SIMILAR PATTERNS OF AMINO ACIDS FOR 2YGO_A_PCFA1213_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1am2 | MXE GYRA INTEIN (Mycobacteriumxenopi) |
no annotation | 6 | ILE A 190ILE A 105PHE A 110ILE A 2VAL A 61VAL A 166 | None | 1.49A | 2ygoA-1am2A:0.0 | 2ygoA-1am2A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1atg | PERIPLASMICMOLYBDATE-BINDINGPROTEIN (Azotobactervinelandii) |
PF13531(SBP_bac_11) | 5 | ILE A 110ILE A 141ILE A 108PHE A 163VAL A 93 | None | 1.06A | 2ygoA-1atgA:0.0 | 2ygoA-1atgA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bg6 | N-(1-D-CARBOXYLETHYL)-L-NORVALINEDEHYDROGENASE (Arthrobactersp. 1C) |
PF02317(Octopine_DH)PF02558(ApbA) | 5 | LEU A 107ILE A 105ILE A 79ILE A 81PHE A 118 | None | 0.90A | 2ygoA-1bg6A:undetectable | 2ygoA-1bg6A:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eke | RIBONUCLEASE HII (Methanocaldococcusjannaschii) |
PF01351(RNase_HII) | 5 | ILE A 109ILE A 4ILE A 6ILE A 132PHE A 125 | None | 0.83A | 2ygoA-1ekeA:0.0 | 2ygoA-1ekeA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ggp | PROTEIN (LECTIN 1 BCHAIN) (Trichosantheskirilowii) |
PF00652(Ricin_B_lectin) | 5 | LEU B 69ILE B 103ILE B 97ILE B 62VAL B 28 | None | 1.09A | 2ygoA-1ggpB:0.0 | 2ygoA-1ggpB:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i21 | GLUCOSAMINE-PHOSPHATEN-ACETYLTRANSFERASE (Saccharomycescerevisiae) |
PF00583(Acetyltransf_1) | 5 | ILE A 81ILE A 97ILE A 131PHE A 148ILE A 9 | None | 1.01A | 2ygoA-1i21A:0.1 | 2ygoA-1i21A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jiu | DNABETA-GLUCOSYLTRANSFERASE (Escherichiavirus T4) |
PF09198(T4-Gluco-transf) | 5 | LEU A 35ILE A 63ILE A 5ILE A 30PHE A 160 | None | 1.03A | 2ygoA-1jiuA:0.0 | 2ygoA-1jiuA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js1 | TRANSCARBAMYLASE (Bacteroidesfragilis) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | LEU X 313ILE X 107ILE X 106MET X 141PHE X 139 | None | 1.03A | 2ygoA-1js1X:undetectable | 2ygoA-1js1X:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n60 | CARBON MONOXIDEDEHYDROGENASE LARGECHAIN (Oligotrophacarboxidovorans) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 6 | ILE B 483ILE B 481MET B 479ILE B 419MET B 447PHE B 663 | None | 1.33A | 2ygoA-1n60B:undetectable | 2ygoA-1n60B:12.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ogo | DEXTRANASE (Talaromycesminioluteus) |
PF03718(Glyco_hydro_49)PF17433(Glyco_hydro_49N) | 6 | ILE X 494ILE X 526PHE X 561MET X 423VAL X 479VAL X 482 | None | 1.48A | 2ygoA-1ogoX:undetectable | 2ygoA-1ogoX:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1olp | ALPHA-TOXIN (Clostridiumsardiniense) |
PF00882(Zn_dep_PLPC)PF01477(PLAT) | 5 | LEU A 309ILE A 280ILE A 258PHE A 278VAL A 343 | None | 0.99A | 2ygoA-1olpA:undetectable | 2ygoA-1olpA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ozh | ACETOLACTATESYNTHASE, CATABOLIC (Klebsiellapneumoniae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 279ILE A 281ILE A 335PHE A 212VAL A 248 | NoneNoneNoneNonePGE A1403 ( 4.1A) | 1.01A | 2ygoA-1ozhA:undetectable | 2ygoA-1ozhA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ozh | ACETOLACTATESYNTHASE, CATABOLIC (Klebsiellapneumoniae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | LEU A 214ILE A 279ILE A 281ILE A 335PHE A 212 | None | 0.94A | 2ygoA-1ozhA:undetectable | 2ygoA-1ozhA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p4p | OUTER SURFACEPROTEIN B (Borreliellaburgdorferi) |
PF00820(Lipoprotein_1) | 5 | LEU A 186ILE A 285ILE A 190ILE A 248VAL A 203 | None | 1.01A | 2ygoA-1p4pA:undetectable | 2ygoA-1p4pA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pdz | ENOLASE (Homarusgammarus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 223ILE A 272MET A 280PHE A 284VAL A 245 | None | 0.88A | 2ygoA-1pdzA:undetectable | 2ygoA-1pdzA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pxt | PEROXISOMAL3-KETOACYL-COATHIOLASE (Saccharomycescerevisiae) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | LEU A 67ILE A 85ILE A 38PHE A 70VAL A 280 | None | 1.08A | 2ygoA-1pxtA:undetectable | 2ygoA-1pxtA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8w | AMP NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1)PF10423(AMNp_N) | 5 | LEU A 453ILE A 460ILE A 457ILE A 266PHE A 213 | None | 0.98A | 2ygoA-1t8wA:undetectable | 2ygoA-1t8wA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tv8 | MOLYBDENUM COFACTORBIOSYNTHESIS PROTEINA (Staphylococcusaureus) |
PF04055(Radical_SAM)PF06463(Mob_synth_C)PF13394(Fer4_14) | 5 | LEU A 101ILE A 99ILE A 70ILE A 72PHE A 52 | None | 0.99A | 2ygoA-1tv8A:undetectable | 2ygoA-1tv8A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ty2 | PUTATIVE EXOTOXIN(SUPERANTIGEN) (Streptococcuspyogenes) |
PF01123(Stap_Strp_toxin)PF02876(Stap_Strp_tox_C) | 5 | LEU A 33ILE A 30ILE A 128PHE A 64VAL A 56 | None | 1.07A | 2ygoA-1ty2A:undetectable | 2ygoA-1ty2A:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2awa | DNA POLYMERASE III,BETA CHAIN (Streptococcuspneumoniae) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 5 | ILE A 6ILE A 58ILE A 104PHE A 11VAL A 34 | None | 1.06A | 2ygoA-2awaA:undetectable | 2ygoA-2awaA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e47 | TIME INTERVALMEASURING ENZYMETIME (Bombyx mori) |
PF00080(Sod_Cu) | 5 | ILE A 101ILE A 39ILE A 153PHE A 49VAL A 148 | None | 1.08A | 2ygoA-2e47A:undetectable | 2ygoA-2e47A:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2edm | 22KDA STRUCTURALPROTEIN VP22 (White spotsyndrome virus) |
PF12175(WSS_VP) | 5 | LEU A 128ILE A 130ILE A 159PHE A 189VAL A 76 | None | 0.71A | 2ygoA-2edmA:undetectable | 2ygoA-2edmA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fbm | Y CHROMOSOMECHROMODOMAIN PROTEIN1, TELOMERIC ISOFORMB (Homo sapiens) |
PF00378(ECH_1) | 5 | LEU A 321ILE A 314ILE A 317PHE A 376VAL A 385 | None | 1.08A | 2ygoA-2fbmA:undetectable | 2ygoA-2fbmA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glw | 92AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
no annotation | 5 | LEU A 84ILE A 39ILE A 37PHE A 52PHE A 7 | None | 0.94A | 2ygoA-2glwA:undetectable | 2ygoA-2glwA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwg | 4-OXALOMESACONATEHYDRATASE (Rhodopseudomonaspalustris) |
PF04909(Amidohydro_2) | 5 | LEU A 65ILE A 5ILE A 3MET A 1ILE A 173 | None | 1.03A | 2ygoA-2gwgA:undetectable | 2ygoA-2gwgA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inv | INSULINFRUCTOTRANSFERASE (Bacillus sp.snu-7) |
no annotation | 5 | LEU A 185ILE A 102ILE A 153ILE A 82PHE A 165 | None | 1.03A | 2ygoA-2invA:undetectable | 2ygoA-2invA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pi5 | DNA-DIRECTED RNAPOLYMERASE (Escherichiavirus T7) |
PF00940(RNA_pol)PF14700(RPOL_N) | 5 | ILE A 117ILE A 145ILE A 141ILE A 82VAL A 227 | None | 1.00A | 2ygoA-2pi5A:undetectable | 2ygoA-2pi5A:11.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qoj | INTRON-ENCODED DNAENDONUCLEASE I-ANII (Aspergillusnidulans) |
PF00961(LAGLIDADG_1) | 5 | ILE Z 169ILE Z 145PHE Z 167ILE Z 132VAL Z 221 | None | 1.02A | 2ygoA-2qojZ:undetectable | 2ygoA-2qojZ:20.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygn | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 7 | LEU A 38ILE A 40ILE A 55ILE A 57ILE A 84MET A 87PHE A 89 | PCF A1179 ( 4.0A)NonePCF A1179 ( 4.5A)PCF A1179 ( 4.7A)NonePCF A1179 (-3.6A)PCF A1179 ( 3.8A) | 1.30A | 2ygoA-2ygnA:28.2 | 2ygoA-2ygnA:82.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygn | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 12 | LEU A 38ILE A 40ILE A 55ILE A 57MET A 63PHE A 66ILE A 80MET A 87PHE A 89VAL A 152VAL A 154PHE A 173 | PCF A1179 ( 4.0A)NonePCF A1179 ( 4.5A)PCF A1179 ( 4.7A)PCF A1179 ( 4.1A)PCF A1179 (-3.8A)NonePCF A1179 (-3.6A)PCF A1179 ( 3.8A)PCF A1179 (-4.4A)PCF A1179 ( 4.7A)PCF A1179 (-3.8A) | 0.12A | 2ygoA-2ygnA:28.2 | 2ygoA-2ygnA:82.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygo | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 7 | LEU A 38ILE A 40ILE A 55ILE A 57ILE A 84MET A 87PHE A 89 | PCF A1213 ( 3.9A)NonePCF A1213 (-4.0A)PCF A1213 ( 4.8A)NonePCF A1213 ( 3.8A)PCF A1213 (-4.1A) | 1.32A | 2ygoA-2ygoA:30.4 | 2ygoA-2ygoA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygo | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF) | 12 | LEU A 38ILE A 40ILE A 55ILE A 57MET A 63PHE A 66ILE A 80MET A 87PHE A 89VAL A 152VAL A 154PHE A 173 | PCF A1213 ( 3.9A)NonePCF A1213 (-4.0A)PCF A1213 ( 4.8A)PCF A1213 ( 4.2A)PCF A1213 ( 3.6A)NonePCF A1213 ( 3.8A)PCF A1213 (-4.1A)PCF A1213 ( 4.7A)PCF A1213 ( 4.7A)PCF A1213 (-3.8A) | 0.00A | 2ygoA-2ygoA:30.4 | 2ygoA-2ygoA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygq | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF)PF12661(hEGF) | 6 | ILE A 40ILE A 55ILE A 57ILE A 84PHE A 89VAL A 152 | NonePCF A1275 ( 4.4A)PCF A1275 ( 4.5A)NonePCF A1275 (-4.6A)PCF A1275 (-3.6A) | 1.39A | 2ygoA-2ygqA:26.4 | 2ygoA-2ygqA:58.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygq | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF)PF12661(hEGF) | 6 | ILE A 40ILE A 55ILE A 57PHE A 66PHE A 89VAL A 152 | NonePCF A1275 ( 4.4A)PCF A1275 ( 4.5A)NonePCF A1275 (-4.6A)PCF A1275 (-3.6A) | 1.25A | 2ygoA-2ygqA:26.4 | 2ygoA-2ygqA:58.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygq | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF)PF12661(hEGF) | 7 | LEU A 38ILE A 40ILE A 55ILE A 57ILE A 84MET A 87PHE A 89 | NoneNonePCF A1275 ( 4.4A)PCF A1275 ( 4.5A)NonePCF A1275 (-3.2A)PCF A1275 (-4.6A) | 1.29A | 2ygoA-2ygqA:26.4 | 2ygoA-2ygqA:58.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygq | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF)PF12661(hEGF) | 12 | LEU A 38ILE A 40ILE A 55ILE A 57MET A 63PHE A 66ILE A 80MET A 87PHE A 89VAL A 152VAL A 154PHE A 173 | NoneNonePCF A1275 ( 4.4A)PCF A1275 ( 4.5A)PCF A1275 ( 4.1A)NonePCF A1275 (-4.7A)PCF A1275 (-3.2A)PCF A1275 (-4.6A)PCF A1275 (-3.6A)PCF A1275 (-4.9A)PCF A1275 ( 4.5A) | 0.39A | 2ygoA-2ygqA:26.4 | 2ygoA-2ygqA:58.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ygq | WNT INHIBITORYFACTOR 1 (Homo sapiens) |
PF02019(WIF)PF12661(hEGF) | 6 | LEU A 38ILE A 40ILE A 57MET A 63ILE A 80PHE A 173 | NoneNonePCF A1275 ( 4.5A)PCF A1275 ( 4.1A)PCF A1275 (-4.7A)PCF A1275 ( 4.5A) | 1.10A | 2ygoA-2ygqA:26.4 | 2ygoA-2ygqA:58.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | ILE A 161ILE A 164MET A 193PHE A 166ILE A 133 | None | 1.00A | 2ygoA-3b2dA:undetectable | 2ygoA-3b2dA:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8v | PUTATIVEACETYLTRANSFERASE (Desulfovibrioalaskensis) |
no annotation | 5 | ILE A 159ILE A 149ILE A 11VAL A 74VAL A 72 | None | 0.98A | 2ygoA-3c8vA:undetectable | 2ygoA-3c8vA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3flt | SAP-LIKE PENTRAXIN (Limuluspolyphemus) |
PF00354(Pentaxin) | 5 | ILE A 194ILE A 4PHE A 201VAL A 209VAL A 207 | None | 1.05A | 2ygoA-3fltA:undetectable | 2ygoA-3fltA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsc | QDTC (Thermoanaerobacteriumthermosaccharolyticum) |
PF00132(Hexapep) | 5 | ILE A 121ILE A 103ILE A 115PHE A 95VAL A 149 | None | 0.91A | 2ygoA-3fscA:undetectable | 2ygoA-3fscA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqj | CELL INHIBITINGFACTOR (CIF) (Photorhabduslaumondii) |
PF16374(CIF) | 5 | ILE A 198ILE A 185ILE A 250PHE A 183VAL A 274 | None | 1.06A | 2ygoA-3gqjA:undetectable | 2ygoA-3gqjA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpe | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF04264(YceI) | 6 | LEU A 84ILE A 70ILE A 73PHE A 90VAL A 171VAL A 33 | ERU A 301 ( 4.8A)NoneNoneERU A 301 (-4.8A)ERU A 301 ( 4.8A)None | 1.31A | 2ygoA-3hpeA:undetectable | 2ygoA-3hpeA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iby | FERROUS IRONTRANSPORT PROTEIN B (Legionellapneumophila) |
PF02421(FeoB_N) | 5 | ILE A 154ILE A 146MET A 120ILE A 52VAL A 114 | None | 1.07A | 2ygoA-3ibyA:undetectable | 2ygoA-3ibyA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m62 | UBIQUITINCONJUGATION FACTORE4 (Saccharomycescerevisiae) |
PF04564(U-box)PF10408(Ufd2P_core) | 5 | LEU A 351ILE A 349ILE A 337PHE A 342VAL A 530 | None | 1.08A | 2ygoA-3m62A:undetectable | 2ygoA-3m62A:10.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o21 | GLUTAMATE RECEPTOR 3 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 5 | LEU A 219ILE A 198ILE A 177VAL A 205VAL A 232 | None | 1.06A | 2ygoA-3o21A:undetectable | 2ygoA-3o21A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oes | GTPASE RHEBL1 (Homo sapiens) |
PF00071(Ras) | 5 | LEU A 103ILE A 96ILE A 159VAL A 9VAL A 78 | None | 1.08A | 2ygoA-3oesA:undetectable | 2ygoA-3oesA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poc | ALPHA-GLUCOSIDASE (Blautia obeum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 5 | ILE A 297ILE A 301PHE A 304ILE A 648PHE A 160 | None | 1.07A | 2ygoA-3pocA:undetectable | 2ygoA-3pocA:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qml | 78 KDAGLUCOSE-REGULATEDPROTEIN HOMOLOG (Saccharomycescerevisiae) |
PF00012(HSP70) | 5 | ILE A 97ILE A 116VAL A 151VAL A 153PHE A 160 | None | 0.99A | 2ygoA-3qmlA:undetectable | 2ygoA-3qmlA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0s | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Campylobacterjejuni) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 40ILE A 22ILE A 34ILE A 63VAL A 81 | None | 1.08A | 2ygoA-3r0sA:undetectable | 2ygoA-3r0sA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rsj | BONT/F (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 5 | ILE A 970ILE A 958ILE A 936ILE A1009PHE A1010 | None | 0.91A | 2ygoA-3rsjA:undetectable | 2ygoA-3rsjA:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tm5 | CRYSTAL STRUCTURE OFTRM14 (Pyrococcusfuriosus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | LEU A 178ILE A 180ILE A 80ILE A 82PHE A 167 | None | 0.48A | 2ygoA-3tm5A:undetectable | 2ygoA-3tm5A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u6n | HIGH-CONDUCTANCECA2+-ACTIVATED K+CHANNEL PROTEIN (Danio rerio) |
PF02254(TrkA_N)PF03493(BK_channel_a) | 5 | LEU A 927ILE A 937ILE A 566MET A 536PHE A 511 | None | 0.79A | 2ygoA-3u6nA:undetectable | 2ygoA-3u6nA:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uvf | INTRON-ENCODED DNAENDONUCLEASE I-HJEMI (Trichodermareesei) |
PF00961(LAGLIDADG_1) | 5 | ILE A 171ILE A 147PHE A 169ILE A 134VAL A 223 | None | 1.05A | 2ygoA-3uvfA:undetectable | 2ygoA-3uvfA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v3k | CASPASE-9 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | ILE A 282ILE A 234ILE A 327VAL A 212PHE A 265 | None | 1.07A | 2ygoA-3v3kA:undetectable | 2ygoA-3v3kA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ag6 | TYPE IV SECRETORYPATHWAY VIRB4COMPONENTS-LIKEPROTEIN (Thermoanaerobacterpseudethanolicus) |
PF01935(DUF87) | 5 | ILE A 242ILE A 505ILE A 503ILE A 579VAL A 226 | None | 0.92A | 2ygoA-4ag6A:undetectable | 2ygoA-4ag6A:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4asm | BETA-AGARASE D (Zobelliagalactanivorans) |
no annotation | 5 | LEU B 147ILE B 145ILE B 318ILE B 316VAL B 128 | None | 0.90A | 2ygoA-4asmB:undetectable | 2ygoA-4asmB:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhi | GAMMA-BUTYROBETAINEDIOXYGENASE (Homo sapiens) |
PF02668(TauD)PF06155(DUF971) | 5 | ILE A 277PHE A 259MET A 321PHE A 317VAL A 286 | None | 0.97A | 2ygoA-4bhiA:undetectable | 2ygoA-4bhiA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cp6 | CHOLINE BINDINGPROTEIN PCPA (Streptococcuspneumoniae) |
PF13306(LRR_5) | 5 | LEU A 386ILE A 392ILE A 410ILE A 374VAL A 358 | None | 0.98A | 2ygoA-4cp6A:undetectable | 2ygoA-4cp6A:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cq6 | ALLENE OXIDE CYCLASE2, CHLOROPLASTIC (Arabidopsisthaliana) |
PF06351(Allene_ox_cyc) | 5 | LEU A 146ILE A 121ILE A 183PHE A 122VAL A 21 | None | 1.00A | 2ygoA-4cq6A:undetectable | 2ygoA-4cq6A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dvy | CYTOTOXICITY-ASSOCIATED IMMUNODOMINANTANTIGEN (Helicobacterpylori) |
no annotation | 5 | ILE P 177ILE P 66ILE P 181MET P 188PHE P 91 | None | 0.93A | 2ygoA-4dvyP:undetectable | 2ygoA-4dvyP:11.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f5c | PRCV SPIKE PROTEIN (Alphacoronavirus1) |
PF01600(Corona_S1) | 5 | LEU E 317ILE E 315ILE E 295ILE E 293PHE E 399 | None | 1.03A | 2ygoA-4f5cE:undetectable | 2ygoA-4f5cE:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fvv | NEUROTOXIN (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 5 | LEU A 870ILE A 936ILE A 954PHE A1069VAL A 889 | None | 1.02A | 2ygoA-4fvvA:undetectable | 2ygoA-4fvvA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxq | PUTATIVEADP-RIBOSYLTRANSFERASE CERTHRAX (Bacillus cereus) |
PF03496(ADPrib_exo_Tox)PF07737(ATLF) | 5 | LEU A 465ILE A 467ILE A 411ILE A 409PHE A 440 | None | 0.82A | 2ygoA-4fxqA:undetectable | 2ygoA-4fxqA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gv1 | RAC-ALPHASERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 5 | LEU A 210ILE A 288ILE A 290ILE A 402VAL A 270 | None | 1.04A | 2ygoA-4gv1A:undetectable | 2ygoA-4gv1A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gzi | GLUCANENDO-1,3-BETA-D-GLUCOSIDASE (Solanumtuberosum) |
PF00332(Glyco_hydro_17) | 5 | LEU A 248ILE A 182ILE A 185ILE A 186PHE A 174 | None | 0.98A | 2ygoA-4gziA:undetectable | 2ygoA-4gziA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpr | THIOREDOXINREDUCTASE 1,CYTOPLASMIC (Rattusnorvegicus) |
no annotation | 5 | ILE E 16ILE E 18PHE E 157VAL E 305VAL E 307 | NoneFAD E 505 (-4.9A)NoneSO3 E 501 (-4.7A)None | 1.03A | 2ygoA-4kprE:undetectable | 2ygoA-4kprE:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kxb | GLUTAMYLAMINOPEPTIDASE (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 6 | ILE A 121ILE A 123ILE A 141MET A 190VAL A 157VAL A 155 | None | 1.31A | 2ygoA-4kxbA:undetectable | 2ygoA-4kxbA:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgv | GLUCOSE-6-PHOSPHATE1-DEHYDROGENASE (Mycobacteriumavium) |
PF00479(G6PD_N)PF02781(G6PD_C) | 5 | LEU A 316ILE A 314ILE A 204ILE A 206MET A 266 | None | 0.99A | 2ygoA-4lgvA:undetectable | 2ygoA-4lgvA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m3c | LECTIN BETA CHAIN (Buteamonosperma) |
PF00139(Lectin_legB) | 5 | LEU B 204ILE B 210ILE B 57ILE B 59VAL B 198 | NoneNoneABU B 303 (-3.7A)NoneNone | 0.96A | 2ygoA-4m3cB:undetectable | 2ygoA-4m3cB:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5m | ISOVALERYL-COADEHYDROGENASE (Brucella suis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ILE A 83ILE A 24PHE A 19PHE A 37VAL A 120 | None | 0.99A | 2ygoA-4o5mA:undetectable | 2ygoA-4o5mA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7d | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homo sapiens) |
PF04960(Glutaminase) | 5 | ILE A 295ILE A 345PHE A 413VAL A 371VAL A 422 | None | 1.04A | 2ygoA-4o7dA:undetectable | 2ygoA-4o7dA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p4s | INTERFERON-INDUCEDGTP-BINDING PROTEINMX1 (Homo sapiens) |
PF00350(Dynamin_N)PF01031(Dynamin_M) | 5 | ILE A 73ILE A 212ILE A 243VAL A 320VAL A 278 | None | 1.07A | 2ygoA-4p4sA:undetectable | 2ygoA-4p4sA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfk | ABC TRANSPORTERPERIPLASMICPEPTIDE-BINDINGPROTEIN (Pseudoalteromonassp. SM9913) |
no annotation | 5 | ILE H 65ILE H 152PHE H 93VAL H 118PHE H 122 | None | 0.90A | 2ygoA-4qfkH:undetectable | 2ygoA-4qfkH:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0m | MCYG PROTEIN (Microcystisaeruginosa) |
no annotation | 5 | LEU B 430ILE B 343ILE B 372MET B 336PHE B 334 | NoneNoneNoneFA5 B 701 (-4.2A)None | 1.07A | 2ygoA-4r0mB:undetectable | 2ygoA-4r0mB:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnz | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF01551(Peptidase_M23) | 5 | LEU A 106ILE A 108ILE A 100ILE A 102PHE A 121 | None | 0.84A | 2ygoA-4rnzA:undetectable | 2ygoA-4rnzA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9l | HEAT SHOCK PROTEIN (Oryza sativa) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | LEU A 209ILE A 207ILE A 66ILE A 68PHE A 32 | None | 1.09A | 2ygoA-4x9lA:undetectable | 2ygoA-4x9lA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yom | SERINE/THREONINE-PROTEIN KINASE BRSK2 (Mus musculus) |
no annotation | 5 | LEU A 561ILE A 630PHE A 623ILE A 594PHE A 555 | None | 1.08A | 2ygoA-4yomA:undetectable | 2ygoA-4yomA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5af3 | VAPBC49 (Mycobacteriumtuberculosis) |
PF04255(DUF433) | 5 | LEU A 96ILE A 55ILE A 54VAL A 87VAL A 137 | None | 0.87A | 2ygoA-5af3A:undetectable | 2ygoA-5af3A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aza | MALTOSE-BINDINGPERIPLASMICPROTEIN,OLIGOSACCHARYL TRANSFERASE STT3SUBUNIT RELATEDPROTEIN (Escherichiacoli;Pyrococcusfuriosus) |
PF13416(SBP_bac_8) | 5 | LEU A 667ILE A 669ILE A 681ILE A 683PHE A 711 | None | 0.89A | 2ygoA-5azaA:undetectable | 2ygoA-5azaA:11.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2o | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Francisellatularensis) |
no annotation | 5 | LEU A1539ILE A1544ILE A1593PHE A1576VAL A1559 | None | 1.06A | 2ygoA-5b2oA:undetectable | 2ygoA-5b2oA:7.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3f | PHOSPHORIBULOKINASE/URIDINE KINASE (Methanospirillumhungatei) |
PF00485(PRK) | 5 | ILE A 274ILE A 226ILE A 305ILE A 230VAL A 212 | None | 1.06A | 2ygoA-5b3fA:undetectable | 2ygoA-5b3fA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by6 | THYMIDYLATE SYNTHASE (Trichinellaspiralis) |
PF00303(Thymidylat_synt) | 5 | LEU A 227ILE A 282ILE A 234ILE A 231VAL A 193 | None | 1.07A | 2ygoA-5by6A:undetectable | 2ygoA-5by6A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3o | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homo sapiens) |
PF04960(Glutaminase) | 5 | ILE A 300ILE A 350PHE A 418VAL A 376VAL A 427 | None | 1.05A | 2ygoA-5d3oA:undetectable | 2ygoA-5d3oA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gan | PRE-MRNA-PROCESSINGFACTOR 31 (Saccharomycescerevisiae) |
PF01798(Nop)PF09785(Prp31_C) | 5 | ILE F 101ILE F 105ILE F 214ILE F 46PHE F 98 | None | 1.03A | 2ygoA-5ganF:undetectable | 2ygoA-5ganF:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5guh | PIWI (Bombyx mori) |
PF02170(PAZ)PF02171(Piwi) | 5 | ILE A 846ILE A 776PHE A 815ILE A 659VAL A 869 | None | 1.03A | 2ygoA-5guhA:undetectable | 2ygoA-5guhA:11.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzx | NUDIX (NUCLEOSIDEDIPHOSPHATE LINKEDMOIETY X)-TYPE MOTIF1 (Danio rerio) |
PF00293(NUDIX) | 5 | LEU A 9ILE A 67ILE A 85PHE A 133ILE A 108 | 2GE A 201 (-4.0A)NoneNoneNoneNone | 1.00A | 2ygoA-5hzxA:undetectable | 2ygoA-5hzxA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idv | LIPID A EXPORTATP-BINDING/PERMEASEPROTEIN MSBA (Acinetobacterbaumannii) |
PF00005(ABC_tran) | 5 | ILE A 96ILE A 197PHE A 41VAL A 68VAL A 245 | None | 1.00A | 2ygoA-5idvA:undetectable | 2ygoA-5idvA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iri | SERINE/THREONINE-PROTEIN KINASE BRSK1 (Mus musculus) |
no annotation | 5 | LEU A 634ILE A 709PHE A 702ILE A 667PHE A 628 | None | 1.07A | 2ygoA-5iriA:undetectable | 2ygoA-5iriA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6c | PUTATIVE REDUCTASE (Clostridioidesdifficile) |
PF00881(Nitroreductase) | 6 | LEU A 60ILE A 151ILE A 119PHE A 74ILE A 105VAL A 25 | NoneNoneFMN A 201 (-4.8A)FMN A 201 (-4.7A)NoneNone | 1.50A | 2ygoA-5j6cA:undetectable | 2ygoA-5j6cA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jk6 | PHENYLALANINE-4-HYDROXYLASE (Dictyosteliumdiscoideum) |
PF00351(Biopterin_H) | 5 | LEU A 282ILE A 230ILE A 218PHE A 251VAL A 317 | None | 0.95A | 2ygoA-5jk6A:undetectable | 2ygoA-5jk6A:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5muw | PACKAGING ENZYME P4 (Pseudomonasvirus phi6) |
PF11602(NTPase_P4) | 5 | LEU A 20ILE A 36ILE A 75ILE A 41ILE A 216 | None | 1.08A | 2ygoA-5muwA:undetectable | 2ygoA-5muwA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nny | WIPB (Legionellapneumophila) |
no annotation | 5 | ILE A 104ILE A 50ILE A 106ILE A 130VAL A 207 | None | 1.09A | 2ygoA-5nnyA:undetectable | 2ygoA-5nnyA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvr | TELOMERE LENGTHREGULATOR PROTEINRIF1 (Saccharomycescerevisiae) |
PF12231(Rif1_N) | 5 | LEU A 530ILE A 412ILE A 463ILE A 378VAL A 423 | None | 0.98A | 2ygoA-5nvrA:undetectable | 2ygoA-5nvrA:9.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sym | ACYL-PROTEINTHIOESTERASE 1 (Homo sapiens) |
PF02230(Abhydrolase_2) | 5 | LEU A 189ILE A 164ILE A 166PHE A 221ILE A 100 | None | 0.97A | 2ygoA-5symA:undetectable | 2ygoA-5symA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u6k | DNA TOPOISOMERASE2-BINDING PROTEIN 1 (Mus musculus) |
PF12738(PTCB-BRCT) | 5 | ILE A 585ILE A 578VAL A 599VAL A 614PHE A 566 | None | 1.05A | 2ygoA-5u6kA:undetectable | 2ygoA-5u6kA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8q | INSULIN-LIKE GROWTHFACTOR 1 RECEPTOR (Homo sapiens) |
no annotation | 5 | ILE A 475ILE A 574ILE A 477VAL A 522VAL A 524 | None | 1.06A | 2ygoA-5u8qA:undetectable | 2ygoA-5u8qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vfr | PROTEASOME SUBUNITALPHA TYPE-2 (Homo sapiens) |
no annotation | 5 | LEU H 134ILE H 68ILE H 72ILE H 136VAL H 117 | None | 0.89A | 2ygoA-5vfrH:undetectable | 2ygoA-5vfrH:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d46 | BETA SLIDING CLAMP (Rickettsiatyphi) |
no annotation | 6 | LEU A 236ILE A 226ILE A 203PHE A 135ILE A 241VAL A 21 | None | 1.45A | 2ygoA-6d46A:undetectable | 2ygoA-6d46A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 5 | LEU A 755ILE A 801ILE A 782ILE A 741ILE A 863 | None | 0.96A | 2ygoA-6eojA:undetectable | 2ygoA-6eojA:8.92 |