SIMILAR PATTERNS OF AMINO ACIDS FOR 2YLO_A_TESA1920

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 LEU A 203
ASN A 204
LEU A 206
GLN A 176
VAL A 174
 None
 1.45A 2yloA-1a2oA:
undetectable		 2yloA-1a2oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE

(Salmonella
enterica) 		PF02283
(CobU) 		5 LEU A  89
ASN A  88
LEU A  90
VAL A 157
THR A  31
 None
None
None
None
5GP  A 604 (-4.6A)
 1.39A 2yloA-1c9kA:
undetectable		 2yloA-1c9kA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 456
LEU A 517
VAL A 657
MET A 661
THR A 651
 None
 1.34A 2yloA-1elvA:
undetectable		 2yloA-1elvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 230
LEU A 229
GLN A 199
VAL A 226
ARG A 284
 None
None
BR  A2008 (-4.0A)
None
None
 1.43A 2yloA-1jhdA:
undetectable		 2yloA-1jhdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		5 GLN B 258
VAL B 360
ARG B 262
THR B 321
PHE B 246
 None
 1.49A 2yloA-1mtyB:
undetectable		 2yloA-1mtyB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  21
LEU A  22
MET A 115
VAL A 113
THR A 226
 None
 1.21A 2yloA-1tqhA:
undetectable		 2yloA-1tqhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 327
MET A 362
VAL A 366
ARG A 372
 None
 0.58A 2yloA-1xb7A:
26.3		 2yloA-1xb7A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2f CELL DIVISION
PROTEIN ZIPA

(Escherichia
coli) 		PF04354
(ZipA_C) 		5 LEU A  23
ASN A  24
LEU A  28
VAL A  65
MET A  64
 None
 1.36A 2yloA-1y2fA:
undetectable		 2yloA-1y2fA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 745
VAL A 746
MET A 749
ARG A 752
PHE A 891
MET A 895
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
None
None
 0.72A 2yloA-2ax9A:
40.2		 2yloA-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 704
ASN A 705
LEU A 707
MET A 742
MET A 745
VAL A 746
MET A 749
ARG A 752
THR A 877
PHE A 891
MET A 895
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.0A)
None
None
 0.57A 2yloA-2ax9A:
40.2		 2yloA-2ax9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhy CUE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02845
(CUE) 		5 LEU A  56
ASN A  59
GLN A  54
VAL A  48
MET A  32
 None
 1.31A 2yloA-2dhyA:
undetectable		 2yloA-2dhyA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		5 LEU D 112
LEU D 115
VAL D 168
MET D 172
PHE D  52
 None
 1.30A 2yloA-2gafD:
undetectable		 2yloA-2gafD:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		5 LEU B 383
LEU B 329
MET B 389
VAL B 388
PHE B 339
 None
 1.41A 2yloA-2jgzB:
undetectable		 2yloA-2jgzB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oez UPF0289 PROTEIN
VP2528

(Vibrio
parahaemolyticus) 		PF07072
(ZapD) 		5 LEU A 202
LEU A 242
GLN A 183
VAL A 238
THR A   3
 None
 1.15A 2yloA-2oezA:
undetectable		 2yloA-2oezA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q12 DCC-INTERACTING
PROTEIN 13 ALPHA

(Homo sapiens) 		PF16746
(BAR_3) 		5 GLN A 234
VAL A 236
ARG A 238
THR A  85
PHE A 225
 None
 1.46A 2yloA-2q12A:
undetectable		 2yloA-2q12A:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
ASN A  33
LEU A  35
MET A  70
MET A  73
ARG A  80
PHE A 219
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
1CA  A 247 (-4.5A)
 0.50A 2yloA-2q3yA:
37.3		 2yloA-2q3yA:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
PHE A 219
 1CA  A 247 (-4.0A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
1CA  A 247 (-4.5A)
 0.69A 2yloA-2q3yA:
37.3		 2yloA-2q3yA:
58.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		5 LEU A 118
LEU A 121
MET A 162
MET A 165
VAL A 166
 None
 1.20A 2yloA-2q6zA:
undetectable		 2yloA-2q6zA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		5 LEU A 177
ASN A 176
LEU A 195
MET A 171
VAL A 167
 None
 1.44A 2yloA-2ra8A:
undetectable		 2yloA-2ra8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		5 LEU A 327
LEU A 324
GLN A 320
VAL A 118
PHE A  75
 None
 1.15A 2yloA-2w7yA:
undetectable		 2yloA-2w7yA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		5 LEU A 481
LEU A 477
MET A 452
MET A 449
PHE A 498
 None
 1.48A 2yloA-2xpiA:
undetectable		 2yloA-2xpiA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 464
LEU A 466
VAL A 429
ARG A 381
THR A 826
 None
 1.47A 2yloA-2y8nA:
undetectable		 2yloA-2y8nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 LEU A 759
ASN A 763
LEU A 760
VAL A 367
THR A 769
 None
 1.22A 2yloA-2yn9A:
undetectable		 2yloA-2yn9A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 319
LEU A 320
MET A 330
MET A 327
VAL A 326
 None
 1.45A 2yloA-2z1aA:
undetectable		 2yloA-2z1aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Agrobacterium
fabrum) 		PF00440
(TetR_N) 		5 LEU A 110
ASN A 111
LEU A 113
GLN A 117
ARG A  57
 None
 1.23A 2yloA-3c2bA:
undetectable		 2yloA-3c2bA:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 718
ASN A 719
LEU A 721
GLN A 725
MET A 756
MET A 759
VAL A 760
ARG A 766
PHE A 905
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.6A)
 0.62A 2yloA-3kbaA:
35.1		 2yloA-3kbaA:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
ASN A 719
LEU A 721
MET A 756
MET A 759
PHE A 905
MET A 909
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.6A)
None
 1.07A 2yloA-3kbaA:
35.1		 2yloA-3kbaA:
53.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN

(Salmonella
enterica) 		PF01380
(SIS) 		5 LEU A 152
LEU A  19
MET A 111
PHE A  52
MET A  53
 None
 1.47A 2yloA-3knzA:
undetectable		 2yloA-3knzA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 LEU A  32
ASN A  33
LEU A  35
MET A  70
MET A  73
ARG A  80
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.3A)
 0.55A 2yloA-3ry9A:
36.8		 2yloA-3ry9A:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 LEU A  32
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.3A)
 0.72A 2yloA-3ry9A:
36.8		 2yloA-3ry9A:
53.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ASN A 384
LEU A 386
MET A 333
ARG A 330
PHE A 418
 None
 1.50A 2yloA-3vu2A:
undetectable		 2yloA-3vu2A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hut COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE

(Salmonella
enterica) 		PF02572
(CobA_CobO_BtuR) 		5 LEU A 126
MET A 123
MET A 115
THR A  48
PHE A  34
 None
 1.45A 2yloA-4hutA:
undetectable		 2yloA-4hutA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.41A 2yloA-4j1yA:
undetectable		 2yloA-4j1yA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 493
LEU A 556
GLN A 714
VAL A 708
THR A 702
 None
 1.40A 2yloA-4kkdA:
undetectable		 2yloA-4kkdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp7 MATRIX PROTEIN M

(Human
metapneumovirus) 		PF03393
(Pneumo_matrix) 		5 LEU A  49
LEU A 117
VAL A  20
THR A  54
MET A  81
 None
 1.50A 2yloA-4lp7A:
undetectable		 2yloA-4lp7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 283
LEU A 286
MET A 321
ARG A 331
PHE A 462
 None
 0.67A 2yloA-4n1yA:
28.3		 2yloA-4n1yA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00764
(Arginosuc_synth) 		5 LEU A 250
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.30A 2yloA-4nzpA:
undetectable		 2yloA-4nzpA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 563
ASN A 564
LEU A 566
MET A 601
MET A 604
ARG A 611
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
 0.93A 2yloA-4p6wA:
33.2		 2yloA-4p6wA:
49.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 566
GLN A 570
MET A 601
MET A 604
ARG A 611
 MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 1.06A 2yloA-4p6wA:
33.2		 2yloA-4p6wA:
49.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU B 354
LEU B 355
GLN B 352
VAL B 347
ARG B  73
 None
 1.42A 2yloA-4qj4B:
undetectable		 2yloA-4qj4B:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 LEU A 585
ASN A 582
GLN A 587
ARG A 591
THR A 628
 None
 1.38A 2yloA-4qmkA:
undetectable		 2yloA-4qmkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum) 		no annotation 5 LEU B 617
LEU B 633
GLN B 693
VAL B 686
THR B 534
 None
None
None
None
GSP  B 901 (-4.3A)
 1.43A 2yloA-4tmzB:
undetectable		 2yloA-4tmzB:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 769
ASN A 770
LEU A 772
MET A 807
ARG A 817
PHE A 956
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.7A)
 0.74A 2yloA-4udbA:
33.8		 2yloA-4udbA:
49.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		5 LEU A  72
LEU A  74
GLN A  87
VAL A 122
PHE A 136
 None
 1.24A 2yloA-4xyiA:
undetectable		 2yloA-4xyiA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus) 		PF00905
(Transpeptidase) 		5 LEU A 109
MET A 157
MET A 146
THR A 114
MET A 166
 None
None
KCX  A 104 ( 4.6A)
None
None
 1.19A 2yloA-5ctmA:
undetectable		 2yloA-5ctmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A 330
ASN A 329
LEU A 327
VAL A 317
PHE A 404
 None
 1.27A 2yloA-5itgA:
undetectable		 2yloA-5itgA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koa CELL DIVISION
PROTEIN ZAPD

(Escherichia
coli) 		PF07072
(ZapD) 		5 LEU A  74
LEU A  91
GLN A  94
MET A 170
VAL A 171
 None
 1.43A 2yloA-5koaA:
undetectable		 2yloA-5koaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlk ACETYL-COA
CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 318
GLN A 222
VAL A 305
ARG A 237
PHE A 323
 None
 1.40A 2yloA-5mlkA:
undetectable		 2yloA-5mlkA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 LEU A 769
ASN A 770
LEU A 772
MET A 807
ARG A 817
PHE A 956
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.7A)
 0.60A 2yloA-5mwpA:
37.0		 2yloA-5mwpA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 244
LEU A 241
GLN A 259
VAL A 217
THR A 232
 None
 1.16A 2yloA-5o8xA:
undetectable		 2yloA-5o8xA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.40A 2yloA-5ubmA:
undetectable		 2yloA-5ubmA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 559
ASN A 560
LEU A 562
MET A 600
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
None
486  A 801 (-3.5A)
 0.74A 2yloA-5uc1A:
23.1		 2yloA-5uc1A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 559
ASN A 560
MET A 597
MET A 600
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.82A 2yloA-5uc1A:
23.1		 2yloA-5uc1A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
ASN A  33
LEU A  35
MET A  70
MET A  73
ARG A  80
PHE A 218
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
1TA  A 301 (-4.0A)
 0.89A 2yloA-5ufsA:
35.2		 2yloA-5ufsA:
54.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 1.01A 2yloA-5ufsA:
35.2		 2yloA-5ufsA:
54.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		5 LEU A 826
LEU A 778
VAL A 772
THR A 819
PHE A 795
 None
 1.35A 2yloA-5uj7A:
undetectable		 2yloA-5uj7A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		5 LEU A 826
LEU A 778
VAL A 772
THR A 819
PHE A 795
 None
 1.35A 2yloA-5ujmA:
undetectable		 2yloA-5ujmA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 LEU A 455
LEU A 459
GLN A 332
VAL A 327
MET A 353
 None
 1.43A 2yloA-5veuA:
undetectable		 2yloA-5veuA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ans UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF06742
(DUF1214) 		5 LEU A 171
GLN A 118
MET A 128
VAL A 249
MET A  59
 None
None
GOL  A 403 ( 4.6A)
None
None
 1.49A 2yloA-6ansA:
undetectable		 2yloA-6ansA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 5 LEU A 505
LEU A 508
THR A 481
PHE A 405
MET A 402
 None
 1.40A 2yloA-6bwmA:
undetectable		 2yloA-6bwmA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila) 		no annotation 5 LEU A  65
ASN A  62
LEU A  60
MET A  21
THR A  78
 None
 1.40A 2yloA-6gebA:
undetectable		 2yloA-6gebA:
14.46