SIMILAR PATTERNS OF AMINO ACIDS FOR 2YOE_C_FL7C1318_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 GLY A 416
ILE A 538
VAL A 514
THR A  41
 None
None
None
ATP  A 700 (-3.5A)
 0.89A 2yoeB-1d9zA:
3.0
2yoeC-1d9zA:
3.1		 2yoeB-1d9zA:
19.64
2yoeC-1d9zA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1goj KINESIN HEAVY CHAIN

(Neurospora
crassa) 		PF00225
(Kinesin) 		5 GLY A  93
ASN A 306
ILE A  69
VAL A  10
SER A  95
 ADP  A 400 (-3.1A)
None
None
None
MG  A 401 ( 2.1A)
 1.30A 2yoeB-1gojA:
0.0
2yoeC-1gojA:
0.0		 2yoeB-1gojA:
22.37
2yoeC-1gojA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi) 		PF00710
(Asparaginase) 		4 ASN A 134
ILE A 166
VAL A 187
TYR A 184
 None
 0.82A 2yoeB-1hg0A:
0.0
2yoeC-1hg0A:
0.0		 2yoeB-1hg0A:
23.38
2yoeC-1hg0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ASN A 685
GLY A 483
ILE A 518
VAL A 675
 None
 0.79A 2yoeB-1j0nA:
3.2
2yoeC-1j0nA:
2.2		 2yoeB-1j0nA:
17.22
2yoeC-1j0nA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 GLY A 419
ASN A 610
ILE A 242
VAL A 274
 None
 0.86A 2yoeB-1mz5A:
0.0
2yoeC-1mz5A:
0.0		 2yoeB-1mz5A:
19.75
2yoeC-1mz5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 GLY A 356
ILE A  33
THR A  52
TYR A  35
 None
 0.86A 2yoeB-1nr0A:
0.0
2yoeC-1nr0A:
0.0		 2yoeB-1nr0A:
20.40
2yoeC-1nr0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		4 GLY A 406
ILE A 398
VAL A 443
SER A 404
 None
 0.97A 2yoeB-1oduA:
0.0
2yoeC-1oduA:
0.0		 2yoeB-1oduA:
22.17
2yoeC-1oduA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		4 ASN A 386
ASN A 345
ILE A 442
VAL A 437
 None
 0.93A 2yoeB-1ofmA:
0.0
2yoeC-1ofmA:
0.0		 2yoeB-1ofmA:
22.98
2yoeC-1ofmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5v F1 CAPSULE ANTIGEN

(Yersinia pestis) 		PF09255
(Antig_Caf1) 		4 GLY B  49
ILE B  98
VAL B 102
SER B 118
 None
 0.84A 2yoeB-1p5vB:
0.0
2yoeC-1p5vB:
0.0		 2yoeB-1p5vB:
18.18
2yoeC-1p5vB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		4 GLY A 363
ASN A 529
ILE A 605
SER A 361
 None
 0.94A 2yoeB-1qafA:
1.3
2yoeC-1qafA:
undetectable		 2yoeB-1qafA:
19.25
2yoeC-1qafA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 GLY A 394
ILE A 340
VAL A 286
SER A 392
 None
 0.93A 2yoeB-1wacA:
undetectable
2yoeC-1wacA:
undetectable		 2yoeB-1wacA:
19.58
2yoeC-1wacA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws0 PEPTIDE DEFORMYLASE
1

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		4 GLY A  53
ILE A  73
VAL A  61
SER A  55
 None
 0.94A 2yoeB-1ws0A:
undetectable
2yoeC-1ws0A:
undetectable		 2yoeB-1ws0A:
19.67
2yoeC-1ws0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		4 ASN A 448
GLY A 361
ASN A 450
VAL A 344
 None
 0.90A 2yoeB-2bf6A:
undetectable
2yoeC-2bf6A:
undetectable		 2yoeB-2bf6A:
22.27
2yoeC-2bf6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		4 ASN A 286
GLY A 300
ILE A  11
VAL A 347
 None
 0.94A 2yoeB-2drwA:
undetectable
2yoeC-2drwA:
undetectable		 2yoeB-2drwA:
23.08
2yoeC-2drwA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 GLY A 421
ILE A 343
VAL A 399
SER A 452
 None
 0.82A 2yoeB-2fwrA:
undetectable
2yoeC-2fwrA:
undetectable		 2yoeB-2fwrA:
21.33
2yoeC-2fwrA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzl DNA REPAIR PROTEIN
RAD25, XPB

(Archaeoglobus
fulgidus) 		PF16203
(ERCC3_RAD25_C) 		4 GLY A 421
ILE A 343
VAL A 399
SER A 452
 None
 0.90A 2yoeB-2fzlA:
2.1
2yoeC-2fzlA:
2.2		 2yoeB-2fzlA:
22.48
2yoeC-2fzlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 215
ASN A 366
SER A 229
THR A 224
 None
None
FAD  A1001 ( 4.9A)
FAD  A1001 (-4.7A)
 0.96A 2yoeB-2h88A:
undetectable
2yoeC-2h88A:
undetectable		 2yoeB-2h88A:
19.05
2yoeC-2h88A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A  31
ASN A  30
ILE A 422
VAL A 453
 None
 0.90A 2yoeB-2ipiA:
undetectable
2yoeC-2ipiA:
undetectable		 2yoeB-2ipiA:
19.77
2yoeC-2ipiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 GLY A 277
ILE A 320
SER A 302
THR A 330
 None
 0.88A 2yoeB-2iu3A:
2.2
2yoeC-2iu3A:
undetectable		 2yoeB-2iu3A:
20.48
2yoeC-2iu3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N) 		4 ILE A 168
VAL A 153
SER A 141
TYR A 177
 None
 0.93A 2yoeB-2ix2A:
undetectable
2yoeC-2ix2A:
undetectable		 2yoeB-2ix2A:
20.77
2yoeC-2ix2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		4 ASN A 134
ILE A 166
VAL A 187
TYR A 184
 None
 0.74A 2yoeB-2jk0A:
undetectable
2yoeC-2jk0A:
undetectable		 2yoeB-2jk0A:
21.63
2yoeC-2jk0A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnj PROTEIN INTERACTING
WITH HSP90 1
TPR
REPEAT-CONTAINING
PROTEIN ASSOCIATED
WITH HSP90

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A   1
ILE B  74
VAL A   6
TYR B  68
 None
 0.85A 2yoeB-2mnjA:
undetectable
2yoeC-2mnjA:
undetectable		 2yoeB-2mnjA:
5.86
2yoeC-2mnjA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mog BACTERIAL IG-LIKE
DOMAIN, GROUP 2

(Leptospira
interrogans) 		PF02368
(Big_2) 		4 ASN A  57
ILE A  75
VAL A  43
SER A  22
 None
 0.92A 2yoeB-2mogA:
undetectable
2yoeC-2mogA:
undetectable		 2yoeB-2mogA:
17.72
2yoeC-2mogA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr7 SECRETION ACTIVATOR
PROTEIN, PUTATIVE

(Porphyromonas
gingivalis) 		PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3) 		4 GLY A 102
ILE A  11
THR A  37
TYR A  10
 None
 0.93A 2yoeB-2nr7A:
undetectable
2yoeC-2nr7A:
undetectable		 2yoeB-2nr7A:
21.38
2yoeC-2nr7A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 ASN A 214
GLY A 209
ILE A 250
SER A 207
 None
None
None
NAD  A1002 (-4.7A)
 0.89A 2yoeB-2o4cA:
undetectable
2yoeC-2o4cA:
undetectable		 2yoeB-2o4cA:
21.13
2yoeC-2o4cA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		4 GLY A  25
ASN A  24
ILE A  60
TYR A  86
 CSF  A1001 (-3.4A)
CSF  A1001 (-4.5A)
None
None
 0.96A 2yoeB-2p2vA:
undetectable
2yoeC-2p2vA:
undetectable		 2yoeB-2p2vA:
22.38
2yoeC-2p2vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
putida) 		PF00106
(adh_short) 		4 GLY A 142
ILE A 135
VAL A 166
SER A 139
 None
 0.95A 2yoeB-2q2vA:
undetectable
2yoeC-2q2vA:
undetectable		 2yoeB-2q2vA:
22.05
2yoeC-2q2vA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 GLY F 559
ILE F 454
THR F 376
TYR F 456
 MES  F1653 (-3.6A)
None
None
None
 0.90A 2yoeB-2v2fF:
undetectable
2yoeC-2v2fF:
undetectable		 2yoeB-2v2fF:
19.80
2yoeC-2v2fF:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 ASN A2001
GLY A1951
SER A1944
THR A1890
 None
 0.86A 2yoeB-2vz9A:
undetectable
2yoeC-2vz9A:
undetectable		 2yoeB-2vz9A:
7.86
2yoeC-2vz9A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 GLY A 688
ILE A 701
VAL A 729
THR A 697
 None
 0.91A 2yoeB-2x0sA:
undetectable
2yoeC-2x0sA:
undetectable		 2yoeB-2x0sA:
16.74
2yoeC-2x0sA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x56 COAGULASE/FIBRINOLYS
IN

(Yersinia pestis) 		PF01278
(Omptin) 		4 ASN A 230
ASN A 191
ILE A   9
THR A  15
 None
 0.82A 2yoeB-2x56A:
undetectable
2yoeC-2x56A:
undetectable		 2yoeB-2x56A:
20.24
2yoeC-2x56A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B
LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 GLY A 105
ILE B  99
VAL B  60
THR A  44
 None
 0.92A 2yoeB-2xdqA:
undetectable
2yoeC-2xdqA:
undetectable		 2yoeB-2xdqA:
21.08
2yoeC-2xdqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASN A 789
GLY A 713
ASN A 714
THR A 893
 None
 0.89A 2yoeB-2y8nA:
2.2
2yoeC-2y8nA:
2.8		 2yoeB-2y8nA:
16.40
2yoeC-2y8nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adk ADENYLATE KINASE

(Sus scrofa) 		PF00406
(ADK) 		4 GLY A  89
ILE A 169
VAL A  14
SER A   8
 None
 0.93A 2yoeB-3adkA:
undetectable
2yoeC-3adkA:
undetectable		 2yoeB-3adkA:
18.57
2yoeC-3adkA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aux DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Methanocaldococcus
jannaschii) 		PF13476
(AAA_23) 		4 GLY A 135
ILE A 931
VAL A 923
THR A 151
 None
 0.96A 2yoeB-3auxA:
2.7
2yoeC-3auxA:
2.7		 2yoeB-3auxA:
21.11
2yoeC-3auxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b57 LIN1889 PROTEIN

(Listeria
innocua) 		PF01966
(HD) 		4 GLY A  46
ILE A 180
VAL A  33
THR A 174
 None
 0.86A 2yoeB-3b57A:
3.8
2yoeC-3b57A:
3.7		 2yoeB-3b57A:
19.29
2yoeC-3b57A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		4 GLY A 240
ILE A 219
VAL A 175
THR A  92
 None
 0.96A 2yoeB-3b6vA:
undetectable
2yoeC-3b6vA:
undetectable		 2yoeB-3b6vA:
21.74
2yoeC-3b6vA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhg ADENYLOSUCCINATE
LYASE

(Legionella
pneumophila) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 GLY A 315
ASN A 318
ILE A 147
VAL A 257
 None
 0.74A 2yoeB-3bhgA:
3.6
2yoeC-3bhgA:
3.6		 2yoeB-3bhgA:
21.23
2yoeC-3bhgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		4 GLY A 249
ILE A 193
VAL A 214
TYR A 188
 None
 0.85A 2yoeB-3cnyA:
undetectable
2yoeC-3cnyA:
undetectable		 2yoeB-3cnyA:
22.28
2yoeC-3cnyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8x THIOREDOXIN
REDUCTASE 1

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 GLY A  44
ILE A 256
SER A  11
THR A  86
 FAD  A1001 (-3.1A)
FAD  A1001 ( 4.7A)
FAD  A1001 (-4.5A)
FAD  A1001 (-4.1A)
 0.80A 2yoeB-3d8xA:
undetectable
2yoeC-3d8xA:
undetectable		 2yoeB-3d8xA:
20.11
2yoeC-3d8xA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 ASN A 270
GLY A  64
SER A 406
THR A 342
 None
 0.97A 2yoeB-3ei8A:
undetectable
2yoeC-3ei8A:
undetectable		 2yoeB-3ei8A:
21.75
2yoeC-3ei8A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		4 GLY A 240
ILE A 228
VAL A 220
SER A 236
 None
 0.79A 2yoeB-3eu8A:
undetectable
2yoeC-3eu8A:
2.0		 2yoeB-3eu8A:
19.95
2yoeC-3eu8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 GLY A1803
ILE A1717
VAL A1749
SER A1801
 None
 0.77A 2yoeB-3ff6A:
2.4
2yoeC-3ff6A:
2.3		 2yoeB-3ff6A:
16.06
2yoeC-3ff6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icy SENSOR PROTEIN

(Chlorobaculum
tepidum) 		PF08447
(PAS_3) 		4 GLY A 102
ILE A 107
SER A  99
TYR A  64
 None
 0.93A 2yoeB-3icyA:
undetectable
2yoeC-3icyA:
undetectable		 2yoeB-3icyA:
15.36
2yoeC-3icyA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igr RIBOSOMAL-PROTEIN-S5
-ALANINE
N-ACETYLTRANSFERASE

(Aliivibrio
fischeri) 		PF13302
(Acetyltransf_3) 		4 GLY A  82
ILE A 121
VAL A   3
SER A 102
 None
 0.92A 2yoeB-3igrA:
undetectable
2yoeC-3igrA:
undetectable		 2yoeB-3igrA:
18.45
2yoeC-3igrA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jza UNCHARACTERIZED
PROTEIN DRRA

(Legionella
pneumophila) 		no annotation 4 ASN B 437
GLY B 411
ILE B 398
SER B 408
 None
 0.80A 2yoeB-3jzaB:
undetectable
2yoeC-3jzaB:
undetectable		 2yoeB-3jzaB:
20.07
2yoeC-3jzaB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		4 GLY A  89
VAL A  44
SER A 113
THR A 131
 None
 0.91A 2yoeB-3khnA:
undetectable
2yoeC-3khnA:
undetectable		 2yoeB-3khnA:
21.09
2yoeC-3khnA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kys TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-1

(Homo sapiens) 		no annotation 4 GLY A 400
ILE A 351
VAL A 293
SER A 395
 None
 0.89A 2yoeB-3kysA:
undetectable
2yoeC-3kysA:
undetectable		 2yoeB-3kysA:
21.43
2yoeC-3kysA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 GLY A  70
ILE A 285
VAL A  36
SER A  67
 None
 0.85A 2yoeB-3m4xA:
undetectable
2yoeC-3m4xA:
undetectable		 2yoeB-3m4xA:
20.59
2yoeC-3m4xA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF08005
(PHR) 		4 GLY A 510
ASN A 509
VAL A 420
TYR A 418
 None
 0.90A 2yoeB-3no8A:
undetectable
2yoeC-3no8A:
undetectable		 2yoeB-3no8A:
18.51
2yoeC-3no8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ASN A 391
ASN A 369
ILE A 336
VAL A 386
 None
 0.90A 2yoeB-3o6nA:
undetectable
2yoeC-3o6nA:
undetectable		 2yoeB-3o6nA:
22.63
2yoeC-3o6nA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 GLY A 265
ILE A 366
VAL A 508
SER A 268
 None
 0.92A 2yoeB-3o8oA:
undetectable
2yoeC-3o8oA:
undetectable		 2yoeB-3o8oA:
15.91
2yoeC-3o8oA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		4 GLY A 613
ILE A 645
SER A 618
THR A 621
 None
 0.86A 2yoeB-3ohnA:
undetectable
2yoeC-3ohnA:
undetectable		 2yoeB-3ohnA:
20.87
2yoeC-3ohnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 ASN B 391
ASN B 369
ILE B 336
VAL B 386
 None
 0.86A 2yoeB-3ojaB:
undetectable
2yoeC-3ojaB:
undetectable		 2yoeB-3ojaB:
18.96
2yoeC-3ojaB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 GLY A 110
ILE A 291
VAL A 265
TYR A 295
 None
CL  A 431 (-4.6A)
None
None
 0.90A 2yoeB-3p1vA:
undetectable
2yoeC-3p1vA:
undetectable		 2yoeB-3p1vA:
21.83
2yoeC-3p1vA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 GLY A 447
ILE A 501
VAL A 508
TYR A 505
 None
 0.87A 2yoeB-3pocA:
undetectable
2yoeC-3pocA:
undetectable		 2yoeB-3pocA:
18.07
2yoeC-3pocA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 GLY A  87
ILE A 306
VAL A 274
SER A  91
 None
 0.90A 2yoeB-3s8mA:
undetectable
2yoeC-3s8mA:
undetectable		 2yoeB-3s8mA:
21.23
2yoeC-3s8mA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2)
PF13855
(LRR_8) 		4 ASN A 205
GLY A 208
ASN A 207
ILE C  78
 GOL  C  12 ( 4.9A)
None
None
None
 0.88A 2yoeB-3t6qA:
undetectable
2yoeC-3t6qA:
undetectable		 2yoeB-3t6qA:
19.14
2yoeC-3t6qA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ASN A 300
ILE A 191
VAL A 297
SER A 254
 None
 0.84A 2yoeB-3to3A:
undetectable
2yoeC-3to3A:
undetectable		 2yoeB-3to3A:
17.79
2yoeC-3to3A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ug7 ARSENICAL
PUMP-DRIVING ATPASE

(Methanocaldococcus
jannaschii) 		PF02374
(ArsA_ATPase) 		4 GLY A  54
ASN A  88
ILE A 322
VAL A  91
 None
 0.75A 2yoeB-3ug7A:
undetectable
2yoeC-3ug7A:
undetectable		 2yoeB-3ug7A:
21.56
2yoeC-3ug7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umb DEHALOGENASE-LIKE
HYDROLASE

(Ralstonia
solanacearum) 		PF00702
(Hydrolase) 		4 GLY A 137
VAL A  18
SER A 139
TYR A  12
 None
 0.89A 2yoeB-3umbA:
undetectable
2yoeC-3umbA:
undetectable		 2yoeB-3umbA:
23.25
2yoeC-3umbA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 GLY A 448
ASN A 445
VAL A 542
SER A 452
 None
 0.93A 2yoeB-3wfzA:
undetectable
2yoeC-3wfzA:
undetectable		 2yoeB-3wfzA:
18.57
2yoeC-3wfzA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 GLY A1729
ILE A1635
VAL A1675
SER A1727
 None
 0.89A 2yoeB-4asiA:
undetectable
2yoeC-4asiA:
undetectable		 2yoeB-4asiA:
16.60
2yoeC-4asiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bko PUTATIVE REDUCTASE
BURPS305_1051

(Burkholderia
pseudomallei) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 GLY A  87
ILE A 305
VAL A 273
SER A  91
 None
None
MES  A1399 (-4.1A)
None
 0.89A 2yoeB-4bkoA:
undetectable
2yoeC-4bkoA:
undetectable		 2yoeB-4bkoA:
21.75
2yoeC-4bkoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg4 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 GLY A 660
ILE A 720
VAL A 775
TYR A 654
 None
 0.87A 2yoeB-4cg4A:
3.9
2yoeC-4cg4A:
3.9		 2yoeB-4cg4A:
20.10
2yoeC-4cg4A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 GLY A 575
ASN A 105
ILE A 128
VAL A 124
 None
 0.72A 2yoeB-4cvcA:
undetectable
2yoeC-4cvcA:
undetectable		 2yoeB-4cvcA:
17.92
2yoeC-4cvcA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di3 TATT (TP0956)

(Treponema
pallidum) 		PF16811
(TAtT) 		4 ASN A  82
VAL A 164
SER A 285
THR A 245
 None
 0.89A 2yoeB-4di3A:
2.8
2yoeC-4di3A:
2.7		 2yoeB-4di3A:
19.40
2yoeC-4di3A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 ASN A 103
GLY A  46
ASN A  45
ILE A 184
 GSH  A 301 (-4.2A)
None
GSH  A 301 (-3.3A)
GSH  A 301 (-4.6A)
 0.83A 2yoeB-4eq9A:
undetectable
2yoeC-4eq9A:
undetectable		 2yoeB-4eq9A:
19.29
2yoeC-4eq9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 GLY B 195
ILE B 129
VAL B 122
THR B 481
 None
 0.87A 2yoeB-4i0wB:
undetectable
2yoeC-4i0wB:
undetectable		 2yoeB-4i0wB:
22.67
2yoeC-4i0wB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		4 GLY A  90
ILE A 244
VAL A 215
TYR A 211
 None
 0.73A 2yoeB-4ofwA:
undetectable
2yoeC-4ofwA:
undetectable		 2yoeB-4ofwA:
19.80
2yoeC-4ofwA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		4 ILE A 244
VAL A 215
THR A  49
TYR A 211
 None
 0.68A 2yoeB-4ofwA:
undetectable
2yoeC-4ofwA:
undetectable		 2yoeB-4ofwA:
19.80
2yoeC-4ofwA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 4 ASN A 700
ILE A 752
VAL A 706
TYR A 729
 None
 0.87A 2yoeB-4oj5A:
undetectable
2yoeC-4oj5A:
undetectable		 2yoeB-4oj5A:
16.56
2yoeC-4oj5A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		4 GLY A 185
ILE A 279
VAL A 268
THR A  69
 EDO  A 407 (-3.6A)
None
None
None
 0.90A 2yoeB-4ovyA:
undetectable
2yoeC-4ovyA:
undetectable		 2yoeB-4ovyA:
22.54
2yoeC-4ovyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		4 ASN A 353
ILE A 500
SER A 373
THR A 434
 None
4NS  A 601 (-3.7A)
None
None
 0.93A 2yoeB-4p05A:
undetectable
2yoeC-4p05A:
undetectable		 2yoeB-4p05A:
21.23
2yoeC-4p05A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 GLY A 139
ILE A  61
VAL A  73
THR A  38
 None
 0.84A 2yoeB-4pfrA:
undetectable
2yoeC-4pfrA:
undetectable		 2yoeB-4pfrA:
21.11
2yoeC-4pfrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 GLY A 133
ILE A 224
VAL A 193
THR A 217
 None
 0.85A 2yoeB-4pfzA:
undetectable
2yoeC-4pfzA:
undetectable		 2yoeB-4pfzA:
21.07
2yoeC-4pfzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 GLY A-270
ASN A-271
ILE A-193
VAL A   9
 None
 0.75A 2yoeB-4qszA:
undetectable
2yoeC-4qszA:
undetectable		 2yoeB-4qszA:
18.68
2yoeC-4qszA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Clostridioides
difficile) 		PF01520
(Amidase_3) 		4 GLY A 124
ASN A 145
ILE A 208
SER A 193
 None
 0.94A 2yoeB-4rn7A:
undetectable
2yoeC-4rn7A:
undetectable		 2yoeB-4rn7A:
21.43
2yoeC-4rn7A:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 ILE A  39
VAL A  73
SER A  84
THR A  87
TYR A 102
 None
 0.42A 2yoeB-4twfA:
34.3
2yoeC-4twfA:
34.4		 2yoeB-4twfA:
99.35
2yoeC-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 ASN A 232
ASN A 210
ILE A 177
VAL A 227
 None
 0.85A 2yoeB-4xgoA:
undetectable
2yoeC-4xgoA:
undetectable		 2yoeB-4xgoA:
17.86
2yoeC-4xgoA:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 ILE A  39
VAL A  73
SER A  84
THR A  87
TYR A 102
 None
 0.59A 2yoeB-4yeuA:
29.5
2yoeC-4yeuA:
29.6		 2yoeB-4yeuA:
71.88
2yoeC-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 GLY C 138
ASN C 139
ILE C  58
VAL C  43
 None
 0.79A 2yoeB-4zohC:
undetectable
2yoeC-4zohC:
undetectable		 2yoeB-4zohC:
19.13
2yoeC-4zohC:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00604
(Flu_PB2) 		4 ILE C 572
VAL C 673
SER C 633
TYR C 568
 None
 0.96A 2yoeB-5d9aC:
undetectable
2yoeC-5d9aC:
undetectable		 2yoeB-5d9aC:
16.88
2yoeC-5d9aC:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		4 GLY A 135
VAL A 353
SER A 133
THR A 185
 None
 0.92A 2yoeB-5ei0A:
undetectable
2yoeC-5ei0A:
undetectable		 2yoeB-5ei0A:
20.81
2yoeC-5ei0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 GLY B  92
ILE B 243
VAL B 104
TYR B 124
 None
 0.79A 2yoeB-5fozB:
undetectable
2yoeC-5fozB:
undetectable		 2yoeB-5fozB:
21.27
2yoeC-5fozB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		4 GLY A 226
ILE A 214
VAL A 206
SER A 222
 None
 0.76A 2yoeB-5gzhA:
1.6
2yoeC-5gzhA:
1.5		 2yoeB-5gzhA:
20.43
2yoeC-5gzhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		4 GLY A 243
ASN A 235
ILE A 208
VAL A 130
 None
 0.96A 2yoeB-5iguA:
undetectable
2yoeC-5iguA:
undetectable		 2yoeB-5iguA:
20.70
2yoeC-5iguA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		4 GLY A  53
ILE A 163
SER A  10
THR A 130
 None
 0.92A 2yoeB-5jijA:
undetectable
2yoeC-5jijA:
undetectable		 2yoeB-5jijA:
21.08
2yoeC-5jijA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juf TRANSCRIPTIONAL
REGULATOR

(Streptococcus
thermophilus) 		PF01381
(HTH_3) 		4 ILE A  74
VAL A 107
SER A  45
TYR A  78
 None
 0.93A 2yoeB-5jufA:
1.9
2yoeC-5jufA:
5.1		 2yoeB-5jufA:
22.85
2yoeC-5jufA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k66 NTA1P

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		4 GLY A 403
ASN A 390
THR A 399
TYR A 140
 None
None
None
ASN  A 501 ( 3.6A)
 0.86A 2yoeB-5k66A:
undetectable
2yoeC-5k66A:
undetectable		 2yoeB-5k66A:
20.56
2yoeC-5k66A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyj ANBU

(Hyphomicrobium
sp. MC1) 		PF00227
(Proteasome) 		4 GLY A 156
ILE A 213
VAL A  13
SER A 183
 None
 0.77A 2yoeB-5nyjA:
undetectable
2yoeC-5nyjA:
undetectable		 2yoeB-5nyjA:
21.20
2yoeC-5nyjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE

(Ilumatobacter
coccineus) 		PF13561
(adh_short_C2) 		5 GLY A 155
ASN A 173
VAL A 179
SER A 152
THR A 101
 None
 1.09A 2yoeB-5o30A:
undetectable
2yoeC-5o30A:
undetectable		 2yoeB-5o30A:
19.62
2yoeC-5o30A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		4 GLY A1105
ASN A1106
ILE A1119
VAL A1032
 None
 0.75A 2yoeB-5tuyA:
undetectable
2yoeC-5tuyA:
undetectable		 2yoeB-5tuyA:
21.64
2yoeC-5tuyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ASN A 185
GLY A 180
ILE A   8
VAL A  28
 None
 0.74A 2yoeB-5tw7A:
undetectable
2yoeC-5tw7A:
undetectable		 2yoeB-5tw7A:
19.55
2yoeC-5tw7A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 ASN A  92
GLY A 135
ILE A 183
TYR A 176
 None
 0.97A 2yoeB-5v1wA:
2.2
2yoeC-5v1wA:
2.2		 2yoeB-5v1wA:
17.29
2yoeC-5v1wA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 GLY A 444
ILE A 233
VAL A 157
THR A 435
 FAD  A 503 (-3.4A)
None
None
None
 0.94A 2yoeB-5vj7A:
undetectable
2yoeC-5vj7A:
undetectable		 2yoeB-5vj7A:
22.33
2yoeC-5vj7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z97 LACTONASE FOR
PROTEIN

(Rhinocladiella
mackenziei) 		no annotation 4 GLY A  80
ILE A 228
SER A 196
THR A 132
 None
 0.81A 2yoeB-5z97A:
undetectable
2yoeC-5z97A:
undetectable		 2yoeB-5z97A:
16.61
2yoeC-5z97A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 GLY C1089
ILE C1158
VAL C1114
TYR C1157
 None
 0.88A 2yoeB-6en4C:
2.7
2yoeC-6en4C:
2.7		 2yoeB-6en4C:
14.77
2yoeC-6en4C:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 4 GLY A 371
ILE A 493
VAL A 486
TYR A 477
 None
 0.90A 2yoeB-6eomA:
3.4
2yoeC-6eomA:
3.5		 2yoeB-6eomA:
14.66
2yoeC-6eomA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 GLY A 389
ASN A 509
ILE A 344
SER A 391
 None
 0.89A 2yoeB-6f9nA:
undetectable
2yoeC-6f9nA:
undetectable		 2yoeB-6f9nA:
13.07
2yoeC-6f9nA:
13.07