SIMILAR PATTERNS OF AMINO ACIDS FOR 2YHD_A_TESA1920_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 LEU A 178
ASN A 233
LEU A 236
GLY A 235
GLN A 112
 None
 1.46A 2yhdA-1d8cA:
undetectable		 2yhdA-1d8cA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 LEU A  24
LEU A  38
GLY A  39
ARG A 569
THR A  48
 None
 1.32A 2yhdA-1d9zA:
undetectable		 2yhdA-1d9zA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 LEU A 455
LEU A 451
GLY A 448
GLN A 447
THR A 457
 None
 1.16A 2yhdA-1gk2A:
undetectable		 2yhdA-1gk2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 317
GLY A 269
GLN A 264
MET A 135
THR A 297
 None
 1.37A 2yhdA-1p31A:
undetectable		 2yhdA-1p31A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri6 PUTATIVE ISOMERASE
YBHE

(Escherichia
coli) 		PF10282
(Lactonase) 		5 LEU A 291
LEU A 312
GLY A 311
GLN A 310
THR A 239
 None
 1.15A 2yhdA-1ri6A:
undetectable		 2yhdA-1ri6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		5 LEU A 124
ASN A 122
LEU A  93
GLY A 107
THR A  73
 None
 1.05A 2yhdA-1t71A:
undetectable		 2yhdA-1t71A:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 700
LEU A 707
GLN A 711
MET A 749
ARG A 752
 None
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
 1.06A 2yhdA-2ax9A:
40.1		 2yhdA-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 LEU A 701
ASN A 705
LEU A 707
GLY A 708
GLN A 711
MET A 742
MET A 745
MET A 749
ARG A 752
MET A 780
THR A 877
MET A 895
 None
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.0A)
None
 0.56A 2yhdA-2ax9A:
40.1		 2yhdA-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 880
GLY A 708
MET A 742
MET A 745
MET A 895
 None
BHM  A   1 ( 3.8A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
None
 1.35A 2yhdA-2ax9A:
40.1		 2yhdA-2ax9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 271
LEU A 245
GLY A 185
MET A 238
THR A 251
 None
 1.41A 2yhdA-2cf5A:
undetectable		 2yhdA-2cf5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ASN A 226
LEU A 228
GLY A 229
MET A 261
THR A 257
 None
 1.35A 2yhdA-2d3lA:
undetectable		 2yhdA-2d3lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2x HYPOTHETICAL PROTEIN

(Mesorhizobium
loti) 		PF13242
(Hydrolase_like) 		5 LEU A  35
GLY A 177
GLN A 176
MET A  60
MET A 166
 None
 1.12A 2yhdA-2o2xA:
undetectable		 2yhdA-2o2xA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2x HYPOTHETICAL PROTEIN

(Mesorhizobium
loti) 		PF13242
(Hydrolase_like) 		5 LEU A  35
LEU A 157
GLY A 177
GLN A 176
MET A 166
 None
 1.13A 2yhdA-2o2xA:
undetectable		 2yhdA-2o2xA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  73
LEU A  47
GLN A 461
MET A  37
THR A  21
 None
 1.33A 2yhdA-2panA:
undetectable		 2yhdA-2panA:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
MET A 108
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.47A 2yhdA-2q3yA:
37.3		 2yhdA-2q3yA:
60.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus) 		PF04916
(Phospholip_B) 		5 LEU B 284
ASN B 300
LEU B 320
GLY B 321
MET B 549
 None
 1.32A 2yhdA-3fgtB:
undetectable		 2yhdA-3fgtB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		5 LEU A 284
ASN A 300
LEU A 320
GLY A 321
MET A 549
 None
 1.30A 2yhdA-3fgwA:
undetectable		 2yhdA-3fgwA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9x COAT PROTEIN

(Sulfolobus
islandicus
rod-shaped
virus 2) 		no annotation 5 LEU A  87
LEU A  81
GLY A  80
GLN A  77
THR A 126
 None
 1.17A 2yhdA-3j9xA:
undetectable		 2yhdA-3j9xA:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 719
LEU A 721
GLY A 722
GLN A 725
MET A 756
MET A 759
ARG A 766
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
 0.71A 2yhdA-3kbaA:
35.1		 2yhdA-3kbaA:
55.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 714
LEU A 721
GLN A 725
MET A 759
ARG A 766
 None
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
 1.10A 2yhdA-3kbaA:
35.1		 2yhdA-3kbaA:
55.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 715
ASN A 719
LEU A 721
GLY A 722
MET A 756
MET A 759
ARG A 766
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
 0.62A 2yhdA-3kbaA:
35.1		 2yhdA-3kbaA:
55.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 715
ASN A 719
LEU A 721
GLY A 722
MET A 756
MET A 759
MET A 909
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
None
 1.05A 2yhdA-3kbaA:
35.1		 2yhdA-3kbaA:
55.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 343
LEU A 322
GLY A 323
MET A 312
MET A 315
 None
None
None
PO4  A 450 (-4.4A)
None
 1.49A 2yhdA-3pdkA:
undetectable		 2yhdA-3pdkA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 LEU A  29
ASN A  33
LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
MET A 108
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.54A 2yhdA-3ry9A:
36.6		 2yhdA-3ry9A:
55.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 242
ASN A 241
MET A 163
THR A 244
MET A 308
 None
None
None
ACY  A 401 ( 4.5A)
None
 1.42A 2yhdA-3u37A:
undetectable		 2yhdA-3u37A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 202
LEU A  83
GLY A  82
ARG A 101
THR A 169
 None
 1.38A 2yhdA-4c23A:
undetectable		 2yhdA-4c23A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 280
LEU A 286
MET A 321
ARG A 331
MET A 358
 None
 0.70A 2yhdA-4n1yA:
28.3		 2yhdA-4n1yA:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
LEU A 566
GLY A 567
GLN A 570
MET A 601
MET A 604
ARG A 611
 MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 0.78A 2yhdA-4p6wA:
33.1		 2yhdA-4p6wA:
50.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Homo sapiens) 		PF01704
(UDPGP) 		5 LEU A 393
LEU A 141
GLY A 414
GLN A 144
THR A 417
 None
 1.43A 2yhdA-4r7pA:
undetectable		 2yhdA-4r7pA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 766
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
 0.70A 2yhdA-4udbA:
33.9		 2yhdA-4udbA:
48.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 LEU A 263
LEU A  26
GLY A  25
MET A  44
ARG A  84
 None
ACP  A 602 (-4.0A)
ACP  A 602 ( 3.1A)
None
None
 1.48A 2yhdA-4zdkA:
undetectable		 2yhdA-4zdkA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA

(Mus musculus) 		PF00989
(PAS)
PF08447
(PAS_3) 		5 LEU B 192
MET B 109
MET B 120
THR B 136
MET B 144
 None
 1.30A 2yhdA-4zprB:
undetectable		 2yhdA-4zprB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 LEU A 344
GLY A 289
GLN A 103
ARG A 297
THR A 319
 None
 1.19A 2yhdA-5b58A:
undetectable		 2yhdA-5b58A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 LEU A 344
LEU A 290
GLY A 289
GLN A 103
THR A 319
 None
 1.40A 2yhdA-5b58A:
undetectable		 2yhdA-5b58A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000906: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		5 LEU G  74
GLY G  81
GLN G  85
MET G  25
THR G  18
 None
None
PT  G 401 (-3.9A)
None
None
 1.35A 2yhdA-5l75G:
undetectable		 2yhdA-5l75G:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 5 ASN A 281
LEU A 299
GLY A 298
GLN A 320
MET A 118
 None
 1.42A 2yhdA-5mhfA:
undetectable		 2yhdA-5mhfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 LEU A 766
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 845
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
 0.66A 2yhdA-5mwpA:
37.1		 2yhdA-5mwpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 256
ASN A 260
LEU A 262
GLY A 263
ARG A  26
 None
 1.41A 2yhdA-5o0jA:
undetectable		 2yhdA-5o0jA:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
GLY A 563
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.61A 2yhdA-5uc1A:
23.1		 2yhdA-5uc1A:
51.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
LEU A 562
GLY A 563
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 0.87A 2yhdA-5uc1A:
23.1		 2yhdA-5uc1A:
51.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
LEU A 562
GLY A 563
GLN A 566
MET A 600
ARG A 607
 486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
486  A 801 (-3.5A)
 0.59A 2yhdA-5uc1A:
23.1		 2yhdA-5uc1A:
51.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
GLN A  39
MET A  70
MET A  73
 1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
 1.43A 2yhdA-5ufsA:
35.1		 2yhdA-5ufsA:
54.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
LEU A  35
GLY A  36
GLN A  39
ARG A  80
MET A 108
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 1.04A 2yhdA-5ufsA:
35.1		 2yhdA-5ufsA:
54.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 ASN A  33
LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 0.79A 2yhdA-5ufsA:
35.1		 2yhdA-5ufsA:
54.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ung CHIMERA PROTEIN OF
TYPE-2 ANGIOTENSIN
II RECEPTOR AND
SOLUBLE CYTOCHROME
B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 LEU B 213
ASN B 216
LEU B 218
GLY B 219
THR B 276
 None
 1.37A 2yhdA-5ungB:
undetectable		 2yhdA-5ungB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		5 LEU A 429
GLY A 385
GLN A 388
MET A 380
MET A 442
 None
 1.34A 2yhdA-5uy7A:
undetectable		 2yhdA-5uy7A:
17.22