SIMILAR PATTERNS OF AMINO ACIDS FOR 2YQZ_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma) 		4 TYR C 179
ARG C 155
ASP C 148
ASP C 210
 None
 1.49A 2yqzA-1e6vC:
undetectable		 2yqzA-1e6vC:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 TYR A 233
GLU A 122
ARG A 243
ASP A 417
 None
 1.37A 2yqzA-1ff9A:
6.0		 2yqzA-1ff9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 687
ARG A 313
ASP A 305
ASP A 749
 None
 1.27A 2yqzA-1qf7A:
undetectable		 2yqzA-1qf7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 GLU A 359
ARG A  49
ASP A 348
ASP A 283
 None
 1.08A 2yqzA-2d1gA:
0.8		 2yqzA-2d1gA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 478
GLU A 233
ARG A 483
ASP A 231
 None
 1.38A 2yqzA-2x50A:
undetectable		 2yqzA-2x50A:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 GLU A  45
ARG A  52
ASP A  68
ASP A  94
 None
 0.79A 2yqzA-2yr0A:
37.5		 2yqzA-2yr0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 TYR A 550
ARG A 558
ASP A 260
ASP A 217
 None
None
ZN  A 665 ( 2.9A)
None
 1.45A 2yqzA-3af5A:
2.3		 2yqzA-3af5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		4 TYR A 223
GLU A 216
ARG A  82
ASP A 210
 None
 1.25A 2yqzA-3ihgA:
2.3		 2yqzA-3ihgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 4 TYR A 308
GLU A 267
ASP A 301
ASP A 233
 None
 1.36A 2yqzA-3kptA:
undetectable		 2yqzA-3kptA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l10 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 GLU A   8
ARG A  14
ASP A  86
ASP A 109
 None
 1.20A 2yqzA-3l10A:
undetectable		 2yqzA-3l10A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 GLU B 185
ARG B  32
ASP B 186
ASP B 189
 None
 1.37A 2yqzA-3lcvB:
11.5		 2yqzA-3lcvB:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLU A  99
ARG A 106
ASP A  83
ASP A  87
 None
 1.32A 2yqzA-3o5aA:
2.3		 2yqzA-3o5aA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		4 TYR A  22
GLU A  52
ASP A  75
ASP A  98
 SAM  A 300 (-4.4A)
None
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
 0.86A 2yqzA-3ou6A:
16.1		 2yqzA-3ou6A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ren GLYCOSYL HYDROLASE,
FAMILY 8

(Clostridium
perfringens) 		PF01270
(Glyco_hydro_8) 		4 TYR A 159
GLU A 111
ARG A 113
ASP A 107
 None
 1.24A 2yqzA-3renA:
undetectable		 2yqzA-3renA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlc A1 PROTEIN

(Escherichia
virus Qbeta) 		PF16814
(Read-through) 		4 TYR A 221
ARG A 327
ASP A 214
ASP A 236
 None
 1.23A 2yqzA-3rlcA:
undetectable		 2yqzA-3rlcA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 GLU A  75
ARG A  82
ASP A 107
ASP A 166
 SAH  A 258 (-3.2A)
SAH  A 258 (-3.7A)
SAH  A 258 (-2.7A)
SAH  A 258 (-3.4A)
 0.85A 2yqzA-3tosA:
12.1		 2yqzA-3tosA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A  15
GLU A 130
ASP A 126
ASP A 184
 D15  A 500 ( 4.1A)
D15  A 500 ( 3.9A)
None
None
 1.44A 2yqzA-4aguA:
undetectable		 2yqzA-4aguA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLU A 228
ARG A 617
ASP A 231
ASP A 267
 MG  A1663 (-3.6A)
ANP  A1664 (-2.5A)
None
None
 1.33A 2yqzA-4c2tA:
undetectable		 2yqzA-4c2tA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhe PROBABLE GTP-BINDING
PROTEIN ENGB

(Burkholderia
thailandensis) 		PF01926
(MMR_HSR1) 		4 TYR A 172
GLU A 127
ASP A 129
ASP A 120
 None
 1.44A 2yqzA-4dheA:
undetectable		 2yqzA-4dheA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		4 GLU A 234
ARG A 188
ASP A 233
ASP A 167
 None
D1D  A 421 (-4.6A)
None
None
 1.40A 2yqzA-4isaA:
undetectable		 2yqzA-4isaA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ERYTHROCYTE-BINDING
ANTIGEN-175

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 TYR A 277
GLU A 370
ARG A 223
ASP A 312
 None
 1.46A 2yqzA-4qexA:
undetectable		 2yqzA-4qexA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		4 TYR A 585
GLU A 647
ASP A 649
ASP A 653
 None
 1.32A 2yqzA-4v1uA:
2.5		 2yqzA-4v1uA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		4 TYR G 323
GLU G 306
ARG G 308
ASP G 433
 None
 1.43A 2yqzA-5b04G:
undetectable		 2yqzA-5b04G:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus;
Influenza C
virus) 		PF00602
(Flu_PB1)
PF00604
(Flu_PB2) 		4 TYR C  11
GLU B 716
ARG B 750
ASP C 177
 None
 1.37A 2yqzA-5d9aC:
undetectable		 2yqzA-5d9aC:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		4 TYR A 104
GLU A 144
ASP A 152
ASP A  95
 DCM  A 401 (-4.6A)
None
None
None
 1.44A 2yqzA-5jp9A:
undetectable		 2yqzA-5jp9A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR B 284
GLU B 782
ASP B 275
ASP B 838
 None
 1.39A 2yqzA-5kyuB:
undetectable		 2yqzA-5kyuB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLU A 375
ARG A 389
ASP A 376
ASP A 418
 None
 1.33A 2yqzA-5macA:
undetectable		 2yqzA-5macA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 TYR A 623
GLU A 771
ARG A 346
ASP A 772
 None
 1.49A 2yqzA-5n6uA:
undetectable		 2yqzA-5n6uA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 4 TYR B 169
GLU B 203
ASP B 230
ASP B 255
 SAH  B 501 ( 4.1A)
None
SAH  B 501 (-2.7A)
SAH  B 501 (-3.9A)
 1.32A 2yqzA-5thzB:
16.4		 2yqzA-5thzB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU 5 637
ARG 5 630
ASP 3 551
ASP 3 524
 None
 1.29A 2yqzA-5udb5:
undetectable		 2yqzA-5udb5:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 701 (-3.9A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
 0.70A 2yqzA-5wp4A:
16.5		 2yqzA-5wp4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 4 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 502 (-4.0A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
 0.55A 2yqzA-5wp5A:
15.7		 2yqzA-5wp5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 TYR A 550
GLU A 243
ASP A 260
ASP A 239
 None
None
None
CA  A 717 (-3.1A)
 1.50A 2yqzA-5ww1A:
undetectable		 2yqzA-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdm -

(-) 		no annotation 4 TYR A  32
GLU A 111
ASP A 125
ASP A 143
 GOL  A 303 (-4.5A)
None
CA  A 301 ( 2.8A)
CA  A 302 (-3.4A)
 1.41A 2yqzA-5zdmA:
undetectable		 2yqzA-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 GLU B 356
ARG B 232
ASP B 108
ASP B 105
 None
 1.46A 2yqzA-6reqB:
undetectable		 2yqzA-6reqB:
19.56