SIMILAR PATTERNS OF AMINO ACIDS FOR 2YGO_A_PCFA1213_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am2 MXE GYRA INTEIN

(Mycobacterium
xenopi)
no annotation 6 ILE A 190
ILE A 105
PHE A 110
ILE A   2
VAL A  61
VAL A 166
None
1.49A 2ygoA-1am2A:
0.0
2ygoA-1am2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN


(Azotobacter
vinelandii)
PF13531
(SBP_bac_11)
5 ILE A 110
ILE A 141
ILE A 108
PHE A 163
VAL A  93
None
1.06A 2ygoA-1atgA:
0.0
2ygoA-1atgA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE


(Arthrobacter
sp. 1C)
PF02317
(Octopine_DH)
PF02558
(ApbA)
5 LEU A 107
ILE A 105
ILE A  79
ILE A  81
PHE A 118
None
0.90A 2ygoA-1bg6A:
undetectable
2ygoA-1bg6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii)
PF01351
(RNase_HII)
5 ILE A 109
ILE A   4
ILE A   6
ILE A 132
PHE A 125
None
0.83A 2ygoA-1ekeA:
0.0
2ygoA-1ekeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 B
CHAIN)


(Trichosanthes
kirilowii)
PF00652
(Ricin_B_lectin)
5 LEU B  69
ILE B 103
ILE B  97
ILE B  62
VAL B  28
None
1.09A 2ygoA-1ggpB:
0.0
2ygoA-1ggpB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i21 GLUCOSAMINE-PHOSPHAT
E
N-ACETYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF00583
(Acetyltransf_1)
5 ILE A  81
ILE A  97
ILE A 131
PHE A 148
ILE A   9
None
1.01A 2ygoA-1i21A:
0.1
2ygoA-1i21A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE


(Escherichia
virus T4)
PF09198
(T4-Gluco-transf)
5 LEU A  35
ILE A  63
ILE A   5
ILE A  30
PHE A 160
None
1.03A 2ygoA-1jiuA:
0.0
2ygoA-1jiuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 LEU X 313
ILE X 107
ILE X 106
MET X 141
PHE X 139
None
1.03A 2ygoA-1js1X:
undetectable
2ygoA-1js1X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN


(Oligotropha
carboxidovorans)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
6 ILE B 483
ILE B 481
MET B 479
ILE B 419
MET B 447
PHE B 663
None
1.33A 2ygoA-1n60B:
undetectable
2ygoA-1n60B:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus)
PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N)
6 ILE X 494
ILE X 526
PHE X 561
MET X 423
VAL X 479
VAL X 482
None
1.48A 2ygoA-1ogoX:
undetectable
2ygoA-1ogoX:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense)
PF00882
(Zn_dep_PLPC)
PF01477
(PLAT)
5 LEU A 309
ILE A 280
ILE A 258
PHE A 278
VAL A 343
None
0.99A 2ygoA-1olpA:
undetectable
2ygoA-1olpA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC


(Klebsiella
pneumoniae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ILE A 279
ILE A 281
ILE A 335
PHE A 212
VAL A 248
None
None
None
None
PGE  A1403 ( 4.1A)
1.01A 2ygoA-1ozhA:
undetectable
2ygoA-1ozhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC


(Klebsiella
pneumoniae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 LEU A 214
ILE A 279
ILE A 281
ILE A 335
PHE A 212
None
0.94A 2ygoA-1ozhA:
undetectable
2ygoA-1ozhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4p OUTER SURFACE
PROTEIN B


(Borreliella
burgdorferi)
PF00820
(Lipoprotein_1)
5 LEU A 186
ILE A 285
ILE A 190
ILE A 248
VAL A 203
None
1.01A 2ygoA-1p4pA:
undetectable
2ygoA-1p4pA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 223
ILE A 272
MET A 280
PHE A 284
VAL A 245
None
0.88A 2ygoA-1pdzA:
undetectable
2ygoA-1pdzA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE


(Saccharomyces
cerevisiae)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A  67
ILE A  85
ILE A  38
PHE A  70
VAL A 280
None
1.08A 2ygoA-1pxtA:
undetectable
2ygoA-1pxtA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli)
PF01048
(PNP_UDP_1)
PF10423
(AMNp_N)
5 LEU A 453
ILE A 460
ILE A 457
ILE A 266
PHE A 213
None
0.98A 2ygoA-1t8wA:
undetectable
2ygoA-1t8wA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A


(Staphylococcus
aureus)
PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14)
5 LEU A 101
ILE A  99
ILE A  70
ILE A  72
PHE A  52
None
0.99A 2ygoA-1tv8A:
undetectable
2ygoA-1tv8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)


(Streptococcus
pyogenes)
PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C)
5 LEU A  33
ILE A  30
ILE A 128
PHE A  64
VAL A  56
None
1.07A 2ygoA-1ty2A:
undetectable
2ygoA-1ty2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN


(Streptococcus
pneumoniae)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 ILE A   6
ILE A  58
ILE A 104
PHE A  11
VAL A  34
None
1.06A 2ygoA-2awaA:
undetectable
2ygoA-2awaA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME


(Bombyx mori)
PF00080
(Sod_Cu)
5 ILE A 101
ILE A  39
ILE A 153
PHE A  49
VAL A 148
None
1.08A 2ygoA-2e47A:
undetectable
2ygoA-2e47A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edm 22KDA STRUCTURAL
PROTEIN VP22


(White spot
syndrome virus)
PF12175
(WSS_VP)
5 LEU A 128
ILE A 130
ILE A 159
PHE A 189
VAL A  76
None
0.71A 2ygoA-2edmA:
undetectable
2ygoA-2edmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B


(Homo sapiens)
PF00378
(ECH_1)
5 LEU A 321
ILE A 314
ILE A 317
PHE A 376
VAL A 385
None
1.08A 2ygoA-2fbmA:
undetectable
2ygoA-2fbmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glw 92AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
no annotation 5 LEU A  84
ILE A  39
ILE A  37
PHE A  52
PHE A   7
None
0.94A 2ygoA-2glwA:
undetectable
2ygoA-2glwA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE


(Rhodopseudomonas
palustris)
PF04909
(Amidohydro_2)
5 LEU A  65
ILE A   5
ILE A   3
MET A   1
ILE A 173
None
1.03A 2ygoA-2gwgA:
undetectable
2ygoA-2gwgA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE


(Bacillus sp.
snu-7)
no annotation 5 LEU A 185
ILE A 102
ILE A 153
ILE A  82
PHE A 165
None
1.03A 2ygoA-2invA:
undetectable
2ygoA-2invA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE


(Escherichia
virus T7)
PF00940
(RNA_pol)
PF14700
(RPOL_N)
5 ILE A 117
ILE A 145
ILE A 141
ILE A  82
VAL A 227
None
1.00A 2ygoA-2pi5A:
undetectable
2ygoA-2pi5A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qoj INTRON-ENCODED DNA
ENDONUCLEASE I-ANII


(Aspergillus
nidulans)
PF00961
(LAGLIDADG_1)
5 ILE Z 169
ILE Z 145
PHE Z 167
ILE Z 132
VAL Z 221
None
1.02A 2ygoA-2qojZ:
undetectable
2ygoA-2qojZ:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygn WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
7 LEU A  38
ILE A  40
ILE A  55
ILE A  57
ILE A  84
MET A  87
PHE A  89
PCF  A1179 ( 4.0A)
None
PCF  A1179 ( 4.5A)
PCF  A1179 ( 4.7A)
None
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
1.30A 2ygoA-2ygnA:
28.2
2ygoA-2ygnA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygn WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
MET A  63
PHE A  66
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PHE A 173
PCF  A1179 ( 4.0A)
None
PCF  A1179 ( 4.5A)
PCF  A1179 ( 4.7A)
PCF  A1179 ( 4.1A)
PCF  A1179 (-3.8A)
None
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
PCF  A1179 (-4.4A)
PCF  A1179 ( 4.7A)
PCF  A1179 (-3.8A)
0.12A 2ygoA-2ygnA:
28.2
2ygoA-2ygnA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
7 LEU A  38
ILE A  40
ILE A  55
ILE A  57
ILE A  84
MET A  87
PHE A  89
PCF  A1213 ( 3.9A)
None
PCF  A1213 (-4.0A)
PCF  A1213 ( 4.8A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
1.32A 2ygoA-2ygoA:
30.4
2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
MET A  63
PHE A  66
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PHE A 173
PCF  A1213 ( 3.9A)
None
PCF  A1213 (-4.0A)
PCF  A1213 ( 4.8A)
PCF  A1213 ( 4.2A)
PCF  A1213 ( 3.6A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 4.7A)
PCF  A1213 ( 4.7A)
PCF  A1213 (-3.8A)
0.00A 2ygoA-2ygoA:
30.4
2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
PF12661
(hEGF)
6 ILE A  40
ILE A  55
ILE A  57
ILE A  84
PHE A  89
VAL A 152
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
None
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
1.39A 2ygoA-2ygqA:
26.4
2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
PF12661
(hEGF)
6 ILE A  40
ILE A  55
ILE A  57
PHE A  66
PHE A  89
VAL A 152
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
None
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
1.25A 2ygoA-2ygqA:
26.4
2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
PF12661
(hEGF)
7 LEU A  38
ILE A  40
ILE A  55
ILE A  57
ILE A  84
MET A  87
PHE A  89
None
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
None
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
1.29A 2ygoA-2ygqA:
26.4
2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
PF12661
(hEGF)
12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
MET A  63
PHE A  66
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PHE A 173
None
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
PCF  A1275 ( 4.1A)
None
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
PCF  A1275 ( 4.5A)
0.39A 2ygoA-2ygqA:
26.4
2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
PF12661
(hEGF)
6 LEU A  38
ILE A  40
ILE A  57
MET A  63
ILE A  80
PHE A 173
None
None
PCF  A1275 ( 4.5A)
PCF  A1275 ( 4.1A)
PCF  A1275 (-4.7A)
PCF  A1275 ( 4.5A)
1.10A 2ygoA-2ygqA:
26.4
2ygoA-2ygqA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 ILE A 161
ILE A 164
MET A 193
PHE A 166
ILE A 133
None
1.00A 2ygoA-3b2dA:
undetectable
2ygoA-3b2dA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE


(Desulfovibrio
alaskensis)
no annotation 5 ILE A 159
ILE A 149
ILE A  11
VAL A  74
VAL A  72
None
0.98A 2ygoA-3c8vA:
undetectable
2ygoA-3c8vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flt SAP-LIKE PENTRAXIN

(Limulus
polyphemus)
PF00354
(Pentaxin)
5 ILE A 194
ILE A   4
PHE A 201
VAL A 209
VAL A 207
None
1.05A 2ygoA-3fltA:
undetectable
2ygoA-3fltA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum)
PF00132
(Hexapep)
5 ILE A 121
ILE A 103
ILE A 115
PHE A  95
VAL A 149
None
0.91A 2ygoA-3fscA:
undetectable
2ygoA-3fscA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)


(Photorhabdus
laumondii)
PF16374
(CIF)
5 ILE A 198
ILE A 185
ILE A 250
PHE A 183
VAL A 274
None
1.06A 2ygoA-3gqjA:
undetectable
2ygoA-3gqjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpe CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF04264
(YceI)
6 LEU A  84
ILE A  70
ILE A  73
PHE A  90
VAL A 171
VAL A  33
ERU  A 301 ( 4.8A)
None
None
ERU  A 301 (-4.8A)
ERU  A 301 ( 4.8A)
None
1.31A 2ygoA-3hpeA:
undetectable
2ygoA-3hpeA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B


(Legionella
pneumophila)
PF02421
(FeoB_N)
5 ILE A 154
ILE A 146
MET A 120
ILE A  52
VAL A 114
None
1.07A 2ygoA-3ibyA:
undetectable
2ygoA-3ibyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4


(Saccharomyces
cerevisiae)
PF04564
(U-box)
PF10408
(Ufd2P_core)
5 LEU A 351
ILE A 349
ILE A 337
PHE A 342
VAL A 530
None
1.08A 2ygoA-3m62A:
undetectable
2ygoA-3m62A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus)
PF01094
(ANF_receptor)
5 LEU A 219
ILE A 198
ILE A 177
VAL A 205
VAL A 232
None
1.06A 2ygoA-3o21A:
undetectable
2ygoA-3o21A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oes GTPASE RHEBL1

(Homo sapiens)
PF00071
(Ras)
5 LEU A 103
ILE A  96
ILE A 159
VAL A   9
VAL A  78
None
1.08A 2ygoA-3oesA:
undetectable
2ygoA-3oesA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 ILE A 297
ILE A 301
PHE A 304
ILE A 648
PHE A 160
None
1.07A 2ygoA-3pocA:
undetectable
2ygoA-3pocA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG


(Saccharomyces
cerevisiae)
PF00012
(HSP70)
5 ILE A  97
ILE A 116
VAL A 151
VAL A 153
PHE A 160
None
0.99A 2ygoA-3qmlA:
undetectable
2ygoA-3qmlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Campylobacter
jejuni)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  40
ILE A  22
ILE A  34
ILE A  63
VAL A  81
None
1.08A 2ygoA-3r0sA:
undetectable
2ygoA-3r0sA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsj BONT/F

(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
5 ILE A 970
ILE A 958
ILE A 936
ILE A1009
PHE A1010
None
0.91A 2ygoA-3rsjA:
undetectable
2ygoA-3rsjA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14


(Pyrococcus
furiosus)
PF01170
(UPF0020)
PF02926
(THUMP)
5 LEU A 178
ILE A 180
ILE A  80
ILE A  82
PHE A 167
None
0.48A 2ygoA-3tm5A:
undetectable
2ygoA-3tm5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN


(Danio rerio)
PF02254
(TrkA_N)
PF03493
(BK_channel_a)
5 LEU A 927
ILE A 937
ILE A 566
MET A 536
PHE A 511
None
0.79A 2ygoA-3u6nA:
undetectable
2ygoA-3u6nA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvf INTRON-ENCODED DNA
ENDONUCLEASE I-HJEMI


(Trichoderma
reesei)
PF00961
(LAGLIDADG_1)
5 ILE A 171
ILE A 147
PHE A 169
ILE A 134
VAL A 223
None
1.05A 2ygoA-3uvfA:
undetectable
2ygoA-3uvfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3k CASPASE-9

(Homo sapiens)
PF00656
(Peptidase_C14)
5 ILE A 282
ILE A 234
ILE A 327
VAL A 212
PHE A 265
None
1.07A 2ygoA-3v3kA:
undetectable
2ygoA-3v3kA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN


(Thermoanaerobacter
pseudethanolicus)
PF01935
(DUF87)
5 ILE A 242
ILE A 505
ILE A 503
ILE A 579
VAL A 226
None
0.92A 2ygoA-4ag6A:
undetectable
2ygoA-4ag6A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asm BETA-AGARASE D

(Zobellia
galactanivorans)
no annotation 5 LEU B 147
ILE B 145
ILE B 318
ILE B 316
VAL B 128
None
0.90A 2ygoA-4asmB:
undetectable
2ygoA-4asmB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE


(Homo sapiens)
PF02668
(TauD)
PF06155
(DUF971)
5 ILE A 277
PHE A 259
MET A 321
PHE A 317
VAL A 286
None
0.97A 2ygoA-4bhiA:
undetectable
2ygoA-4bhiA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA


(Streptococcus
pneumoniae)
PF13306
(LRR_5)
5 LEU A 386
ILE A 392
ILE A 410
ILE A 374
VAL A 358
None
0.98A 2ygoA-4cp6A:
undetectable
2ygoA-4cp6A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cq6 ALLENE OXIDE CYCLASE
2, CHLOROPLASTIC


(Arabidopsis
thaliana)
PF06351
(Allene_ox_cyc)
5 LEU A 146
ILE A 121
ILE A 183
PHE A 122
VAL A  21
None
1.00A 2ygoA-4cq6A:
undetectable
2ygoA-4cq6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN


(Helicobacter
pylori)
no annotation 5 ILE P 177
ILE P  66
ILE P 181
MET P 188
PHE P  91
None
0.93A 2ygoA-4dvyP:
undetectable
2ygoA-4dvyP:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5c PRCV SPIKE PROTEIN

(Alphacoronavirus
1)
PF01600
(Corona_S1)
5 LEU E 317
ILE E 315
ILE E 295
ILE E 293
PHE E 399
None
1.03A 2ygoA-4f5cE:
undetectable
2ygoA-4f5cE:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvv NEUROTOXIN

(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
5 LEU A 870
ILE A 936
ILE A 954
PHE A1069
VAL A 889
None
1.02A 2ygoA-4fvvA:
undetectable
2ygoA-4fvvA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX


(Bacillus cereus)
PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF)
5 LEU A 465
ILE A 467
ILE A 411
ILE A 409
PHE A 440
None
0.82A 2ygoA-4fxqA:
undetectable
2ygoA-4fxqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 LEU A 210
ILE A 288
ILE A 290
ILE A 402
VAL A 270
None
1.04A 2ygoA-4gv1A:
undetectable
2ygoA-4gv1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE


(Solanum
tuberosum)
PF00332
(Glyco_hydro_17)
5 LEU A 248
ILE A 182
ILE A 185
ILE A 186
PHE A 174
None
0.98A 2ygoA-4gziA:
undetectable
2ygoA-4gziA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC


(Rattus
norvegicus)
no annotation 5 ILE E  16
ILE E  18
PHE E 157
VAL E 305
VAL E 307
None
FAD  E 505 (-4.9A)
None
SO3  E 501 (-4.7A)
None
1.03A 2ygoA-4kprE:
undetectable
2ygoA-4kprE:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
6 ILE A 121
ILE A 123
ILE A 141
MET A 190
VAL A 157
VAL A 155
None
1.31A 2ygoA-4kxbA:
undetectable
2ygoA-4kxbA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE


(Mycobacterium
avium)
PF00479
(G6PD_N)
PF02781
(G6PD_C)
5 LEU A 316
ILE A 314
ILE A 204
ILE A 206
MET A 266
None
0.99A 2ygoA-4lgvA:
undetectable
2ygoA-4lgvA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3c LECTIN BETA CHAIN

(Butea
monosperma)
PF00139
(Lectin_legB)
5 LEU B 204
ILE B 210
ILE B  57
ILE B  59
VAL B 198
None
None
ABU  B 303 (-3.7A)
None
None
0.96A 2ygoA-4m3cB:
undetectable
2ygoA-4m3cB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE


(Brucella suis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 ILE A  83
ILE A  24
PHE A  19
PHE A  37
VAL A 120
None
0.99A 2ygoA-4o5mA:
undetectable
2ygoA-4o5mA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL


(Homo sapiens)
PF04960
(Glutaminase)
5 ILE A 295
ILE A 345
PHE A 413
VAL A 371
VAL A 422
None
1.04A 2ygoA-4o7dA:
undetectable
2ygoA-4o7dA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1


(Homo sapiens)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
5 ILE A  73
ILE A 212
ILE A 243
VAL A 320
VAL A 278
None
1.07A 2ygoA-4p4sA:
undetectable
2ygoA-4p4sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN


(Pseudoalteromonas
sp. SM9913)
no annotation 5 ILE H  65
ILE H 152
PHE H  93
VAL H 118
PHE H 122
None
0.90A 2ygoA-4qfkH:
undetectable
2ygoA-4qfkH:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa)
no annotation 5 LEU B 430
ILE B 343
ILE B 372
MET B 336
PHE B 334
None
None
None
FA5  B 701 (-4.2A)
None
1.07A 2ygoA-4r0mB:
undetectable
2ygoA-4r0mB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF01551
(Peptidase_M23)
5 LEU A 106
ILE A 108
ILE A 100
ILE A 102
PHE A 121
None
0.84A 2ygoA-4rnzA:
undetectable
2ygoA-4rnzA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9l HEAT SHOCK PROTEIN

(Oryza sativa)
PF00183
(HSP90)
PF02518
(HATPase_c)
5 LEU A 209
ILE A 207
ILE A  66
ILE A  68
PHE A  32
None
1.09A 2ygoA-4x9lA:
undetectable
2ygoA-4x9lA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2


(Mus musculus)
no annotation 5 LEU A 561
ILE A 630
PHE A 623
ILE A 594
PHE A 555
None
1.08A 2ygoA-4yomA:
undetectable
2ygoA-4yomA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af3 VAPBC49

(Mycobacterium
tuberculosis)
PF04255
(DUF433)
5 LEU A  96
ILE A  55
ILE A  54
VAL A  87
VAL A 137
None
0.87A 2ygoA-5af3A:
undetectable
2ygoA-5af3A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN


(Escherichia
coli;
Pyrococcus
furiosus)
PF13416
(SBP_bac_8)
5 LEU A 667
ILE A 669
ILE A 681
ILE A 683
PHE A 711
None
0.89A 2ygoA-5azaA:
undetectable
2ygoA-5azaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Francisella
tularensis)
no annotation 5 LEU A1539
ILE A1544
ILE A1593
PHE A1576
VAL A1559
None
1.06A 2ygoA-5b2oA:
undetectable
2ygoA-5b2oA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE


(Methanospirillum
hungatei)
PF00485
(PRK)
5 ILE A 274
ILE A 226
ILE A 305
ILE A 230
VAL A 212
None
1.06A 2ygoA-5b3fA:
undetectable
2ygoA-5b3fA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis)
PF00303
(Thymidylat_synt)
5 LEU A 227
ILE A 282
ILE A 234
ILE A 231
VAL A 193
None
1.07A 2ygoA-5by6A:
undetectable
2ygoA-5by6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL


(Homo sapiens)
PF04960
(Glutaminase)
5 ILE A 300
ILE A 350
PHE A 418
VAL A 376
VAL A 427
None
1.05A 2ygoA-5d3oA:
undetectable
2ygoA-5d3oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gan PRE-MRNA-PROCESSING
FACTOR 31


(Saccharomyces
cerevisiae)
PF01798
(Nop)
PF09785
(Prp31_C)
5 ILE F 101
ILE F 105
ILE F 214
ILE F  46
PHE F  98
None
1.03A 2ygoA-5ganF:
undetectable
2ygoA-5ganF:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori)
PF02170
(PAZ)
PF02171
(Piwi)
5 ILE A 846
ILE A 776
PHE A 815
ILE A 659
VAL A 869
None
1.03A 2ygoA-5guhA:
undetectable
2ygoA-5guhA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzx NUDIX (NUCLEOSIDE
DIPHOSPHATE LINKED
MOIETY X)-TYPE MOTIF
1


(Danio rerio)
PF00293
(NUDIX)
5 LEU A   9
ILE A  67
ILE A  85
PHE A 133
ILE A 108
2GE  A 201 (-4.0A)
None
None
None
None
1.00A 2ygoA-5hzxA:
undetectable
2ygoA-5hzxA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA


(Acinetobacter
baumannii)
PF00005
(ABC_tran)
5 ILE A  96
ILE A 197
PHE A  41
VAL A  68
VAL A 245
None
1.00A 2ygoA-5idvA:
undetectable
2ygoA-5idvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1


(Mus musculus)
no annotation 5 LEU A 634
ILE A 709
PHE A 702
ILE A 667
PHE A 628
None
1.07A 2ygoA-5iriA:
undetectable
2ygoA-5iriA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6c PUTATIVE REDUCTASE

(Clostridioides
difficile)
PF00881
(Nitroreductase)
6 LEU A  60
ILE A 151
ILE A 119
PHE A  74
ILE A 105
VAL A  25
None
None
FMN  A 201 (-4.8A)
FMN  A 201 (-4.7A)
None
None
1.50A 2ygoA-5j6cA:
undetectable
2ygoA-5j6cA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE


(Dictyostelium
discoideum)
PF00351
(Biopterin_H)
5 LEU A 282
ILE A 230
ILE A 218
PHE A 251
VAL A 317
None
0.95A 2ygoA-5jk6A:
undetectable
2ygoA-5jk6A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muw PACKAGING ENZYME P4

(Pseudomonas
virus phi6)
PF11602
(NTPase_P4)
5 LEU A  20
ILE A  36
ILE A  75
ILE A  41
ILE A 216
None
1.08A 2ygoA-5muwA:
undetectable
2ygoA-5muwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila)
no annotation 5 ILE A 104
ILE A  50
ILE A 106
ILE A 130
VAL A 207
None
1.09A 2ygoA-5nnyA:
undetectable
2ygoA-5nnyA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1


(Saccharomyces
cerevisiae)
PF12231
(Rif1_N)
5 LEU A 530
ILE A 412
ILE A 463
ILE A 378
VAL A 423
None
0.98A 2ygoA-5nvrA:
undetectable
2ygoA-5nvrA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sym ACYL-PROTEIN
THIOESTERASE 1


(Homo sapiens)
PF02230
(Abhydrolase_2)
5 LEU A 189
ILE A 164
ILE A 166
PHE A 221
ILE A 100
None
0.97A 2ygoA-5symA:
undetectable
2ygoA-5symA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6k DNA TOPOISOMERASE
2-BINDING PROTEIN 1


(Mus musculus)
PF12738
(PTCB-BRCT)
5 ILE A 585
ILE A 578
VAL A 599
VAL A 614
PHE A 566
None
1.05A 2ygoA-5u6kA:
undetectable
2ygoA-5u6kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR


(Homo sapiens)
no annotation 5 ILE A 475
ILE A 574
ILE A 477
VAL A 522
VAL A 524
None
1.06A 2ygoA-5u8qA:
undetectable
2ygoA-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2


(Homo sapiens)
no annotation 5 LEU H 134
ILE H  68
ILE H  72
ILE H 136
VAL H 117
None
0.89A 2ygoA-5vfrH:
undetectable
2ygoA-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi)
no annotation 6 LEU A 236
ILE A 226
ILE A 203
PHE A 135
ILE A 241
VAL A  21
None
1.45A 2ygoA-6d46A:
undetectable
2ygoA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae)
no annotation 5 LEU A 755
ILE A 801
ILE A 782
ILE A 741
ILE A 863
None
0.96A 2ygoA-6eojA:
undetectable
2ygoA-6eojA:
8.92