14681
(UPRTase) 		6 GLY A  80
ILE A  99
ALA A  36
VAL A  74
LEU A  73
LEU A  88
 None
 1.38A 2yqzB-1v9sA:
3.4		 2yqzB-1v9sA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 GLY A 153
GLY A 156
ALA A 187
LEU A   7
LEU A   4
 None
 0.96A 2yqzB-1ve5A:
2.0		 2yqzB-1ve5A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A 289
ALA A 153
ALA A 157
LEU A 299
VAL A 243
 None
 0.95A 2yqzB-1vknA:
2.9		 2yqzB-1vknA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		5 GLY A 229
ILE A 209
ALA A 221
LEU A 194
LEU A 284
 None
 0.96A 2yqzB-1vliA:
undetectable		 2yqzB-1vliA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		5 GLY A 181
GLY A 147
ALA A 204
LEU A 200
VAL A 199
 PO4  A1226 (-3.6A)
PO4  A1226 (-3.7A)
None
None
None
 0.82A 2yqzB-1w0mA:
undetectable		 2yqzB-1w0mA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa3 2-KETO-3-DEOXY-6-PHO
SPHOGLUCONATE
ALDOLASE

(Thermotoga
maritima) 		PF01081
(Aldolase) 		6 GLY A  66
ILE A  64
LEU A  16
ALA A  48
ALA A  24
LEU A  55
 None
 1.43A 2yqzB-1wa3A:
undetectable		 2yqzB-1wa3A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 GLY A  36
ILE A 222
ALA A  34
ALA A 143
VAL A  38
 None
 0.94A 2yqzB-1wuuA:
undetectable		 2yqzB-1wuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Pseudomonas
aeruginosa) 		PF05690
(ThiG) 		5 GLY A1195
GLY A1168
ALA A1218
LEU A1214
VAL A1213
 None
 0.91A 2yqzB-1wv2A:
undetectable		 2yqzB-1wv2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  14
GLY A  11
ALA A 329
LEU A  19
VAL A  20
 None
FAD  A 999 (-3.3A)
None
None
None
 0.91A 2yqzB-1xdiA:
4.0		 2yqzB-1xdiA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Helicobacter
pylori) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		6 GLY A  45
ILE A 103
ALA A  49
LEU A  97
LEU A  76
VAL A  35
 None
 1.14A 2yqzB-2b7nA:
undetectable		 2yqzB-2b7nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		6 GLY A  29
GLY A 129
ILE A  26
LEU A  35
ALA A 135
HIS A 100
 None
 1.05A 2yqzB-2cbfA:
3.3		 2yqzB-2cbfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		6 GLY A 360
ILE A 330
ALA A 354
ALA A 340
HIS A 416
LEU A 424
 None
 1.26A 2yqzB-2cy8A:
undetectable		 2yqzB-2cy8A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		6 GLY A 360
ILE A 330
ALA A 354
HIS A 416
LEU A 424
VAL A 425
 None
 1.02A 2yqzB-2cy8A:
undetectable		 2yqzB-2cy8A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1y HYPOTHETICAL PROTEIN
TT0321

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		6 GLY A  13
ILE A  22
ALA A  71
VAL A  82
LEU A  10
LEU A 115
 NAD  A1001 (-3.5A)
None
None
None
None
None
 1.39A 2yqzB-2d1yA:
6.4		 2yqzB-2d1yA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		6 GLY A  32
GLY A  34
ILE A  39
ALA A  68
LEU A  99
VAL A 110
 None
 1.26A 2yqzB-2dhtA:
undetectable		 2yqzB-2dhtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 GLY A  78
ILE A  76
LEU A 179
VAL A 189
LEU A 198
 GOL  A2003 ( 4.8A)
None
None
None
None
 0.89A 2yqzB-2elcA:
2.4		 2yqzB-2elcA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE

(Streptococcus
mutans) 		PF04371
(PAD_porph) 		6 GLY A 233
ALA A 227
VAL A 167
LEU A 174
LEU A 208
VAL A 210
 None
 1.20A 2yqzB-2ewoA:
undetectable		 2yqzB-2ewoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		6 ILE A 302
ALA A 263
ASP A 260
ALA A 267
VAL A 304
LEU A 292
 None
 1.35A 2yqzB-2fgyA:
undetectable		 2yqzB-2fgyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 GLY A 267
ILE A 264
ASP A 269
VAL A   7
LEU A  42
 None
 0.95A 2yqzB-2ftpA:
undetectable		 2yqzB-2ftpA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2geb HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		6 ILE A  99
LEU A  62
ASP A  32
LEU A  54
LEU A  25
VAL A  22
 None
 1.50A 2yqzB-2gebA:
3.9		 2yqzB-2gebA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 GLY A 153
ILE A 235
VAL A 151
LEU A 173
VAL A 202
 None
 0.90A 2yqzB-2gqwA:
3.4		 2yqzB-2gqwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Chlorobaculum
tepidum) 		PF13419
(HAD_2) 		6 ILE A 227
LEU A 111
ALA A 159
VAL A 173
LEU A   7
LEU A 115
 None
 1.50A 2yqzB-2hcfA:
2.7		 2yqzB-2hcfA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		5 GLY A 186
GLY A 157
ALA A 209
LEU A 205
VAL A 204
 None
 0.94A 2yqzB-2htmA:
undetectable		 2yqzB-2htmA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihf SINGLE-STRANDED
DNA-BINDING PROTEIN

(Thermus
aquaticus) 		PF00436
(SSB) 		5 GLY A 135
GLY A   4
LEU A 157
LEU A 174
VAL A 176
 None
 0.91A 2yqzB-2ihfA:
undetectable		 2yqzB-2ihfA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 234
GLY A 212
ALA A 280
HIS A 203
VAL A 192
 None
 0.84A 2yqzB-2iwzA:
undetectable		 2yqzB-2iwzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 GLY A 212
GLY A 234
ILE A 400
ALA A 205
ALA A 210
VAL A 397
 None
 1.47A 2yqzB-2ix4A:
undetectable		 2yqzB-2ix4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpo PHEROMONE-BINDING
PROTEIN

(Antheraea
polyphemus) 		PF01395
(PBP_GOBP) 		5 GLY A  13
ASP A  17
ALA A  51
LEU A  33
VAL A  29
 None
 0.95A 2yqzB-2jpoA:
undetectable		 2yqzB-2jpoA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 205
ILE A 208
ASP A 170
LEU A 431
VAL A 239
 None
 0.95A 2yqzB-2nlxA:
undetectable		 2yqzB-2nlxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ns9 HYPOTHETICAL PROTEIN
APE2225

(Aeropyrum
pernix) 		PF06240
(COXG) 		5 LEU A  62
ALA A 138
ASP A 135
LEU A  10
VAL A 122
 None
 0.96A 2yqzB-2ns9A:
undetectable		 2yqzB-2ns9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob5 HYPOTHETICAL PROTEIN
ATU2016

(Agrobacterium
fabrum) 		PF05025
(RbsD_FucU) 		6 ILE A 146
LEU A  63
ALA A  61
LEU A  17
LEU A  14
VAL A  13
 None
 1.27A 2yqzB-2ob5A:
undetectable		 2yqzB-2ob5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		6 GLY A 239
GLY A 235
LEU A 242
ALA A 243
LEU A 255
LEU A 277
 None
 1.43A 2yqzB-2opjA:
undetectable		 2yqzB-2opjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov9 HYPOTHETICAL PROTEIN

(Rhodococcus
jostii) 		PF03061
(4HBT) 		5 GLY A 131
LEU A 136
LEU A 118
LEU A 172
VAL A 116
 None
 0.94A 2yqzB-2ov9A:
undetectable		 2yqzB-2ov9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		6 GLY A   8
ILE A  17
ALA A  59
VAL A  85
LEU A   5
VAL A  71
 None
 1.49A 2yqzB-2ph3A:
6.3		 2yqzB-2ph3A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 GLY A 336
ALA A 284
ASP A 302
VAL A 333
LEU A 320
 None
 0.85A 2yqzB-2pljA:
undetectable		 2yqzB-2pljA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 124
GLY A 126
ILE A 130
ASP A 149
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
None
None
S4M  A 501 (-3.5A)
 0.80A 2yqzB-2pt6A:
12.0		 2yqzB-2pt6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		6 GLY A 167
ALA A 131
ASP A  74
ALA A 122
LEU A 135
VAL A 136
 None
 1.45A 2yqzB-2qnyA:
undetectable		 2yqzB-2qnyA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		6 GLY A  10
GLY A  11
ILE A  18
ALA A  34
ALA A 172
VAL A 203
 FAD  A 600 ( 3.7A)
FAD  A 600 ( 4.6A)
None
FAD  A 600 ( 3.3A)
FAD  A 600 (-3.7A)
None
 1.42A 2yqzB-2r4jA:
3.9		 2yqzB-2r4jA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		6 GLY A  10
GLY A  11
ILE A  18
LEU A  32
ALA A  34
ALA A 172
 FAD  A 600 ( 3.7A)
FAD  A 600 ( 4.6A)
None
None
FAD  A 600 ( 3.3A)
FAD  A 600 (-3.7A)
 1.14A 2yqzB-2r4jA:
3.9		 2yqzB-2r4jA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus) 		PF12146
(Hydrolase_4) 		5 GLY A 149
GLY A 153
LEU A 175
LEU A  53
VAL A  52
 None
 0.75A 2yqzB-2rauA:
undetectable		 2yqzB-2rauA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rng BIG DEFENSIN

(Tachypleus
tridentatus) 		PF14862
(Defensin_big) 		5 ALA A  33
VAL A  17
LEU A  21
LEU A  24
VAL A  25
 None
 0.89A 2yqzB-2rngA:
undetectable		 2yqzB-2rngA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		5 LEU A 320
ALA A 335
HIS A  79
LEU A  80
LEU A  81
 None
 0.92A 2yqzB-2vx4A:
undetectable		 2yqzB-2vx4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 110
ILE A 117
ALA A 147
VAL A 101
VAL A 163
 CIT  A 401 (-4.0A)
None
None
None
None
 0.93A 2yqzB-2vxyA:
4.2		 2yqzB-2vxyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		6 GLY A 178
GLY A 124
LEU A 121
ALA A 228
LEU A 240
LEU A 239
 None
 1.27A 2yqzB-2x4gA:
5.4		 2yqzB-2x4gA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		12 GLY A  47
GLY A  49
ILE A  53
LEU A  67
ALA A  69
ASP A  70
ALA A  95
VAL A 111
HIS A 112
LEU A 113
LEU A 116
VAL A 117
 None
 0.42A 2yqzB-2yr0A:
36.8		 2yqzB-2yr0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		7 GLY A  47
ILE A 109
ALA A  69
ASP A  70
LEU A 113
LEU A 116
VAL A 117
 None
 1.29A 2yqzB-2yr0A:
36.8		 2yqzB-2yr0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Methanocaldococcus
jannaschii) 		PF01680
(SOR_SNZ)
PF05690
(ThiG) 		5 GLY A 149
ILE A 156
ALA A 128
VAL A 160
LEU A 165
 None
 0.94A 2yqzB-2yzrA:
undetectable		 2yqzB-2yzrA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		6 GLY A 282
LEU A 280
ALA A 327
VAL A 284
LEU A 283
VAL A 297
 None
 1.35A 2yqzB-3a8kA:
undetectable		 2yqzB-3a8kA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  85
GLY A  87
ASP A 110
ALA A 141
LEU A 159
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
None
MTA  A 315 (-3.5A)
None
 0.66A 2yqzB-3anxA:
11.1		 2yqzB-3anxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 198
GLY A 200
ILE A 204
ASP A 222
LEU A 277
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
None
None
MTA  A 401 ( 4.4A)
 0.89A 2yqzB-3c6mA:
12.5		 2yqzB-3c6mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 331
ALA A 338
HIS A 320
LEU A 292
VAL A 290
 None
None
SIC  A 321 ( 3.1A)
None
None
 0.90A 2yqzB-3dipA:
undetectable		 2yqzB-3dipA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 GLY A 475
ILE A 469
ALA A 380
LEU A 478
VAL A 504
 None
 0.95A 2yqzB-3dlaA:
5.1		 2yqzB-3dlaA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		5 GLY A 364
GLY A 351
ILE A 361
LEU A 326
VAL A 310
 None
 0.87A 2yqzB-3ecdA:
undetectable		 2yqzB-3ecdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  79
ILE A  86
ALA A  21
ASP A  22
VAL A 294
 None
 0.94A 2yqzB-3ekgA:
undetectable		 2yqzB-3ekgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		6 GLY A 342
ILE A 352
ALA A 337
VAL A 370
LEU A 374
LEU A 379
 None
 1.14A 2yqzB-3fy4A:
3.3		 2yqzB-3fy4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		6 GLY A  16
GLY A  11
LEU A  19
ALA A 357
ALA A 369
VAL A 154
 None
FAD  A 902 (-3.2A)
None
None
None
None
 1.17A 2yqzB-3gsiA:
undetectable		 2yqzB-3gsiA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		6 GLY A 108
GLY A 106
LEU A  77
ALA A  73
VAL A 133
LEU A 132
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.7A)
None
None
SAH  A 301 ( 4.9A)
 1.48A 2yqzB-3h2bA:
15.1		 2yqzB-3h2bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE

(Deinococcus
radiodurans) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A  41
GLY A  36
ILE A  64
LEU A  44
ALA A 380
 None
FAD  A 450 (-3.4A)
None
None
None
 0.91A 2yqzB-3hdyA:
undetectable		 2yqzB-3hdyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 GLY A  92
GLY A  96
LEU A 118
LEU A  23
VAL A  22
 None
 0.67A 2yqzB-3heaA:
2.4		 2yqzB-3heaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		5 GLY A  22
LEU A  50
ALA A  95
LEU A  90
VAL A  89
 None
 0.85A 2yqzB-3hi0A:
undetectable		 2yqzB-3hi0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE

(Pyrococcus
horikoshii) 		PF02110
(HK) 		5 GLY A 119
ALA A  96
VAL A  90
LEU A  91
LEU A 110
 None
 0.90A 2yqzB-3hpdA:
4.5		 2yqzB-3hpdA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		6 ILE A  97
LEU A  60
ALA A  28
ASP A  30
LEU A  52
LEU A  23
 None
 1.30A 2yqzB-3hvuA:
3.3		 2yqzB-3hvuA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		6 ILE A  97
LEU A  60
ASP A  30
LEU A  52
LEU A  23
VAL A  20
 None
 1.47A 2yqzB-3hvuA:
3.3		 2yqzB-3hvuA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		5 GLY A  25
LEU A  30
ASP A  22
LEU A  41
LEU A  49
 None
None
NAP  A 254 (-4.4A)
None
None
 0.96A 2yqzB-3iahA:
7.6		 2yqzB-3iahA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q SHEATH

(Pseudomonas
aeruginosa) 		PF04984
(Phage_sheath_1)
PF17482
(Phage_sheath_1C) 		5 GLY A 145
ALA A 140
ALA A 130
LEU A 111
VAL A  98
 None
 0.96A 2yqzB-3j9qA:
undetectable		 2yqzB-3j9qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 GLY A 178
ILE A 184
ALA A 294
ALA A 298
VAL A   4
LEU A 415
 None
 1.27A 2yqzB-3kzuA:
undetectable		 2yqzB-3kzuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm2 PUTATIVE KINASE

(Agrobacterium
fabrum) 		PF00480
(ROK) 		5 GLY A 117
GLY A 189
VAL A 186
LEU A 116
VAL A 172
 EDO  A 227 (-3.6A)
EDO  A 227 (-3.1A)
None
None
None
 0.89A 2yqzB-3lm2A:
undetectable		 2yqzB-3lm2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2

(Mus musculus) 		PF00412
(LIM) 		5 LEU A 275
ALA A 277
ASP A 128
ALA A 105
LEU A 138
 None
 0.94A 2yqzB-3mmkA:
undetectable		 2yqzB-3mmkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		6 GLY A  32
GLY A  34
LEU A  54
ALA A  56
ASP A  57
ALA A  87
 SAH  A 216 (-3.5A)
SAH  A 216 (-3.4A)
None
SAH  A 216 (-3.8A)
None
SAH  A 216 (-3.5A)
 0.70A 2yqzB-3mq2A:
10.9		 2yqzB-3mq2A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		6 GLY A  32
GLY A  34
LEU A  54
ALA A  56
ASP A  57
LEU A 108
 SAH  A 216 (-3.5A)
SAH  A 216 (-3.4A)
None
SAH  A 216 (-3.8A)
None
SAH  A 216 (-4.0A)
 0.99A 2yqzB-3mq2A:
10.9		 2yqzB-3mq2A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Shewanella
loihica) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 160
ILE A 263
VAL A 157
LEU A 209
VAL A 207
 None
 0.96A 2yqzB-3ntdA:
undetectable		 2yqzB-3ntdA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 313
ASP A 314
ALA A 327
HIS A 354
LEU A 320
 None
 0.82A 2yqzB-3pfrA:
undetectable		 2yqzB-3pfrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma) 		4 TYR C 179
ARG C 155
ASP C 148
ASP C 210
 None
 1.50A 2yqzB-1e6vC:
undetectable		 2yqzB-1e6vC:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 TYR A 233
GLU A 122
ARG A 243
ASP A 417
 None
 1.36A 2yqzB-1ff9A:
5.6		 2yqzB-1ff9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 687
ARG A 313
ASP A 305
ASP A 749
 None
 1.25A 2yqzB-1qf7A:
undetectable		 2yqzB-1qf7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 GLU A 359
ARG A  49
ASP A 348
ASP A 283
 None
 1.11A 2yqzB-2d1gA:
undetectable		 2yqzB-2d1gA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 478
GLU A 233
ARG A 483
ASP A 231
 None
 1.40A 2yqzB-2x50A:
2.0		 2yqzB-2x50A:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 GLU A  45
ARG A  52
ASP A  68
ASP A  94
 None
 0.78A 2yqzB-2yr0A:
36.8		 2yqzB-2yr0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 TYR A 550
ARG A 558
ASP A 260
ASP A 217
 None
None
ZN  A 665 ( 2.9A)
None
 1.44A 2yqzB-3af5A:
2.3		 2yqzB-3af5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		4 TYR A 223
GLU A 216
ARG A  82
ASP A 210
 None
 1.25A 2yqzB-3ihgA:
2.4		 2yqzB-3ihgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 4 TYR A 308
GLU A 267
ASP A 301
ASP A 233
 None
 1.32A 2yqzB-3kptA:
undetectable		 2yqzB-3kptA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l10 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 GLU A   8
ARG A  14
ASP A  86
ASP A 109
 None
 1.21A 2yqzB-3l10A:
undetectable		 2yqzB-3l10A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 GLU B 185
ARG B  32
ASP B 186
ASP B 189
 None
 1.38A 2yqzB-3lcvB:
11.8		 2yqzB-3lcvB:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLU A  99
ARG A 106
ASP A  83
ASP A  87
 None
 1.29A 2yqzB-3o5aA:
2.8		 2yqzB-3o5aA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		4 TYR A 136
ARG A  26
ASP A 207
ASP A 261
 TAR  A 504 (-4.2A)
None
MG  A 501 ( 2.8A)
MG  A 500 (-2.4A)
 1.49A 2yqzB-3opsA:
undetectable		 2yqzB-3opsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		4 TYR A  22
GLU A  52
ASP A  75
ASP A  98
 SAM  A 300 (-4.4A)
None
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
 0.86A 2yqzB-3ou6A:
16.3		 2yqzB-3ou6A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ren GLYCOSYL HYDROLASE,
FAMILY 8

(Clostridium
perfringens) 		PF01270
(Glyco_hydro_8) 		4 TYR A 159
GLU A 111
ARG A 113
ASP A 107
 None
 1.23A 2yqzB-3renA:
undetectable		 2yqzB-3renA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlc A1 PROTEIN

(Escherichia
virus Qbeta) 		PF16814
(Read-through) 		4 TYR A 221
ARG A 327
ASP A 214
ASP A 236
 None
 1.19A 2yqzB-3rlcA:
undetectable		 2yqzB-3rlcA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 GLU A  75
ARG A  82
ASP A 107
ASP A 166
 SAH  A 258 (-3.2A)
SAH  A 258 (-3.7A)
SAH  A 258 (-2.7A)
SAH  A 258 (-3.4A)
 0.88A 2yqzB-3tosA:
11.9		 2yqzB-3tosA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A  15
GLU A 130
ASP A 126
ASP A 184
 D15  A 500 ( 4.1A)
D15  A 500 ( 3.9A)
None
None
 1.46A 2yqzB-4aguA:
undetectable		 2yqzB-4aguA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLU A 228
ARG A 617
ASP A 231
ASP A 267
 MG  A1663 (-3.6A)
ANP  A1664 (-2.5A)
None
None
 1.35A 2yqzB-4c2tA:
undetectable		 2yqzB-4c2tA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhe PROBABLE GTP-BINDING
PROTEIN ENGB

(Burkholderia
thailandensis) 		PF01926
(MMR_HSR1) 		4 TYR A 172
GLU A 127
ASP A 129
ASP A 120
 None
 1.44A 2yqzB-4dheA:
undetectable		 2yqzB-4dheA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		4 GLU A 234
ARG A 188
ASP A 233
ASP A 167
 None
D1D  A 421 (-4.6A)
None
None
 1.42A 2yqzB-4isaA:
undetectable		 2yqzB-4isaA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 4 TYR D 523
GLU D 247
ARG D 405
ASP D 187
 None
None
SO4  D 608 (-2.6A)
None
 1.49A 2yqzB-4jf7D:
undetectable		 2yqzB-4jf7D:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ERYTHROCYTE-BINDING
ANTIGEN-175

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 TYR A 277
GLU A 370
ARG A 223
ASP A 312
 None
 1.43A 2yqzB-4qexA:
undetectable		 2yqzB-4qexA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		4 TYR A 585
GLU A 647
ASP A 649
ASP A 653
 None
 1.30A 2yqzB-4v1uA:
undetectable		 2yqzB-4v1uA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		4 TYR G 323
GLU G 306
ARG G 308
ASP G 433
 None
 1.43A 2yqzB-5b04G:
5.0		 2yqzB-5b04G:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus;
Influenza C
virus) 		PF00602
(Flu_PB1)
PF00604
(Flu_PB2) 		4 TYR C  11
GLU B 716
ARG B 750
ASP C 177
 None
 1.35A 2yqzB-5d9aC:
undetectable		 2yqzB-5d9aC:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		4 TYR A 104
GLU A 144
ASP A 152
ASP A  95
 DCM  A 401 (-4.6A)
None
None
None
 1.43A 2yqzB-5jp9A:
undetectable		 2yqzB-5jp9A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		4 TYR A 294
GLU A  93
ARG A 290
ASP A  84
 None
 1.47A 2yqzB-5k1rA:
3.5		 2yqzB-5k1rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR B 284
GLU B 782
ASP B 275
ASP B 838
 None
 1.39A 2yqzB-5kyuB:
undetectable		 2yqzB-5kyuB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLU A 375
ARG A 389
ASP A 376
ASP A 418
 None
 1.32A 2yqzB-5macA:
undetectable		 2yqzB-5macA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 TYR A 623
GLU A 771
ARG A 346
ASP A 772
 None
 1.46A 2yqzB-5n6uA:
undetectable		 2yqzB-5n6uA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 4 TYR B 169
GLU B 203
ASP B 230
ASP B 255
 SAH  B 501 ( 4.1A)
None
SAH  B 501 (-2.7A)
SAH  B 501 (-3.9A)
 1.36A 2yqzB-5thzB:
16.3		 2yqzB-5thzB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU 5 637
ARG 5 630
ASP 3 551
ASP 3 524
 None
 1.29A 2yqzB-5udb5:
undetectable		 2yqzB-5udb5:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 701 (-3.9A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
 0.68A 2yqzB-5wp4A:
16.5		 2yqzB-5wp4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 4 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 502 (-4.0A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
 0.54A 2yqzB-5wp5A:
15.8		 2yqzB-5wp5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 TYR A 550
GLU A 243
ASP A 260
ASP A 239
 None
None
None
CA  A 717 (-3.1A)
 1.50A 2yqzB-5ww1A:
undetectable		 2yqzB-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdm -

(-) 		no annotation 4 TYR A  32
GLU A 111
ASP A 125
ASP A 143
 GOL  A 303 (-4.5A)
None
CA  A 301 ( 2.8A)
CA  A 302 (-3.4A)
 1.42A 2yqzB-5zdmA:
undetectable		 2yqzB-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 GLU B 356
ARG B 232
ASP B 108
ASP B 105
 None
 1.45A 2yqzB-6reqB:
undetectable		 2yqzB-6reqB:
19.56