SIMILAR PATTERNS OF AMINO ACIDS FOR 2YGO_A_PCFA1213_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csm CHORISMATE MUTASE

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 104
ILE A 103
PRO A  80
VAL A 197
 None
 1.08A 2ygoA-1csmA:
undetectable		 2ygoA-1csmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1del DEOXYNUCLEOSIDE
MONOPHOSPHATE KINASE

(Escherichia
virus T4) 		no annotation 4 LEU A 238
ILE A 234
MET A  22
VAL A 153
 None
 1.03A 2ygoA-1delA:
undetectable		 2ygoA-1delA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LEU A 104
ILE A 123
ARG A 384
PRO A 106
 None
 1.18A 2ygoA-1dq3A:
undetectable		 2ygoA-1dq3A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 159
ILE A 157
PRO A 176
VAL A  80
 None
 1.14A 2ygoA-1gg4A:
0.0		 2ygoA-1gg4A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 LEU B 416
ILE B 415
PRO B 396
VAL B 439
 None
 1.14A 2ygoA-1gh6B:
undetectable		 2ygoA-1gh6B:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A 170
ILE A 172
PRO A 269
VAL A 203
 None
 1.12A 2ygoA-1h74A:
0.0		 2ygoA-1h74A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 362
ARG A 199
PRO A 201
VAL A 348
 None
ADX  A 574 (-3.7A)
None
None
 1.16A 2ygoA-1i2dA:
0.0		 2ygoA-1i2dA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00977
(His_biosynth) 		4 LEU F 238
ILE F 235
ARG F 250
VAL F 191
 None
 1.01A 2ygoA-1ka9F:
undetectable		 2ygoA-1ka9F:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 999
MET A 968
PRO A1001
VAL A 801
 None
 1.19A 2ygoA-1kcwA:
2.0		 2ygoA-1kcwA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 LEU A 464
ILE A 466
PRO A 478
VAL A 153
 None
 1.13A 2ygoA-1nr6A:
0.0		 2ygoA-1nr6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 4 LEU A  74
ILE A  78
PRO A 105
VAL A 141
 None
 1.18A 2ygoA-1qi9A:
0.0		 2ygoA-1qi9A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 LEU A 518
ILE A 515
PRO A 367
VAL A 645
 None
 1.17A 2ygoA-1uf2A:
undetectable		 2ygoA-1uf2A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjt LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		4 LEU A 182
ARG A  97
MET A 101
VAL A 157
 None
 1.19A 2ygoA-1xjtA:
undetectable		 2ygoA-1xjtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xju LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		4 LEU A 182
ARG A  97
MET A 101
VAL A 157
 None
 1.07A 2ygoA-1xjuA:
undetectable		 2ygoA-1xjuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		4 LEU A 297
ILE A 325
ARG A  73
VAL A 140
 None
 1.18A 2ygoA-1xknA:
undetectable		 2ygoA-1xknA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 LEU A  78
ILE A  81
PRO A 220
VAL A  39
 None
 1.16A 2ygoA-1yirA:
undetectable		 2ygoA-1yirA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A  36
ILE A  70
MET A   1
PRO A   0
 None
 1.12A 2ygoA-1yw6A:
undetectable		 2ygoA-1yw6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 770
ILE A 774
ARG A 530
VAL A 314
 None
 1.08A 2ygoA-1z1wA:
undetectable		 2ygoA-1z1wA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 LEU A 220
ILE A 279
MET A 272
VAL A 103
 None
 1.17A 2ygoA-1zg4A:
undetectable		 2ygoA-1zg4A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axc COLICIN E7

(Escherichia
coli) 		PF03515
(Cloacin) 		4 LEU A 131
ILE A 191
PRO A  88
VAL A 162
 None
 1.15A 2ygoA-2axcA:
undetectable		 2ygoA-2axcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b61 HOMOSERINE
O-ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00561
(Abhydrolase_1) 		4 LEU A 355
ILE A 351
MET A  69
VAL A  27
 None
 0.95A 2ygoA-2b61A:
undetectable		 2ygoA-2b61A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		4 ILE A 483
ARG A 247
PRO A 899
VAL A  61
 None
 1.02A 2ygoA-2btvA:
undetectable		 2ygoA-2btvA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LEU A  78
ILE A  73
PRO A 101
VAL A 274
 None
 1.03A 2ygoA-2c2yA:
undetectable		 2ygoA-2c2yA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egp TRIPARTITE
MOTIF-CONTAINING
PROTEIN 34

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 LEU A  34
ILE A  39
PRO A  57
VAL A  78
 None
 1.06A 2ygoA-2egpA:
undetectable		 2ygoA-2egpA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ius DNA TRANSLOCASE FTSK

(Escherichia
coli) 		PF01580
(FtsK_SpoIIIE) 		4 ILE A1172
MET A 984
PRO A 985
VAL A1227
 None
 1.05A 2ygoA-2iusA:
undetectable		 2ygoA-2iusA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 ILE A 646
MET A 459
PRO A 460
VAL A 701
 None
 1.19A 2ygoA-2iutA:
undetectable		 2ygoA-2iutA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 ILE A 646
MET A 459
PRO A 460
VAL A 701
 None
 1.14A 2ygoA-2iuuA:
undetectable		 2ygoA-2iuuA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		4 LEU A  73
ILE A  70
MET A  61
VAL A 155
 None
 1.14A 2ygoA-2jfwA:
undetectable		 2ygoA-2jfwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 ILE A 331
ARG A 385
PRO A 351
VAL A 295
 None
 0.99A 2ygoA-2jgdA:
undetectable		 2ygoA-2jgdA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p19 TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF07702
(UTRA) 		4 LEU A  78
ILE A 128
PRO A  58
VAL A  50
 None
 0.90A 2ygoA-2p19A:
undetectable		 2ygoA-2p19A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 160
ILE A 157
MET A 457
VAL A 365
 None
 1.12A 2ygoA-2pg6A:
undetectable		 2ygoA-2pg6A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		4 LEU A 585
ILE A 594
PRO A 558
VAL A 515
 None
 1.06A 2ygoA-2rkcA:
undetectable		 2ygoA-2rkcA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ILE A 441
MET A 431
PRO A 430
VAL A 608
 None
 1.13A 2ygoA-2v5dA:
undetectable		 2ygoA-2v5dA:
11.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygn WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		5 LEU A  48
ILE A  49
MET A  77
PRO A  78
VAL A 156
 PCF  A1179 (-4.1A)
PCF  A1179 (-4.8A)
PCF  A1179 (-4.0A)
PCF  A1179 (-4.3A)
None
 0.25A 2ygoA-2ygnA:
28.2		 2ygoA-2ygnA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		6 LEU A  48
ILE A  49
ARG A  76
MET A  77
PRO A  78
VAL A 156
 PCF  A1213 (-4.3A)
PCF  A1213 (-4.6A)
PCF  A1213 (-3.6A)
PCF  A1213 (-3.5A)
PCF  A1213 (-4.0A)
None
 0.00A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		4 LEU A  48
ILE A  49
PRO A  78
VAL A 127
 PCF  A1213 (-4.3A)
PCF  A1213 (-4.6A)
PCF  A1213 (-4.0A)
None
 1.12A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF)
PF12661
(hEGF) 		4 LEU A  48
ILE A  49
MET A  77
VAL A 156
 PCF  A1275 (-4.6A)
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
None
 0.95A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb3 PROSTAGLANDIN
REDUCTASE 2

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 LEU A 217
ARG A 280
MET A 244
VAL A 263
 None
 1.04A 2ygoA-2zb3A:
undetectable		 2ygoA-2zb3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 ILE A 416
MET A 421
PRO A 420
VAL A 482
 None
 1.12A 2ygoA-3d8bA:
undetectable		 2ygoA-3d8bA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		4 LEU B 292
ILE B 293
PRO B 297
VAL B 242
 None
 1.07A 2ygoA-3hrdB:
undetectable		 2ygoA-3hrdB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri;
Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF02738
(Ald_Xan_dh_C2) 		4 ILE B  15
ARG A 319
PRO B 290
VAL A 205
 None
NIO  B5661 (-4.3A)
None
None
 1.08A 2ygoA-3hrdB:
undetectable		 2ygoA-3hrdB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		4 LEU A 392
ILE A 402
MET A 465
VAL A 438
 None
 1.13A 2ygoA-3j4jA:
undetectable		 2ygoA-3j4jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		4 LEU X 257
ARG X 215
MET X 214
VAL X 229
 None
 1.04A 2ygoA-3o59X:
undetectable		 2ygoA-3o59X:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 LEU A 429
ILE A 417
MET A 410
VAL A 164
 None
 0.79A 2ygoA-3odmA:
undetectable		 2ygoA-3odmA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 160
ILE A 161
PRO A 164
VAL A 246
 None
 1.17A 2ygoA-3olzA:
undetectable		 2ygoA-3olzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		4 LEU A  71
ILE A  90
ARG A 125
VAL A 189
 None
 1.01A 2ygoA-3pmmA:
undetectable		 2ygoA-3pmmA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqy ALPHA CHAIN OF THE
6218-TCR

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 LEU D  89
ILE D  90
MET D  78
VAL D 174
 None
 0.99A 2ygoA-3pqyD:
undetectable		 2ygoA-3pqyD:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOA

(Methylocystis
sp. M) 		no annotation 4 ILE J 189
ARG J 195
PRO J 120
VAL J  98
 None
 1.17A 2ygoA-3rfrJ:
undetectable		 2ygoA-3rfrJ:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 LEU A 517
ILE A 386
PRO A 498
VAL A 403
 None
 0.95A 2ygoA-3sqlA:
undetectable		 2ygoA-3sqlA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE C1007
ARG C 880
PRO C1262
VAL C 764
 None
 1.10A 2ygoA-3sr6C:
undetectable		 2ygoA-3sr6C:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 LEU A  63
ILE A  67
MET A 289
VAL A 186
 None
 1.10A 2ygoA-3tsyA:
undetectable		 2ygoA-3tsyA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vaa SHIKIMATE KINASE

(Bacteroides
thetaiotaomicron) 		PF01202
(SKI) 		4 LEU A 156
ILE A 162
ARG A  23
VAL A  44
 None
 1.18A 2ygoA-3vaaA:
undetectable		 2ygoA-3vaaA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		4 LEU A  55
ILE A  53
PRO A  80
VAL A 187
 None
 1.11A 2ygoA-3w5iA:
undetectable		 2ygoA-3w5iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		4 LEU A 327
ILE A  48
PRO A  17
VAL A 252
 None
 1.15A 2ygoA-3wecA:
undetectable		 2ygoA-3wecA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 169
ILE A 172
PRO A 246
VAL A  38
 None
 1.11A 2ygoA-3wgkA:
undetectable		 2ygoA-3wgkA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 LEU A 220
ILE A 279
MET A 272
VAL A 103
 None
None
SO4  A1292 (-4.1A)
None
 1.03A 2ygoA-3zdjA:
undetectable		 2ygoA-3zdjA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 LEU A 441
ILE A 436
ARG A 274
VAL A 376
 None
 1.03A 2ygoA-4atqA:
undetectable		 2ygoA-4atqA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 165
ILE A 211
PRO A 182
VAL A 320
 None
 1.17A 2ygoA-4cvmA:
undetectable		 2ygoA-4cvmA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		4 LEU A 318
ILE A 319
PRO A 321
VAL A 111
 None
 1.02A 2ygoA-4d1iA:
undetectable		 2ygoA-4d1iA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 LEU A 449
ILE A 369
PRO A 433
VAL A  57
 None
 1.03A 2ygoA-4djiA:
undetectable		 2ygoA-4djiA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A  47
MET A  45
PRO A  44
VAL A 129
 None
 1.12A 2ygoA-4eqaA:
undetectable		 2ygoA-4eqaA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmr UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
vulgatus) 		PF14734
(DUF4469)
PF14848
(HU-DNA_bdg) 		4 ILE A  37
ARG A  51
MET A  42
VAL A  75
 None
 1.15A 2ygoA-4fmrA:
undetectable		 2ygoA-4fmrA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 LEU A  36
ARG A  46
MET A  45
VAL A 216
 None
 0.98A 2ygoA-4gtnA:
undetectable		 2ygoA-4gtnA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA
ARSB

(Sporomusa
ovata;
Sporomusa ovata) 		PF02277
(DBI_PRT)
PF02277
(DBI_PRT) 		4 LEU A  36
ARG B  83
PRO B  93
VAL B 291
 None
 1.17A 2ygoA-4hdsA:
undetectable		 2ygoA-4hdsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Mycobacterium
tuberculosis) 		PF00925
(GTP_cyclohydro2)
PF00926
(DHBP_synthase) 		4 ILE A  96
ARG A 110
MET A 109
VAL A 167
 None
 1.13A 2ygoA-4i14A:
undetectable		 2ygoA-4i14A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		4 ILE A  87
MET A 133
PRO A 132
VAL A  46
 None
 1.12A 2ygoA-4icqA:
undetectable		 2ygoA-4icqA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 LEU A  32
ILE A  55
ARG A  24
MET A  20
VAL A 134
 None
 1.36A 2ygoA-4inaA:
undetectable		 2ygoA-4inaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		4 ILE A 313
MET A 309
PRO A 310
VAL A 166
 None
 1.17A 2ygoA-4iqlA:
undetectable		 2ygoA-4iqlA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 111
ILE A  98
MET A 100
VAL A 299
 None
 1.02A 2ygoA-4l1fA:
undetectable		 2ygoA-4l1fA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 LEU B 395
ILE B 398
MET B 373
VAL B  81
 None
 1.01A 2ygoA-4mrmB:
undetectable		 2ygoA-4mrmB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 LEU A 276
ILE A 277
MET A 328
VAL A  70
 None
 1.15A 2ygoA-4n7tA:
undetectable		 2ygoA-4n7tA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 LEU A 405
ILE A 406
ARG A 247
VAL A  83
 None
 1.08A 2ygoA-4ofzA:
undetectable		 2ygoA-4ofzA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6g PYRROLYSINE--TRNA
LIGASE

(Methanosarcina
mazei) 		PF01409
(tRNA-synt_2d) 		4 LEU A 284
ILE A 278
PRO A 299
VAL A 377
 None
 1.16A 2ygoA-4q6gA:
undetectable		 2ygoA-4q6gA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_5) 		4 ILE C  58
MET A 880
PRO A 879
VAL A 421
 None
 1.10A 2ygoA-4qiwC:
undetectable		 2ygoA-4qiwC:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  80
ARG A 361
PRO A  28
VAL A 348
 None
 1.07A 2ygoA-4uzsA:
undetectable		 2ygoA-4uzsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF00155
(Aminotran_1_2) 		4 LEU A 359
ILE A 292
PRO A 364
VAL A 339
 None
 1.17A 2ygoA-4wbtA:
undetectable		 2ygoA-4wbtA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 LEU A 536
ILE A 210
ARG A 522
PRO A 529
 EDO  A1001 ( 4.8A)
None
None
None
 1.10A 2ygoA-4xprA:
undetectable		 2ygoA-4xprA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 LEU D 350
ILE D 347
ARG D 432
VAL D 217
 None
 1.19A 2ygoA-4yg7D:
undetectable		 2ygoA-4yg7D:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ILE A 441
MET A 431
PRO A 430
VAL A 608
 None
 1.17A 2ygoA-4zxlA:
undetectable		 2ygoA-4zxlA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 4 LEU A 307
ILE A 301
ARG A 322
VAL A 141
 None
 1.15A 2ygoA-5aa6A:
undetectable		 2ygoA-5aa6A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		4 LEU A 350
ILE A 407
MET A 400
VAL A 233
 None
 1.10A 2ygoA-5aqaA:
undetectable		 2ygoA-5aqaA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 LEU A 934
ILE A 935
ARG A1006
VAL A 364
 None
 1.17A 2ygoA-5aw4A:
undetectable		 2ygoA-5aw4A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A  12
ILE A  13
ARG A  69
VAL A 314
 None
 1.02A 2ygoA-5c70A:
undetectable		 2ygoA-5c70A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 454
ILE A 471
ARG A 532
VAL A   5
 None
 1.02A 2ygoA-5e6sA:
undetectable		 2ygoA-5e6sA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  76
ARG A 355
PRO A  22
VAL A 342
 None
 1.16A 2ygoA-5e9aA:
undetectable		 2ygoA-5e9aA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 LEU A 265
ILE A 178
PRO A  98
VAL A 135
 None
 1.13A 2ygoA-5gslA:
undetectable		 2ygoA-5gslA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A 352
ILE A 366
PRO A 292
VAL A  96
 None
 1.17A 2ygoA-5h1kA:
undetectable		 2ygoA-5h1kA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 LEU A 514
ILE A 517
MET A 536
VAL A 624
 None
 1.10A 2ygoA-5h2vA:
undetectable		 2ygoA-5h2vA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 LEU A  94
ILE A  92
MET A  85
VAL A 189
 None
 1.19A 2ygoA-5husA:
undetectable		 2ygoA-5husA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgy ALDOSE REDUCTASE,
AKR4C13

(Zea mays) 		PF00248
(Aldo_ket_red) 		4 LEU A 141
ARG A 148
PRO A  95
VAL A 210
 None
 1.10A 2ygoA-5jgyA:
undetectable		 2ygoA-5jgyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Homo sapiens) 		PF00076
(RRM_1)
PF08662
(eIF2A) 		4 LEU B 346
ILE B 370
ARG B 395
PRO B 387
 None
 1.17A 2ygoA-5k1hB:
undetectable		 2ygoA-5k1hB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o00 GLUTATHIONE
TRANSFERASE URE2P5

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  78
ILE A 168
MET A  23
VAL A 185
 None
 1.19A 2ygoA-5o00A:
undetectable		 2ygoA-5o00A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5

(Homo sapiens) 		no annotation 4 LEU A  79
ILE A  77
PRO A 120
VAL A 111
 None
 1.17A 2ygoA-5o8fA:
undetectable		 2ygoA-5o8fA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		4 ARG A  27
MET A  26
PRO A  25
VAL A 138
 CL  A 404 (-4.5A)
None
None
None
 1.15A 2ygoA-5trwA:
undetectable		 2ygoA-5trwA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE

(Homo sapiens) 		no annotation 4 LEU A 107
ILE A 104
PRO A 116
VAL A 223
 None
 1.03A 2ygoA-5wy0A:
undetectable		 2ygoA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		4 LEU F  68
ILE F  72
MET F 103
PRO F 105
 None
 1.07A 2ygoA-5x5yF:
undetectable		 2ygoA-5x5yF:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 4 ILE U  66
ARG U  40
MET U 145
VAL U 111
 None
 0.96A 2ygoA-5zvtU:
undetectable		 2ygoA-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 4 LEU A 240
ILE A 239
ARG A 227
VAL A 278
 None
None
EDO  A 502 ( 4.6A)
CL  A 503 ( 4.5A)
 1.14A 2ygoA-6bqlA:
undetectable		 2ygoA-6bqlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 4 LEU A  23
ARG A  76
PRO A  91
VAL A 285
 None
 1.03A 2ygoA-6dawA:
undetectable		 2ygoA-6dawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 4 LEU E  79
ILE E  77
PRO E 120
VAL E 111
 None
 1.12A 2ygoA-6dw1E:
undetectable		 2ygoA-6dw1E:
undetectable