SIMILAR PATTERNS OF AMINO ACIDS FOR 2YGQ_A_PCFA1275_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c30 | CARBAMOYL PHOSPHATESYNTHETASE: LARGESUBUNIT (Escherichiacoli) |
PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 5 | ILE A 439ILE A 359PRO A 360PHE A 409PHE A 497 | None | 0.97A | 2ygqA-1c30A:0.0 | 2ygqA-1c30A:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1di6 | MOLYBDENUM COFACTORBIOSYNTHETIC ENZYME (Escherichiacoli) |
PF00994(MoCF_biosynth) | 5 | LEU A 58ILE A 11PRO A 26ILE A 139PRO A 136 | None | 0.99A | 2ygqA-1di6A:0.0 | 2ygqA-1di6A:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1elv | COMPLEMENT C1SCOMPONENT (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 6 | ILE A 660LEU A 535ILE A 515ILE A 533PHE A 440VAL A 461 | None | 1.28A | 2ygqA-1elvA:0.0 | 2ygqA-1elvA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f51 | SPORULATIONINITIATIONPHOSPHOTRANSFERASE F (Bacillussubtilis) |
PF00072(Response_reg) | 5 | ILE E1311LEU E1252ILE E1308MET E1281PHE E1306 | None | 0.84A | 2ygqA-1f51E:undetectable | 2ygqA-1f51E:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2s | SENSORY RHODOPSIN IISENSORY RHODOPSIN IITRANSDUCER (Natronomonaspharaonis;Natronomonaspharaonis) |
PF01036(Bac_rhodopsin)no annotation | 5 | ILE B 69LEU A 188ILE A 173PRO A 190VAL A 203 | None | 0.95A | 2ygqA-1h2sB:undetectable | 2ygqA-1h2sB:11.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j83 | ENDO-1,4-BETAGLUCANASE ENGF (Clostridiumcellulovorans) |
PF03424(CBM_17_28) | 5 | ILE A1071ILE A1163MET A1112PHE A1149VAL A1120 | None | 1.01A | 2ygqA-1j83A:0.2 | 2ygqA-1j83A:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jd0 | CARBONIC ANHYDRASEXII (Homo sapiens) |
PF00194(Carb_anhydrase) | 5 | LEU A 164ILE A 160LEU A 184PRO A 186PHE A 161 | None | 1.05A | 2ygqA-1jd0A:undetectable | 2ygqA-1jd0A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsc | ACETOHYDROXY-ACIDSYNTHASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 125MET A 102PHE A 98PHE A 234VAL A 220 | None | 1.01A | 2ygqA-1jscA:undetectable | 2ygqA-1jscA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | LEU A 372ILE A 409ILE A 407PHE A 365PHE A 390 | None | 0.96A | 2ygqA-1n5xA:0.0 | 2ygqA-1n5xA:12.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | LEU A 372ILE A 409LEU A 312ILE A 407PHE A 365 | None | 1.00A | 2ygqA-1n5xA:0.0 | 2ygqA-1n5xA:12.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ozh | ACETOLACTATESYNTHASE, CATABOLIC (Klebsiellapneumoniae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 279ILE A 281ILE A 335PHE A 212VAL A 248 | NoneNoneNoneNonePGE A1403 ( 4.1A) | 1.01A | 2ygqA-1ozhA:0.0 | 2ygqA-1ozhA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ozh | ACETOLACTATESYNTHASE, CATABOLIC (Klebsiellapneumoniae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | LEU A 214ILE A 279ILE A 281ILE A 335PHE A 212 | None | 0.88A | 2ygqA-1ozhA:0.0 | 2ygqA-1ozhA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1px8 | BETA-XYLOSIDASE (Thermoanaerobacteriumsaccharolyticum) |
PF01229(Glyco_hydro_39) | 5 | ILE A 100LEU A 57ILE A 186ILE A 82PHE A 86 | None | 1.01A | 2ygqA-1px8A:undetectable | 2ygqA-1px8A:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pzx | HYPOTHETICAL PROTEINAPC36103 (Geobacillusstearothermophilus) |
PF02645(DegV) | 5 | LEU A 260ILE A 231LEU A 226ILE A 233PHE A 258 | None | 0.96A | 2ygqA-1pzxA:undetectable | 2ygqA-1pzxA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ty2 | PUTATIVE EXOTOXIN(SUPERANTIGEN) (Streptococcuspyogenes) |
PF01123(Stap_Strp_toxin)PF02876(Stap_Strp_tox_C) | 6 | LEU A 33ILE A 30ILE A 128PRO A 127PHE A 64VAL A 56 | None | 1.37A | 2ygqA-1ty2A:undetectable | 2ygqA-1ty2A:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1um8 | ATP-DEPENDENT CLPPROTEASE ATP-BINDINGSUBUNIT CLPX (Helicobacterpylori) |
PF07724(AAA_2)PF10431(ClpB_D2-small) | 6 | ILE A 216LEU A 326ILE A 213ILE A 327PRO A 328VAL A 188 | None | 1.40A | 2ygqA-1um8A:undetectable | 2ygqA-1um8A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x0m | AMINOTRANSFERASE IIHOMOLOGUE (Pyrococcushorikoshii) |
PF00155(Aminotran_1_2) | 6 | LEU A 141ILE A 136LEU A 264PRO A 204PRO A 238PHE A 161 | None | 1.35A | 2ygqA-1x0mA:undetectable | 2ygqA-1x0mA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 137ILE A 146LEU A 121ILE A 58VAL A 23 | HYM A 400 (-4.5A)NoneNoneNoneHYM A 400 (-4.3A) | 1.08A | 2ygqA-1zltA:undetectable | 2ygqA-1zltA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bzu | FIBER PROTEIN 2 (HumanmastadenovirusF) |
PF00541(Adeno_knob) | 5 | LEU A 254ILE A 269LEU A 284ILE A 267PHE A 290 | None | 1.06A | 2ygqA-2bzuA:undetectable | 2ygqA-2bzuA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e47 | TIME INTERVALMEASURING ENZYMETIME (Bombyx mori) |
PF00080(Sod_Cu) | 5 | ILE A 101ILE A 39ILE A 153PHE A 49VAL A 148 | None | 1.00A | 2ygqA-2e47A:undetectable | 2ygqA-2e47A:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gv8 | MONOOXYGENASE (Schizosaccharomycespombe) |
PF00743(FMO-like)PF13450(NAD_binding_8) | 5 | LEU A 231LEU A 278ILE A 239PRO A 258ILE A 260 | None | 0.97A | 2ygqA-2gv8A:undetectable | 2ygqA-2gv8A:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0e | TRANSTHYRETIN-LIKEPROTEIN PUCM (Bacillussubtilis) |
PF00576(Transthyretin) | 6 | ILE A 29LEU A 54ILE A 15MET A 67PHE A 69PHE A 95 | None | 1.10A | 2ygqA-2h0eA:undetectable | 2ygqA-2h0eA:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hrz | NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE (Agrobacteriumfabrum) |
PF01370(Epimerase) | 5 | LEU A 44ILE A 11LEU A 34ILE A 13PHE A 42 | None | 1.02A | 2ygqA-2hrzA:undetectable | 2ygqA-2hrzA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pg0 | ACYL-COADEHYDROGENASE (Geobacilluskaustophilus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 6 | LEU A 56ILE A 42ILE A 77PRO A 58PHE A 46PHE A 21 | None | 1.41A | 2ygqA-2pg0A:undetectable | 2ygqA-2pg0A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q5o | PHENYLPYRUVATEDECARBOXYLASE (Azospirillumbrasilense) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 96LEU A 11ILE A 163ILE A 39PHE A 30 | None | 1.01A | 2ygqA-2q5oA:undetectable | 2ygqA-2q5oA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qxl | HEAT SHOCK PROTEINHOMOLOG SSE1 (Saccharomycescerevisiae) |
PF00012(HSP70) | 5 | LEU A 366ILE A 372ILE A 341PHE A 216VAL A 199 | None | 0.79A | 2ygqA-2qxlA:undetectable | 2ygqA-2qxlA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vvf | MAJOR CAPSID PROTEINP2 (Pseudoalteromonasvirus PM2) |
no annotation | 5 | ILE A 177ILE A 246PRO A 165ILE A 172PHE A 223 | None | 0.99A | 2ygqA-2vvfA:undetectable | 2ygqA-2vvfA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whx | SERINEPROTEASE/NTPASE/HELICASE NS3 (Dengue virus) |
PF00949(Peptidase_S7)PF07652(Flavi_DEAD) | 5 | LEU A 65ILE A 58PRO A 102ILE A 100PHE A 46 | None | 1.07A | 2ygqA-2whxA:undetectable | 2ygqA-2whxA:18.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygn | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 11 | LEU A 38ILE A 40ILE A 57PRO A 78ILE A 80PRO A 81MET A 87PHE A 89PHE A 103PHE A 138VAL A 154 | PCF A1179 ( 4.0A)NonePCF A1179 ( 4.7A)PCF A1179 (-4.3A)NoneNonePCF A1179 (-3.6A)PCF A1179 ( 3.8A)NoneNonePCF A1179 ( 4.7A) | 0.42A | 2ygqA-2ygnA:26.1 | 2ygqA-2ygnA:48.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygn | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 9 | LEU A 38ILE A 40LEU A 48ILE A 57MET A 87PHE A 89PHE A 103PHE A 138VAL A 154 | PCF A1179 ( 4.0A)NonePCF A1179 (-4.1A)PCF A1179 ( 4.7A)PCF A1179 (-3.6A)PCF A1179 ( 3.8A)NoneNonePCF A1179 ( 4.7A) | 0.66A | 2ygqA-2ygnA:26.1 | 2ygqA-2ygnA:48.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygn | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 6 | LEU A 38ILE A 40PRO A 81PHE A 89PHE A 103VAL A 154 | PCF A1179 ( 4.0A)NoneNonePCF A1179 ( 3.8A)NonePCF A1179 ( 4.7A) | 1.29A | 2ygqA-2ygnA:26.1 | 2ygqA-2ygnA:48.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygo | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 11 | LEU A 38ILE A 40ILE A 57PRO A 78ILE A 80PRO A 81MET A 87PHE A 89PHE A 103PHE A 138VAL A 154 | PCF A1213 ( 3.9A)NonePCF A1213 ( 4.8A)PCF A1213 (-4.0A)NoneNonePCF A1213 ( 3.8A)PCF A1213 (-4.1A)NoneNonePCF A1213 ( 4.7A) | 0.52A | 2ygqA-2ygoA:26.4 | 2ygqA-2ygoA:58.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygo | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 8 | LEU A 38ILE A 40LEU A 48ILE A 57MET A 87PHE A 89PHE A 103VAL A 154 | PCF A1213 ( 3.9A)NonePCF A1213 (-4.3A)PCF A1213 ( 4.8A)PCF A1213 ( 3.8A)PCF A1213 (-4.1A)NonePCF A1213 ( 4.7A) | 0.64A | 2ygqA-2ygoA:26.4 | 2ygqA-2ygoA:58.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygo | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 6 | LEU A 38ILE A 40PRO A 81PHE A 89PHE A 103VAL A 154 | PCF A1213 ( 3.9A)NoneNonePCF A1213 (-4.1A)NonePCF A1213 ( 4.7A) | 1.38A | 2ygqA-2ygoA:26.4 | 2ygqA-2ygoA:58.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygq | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF)PF12661(hEGF) | 12 | LEU A 38ILE A 40LEU A 48ILE A 57PRO A 78ILE A 80PRO A 81MET A 87PHE A 89PHE A 103PHE A 138VAL A 154 | NoneNonePCF A1275 (-4.6A)PCF A1275 ( 4.5A)PCF A1275 (-4.1A)PCF A1275 (-4.7A)PCF A1275 (-4.6A)PCF A1275 (-3.2A)PCF A1275 (-4.6A)PCF A1275 (-4.6A)NonePCF A1275 (-4.9A) | 0.00A | 2ygqA-2ygqA:38.3 | 2ygqA-2ygqA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z83 | HELICASE/NUCLEOSIDETRIPHOSPHATASE (Japaneseencephalitisvirus) |
PF00271(Helicase_C)PF07652(Flavi_DEAD) | 5 | ILE A 204LEU A 194ILE A 208PRO A 319VAL A 260 | None | 0.98A | 2ygqA-2z83A:undetectable | 2ygqA-2z83A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zts | PUTATIVEUNCHARACTERIZEDPROTEIN PH0186 (Pyrococcushorikoshii) |
PF06745(ATPase) | 5 | LEU A 35ILE A 176PRO A 61ILE A 94PHE A 85 | None | 0.93A | 2ygqA-2ztsA:undetectable | 2ygqA-2ztsA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2b | SERINEPALMITOYLTRANSFERASE (Sphingobacteriummultivorum) |
PF00155(Aminotran_1_2) | 5 | ILE A 383ILE A 379PRO A 328ILE A 366MET A 386 | None | 1.00A | 2ygqA-3a2bA:undetectable | 2ygqA-3a2bA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aov | PUTATIVEUNCHARACTERIZEDPROTEIN PH0207 (Pyrococcushorikoshii) |
PF00155(Aminotran_1_2) | 6 | LEU A 141ILE A 136LEU A 264PRO A 204PRO A 238PHE A 161 | NoneNoneNoneNonePLP A 429 (-4.5A)None | 1.33A | 2ygqA-3aovA:undetectable | 2ygqA-3aovA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9j | XANTHINE OXIDASE (Bos taurus) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | LEU B 372ILE B 409ILE B 407PHE B 365PHE B 390 | None | 1.02A | 2ygqA-3b9jB:undetectable | 2ygqA-3b9jB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9j | XANTHINE OXIDASE (Bos taurus) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | LEU B 372ILE B 409LEU B 312ILE B 407PHE B 365 | None | 1.03A | 2ygqA-3b9jB:undetectable | 2ygqA-3b9jB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bqr | DEATH-ASSOCIATEDPROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 210ILE A 123LEU A 159ILE A 206ILE A 160 | NoneNoneNoneNone4RB A 401 (-3.5A) | 1.04A | 2ygqA-3bqrA:undetectable | 2ygqA-3bqrA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cc8 | PUTATIVEMETHYLTRANSFERASE (Bacillus cereus) |
PF13489(Methyltransf_23) | 5 | LEU A 105ILE A 38LEU A 36ILE A 119PHE A 98 | None | 1.06A | 2ygqA-3cc8A:undetectable | 2ygqA-3cc8A:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ciy | TOLL-LIKE RECEPTOR 3 (Mus musculus) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | LEU A 357LEU A 386ILE A 367MET A 362PHE A 333 | None | 1.00A | 2ygqA-3ciyA:undetectable | 2ygqA-3ciyA:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fe1 | HEAT SHOCK 70 KDAPROTEIN 6 (Homo sapiens) |
PF00012(HSP70) | 5 | ILE A 299LEU A 276ILE A 345PRO A 346PHE A 312 | NoneNoneADP A 386 (-4.8A)NoneNone | 1.06A | 2ygqA-3fe1A:undetectable | 2ygqA-3fe1A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j0a | TOLL-LIKE RECEPTOR 5 (Homo sapiens) |
PF01582(TIR)PF13855(LRR_8) | 5 | LEU A 150ILE A 157PHE A 177PHE A 201VAL A 185 | None | 0.94A | 2ygqA-3j0aA:undetectable | 2ygqA-3j0aA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k5s | CADHERIN-13 (Gallus gallus) |
PF00028(Cadherin) | 5 | LEU A 65ILE A 95LEU A 93ILE A 9ILE A 52 | LEU A 65 ( 0.5A)ILE A 95 ( 0.6A)LEU A 93 ( 0.6A)ILE A 9 ( 0.7A)ILE A 52 ( 0.6A) | 0.97A | 2ygqA-3k5sA:undetectable | 2ygqA-3k5sA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k60 | HEAT SHOCK PROTEIN86 (Plasmodiumfalciparum) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | LEU A 34LEU A 89ILE A 173PHE A 124PHE A 8 | None | 0.88A | 2ygqA-3k60A:undetectable | 2ygqA-3k60A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6d | T-CADHERIN (Xenopus laevis) |
PF00028(Cadherin) | 5 | LEU A 65ILE A 95LEU A 93ILE A 9ILE A 52 | None | 0.95A | 2ygqA-3k6dA:undetectable | 2ygqA-3k6dA:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6i | T-CADHERIN (Gallus gallus) |
PF00028(Cadherin) | 5 | LEU A 65ILE A 95LEU A 93ILE A 9ILE A 52 | None | 1.04A | 2ygqA-3k6iA:undetectable | 2ygqA-3k6iA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khn | MOTB PROTEIN,PUTATIVE (Desulfovibriovulgaris) |
PF00691(OmpA) | 5 | LEU A 160ILE A 87ILE A 85PHE A 158PHE A 27 | None | 0.97A | 2ygqA-3khnA:undetectable | 2ygqA-3khnA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4i | HEAT SHOCK 70(HSP70) PROTEIN (Cryptosporidiumparvum) |
PF00012(HSP70) | 5 | ILE A 314LEU A 291ILE A 360PRO A 361PHE A 327 | NoneNoneADP A 401 ( 4.9A)NoneNone | 1.07A | 2ygqA-3l4iA:undetectable | 2ygqA-3l4iA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lvv | GLUTAMATE--CYSTEINELIGASE (Saccharomycescerevisiae) |
PF03074(GCS) | 5 | ILE A 561LEU A 489ILE A 553PHE A 471VAL A 513 | None | 1.02A | 2ygqA-3lvvA:undetectable | 2ygqA-3lvvA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6o | HEAT SHOCK PROTEIN83 (Trypanosomabrucei) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | LEU A 33LEU A 88ILE A 171PHE A 123PHE A 7 | None94M A 214 (-4.5A)None94M A 214 (-3.7A)None | 0.79A | 2ygqA-3o6oA:undetectable | 2ygqA-3o6oA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p13 | D-RIBOSE PYRANASE (Staphylococcusaureus) |
PF05025(RbsD_FucU) | 5 | ILE A 90LEU A 61ILE A 96ILE A 28PHE A 53 | None | 1.04A | 2ygqA-3p13A:undetectable | 2ygqA-3p13A:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhd | LACTALDEHYDEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF00171(Aldedh) | 5 | ILE A 249LEU A 251ILE A 387ILE A 287VAL A 358 | None | 1.07A | 2ygqA-3rhdA:undetectable | 2ygqA-3rhdA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3she | MAP KINASE-ACTIVATEDPROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 130LEU A 321ILE A 146PRO A 240PHE A 138VAL A 310 | None | 1.33A | 2ygqA-3sheA:undetectable | 2ygqA-3sheA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u6n | HIGH-CONDUCTANCECA2+-ACTIVATED K+CHANNEL PROTEIN (Danio rerio) |
PF02254(TrkA_N)PF03493(BK_channel_a) | 5 | LEU A 927ILE A 937ILE A 566MET A 536PHE A 511 | None | 0.91A | 2ygqA-3u6nA:undetectable | 2ygqA-3u6nA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uj2 | ENOLASE 1 (Anaerostipescaccae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 132ILE A 411LEU A 144PRO A 147VAL A 348 | None | 1.05A | 2ygqA-3uj2A:undetectable | 2ygqA-3uj2A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwh | (R)-AMINETRANSAMINASE (Arthrobactersp. KNK168) |
PF01063(Aminotran_4) | 5 | LEU A 219LEU A 252ILE A 267ILE A 310VAL A 293 | None | 0.81A | 2ygqA-3wwhA:undetectable | 2ygqA-3wwhA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d8m | PESTICIDAL CRYSTALPROTEIN CRY5BA (Bacillusthuringiensis) |
PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | ILE A 678LEU A 688PRO A 565PHE A 627VAL A 667 | None | 0.99A | 2ygqA-4d8mA:undetectable | 2ygqA-4d8mA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhz | UBIQUITINTHIOESTERASEOTUBAIN-LIKE (Caenorhabditiselegans;Homo sapiens) |
PF10275(Peptidase_C65) | 5 | ILE A 169LEU A 94ILE A 159PHE A 142VAL A 150 | None | 1.04A | 2ygqA-4dhzA:undetectable | 2ygqA-4dhzA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fvv | NEUROTOXIN (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 5 | LEU A 870ILE A 936ILE A 954PHE A1069VAL A 889 | None | 0.92A | 2ygqA-4fvvA:undetectable | 2ygqA-4fvvA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwi | ABC-TYPEDIPEPTIDE/OLIGOPEPTIDE/NICKEL TRANSPORTSYSTEM, ATPASECOMPONENT (Caldanaerobactersubterraneus) |
PF00005(ABC_tran)PF08352(oligo_HPY) | 5 | ILE B 255ILE B 242ILE B 271PRO B 270VAL B 314 | None | 1.06A | 2ygqA-4fwiB:undetectable | 2ygqA-4fwiB:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gip | FUSION GLYCOPROTEINF2FUSION GLYCOPROTEINF1 (Mammalianrubulavirus 5;Mammalianrubulavirus 5) |
PF00523(Fusion_gly)PF00523(Fusion_gly) | 5 | LEU D 413ILE D 405ILE A 31PRO A 32PHE D 365 | None | 0.94A | 2ygqA-4gipD:undetectable | 2ygqA-4gipD:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gq2 | NUCLEOPORIN NUP120 (Schizosaccharomycespombe) |
PF11715(Nup160) | 5 | ILE M 463LEU M 741ILE M 433PHE M 505VAL M 509 | None | 0.96A | 2ygqA-4gq2M:undetectable | 2ygqA-4gq2M:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqt | HEAT SHOCK PROTEIN90 (Caenorhabditiselegans) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | LEU A 36LEU A 91ILE A 174PHE A 126PHE A 10 | None | 0.82A | 2ygqA-4gqtA:undetectable | 2ygqA-4gqtA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwi | HEAT SHOCK COGNATE71 KDA PROTEIN (Homo sapiens) |
PF00012(HSP70) | 5 | ILE A 297LEU A 274ILE A 343PRO A 344PHE A 310 | None | 1.07A | 2ygqA-4hwiA:undetectable | 2ygqA-4hwiA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jmo | CYTOHESIN-2 (Homo sapiens) |
PF01369(Sec7) | 5 | ILE A 193LEU A 148ILE A 245PRO A 246VAL A 204 | JAF A 301 (-3.7A)JAF A 301 (-3.9A)JAF A 301 (-3.9A)JAF A 301 (-4.7A)None | 0.99A | 2ygqA-4jmoA:undetectable | 2ygqA-4jmoA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmh | EXTRACELLULAR IRONOXIDE RESPIRATORYSYSTEM SURFACEDECAHEME CYTOCHROMEC COMPONENT OMCA (Shewanellaoneidensis) |
no annotation | 6 | LEU A 411ILE A 484LEU A 467PHE A 413PHE A 543VAL A 502 | None | 1.13A | 2ygqA-4lmhA:undetectable | 2ygqA-4lmhA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mjk | CRISPR PROTEIN (Archaeoglobusfulgidus) |
PF09704(Cas_Cas5d) | 5 | LEU A 132ILE A 69PRO A 78PHE A 10VAL A 40 | None | 0.96A | 2ygqA-4mjkA:undetectable | 2ygqA-4mjkA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mlo | TCP PILUS VIRULENCEREGULATORY PROTEIN (Vibrio cholerae) |
PF00165(HTH_AraC) | 5 | ILE A 59LEU A 114ILE A 58ILE A 27VAL A 131 | None | 1.05A | 2ygqA-4mloA:1.2 | 2ygqA-4mloA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mq0 | PARKIA BIGLOBOSALECTIN (PBL) (Parkiabiglobosa) |
PF01419(Jacalin) | 5 | LEU A 139ILE A 95ILE A 121PRO A 122PHE A 43 | None | 0.93A | 2ygqA-4mq0A:undetectable | 2ygqA-4mq0A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pd4 | CYTOCHROME B (Saccharomycescerevisiae) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 5 | ILE C 125LEU C 275ILE C 122PHE C 121PHE C 333 | AOQ C4003 ( 4.4A)AOQ C4003 (-3.8A)None3PH C4006 ( 4.6A)3PH C4006 (-4.1A) | 1.01A | 2ygqA-4pd4C:undetectable | 2ygqA-4pd4C:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qnn | PHOSPHOLIPASE A 1 FROM HORNET(VESPABASALIS) VENOM (Vespa basalis) |
PF00151(Lipase) | 5 | LEU A 133ILE A 80ILE A 31PHE A 48PHE A 37 | None | 1.01A | 2ygqA-4qnnA:undetectable | 2ygqA-4qnnA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9l | HEAT SHOCK PROTEIN (Oryza sativa) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | LEU A 36LEU A 91ILE A 175PHE A 126PHE A 10 | None | 0.94A | 2ygqA-4x9lA:undetectable | 2ygqA-4x9lA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zow | MULTIDRUGTRANSPORTER MDFA (Escherichiacoli) |
PF07690(MFS_1) | 5 | ILE A 122LEU A 22ILE A 142MET A 146VAL A 335 | None | 0.97A | 2ygqA-4zowA:undetectable | 2ygqA-4zowA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0t | RIBONUCLEASE J (Streptomycescoelicolor) |
PF00753(Lactamase_B)PF07521(RMMBL) | 6 | LEU A 44ILE A 103LEU A 97ILE A 115PHE A 146VAL A 159 | None | 1.08A | 2ygqA-5a0tA:undetectable | 2ygqA-5a0tA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bop | OCTARELLIN V.1 (syntheticconstruct) |
no annotation | 5 | ILE B 129LEU B 4ILE B 100ILE B 5PHE B 45 | None | 1.06A | 2ygqA-5bopB:undetectable | 2ygqA-5bopB:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eul | PROTEIN TRANSLOCASESUBUNIT SECY (Geobacillusthermodenitrificans) |
PF00344(SecY) | 5 | ILE Y 228LEU Y 402PRO Y 382ILE Y 378PHE Y 374 | None | 1.07A | 2ygqA-5eulY:undetectable | 2ygqA-5eulY:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f5r | HEAT SHOCK PROTEIN75 KDA,MITOCHONDRIAL (Homo sapiens) |
PF13589(HATPase_c_3) | 5 | LEU A 116LEU A 168ILE A 253PHE A 205PHE A 90 | None | 0.86A | 2ygqA-5f5rA:undetectable | 2ygqA-5f5rA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fpn | HEAT SHOCK-RELATED70 KDA PROTEIN 2 (Homo sapiens) |
PF00012(HSP70) | 5 | ILE A 299LEU A 276ILE A 345PRO A 346PHE A 312 | NoneNoneKYD A1386 ( 4.2A)NoneNone | 1.05A | 2ygqA-5fpnA:undetectable | 2ygqA-5fpnA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h71 | ALGQ2 (Sphingomonassp.) |
PF01547(SBP_bac_1) | 5 | LEU A 13ILE A 319LEU A 92PRO A 128ILE A 103 | None | 1.07A | 2ygqA-5h71A:undetectable | 2ygqA-5h71A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l22 | ABC TRANSPORTER(HLYB SUBFAMILY) (Aquifexaeolicus) |
no annotation | 5 | LEU B 349ILE B 522PRO B 341PHE B 405VAL B 409 | NoneNoneADP B 601 (-4.1A)NoneNone | 1.07A | 2ygqA-5l22B:undetectable | 2ygqA-5l22B:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lxr | RNA-BINDING PROTEIN7ZINC FINGER CCHCDOMAIN-CONTAININGPROTEIN 8 (Homo sapiens;Homo sapiens) |
PF00076(RRM_1)PF04046(PSP) | 5 | ILE A 73ILE A 80ILE B 291PHE A 57VAL A 55 | None | 0.91A | 2ygqA-5lxrA:undetectable | 2ygqA-5lxrA:14.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5moy | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 6 | ILE A1053LEU A 928ILE A 965ILE A 878PHE A1072VAL A1017 | None | 1.43A | 2ygqA-5moyA:undetectable | 2ygqA-5moyA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5my5 | ABC TRANSPORTERPERIPLASMICSUBSTRATE-BINDINGPROTEIN (Desulfovibrioalaskensis) |
PF12849(PBP_like_2) | 6 | LEU A 5LEU A 79ILE A 55ILE A 235MET A 226PHE A 222 | None | 1.50A | 2ygqA-5my5A:undetectable | 2ygqA-5my5A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nem | INTEGRIN BETA-6 (Homo sapiens) |
PF00362(Integrin_beta)PF17205(PSI_integrin) | 5 | LEU B 424ILE B 413LEU B 366ILE B 415PRO B 404 | None | 0.95A | 2ygqA-5nemB:undetectable | 2ygqA-5nemB:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvr | TELOMERE LENGTHREGULATOR PROTEINRIF1 (Saccharomycescerevisiae) |
PF12231(Rif1_N) | 5 | ILE A 579LEU A 595ILE A 652PRO A 651PHE A 602 | None | 1.04A | 2ygqA-5nvrA:undetectable | 2ygqA-5nvrA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tpc | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 6 | ILE A1053LEU A 928ILE A 965ILE A 878PHE A1072VAL A1017 | None | 1.42A | 2ygqA-5tpcA:undetectable | 2ygqA-5tpcA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4s | PUTATIVE SHORT CHAINDEHYDROGENASE (Burkholderiacenocepacia) |
PF00106(adh_short) | 5 | ILE A 55ILE A 57PRO A 117ILE A 73VAL A 129 | NoneNAP A 300 (-4.1A)NoneNoneNAP A 300 (-4.8A) | 1.06A | 2ygqA-5u4sA:undetectable | 2ygqA-5u4sA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqd | DUMPY: SHORTER THANWILD-TYPE (Caenorhabditiselegans) |
no annotation | 6 | LEU A1579LEU A1383PRO A1388ILE A1386PHE A1279VAL A1530 | None | 1.28A | 2ygqA-5uqdA:undetectable | 2ygqA-5uqdA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqi | PHOSPHOSUGARISOMERASE (Escherichiacoli) |
no annotation | 5 | LEU A 172ILE A 36ILE A 141PRO A 142VAL A 46 | None | 0.97A | 2ygqA-5uqiA:undetectable | 2ygqA-5uqiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v38 | HCHA (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 6 | ILE A1045LEU A 918ILE A 953ILE A 866PHE A1064VAL A1009 | NoneNoneNoneACY A1304 ( 4.9A)NoneNone | 1.40A | 2ygqA-5v38A:undetectable | 2ygqA-5v38A:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vbu | CYTOCHROME P45021-HYDROXYLASE (Homo sapiens) |
PF00067(p450) | 5 | LEU A 439LEU A 452PRO A 454PHE A 477VAL A 359 | NoneNoneNoneNoneHEM A 501 (-4.7A) | 0.96A | 2ygqA-5vbuA:undetectable | 2ygqA-5vbuA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wx8 | IMMEDIATE-EARLYPROTEIN 2 (Humanbetaherpesvirus6A) |
PF03361(Herpes_IE2_3) | 5 | ILE A1466ILE A1367ILE A1354MET A1356PHE A1358 | None | 1.07A | 2ygqA-5wx8A:undetectable | 2ygqA-5wx8A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvm | STEROL3-BETA-GLUCOSYLTRANSFERASE (Saccharomycescerevisiae) |
PF00201(UDPGT)PF03033(Glyco_transf_28) | 5 | LEU A 744ILE A 843LEU A1159ILE A 845PHE A 742 | None | 1.04A | 2ygqA-5xvmA:undetectable | 2ygqA-5xvmA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aom | ENDOPLASMIN (Canis lupus) |
no annotation | 5 | LEU A 104LEU A 159ILE A 247PHE A 199PHE A 78 | VC5 A 409 (-4.5A)NoneVC5 A 409 (-4.4A)VC5 A 409 (-4.2A)None | 0.94A | 2ygqA-6aomA:undetectable | 2ygqA-6aomA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cmj | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 2 (Homo sapiens) |
no annotation | 5 | LEU A 319ILE A 328LEU A 303ILE A 239VAL A 179 | F6J A 501 (-4.5A)NoneNoneNoneF6J A 501 (-4.6A) | 1.07A | 2ygqA-6cmjA:undetectable | 2ygqA-6cmjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ekt | P-47 PROTEIN (Clostridiumbotulinum) |
no annotation | 5 | ILE A 111ILE A 139PRO A 87ILE A 46PHE A 131 | None | 1.05A | 2ygqA-6ektA:undetectable | 2ygqA-6ektA:18.78 |