SIMILAR PATTERNS OF AMINO ACIDS FOR 2YQZ_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A  72
GLY A  45
LEU A  70
ASP A 102
LEU A  75
 None
 1.01A 2yqzA-1a1sA:
4.2		 2yqzA-1a1sA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		6 GLY A 162
ILE A 169
ASP A 160
VAL A  84
HIS A 180
LEU A  85
 None
None
ACT  A 301 (-3.5A)
None
None
None
 1.38A 2yqzA-1atgA:
undetectable		 2yqzA-1atgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE

(Rhodococcus sp.) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 187
GLY A 182
LEU A 190
ALA A 260
ALA A 154
 None
NAI  A 360 (-3.6A)
None
NAI  A 360 (-3.7A)
None
 0.92A 2yqzA-1c1dA:
7.3		 2yqzA-1c1dA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		6 GLY A  29
GLY A 129
ILE A  26
LEU A  35
ALA A 135
HIS A 100
 None
None
None
None
None
PO4  A 401 (-3.5A)
 1.07A 2yqzA-1cbfA:
3.3		 2yqzA-1cbfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		5 GLY A 115
GLY A  91
ILE A 207
ASP A  89
LEU A 113
 None
None
None
MG  A 378 ( 4.7A)
None
 0.94A 2yqzA-1e0cA:
undetectable		 2yqzA-1e0cA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 GLY P  79
ASP P 335
ALA P 341
VAL P 351
LEU P 348
 None
 1.00A 2yqzA-1e33P:
undetectable		 2yqzA-1e33P:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		5 GLY A 246
GLY A 248
LEU A 290
ALA A 220
LEU A 212
 None
 0.94A 2yqzA-1e7sA:
undetectable		 2yqzA-1e7sA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		6 GLY A 110
LEU A 120
ALA A 164
ASP A 163
VAL A 107
LEU A 157
 None
 1.47A 2yqzA-1eyeA:
undetectable		 2yqzA-1eyeA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 ILE A 106
ALA A 239
ALA A 246
VAL A  52
LEU A 123
 None
 0.94A 2yqzA-1fizA:
undetectable		 2yqzA-1fizA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		6 GLY P 270
LEU P  64
ASP P 235
ALA P 156
ARG P 155
LEU P 153
 None
 1.47A 2yqzA-1hynP:
undetectable		 2yqzA-1hynP:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ja9 1,3,6,8-TETRAHYDROXY
NAPHTHALENE
REDUCTASE

(Magnaporthe
grisea) 		PF13561
(adh_short_C2) 		5 GLY A  50
GLY A  53
ALA A  32
ALA A  46
LEU A  74
 None
 0.88A 2yqzA-1ja9A:
6.8		 2yqzA-1ja9A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ILE A 362
LEU A 476
ALA A 374
VAL A  66
LEU A  65
LEU A 460
 None
 1.49A 2yqzA-1jr1A:
undetectable		 2yqzA-1jr1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 GLY A  77
ALA A  99
ASP A  98
VAL A  51
LEU A  50
 None
 0.99A 2yqzA-1mb9A:
4.4		 2yqzA-1mb9A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		6 GLY A 281
GLY A 279
LEU A 273
ALA A 154
ARG A 159
VAL A 295
 None
 1.33A 2yqzA-1ps6A:
undetectable		 2yqzA-1ps6A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 420
ILE A 442
ALA A  58
ASP A  59
LEU A  52
 None
 0.88A 2yqzA-1pvdA:
3.9		 2yqzA-1pvdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 420
ILE A 442
LEU A 423
ASP A  59
LEU A  52
 None
 0.92A 2yqzA-1pvdA:
3.9		 2yqzA-1pvdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		5 ILE A 107
ASP A 184
ALA A 240
HIS A 229
LEU A 233
 None
 0.96A 2yqzA-1pwwA:
undetectable		 2yqzA-1pwwA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 GLY A 249
GLY A 246
ALA A 295
ARG A 341
LEU A 339
 None
 0.97A 2yqzA-1q5nA:
undetectable		 2yqzA-1q5nA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3d CONSERVED
HYPOTHETICAL PROTEIN
VC1974

(Vibrio cholerae) 		PF12697
(Abhydrolase_6) 		5 ILE A  86
ALA A  77
VAL A  18
LEU A  46
LEU A   6
 None
 0.92A 2yqzA-1r3dA:
undetectable		 2yqzA-1r3dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA

(Leishmania
major) 		PF02580
(Tyr_Deacylase) 		5 ILE A 194
ALA A 136
VAL A  64
LEU A  66
LEU A  86
 None
 0.92A 2yqzA-1tc5A:
undetectable		 2yqzA-1tc5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 GLY B 169
ILE B 175
ALA B 280
ALA B 284
VAL B   3
LEU B 400
 None
 1.16A 2yqzA-1tqyB:
undetectable		 2yqzA-1tqyB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		5 GLY A 341
LEU A 340
ASP A 347
LEU A 317
LEU A 320
 None
 0.99A 2yqzA-1u2xA:
4.6		 2yqzA-1u2xA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		6 GLY A 256
GLY A 260
LEU A  43
ALA A  42
LEU A 277
LEU A 276
 None
 1.46A 2yqzA-1v19A:
3.9		 2yqzA-1v19A:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF14681
(UPRTase) 		6 GLY A  80
ILE A  99
ALA A  36
VAL A  74
LEU A  73
LEU A  88
 None
 1.40A 2yqzA-1v9sA:
2.0		 2yqzA-1v9sA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 GLY A 153
GLY A 156
ALA A 187
LEU A   7
LEU A   4
 None
 0.96A 2yqzA-1ve5A:
2.1		 2yqzA-1ve5A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		5 GLY A 229
ILE A 209
ALA A 221
LEU A 194
LEU A 284
 None
 0.96A 2yqzA-1vliA:
undetectable		 2yqzA-1vliA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yix DEOXYRIBONUCLEASE
YCFH

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 ALA A  29
VAL A  40
HIS A   9
LEU A  10
LEU A  13
 None
None
ZN  A 601 (-3.2A)
None
None
 0.98A 2yqzA-1yixA:
undetectable		 2yqzA-1yixA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		5 GLY A 209
GLY A 205
LEU A 164
ALA A 118
ARG A 215
 None
 1.00A 2yqzA-2akcA:
undetectable		 2yqzA-2akcA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Helicobacter
pylori) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 GLY A  45
ILE A 103
ALA A  49
LEU A  97
LEU A  76
 None
 0.98A 2yqzA-2b7nA:
2.1		 2yqzA-2b7nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		6 GLY A  29
GLY A 129
ILE A  26
LEU A  35
ALA A 135
HIS A 100
 None
 1.07A 2yqzA-2cbfA:
3.3		 2yqzA-2cbfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		5 GLY A 188
ILE A 233
LEU A 137
ASP A 255
ARG A  44
 None
 0.98A 2yqzA-2cu2A:
undetectable		 2yqzA-2cu2A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		6 GLY A 360
ILE A 330
ALA A 354
ALA A 340
HIS A 416
LEU A 424
 None
 1.25A 2yqzA-2cy8A:
2.5		 2yqzA-2cy8A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 GLY A  78
ILE A  76
LEU A 179
VAL A 189
LEU A 198
 GOL  A2003 ( 4.8A)
None
None
None
None
 0.90A 2yqzA-2elcA:
2.3		 2yqzA-2elcA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		6 ILE A 302
ALA A 263
ASP A 260
ALA A 267
VAL A 304
LEU A 292
 None
 1.35A 2yqzA-2fgyA:
undetectable		 2yqzA-2fgyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 396
GLY A 400
ALA A 443
ALA A 441
ARG A 427
 None
 0.99A 2yqzA-2fjaA:
undetectable		 2yqzA-2fjaA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 GLY A 267
ILE A 264
ASP A 269
VAL A   7
LEU A  42
 None
 0.94A 2yqzA-2ftpA:
undetectable		 2yqzA-2ftpA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		5 GLY A 220
GLY A 171
ILE A 209
ALA A 257
VAL A 344
 None
 0.97A 2yqzA-2g85A:
undetectable		 2yqzA-2g85A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Chlorobaculum
tepidum) 		PF13419
(HAD_2) 		6 ILE A 227
LEU A 111
ALA A 159
VAL A 173
LEU A   7
LEU A 115
 None
 1.48A 2yqzA-2hcfA:
2.9		 2yqzA-2hcfA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		6 ILE A  45
LEU A 210
ALA A 212
ASP A 213
LEU A  56
LEU A  68
 None
 1.39A 2yqzA-2ibpA:
undetectable		 2yqzA-2ibpA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 LEU A  28
ASP A  63
ALA A  19
VAL A   6
LEU A  66
 None
 1.00A 2yqzA-2ip4A:
3.9		 2yqzA-2ip4A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 GLY A 212
GLY A 234
ILE A 400
ALA A 205
ALA A 210
VAL A 397
 None
 1.48A 2yqzA-2ix4A:
undetectable		 2yqzA-2ix4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odo ALANINE RACEMASE

(Pseudomonas
fluorescens) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 131
LEU A 102
ALA A 140
VAL A  98
LEU A 121
 KCX  A 122 ( 3.5A)
None
None
None
KCX  A 122 ( 3.9A)
 0.98A 2yqzA-2odoA:
undetectable		 2yqzA-2odoA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		6 GLY A 239
GLY A 235
LEU A 242
ALA A 243
LEU A 255
LEU A 277
 None
 1.42A 2yqzA-2opjA:
undetectable		 2yqzA-2opjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		5 GLY A 230
LEU A 199
ALA A 244
LEU A 240
LEU A 265
 None
 1.01A 2yqzA-2pcqA:
undetectable		 2yqzA-2pcqA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 GLY A 336
ALA A 284
ASP A 302
VAL A 333
LEU A 320
 None
 0.86A 2yqzA-2pljA:
undetectable		 2yqzA-2pljA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 124
GLY A 126
ILE A 130
ASP A 149
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
None
None
S4M  A 501 (-3.5A)
 0.82A 2yqzA-2pt6A:
12.0		 2yqzA-2pt6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		5 GLY A  84
GLY A  86
ASP A 112
ARG A 137
VAL A 163
 SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
None
SAM  A 400 (-4.6A)
SAM  A 400 (-4.2A)
 0.68A 2yqzA-2qe6A:
9.9		 2yqzA-2qe6A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		6 GLY A  10
GLY A  11
ILE A  18
ALA A  34
ALA A 172
VAL A 203
 FAD  A 600 ( 3.7A)
FAD  A 600 ( 4.6A)
None
FAD  A 600 ( 3.3A)
FAD  A 600 (-3.7A)
None
 1.42A 2yqzA-2r4jA:
3.8		 2yqzA-2r4jA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		6 GLY A  10
GLY A  11
ILE A  18
LEU A  32
ALA A  34
ALA A 172
 FAD  A 600 ( 3.7A)
FAD  A 600 ( 4.6A)
None
None
FAD  A 600 ( 3.3A)
FAD  A 600 (-3.7A)
 1.14A 2yqzA-2r4jA:
3.8		 2yqzA-2r4jA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		5 GLY A  17
GLY A  13
ALA A 326
ARG A 327
LEU A  22
 None
FAD  A1395 ( 4.7A)
None
None
None
 0.98A 2yqzA-2vouA:
undetectable		 2yqzA-2vouA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		5 LEU A 320
ALA A 335
HIS A  79
LEU A  80
LEU A  81
 None
 0.93A 2yqzA-2vx4A:
undetectable		 2yqzA-2vx4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		6 GLY A 178
GLY A 124
LEU A 121
ALA A 228
LEU A 240
LEU A 239
 None
 1.29A 2yqzA-2x4gA:
5.2		 2yqzA-2x4gA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		11 GLY A  47
GLY A  49
ILE A  53
LEU A  67
ALA A  69
ASP A  70
ALA A  95
VAL A 111
HIS A 112
LEU A 113
LEU A 116
 None
 0.36A 2yqzA-2yr0A:
37.5		 2yqzA-2yr0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		6 GLY A  47
ILE A 109
ALA A  69
ASP A  70
LEU A 113
LEU A 116
 None
 1.29A 2yqzA-2yr0A:
37.5		 2yqzA-2yr0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 LEU A  67
ALA A  69
ASP A  70
ALA A  95
ARG A  96
 None
 0.81A 2yqzA-2yr0A:
37.5		 2yqzA-2yr0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		5 GLY A  68
GLY A  42
ALA A  22
HIS A  40
LEU A  77
 None
None
None
ZN  A 251 ( 3.2A)
None
 0.97A 2yqzA-3a9lA:
undetectable		 2yqzA-3a9lA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		5 GLY A  68
GLY A  42
ALA A  22
HIS A  78
LEU A  77
 None
None
None
PO4  A 261 (-3.9A)
None
 1.01A 2yqzA-3a9lA:
undetectable		 2yqzA-3a9lA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  85
GLY A  87
ASP A 110
ALA A 141
LEU A 159
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
None
MTA  A 315 (-3.5A)
None
 0.69A 2yqzA-3anxA:
11.0		 2yqzA-3anxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		5 GLY A 504
LEU A 470
ALA A 490
ASP A 491
ALA A 445
 None
 1.01A 2yqzA-3b2zA:
undetectable		 2yqzA-3b2zA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 198
GLY A 200
ILE A 204
ASP A 222
LEU A 277
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
None
None
MTA  A 401 ( 4.4A)
 0.91A 2yqzA-3c6mA:
12.6		 2yqzA-3c6mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		5 GLY A 143
ALA A 141
ASP A 140
VAL A 216
HIS A 149
 None
CL  A 267 ( 4.3A)
None
None
None
 1.01A 2yqzA-3dl1A:
undetectable		 2yqzA-3dl1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		5 GLY A  19
GLY A  14
LEU A  22
ASP A 166
ALA A 323
 None
FAD  A 600 (-3.2A)
None
None
None
 1.01A 2yqzA-3e1tA:
undetectable		 2yqzA-3e1tA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 GLY A 959
ALA A1023
VAL A1111
HIS A1112
LEU A1113
 None
 1.01A 2yqzA-3eh1A:
undetectable		 2yqzA-3eh1A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803) 		PF03575
(Peptidase_S51) 		5 GLY A 196
ILE A 143
ASP A 225
LEU A 185
LEU A 245
 None
 0.96A 2yqzA-3en0A:
undetectable		 2yqzA-3en0A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftp 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		5 GLY A  58
GLY A  60
ALA A  24
ALA A  28
ARG A  29
 None
 1.00A 2yqzA-3ftpA:
6.3		 2yqzA-3ftpA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		6 GLY A 342
ILE A 352
ALA A 337
VAL A 370
LEU A 374
LEU A 379
 None
 1.15A 2yqzA-3fy4A:
2.2		 2yqzA-3fy4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		6 GLY A  16
GLY A  11
LEU A  19
ALA A 357
ALA A 369
VAL A 154
 None
FAD  A 902 (-3.2A)
None
None
None
None
 1.17A 2yqzA-3gsiA:
undetectable		 2yqzA-3gsiA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		6 GLY A 108
GLY A 106
LEU A  77
ALA A  73
VAL A 133
LEU A 132
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.7A)
None
None
SAH  A 301 ( 4.9A)
 1.48A 2yqzA-3h2bA:
15.0		 2yqzA-3h2bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE

(Deinococcus
radiodurans) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A  41
GLY A  36
ILE A  64
LEU A  44
ALA A 380
 None
FAD  A 450 (-3.4A)
None
None
None
 0.91A 2yqzA-3hdyA:
undetectable		 2yqzA-3hdyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE

(Pyrococcus
horikoshii) 		PF02110
(HK) 		5 GLY A 119
ALA A  96
VAL A  90
LEU A  91
LEU A 110
 None
 0.89A 2yqzA-3hpdA:
4.4		 2yqzA-3hpdA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		6 ILE A  97
LEU A  60
ALA A  28
ASP A  30
LEU A  52
LEU A  23
 None
 1.27A 2yqzA-3hvuA:
2.9		 2yqzA-3hvuA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		6 GLY A  19
ILE A 322
LEU A  20
ALA A 118
ARG A 119
VAL A   6
 None
 1.26A 2yqzA-3i3lA:
3.1		 2yqzA-3i3lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9s INTEGRON CASSETTE
PROTEIN

(Vibrio cholerae) 		PF00583
(Acetyltransf_1) 		5 ILE A  21
ALA A  68
ASP A  87
ALA A  57
LEU A  16
 None
 0.95A 2yqzA-3i9sA:
undetectable		 2yqzA-3i9sA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		5 GLY A  25
LEU A  30
ASP A  22
LEU A  41
LEU A  49
 None
None
NAP  A 254 (-4.4A)
None
None
 0.96A 2yqzA-3iahA:
8.1		 2yqzA-3iahA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
horikoshii) 		PF07969
(Amidohydro_3) 		5 GLY X 265
GLY X 324
ALA X 275
ASP X 326
LEU X 259
 None
SO4  X 504 ( 4.3A)
None
None
None
 0.99A 2yqzA-3ighX:
undetectable		 2yqzA-3ighX:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 GLY A 128
GLY A 282
ILE A 289
ALA A 259
VAL A 316
LEU A 299
 None
 1.47A 2yqzA-3imlA:
undetectable		 2yqzA-3imlA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky8 PUTATIVE RIBOFLAVIN
BIOSYNTHESIS PROTEIN

(Shewanella
loihica) 		PF01872
(RibD_C) 		5 ILE A   4
LEU A  -4
ALA A 101
LEU A 127
LEU A  96
 None
 0.99A 2yqzA-3ky8A:
undetectable		 2yqzA-3ky8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 GLY A 178
ILE A 184
ALA A 294
ALA A 298
VAL A   4
LEU A 415
 None
 1.29A 2yqzA-3kzuA:
undetectable		 2yqzA-3kzuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 GLY A  15
GLY A  10
ILE A 250
LEU A 281
ALA A 453
 None
FAD  A 500 (-3.3A)
None
None
None
 0.99A 2yqzA-3lovA:
undetectable		 2yqzA-3lovA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqn CBS DOMAIN PROTEIN

(Bacillus
anthracis) 		PF00571
(CBS) 		5 GLY A  59
ILE A  29
LEU A  60
ASP A  93
LEU A  57
 None
 1.00A 2yqzA-3lqnA:
undetectable		 2yqzA-3lqnA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8o IMMUNOGLOBULIN A1
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H 110
ALA H  23
ALA H  81
VAL H  37
LEU H  20
 None
 0.96A 2yqzA-3m8oH:
undetectable		 2yqzA-3m8oH:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A 143
ALA A 146
ALA A 194
LEU A  78
LEU A 187
 None
 0.93A 2yqzA-3m9uA:
undetectable		 2yqzA-3m9uA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2

(Mus musculus) 		PF00412
(LIM) 		5 LEU A 275
ALA A 277
ASP A 128
ALA A 105
LEU A 138
 None
 0.90A 2yqzA-3mmkA:
undetectable		 2yqzA-3mmkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 ILE A 480
ALA A 456
ASP A 457
ALA A 447
VAL A 396
 None
 1.00A 2yqzA-3mplA:
undetectable		 2yqzA-3mplA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		6 GLY A  32
GLY A  34
LEU A  54
ALA A  56
ASP A  57
ALA A  87
 SAH  A 216 (-3.5A)
SAH  A 216 (-3.4A)
None
SAH  A 216 (-3.8A)
None
SAH  A 216 (-3.5A)
 0.73A 2yqzA-3mq2A:
10.7		 2yqzA-3mq2A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		6 GLY A  32
GLY A  34
LEU A  54
ALA A  56
ASP A  57
LEU A 108
 SAH  A 216 (-3.5A)
SAH  A 216 (-3.4A)
None
SAH  A 216 (-3.8A)
None
SAH  A 216 (-4.0A)
 1.02A 2yqzA-3mq2A:
10.7		 2yqzA-3mq2A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 GLY A 205
LEU A 160
ALA A 214
HIS A 231
LEU A 182
 None
None
None
PLP  A 701 (-4.5A)
None
 0.98A 2yqzA-3nzpA:
2.4		 2yqzA-3nzpA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		5 GLY A 310
ILE A 358
LEU A 313
ALA A 364
VAL A 123
 None
 1.00A 2yqzA-3nzqA:
undetectable		 2yqzA-3nzqA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1w RABGDI PROTEIN

(Plasmodium
falciparum) 		PF00996
(GDI) 		5 ILE A 311
ALA A  44
ASP A  74
VAL A 394
LEU A  51
 None
 0.99A 2yqzA-3p1wA:
undetectable		 2yqzA-3p1wA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ILE A 365
LEU A 360
ALA A 333
ASP A 332
ALA A 431
 None
CL  A 496 (-4.4A)
CL  A 496 ( 4.3A)
None
None
 0.93A 2yqzA-3peiA:
undetectable		 2yqzA-3peiA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 313
ASP A 314
ALA A 327
HIS A 354
LEU A 320
 None
 0.81A 2yqzA-3pfrA:
undetectable		 2yqzA-3pfrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxh RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F

(Mus musculus) 		PF07679
(I-set) 		5 GLY A  44
ALA A  50
ARG A  92
VAL A  98
LEU A  96
 None
None
None
SO4  A   2 (-4.0A)
None
 1.01A 2yqzA-3pxhA:
undetectable		 2yqzA-3pxhA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3k CASPASE-9

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 GLY A 163
LEU A 196
ASP A 228
VAL A 232
LEU A 279
 None
 0.98A 2yqzA-3v3kA:
undetectable		 2yqzA-3v3kA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLY A 428
GLY A 430
ILE A 415
ALA A 294
ASP A 293
 None
 1.01A 2yqzA-3v98A:
2.7		 2yqzA-3v98A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		5 LEU A 316
ASP A 292
ALA A 306
HIS A 333
LEU A 299
 None
 0.98A 2yqzA-3va8A:
undetectable		 2yqzA-3va8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve9 OROTIDINE-5'-PHOSPHA
TE DECARBOXYLASE

(Metallosphaera
sedula) 		PF00215
(OMPdecase) 		5 ILE A  81
ALA A  93
ARG A 126
VAL A 104
HIS A  83
 GOL  A 301 ( 4.7A)
None
None
None
None
 1.00A 2yqzA-3ve9A:
undetectable		 2yqzA-3ve9A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		5 GLY A 125
ILE A  74
ALA A 164
VAL A 118
LEU A 120
 None
 0.97A 2yqzA-3vtzA:
5.2		 2yqzA-3vtzA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		5 ILE A 202
ALA A 134
HIS A 178
LEU A 146
LEU A 107
 None
 0.98A 2yqzA-3vylA:
undetectable		 2yqzA-3vylA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv7 HMD CO-OCCURRING
PROTEIN HCGE

(Methanothermobacter
marburgensis) 		PF00899
(ThiF) 		5 GLY A  25
GLY A  22
ILE A 109
VAL A  19
LEU A  18
 None
ADP  A 301 (-3.2A)
ADP  A 301 (-3.8A)
ADP  A 301 ( 4.9A)
None
 0.94A 2yqzA-3wv7A:
6.3		 2yqzA-3wv7A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 ILE A 892
ALA A  35
ARG A  17
LEU A 887
LEU A  30
 None
 0.96A 2yqzA-3zgbA:
undetectable		 2yqzA-3zgbA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma) 		4 TYR C 179
ARG C 155
ASP C 148
ASP C 210
 None
 1.49A 2yqzA-1e6vC:
undetectable		 2yqzA-1e6vC:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 TYR A 233
GLU A 122
ARG A 243
ASP A 417
 None
 1.37A 2yqzA-1ff9A:
6.0		 2yqzA-1ff9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 687
ARG A 313
ASP A 305
ASP A 749
 None
 1.27A 2yqzA-1qf7A:
undetectable		 2yqzA-1qf7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 GLU A 359
ARG A  49
ASP A 348
ASP A 283
 None
 1.08A 2yqzA-2d1gA:
0.8		 2yqzA-2d1gA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 478
GLU A 233
ARG A 483
ASP A 231
 None
 1.38A 2yqzA-2x50A:
undetectable		 2yqzA-2x50A:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 GLU A  45
ARG A  52
ASP A  68
ASP A  94
 None
 0.79A 2yqzA-2yr0A:
37.5		 2yqzA-2yr0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 TYR A 550
ARG A 558
ASP A 260
ASP A 217
 None
None
ZN  A 665 ( 2.9A)
None
 1.45A 2yqzA-3af5A:
2.3		 2yqzA-3af5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		4 TYR A 223
GLU A 216
ARG A  82
ASP A 210
 None
 1.25A 2yqzA-3ihgA:
2.3		 2yqzA-3ihgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 4 TYR A 308
GLU A 267
ASP A 301
ASP A 233
 None
 1.36A 2yqzA-3kptA:
undetectable		 2yqzA-3kptA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l10 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 GLU A   8
ARG A  14
ASP A  86
ASP A 109
 None
 1.20A 2yqzA-3l10A:
undetectable		 2yqzA-3l10A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 GLU B 185
ARG B  32
ASP B 186
ASP B 189
 None
 1.37A 2yqzA-3lcvB:
11.5		 2yqzA-3lcvB:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLU A  99
ARG A 106
ASP A  83
ASP A  87
 None
 1.32A 2yqzA-3o5aA:
2.3		 2yqzA-3o5aA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		4 TYR A  22
GLU A  52
ASP A  75
ASP A  98
 SAM  A 300 (-4.4A)
None
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
 0.86A 2yqzA-3ou6A:
16.1		 2yqzA-3ou6A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ren GLYCOSYL HYDROLASE,
FAMILY 8

(Clostridium
perfringens) 		PF01270
(Glyco_hydro_8) 		4 TYR A 159
GLU A 111
ARG A 113
ASP A 107
 None
 1.24A 2yqzA-3renA:
undetectable		 2yqzA-3renA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlc A1 PROTEIN

(Escherichia
virus Qbeta) 		PF16814
(Read-through) 		4 TYR A 221
ARG A 327
ASP A 214
ASP A 236
 None
 1.23A 2yqzA-3rlcA:
undetectable		 2yqzA-3rlcA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 GLU A  75
ARG A  82
ASP A 107
ASP A 166
 SAH  A 258 (-3.2A)
SAH  A 258 (-3.7A)
SAH  A 258 (-2.7A)
SAH  A 258 (-3.4A)
 0.85A 2yqzA-3tosA:
12.1		 2yqzA-3tosA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A  15
GLU A 130
ASP A 126
ASP A 184
 D15  A 500 ( 4.1A)
D15  A 500 ( 3.9A)
None
None
 1.44A 2yqzA-4aguA:
undetectable		 2yqzA-4aguA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLU A 228
ARG A 617
ASP A 231
ASP A 267
 MG  A1663 (-3.6A)
ANP  A1664 (-2.5A)
None
None
 1.33A 2yqzA-4c2tA:
undetectable		 2yqzA-4c2tA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhe PROBABLE GTP-BINDING
PROTEIN ENGB

(Burkholderia
thailandensis) 		PF01926
(MMR_HSR1) 		4 TYR A 172
GLU A 127
ASP A 129
ASP A 120
 None
 1.44A 2yqzA-4dheA:
undetectable		 2yqzA-4dheA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		4 GLU A 234
ARG A 188
ASP A 233
ASP A 167
 None
D1D  A 421 (-4.6A)
None
None
 1.40A 2yqzA-4isaA:
undetectable		 2yqzA-4isaA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ERYTHROCYTE-BINDING
ANTIGEN-175

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 TYR A 277
GLU A 370
ARG A 223
ASP A 312
 None
 1.46A 2yqzA-4qexA:
undetectable		 2yqzA-4qexA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		4 TYR A 585
GLU A 647
ASP A 649
ASP A 653
 None
 1.32A 2yqzA-4v1uA:
2.5		 2yqzA-4v1uA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		4 TYR G 323
GLU G 306
ARG G 308
ASP G 433
 None
 1.43A 2yqzA-5b04G:
undetectable		 2yqzA-5b04G:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus;
Influenza C
virus) 		PF00602
(Flu_PB1)
PF00604
(Flu_PB2) 		4 TYR C  11
GLU B 716
ARG B 750
ASP C 177
 None
 1.37A 2yqzA-5d9aC:
undetectable		 2yqzA-5d9aC:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		4 TYR A 104
GLU A 144
ASP A 152
ASP A  95
 DCM  A 401 (-4.6A)
None
None
None
 1.44A 2yqzA-5jp9A:
undetectable		 2yqzA-5jp9A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR B 284
GLU B 782
ASP B 275
ASP B 838
 None
 1.39A 2yqzA-5kyuB:
undetectable		 2yqzA-5kyuB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLU A 375
ARG A 389
ASP A 376
ASP A 418
 None
 1.33A 2yqzA-5macA:
undetectable		 2yqzA-5macA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 TYR A 623
GLU A 771
ARG A 346
ASP A 772
 None
 1.49A 2yqzA-5n6uA:
undetectable		 2yqzA-5n6uA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 4 TYR B 169
GLU B 203
ASP B 230
ASP B 255
 SAH  B 501 ( 4.1A)
None
SAH  B 501 (-2.7A)
SAH  B 501 (-3.9A)
 1.32A 2yqzA-5thzB:
16.4		 2yqzA-5thzB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU 5 637
ARG 5 630
ASP 3 551
ASP 3 524
 None
 1.29A 2yqzA-5udb5:
undetectable		 2yqzA-5udb5:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 701 (-3.9A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
 0.70A 2yqzA-5wp4A:
16.5		 2yqzA-5wp4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 4 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 502 (-4.0A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
 0.55A 2yqzA-5wp5A:
15.7		 2yqzA-5wp5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 TYR A 550
GLU A 243
ASP A 260
ASP A 239
 None
None
None
CA  A 717 (-3.1A)
 1.50A 2yqzA-5ww1A:
undetectable		 2yqzA-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdm -

(-) 		no annotation 4 TYR A  32
GLU A 111
ASP A 125
ASP A 143
 GOL  A 303 (-4.5A)
None
CA  A 301 ( 2.8A)
CA  A 302 (-3.4A)
 1.41A 2yqzA-5zdmA:
undetectable		 2yqzA-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 GLU B 356
ARG B 232
ASP B 108
ASP B 105
 None
 1.46A 2yqzA-6reqB:
undetectable		 2yqzA-6reqB:
19.56