SIMILAR PATTERNS OF AMINO ACIDS FOR 2YGO_A_PCFA1213

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am2 MXE GYRA INTEIN

(Mycobacterium
xenopi) 		no annotation 6 ILE A 190
ILE A 105
PHE A 110
ILE A   2
VAL A  61
VAL A 166
 None
 1.49A 2ygoA-1am2A:
0.0		 2ygoA-1am2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		5 ILE A 110
ILE A 141
ILE A 108
PHE A 163
VAL A  93
 None
 1.06A 2ygoA-1atgA:
0.0		 2ygoA-1atgA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		5 LEU A 107
ILE A 105
ILE A  79
ILE A  81
PHE A 118
 None
 0.90A 2ygoA-1bg6A:
undetectable		 2ygoA-1bg6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii) 		PF01351
(RNase_HII) 		5 ILE A 109
ILE A   4
ILE A   6
ILE A 132
PHE A 125
 None
 0.83A 2ygoA-1ekeA:
0.0		 2ygoA-1ekeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 B
CHAIN)

(Trichosanthes
kirilowii) 		PF00652
(Ricin_B_lectin) 		5 LEU B  69
ILE B 103
ILE B  97
ILE B  62
VAL B  28
 None
 1.09A 2ygoA-1ggpB:
0.0		 2ygoA-1ggpB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i21 GLUCOSAMINE-PHOSPHAT
E
N-ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1) 		5 ILE A  81
ILE A  97
ILE A 131
PHE A 148
ILE A   9
 None
 1.01A 2ygoA-1i21A:
0.1		 2ygoA-1i21A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		5 LEU A  35
ILE A  63
ILE A   5
ILE A  30
PHE A 160
 None
 1.03A 2ygoA-1jiuA:
0.0		 2ygoA-1jiuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU X 313
ILE X 107
ILE X 106
MET X 141
PHE X 139
 None
 1.03A 2ygoA-1js1X:
undetectable		 2ygoA-1js1X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 ILE B 483
ILE B 481
MET B 479
ILE B 419
MET B 447
PHE B 663
 None
 1.33A 2ygoA-1n60B:
undetectable		 2ygoA-1n60B:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		6 ILE X 494
ILE X 526
PHE X 561
MET X 423
VAL X 479
VAL X 482
 None
 1.48A 2ygoA-1ogoX:
undetectable		 2ygoA-1ogoX:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		5 LEU A 309
ILE A 280
ILE A 258
PHE A 278
VAL A 343
 None
 0.99A 2ygoA-1olpA:
undetectable		 2ygoA-1olpA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 279
ILE A 281
ILE A 335
PHE A 212
VAL A 248
 None
None
None
None
PGE  A1403 ( 4.1A)
 1.01A 2ygoA-1ozhA:
undetectable		 2ygoA-1ozhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 214
ILE A 279
ILE A 281
ILE A 335
PHE A 212
 None
 0.94A 2ygoA-1ozhA:
undetectable		 2ygoA-1ozhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4p OUTER SURFACE
PROTEIN B

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		5 LEU A 186
ILE A 285
ILE A 190
ILE A 248
VAL A 203
 None
 1.01A 2ygoA-1p4pA:
undetectable		 2ygoA-1p4pA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 223
ILE A 272
MET A 280
PHE A 284
VAL A 245
 None
 0.88A 2ygoA-1pdzA:
undetectable		 2ygoA-1pdzA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  67
ILE A  85
ILE A  38
PHE A  70
VAL A 280
 None
 1.08A 2ygoA-1pxtA:
undetectable		 2ygoA-1pxtA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		5 LEU A 453
ILE A 460
ILE A 457
ILE A 266
PHE A 213
 None
 0.98A 2ygoA-1t8wA:
undetectable		 2ygoA-1t8wA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		5 LEU A 101
ILE A  99
ILE A  70
ILE A  72
PHE A  52
 None
 0.99A 2ygoA-1tv8A:
undetectable		 2ygoA-1tv8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 LEU A  33
ILE A  30
ILE A 128
PHE A  64
VAL A  56
 None
 1.07A 2ygoA-1ty2A:
undetectable		 2ygoA-1ty2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A   6
ILE A  58
ILE A 104
PHE A  11
VAL A  34
 None
 1.06A 2ygoA-2awaA:
undetectable		 2ygoA-2awaA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		5 ILE A 101
ILE A  39
ILE A 153
PHE A  49
VAL A 148
 None
 1.08A 2ygoA-2e47A:
undetectable		 2ygoA-2e47A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edm 22KDA STRUCTURAL
PROTEIN VP22

(White spot
syndrome virus) 		PF12175
(WSS_VP) 		5 LEU A 128
ILE A 130
ILE A 159
PHE A 189
VAL A  76
 None
 0.71A 2ygoA-2edmA:
undetectable		 2ygoA-2edmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B

(Homo sapiens) 		PF00378
(ECH_1) 		5 LEU A 321
ILE A 314
ILE A 317
PHE A 376
VAL A 385
 None
 1.08A 2ygoA-2fbmA:
undetectable		 2ygoA-2fbmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 5 LEU A  84
ILE A  39
ILE A  37
PHE A  52
PHE A   7
 None
 0.94A 2ygoA-2glwA:
undetectable		 2ygoA-2glwA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		5 LEU A  65
ILE A   5
ILE A   3
MET A   1
ILE A 173
 None
 1.03A 2ygoA-2gwgA:
undetectable		 2ygoA-2gwgA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 5 LEU A 185
ILE A 102
ILE A 153
ILE A  82
PHE A 165
 None
 1.03A 2ygoA-2invA:
undetectable		 2ygoA-2invA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 ILE A 117
ILE A 145
ILE A 141
ILE A  82
VAL A 227
 None
 1.00A 2ygoA-2pi5A:
undetectable		 2ygoA-2pi5A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qoj INTRON-ENCODED DNA
ENDONUCLEASE I-ANII

(Aspergillus
nidulans) 		PF00961
(LAGLIDADG_1) 		5 ILE Z 169
ILE Z 145
PHE Z 167
ILE Z 132
VAL Z 221
 None
 1.02A 2ygoA-2qojZ:
undetectable		 2ygoA-2qojZ:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygn WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		7 LEU A  38
ILE A  40
ILE A  55
ILE A  57
ILE A  84
MET A  87
PHE A  89
 PCF  A1179 ( 4.0A)
None
PCF  A1179 ( 4.5A)
PCF  A1179 ( 4.7A)
None
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
 1.30A 2ygoA-2ygnA:
28.2		 2ygoA-2ygnA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygn WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
MET A  63
PHE A  66
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PHE A 173
 PCF  A1179 ( 4.0A)
None
PCF  A1179 ( 4.5A)
PCF  A1179 ( 4.7A)
PCF  A1179 ( 4.1A)
PCF  A1179 (-3.8A)
None
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
PCF  A1179 (-4.4A)
PCF  A1179 ( 4.7A)
PCF  A1179 (-3.8A)
 0.12A 2ygoA-2ygnA:
28.2		 2ygoA-2ygnA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		7 LEU A  38
ILE A  40
ILE A  55
ILE A  57
ILE A  84
MET A  87
PHE A  89
 PCF  A1213 ( 3.9A)
None
PCF  A1213 (-4.0A)
PCF  A1213 ( 4.8A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
 1.32A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
MET A  63
PHE A  66
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PHE A 173
 PCF  A1213 ( 3.9A)
None
PCF  A1213 (-4.0A)
PCF  A1213 ( 4.8A)
PCF  A1213 ( 4.2A)
PCF  A1213 ( 3.6A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 4.7A)
PCF  A1213 ( 4.7A)
PCF  A1213 (-3.8A)
 0.00A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF)
PF12661
(hEGF) 		6 ILE A  40
ILE A  55
ILE A  57
ILE A  84
PHE A  89
VAL A 152
 None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
None
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
 1.39A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF)
PF12661
(hEGF) 		6 ILE A  40
ILE A  55
ILE A  57
PHE A  66
PHE A  89
VAL A 152
 None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
None
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
 1.25A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF)
PF12661
(hEGF) 		7 LEU A  38
ILE A  40
ILE A  55
ILE A  57
ILE A  84
MET A  87
PHE A  89
 None
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
None
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
 1.29A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF)
PF12661
(hEGF) 		12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
MET A  63
PHE A  66
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PHE A 173
 None
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
PCF  A1275 ( 4.1A)
None
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
PCF  A1275 ( 4.5A)
 0.39A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF)
PF12661
(hEGF) 		6 LEU A  38
ILE A  40
ILE A  57
MET A  63
ILE A  80
PHE A 173
 None
None
PCF  A1275 ( 4.5A)
PCF  A1275 ( 4.1A)
PCF  A1275 (-4.7A)
PCF  A1275 ( 4.5A)
 1.10A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ILE A 161
ILE A 164
MET A 193
PHE A 166
ILE A 133
 None
 1.00A 2ygoA-3b2dA:
undetectable		 2ygoA-3b2dA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 5 ILE A 159
ILE A 149
ILE A  11
VAL A  74
VAL A  72
 None
 0.98A 2ygoA-3c8vA:
undetectable		 2ygoA-3c8vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flt SAP-LIKE PENTRAXIN

(Limulus
polyphemus) 		PF00354
(Pentaxin) 		5 ILE A 194
ILE A   4
PHE A 201
VAL A 209
VAL A 207
 None
 1.05A 2ygoA-3fltA:
undetectable		 2ygoA-3fltA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00132
(Hexapep) 		5 ILE A 121
ILE A 103
ILE A 115
PHE A  95
VAL A 149
 None
 0.91A 2ygoA-3fscA:
undetectable		 2ygoA-3fscA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)

(Photorhabdus
laumondii) 		PF16374
(CIF) 		5 ILE A 198
ILE A 185
ILE A 250
PHE A 183
VAL A 274
 None
 1.06A 2ygoA-3gqjA:
undetectable		 2ygoA-3gqjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpe CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF04264
(YceI) 		6 LEU A  84
ILE A  70
ILE A  73
PHE A  90
VAL A 171
VAL A  33
 ERU  A 301 ( 4.8A)
None
None
ERU  A 301 (-4.8A)
ERU  A 301 ( 4.8A)
None
 1.31A 2ygoA-3hpeA:
undetectable		 2ygoA-3hpeA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B

(Legionella
pneumophila) 		PF02421
(FeoB_N) 		5 ILE A 154
ILE A 146
MET A 120
ILE A  52
VAL A 114
 None
 1.07A 2ygoA-3ibyA:
undetectable		 2ygoA-3ibyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 LEU A 351
ILE A 349
ILE A 337
PHE A 342
VAL A 530
 None
 1.08A 2ygoA-3m62A:
undetectable		 2ygoA-3m62A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 LEU A 219
ILE A 198
ILE A 177
VAL A 205
VAL A 232
 None
 1.06A 2ygoA-3o21A:
undetectable		 2ygoA-3o21A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oes GTPASE RHEBL1

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A 103
ILE A  96
ILE A 159
VAL A   9
VAL A  78
 None
 1.08A 2ygoA-3oesA:
undetectable		 2ygoA-3oesA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ILE A 297
ILE A 301
PHE A 304
ILE A 648
PHE A 160
 None
 1.07A 2ygoA-3pocA:
undetectable		 2ygoA-3pocA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 ILE A  97
ILE A 116
VAL A 151
VAL A 153
PHE A 160
 None
 0.99A 2ygoA-3qmlA:
undetectable		 2ygoA-3qmlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ILE A  40
ILE A  22
ILE A  34
ILE A  63
VAL A  81
 None
 1.08A 2ygoA-3r0sA:
undetectable		 2ygoA-3r0sA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsj BONT/F

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 ILE A 970
ILE A 958
ILE A 936
ILE A1009
PHE A1010
 None
 0.91A 2ygoA-3rsjA:
undetectable		 2ygoA-3rsjA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 LEU A 178
ILE A 180
ILE A  80
ILE A  82
PHE A 167
 None
 0.48A 2ygoA-3tm5A:
undetectable		 2ygoA-3tm5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 LEU A 927
ILE A 937
ILE A 566
MET A 536
PHE A 511
 None
 0.79A 2ygoA-3u6nA:
undetectable		 2ygoA-3u6nA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvf INTRON-ENCODED DNA
ENDONUCLEASE I-HJEMI

(Trichoderma
reesei) 		PF00961
(LAGLIDADG_1) 		5 ILE A 171
ILE A 147
PHE A 169
ILE A 134
VAL A 223
 None
 1.05A 2ygoA-3uvfA:
undetectable		 2ygoA-3uvfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3k CASPASE-9

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 ILE A 282
ILE A 234
ILE A 327
VAL A 212
PHE A 265
 None
 1.07A 2ygoA-3v3kA:
undetectable		 2ygoA-3v3kA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		5 ILE A 242
ILE A 505
ILE A 503
ILE A 579
VAL A 226
 None
 0.92A 2ygoA-4ag6A:
undetectable		 2ygoA-4ag6A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asm BETA-AGARASE D

(Zobellia
galactanivorans) 		no annotation 5 LEU B 147
ILE B 145
ILE B 318
ILE B 316
VAL B 128
 None
 0.90A 2ygoA-4asmB:
undetectable		 2ygoA-4asmB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		5 ILE A 277
PHE A 259
MET A 321
PHE A 317
VAL A 286
 None
 0.97A 2ygoA-4bhiA:
undetectable		 2ygoA-4bhiA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 LEU A 386
ILE A 392
ILE A 410
ILE A 374
VAL A 358
 None
 0.98A 2ygoA-4cp6A:
undetectable		 2ygoA-4cp6A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cq6 ALLENE OXIDE CYCLASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06351
(Allene_ox_cyc) 		5 LEU A 146
ILE A 121
ILE A 183
PHE A 122
VAL A  21
 None
 1.00A 2ygoA-4cq6A:
undetectable		 2ygoA-4cq6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 5 ILE P 177
ILE P  66
ILE P 181
MET P 188
PHE P  91
 None
 0.93A 2ygoA-4dvyP:
undetectable		 2ygoA-4dvyP:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5c PRCV SPIKE PROTEIN

(Alphacoronavirus
1) 		PF01600
(Corona_S1) 		5 LEU E 317
ILE E 315
ILE E 295
ILE E 293
PHE E 399
 None
 1.03A 2ygoA-4f5cE:
undetectable		 2ygoA-4f5cE:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvv NEUROTOXIN

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 LEU A 870
ILE A 936
ILE A 954
PHE A1069
VAL A 889
 None
 1.02A 2ygoA-4fvvA:
undetectable		 2ygoA-4fvvA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		5 LEU A 465
ILE A 467
ILE A 411
ILE A 409
PHE A 440
 None
 0.82A 2ygoA-4fxqA:
undetectable		 2ygoA-4fxqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 210
ILE A 288
ILE A 290
ILE A 402
VAL A 270
 None
 1.04A 2ygoA-4gv1A:
undetectable		 2ygoA-4gv1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE

(Solanum
tuberosum) 		PF00332
(Glyco_hydro_17) 		5 LEU A 248
ILE A 182
ILE A 185
ILE A 186
PHE A 174
 None
 0.98A 2ygoA-4gziA:
undetectable		 2ygoA-4gziA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 5 ILE E  16
ILE E  18
PHE E 157
VAL E 305
VAL E 307
 None
FAD  E 505 (-4.9A)
None
SO3  E 501 (-4.7A)
None
 1.03A 2ygoA-4kprE:
undetectable		 2ygoA-4kprE:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		6 ILE A 121
ILE A 123
ILE A 141
MET A 190
VAL A 157
VAL A 155
 None
 1.31A 2ygoA-4kxbA:
undetectable		 2ygoA-4kxbA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Mycobacterium
avium) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 LEU A 316
ILE A 314
ILE A 204
ILE A 206
MET A 266
 None
 0.99A 2ygoA-4lgvA:
undetectable		 2ygoA-4lgvA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3c LECTIN BETA CHAIN

(Butea
monosperma) 		PF00139
(Lectin_legB) 		5 LEU B 204
ILE B 210
ILE B  57
ILE B  59
VAL B 198
 None
None
ABU  B 303 (-3.7A)
None
None
 0.96A 2ygoA-4m3cB:
undetectable		 2ygoA-4m3cB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE

(Brucella suis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A  83
ILE A  24
PHE A  19
PHE A  37
VAL A 120
 None
 0.99A 2ygoA-4o5mA:
undetectable		 2ygoA-4o5mA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 295
ILE A 345
PHE A 413
VAL A 371
VAL A 422
 None
 1.04A 2ygoA-4o7dA:
undetectable		 2ygoA-4o7dA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 ILE A  73
ILE A 212
ILE A 243
VAL A 320
VAL A 278
 None
 1.07A 2ygoA-4p4sA:
undetectable		 2ygoA-4p4sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 5 ILE H  65
ILE H 152
PHE H  93
VAL H 118
PHE H 122
 None
 0.90A 2ygoA-4qfkH:
undetectable		 2ygoA-4qfkH:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 5 LEU B 430
ILE B 343
ILE B 372
MET B 336
PHE B 334
 None
None
None
FA5  B 701 (-4.2A)
None
 1.07A 2ygoA-4r0mB:
undetectable		 2ygoA-4r0mB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		5 LEU A 106
ILE A 108
ILE A 100
ILE A 102
PHE A 121
 None
 0.84A 2ygoA-4rnzA:
undetectable		 2ygoA-4rnzA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9l HEAT SHOCK PROTEIN

(Oryza sativa) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 209
ILE A 207
ILE A  66
ILE A  68
PHE A  32
 None
 1.09A 2ygoA-4x9lA:
undetectable		 2ygoA-4x9lA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		no annotation 5 LEU A 561
ILE A 630
PHE A 623
ILE A 594
PHE A 555
 None
 1.08A 2ygoA-4yomA:
undetectable		 2ygoA-4yomA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af3 VAPBC49

(Mycobacterium
tuberculosis) 		PF04255
(DUF433) 		5 LEU A  96
ILE A  55
ILE A  54
VAL A  87
VAL A 137
 None
 0.87A 2ygoA-5af3A:
undetectable		 2ygoA-5af3A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 LEU A 667
ILE A 669
ILE A 681
ILE A 683
PHE A 711
 None
 0.89A 2ygoA-5azaA:
undetectable		 2ygoA-5azaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 5 LEU A1539
ILE A1544
ILE A1593
PHE A1576
VAL A1559
 None
 1.06A 2ygoA-5b2oA:
undetectable		 2ygoA-5b2oA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		5 ILE A 274
ILE A 226
ILE A 305
ILE A 230
VAL A 212
 None
 1.06A 2ygoA-5b3fA:
undetectable		 2ygoA-5b3fA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		5 LEU A 227
ILE A 282
ILE A 234
ILE A 231
VAL A 193
 None
 1.07A 2ygoA-5by6A:
undetectable		 2ygoA-5by6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 300
ILE A 350
PHE A 418
VAL A 376
VAL A 427
 None
 1.05A 2ygoA-5d3oA:
undetectable		 2ygoA-5d3oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gan PRE-MRNA-PROCESSING
FACTOR 31

(Saccharomyces
cerevisiae) 		PF01798
(Nop)
PF09785
(Prp31_C) 		5 ILE F 101
ILE F 105
ILE F 214
ILE F  46
PHE F  98
 None
 1.03A 2ygoA-5ganF:
undetectable		 2ygoA-5ganF:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori) 		PF02170
(PAZ)
PF02171
(Piwi) 		5 ILE A 846
ILE A 776
PHE A 815
ILE A 659
VAL A 869
 None
 1.03A 2ygoA-5guhA:
undetectable		 2ygoA-5guhA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzx NUDIX (NUCLEOSIDE
DIPHOSPHATE LINKED
MOIETY X)-TYPE MOTIF
1

(Danio rerio) 		PF00293
(NUDIX) 		5 LEU A   9
ILE A  67
ILE A  85
PHE A 133
ILE A 108
 2GE  A 201 (-4.0A)
None
None
None
None
 1.00A 2ygoA-5hzxA:
undetectable		 2ygoA-5hzxA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Acinetobacter
baumannii) 		PF00005
(ABC_tran) 		5 ILE A  96
ILE A 197
PHE A  41
VAL A  68
VAL A 245
 None
 1.00A 2ygoA-5idvA:
undetectable		 2ygoA-5idvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus musculus) 		no annotation 5 LEU A 634
ILE A 709
PHE A 702
ILE A 667
PHE A 628
 None
 1.07A 2ygoA-5iriA:
undetectable		 2ygoA-5iriA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6c PUTATIVE REDUCTASE

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		6 LEU A  60
ILE A 151
ILE A 119
PHE A  74
ILE A 105
VAL A  25
 None
None
FMN  A 201 (-4.8A)
FMN  A 201 (-4.7A)
None
None
 1.50A 2ygoA-5j6cA:
undetectable		 2ygoA-5j6cA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE

(Dictyostelium
discoideum) 		PF00351
(Biopterin_H) 		5 LEU A 282
ILE A 230
ILE A 218
PHE A 251
VAL A 317
 None
 0.95A 2ygoA-5jk6A:
undetectable		 2ygoA-5jk6A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muw PACKAGING ENZYME P4

(Pseudomonas
virus phi6) 		PF11602
(NTPase_P4) 		5 LEU A  20
ILE A  36
ILE A  75
ILE A  41
ILE A 216
 None
 1.08A 2ygoA-5muwA:
undetectable		 2ygoA-5muwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 5 ILE A 104
ILE A  50
ILE A 106
ILE A 130
VAL A 207
 None
 1.09A 2ygoA-5nnyA:
undetectable		 2ygoA-5nnyA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		5 LEU A 530
ILE A 412
ILE A 463
ILE A 378
VAL A 423
 None
 0.98A 2ygoA-5nvrA:
undetectable		 2ygoA-5nvrA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sym ACYL-PROTEIN
THIOESTERASE 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 LEU A 189
ILE A 164
ILE A 166
PHE A 221
ILE A 100
 None
 0.97A 2ygoA-5symA:
undetectable		 2ygoA-5symA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6k DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Mus musculus) 		PF12738
(PTCB-BRCT) 		5 ILE A 585
ILE A 578
VAL A 599
VAL A 614
PHE A 566
 None
 1.05A 2ygoA-5u6kA:
undetectable		 2ygoA-5u6kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		no annotation 5 ILE A 475
ILE A 574
ILE A 477
VAL A 522
VAL A 524
 None
 1.06A 2ygoA-5u8qA:
undetectable		 2ygoA-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2

(Homo sapiens) 		no annotation 5 LEU H 134
ILE H  68
ILE H  72
ILE H 136
VAL H 117
 None
 0.89A 2ygoA-5vfrH:
undetectable		 2ygoA-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 6 LEU A 236
ILE A 226
ILE A 203
PHE A 135
ILE A 241
VAL A  21
 None
 1.45A 2ygoA-6d46A:
undetectable		 2ygoA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 755
ILE A 801
ILE A 782
ILE A 741
ILE A 863
 None
 0.96A 2ygoA-6eojA:
undetectable		 2ygoA-6eojA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csm CHORISMATE MUTASE

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 104
ILE A 103
PRO A  80
VAL A 197
 None
 1.08A 2ygoA-1csmA:
undetectable		 2ygoA-1csmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1del DEOXYNUCLEOSIDE
MONOPHOSPHATE KINASE

(Escherichia
virus T4) 		no annotation 4 LEU A 238
ILE A 234
MET A  22
VAL A 153
 None
 1.03A 2ygoA-1delA:
undetectable		 2ygoA-1delA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LEU A 104
ILE A 123
ARG A 384
PRO A 106
 None
 1.18A 2ygoA-1dq3A:
undetectable		 2ygoA-1dq3A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 159
ILE A 157
PRO A 176
VAL A  80
 None
 1.14A 2ygoA-1gg4A:
0.0		 2ygoA-1gg4A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 LEU B 416
ILE B 415
PRO B 396
VAL B 439
 None
 1.14A 2ygoA-1gh6B:
undetectable		 2ygoA-1gh6B:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A 170
ILE A 172
PRO A 269
VAL A 203
 None
 1.12A 2ygoA-1h74A:
0.0		 2ygoA-1h74A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 362
ARG A 199
PRO A 201
VAL A 348
 None
ADX  A 574 (-3.7A)
None
None
 1.16A 2ygoA-1i2dA:
0.0		 2ygoA-1i2dA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00977
(His_biosynth) 		4 LEU F 238
ILE F 235
ARG F 250
VAL F 191
 None
 1.01A 2ygoA-1ka9F:
undetectable		 2ygoA-1ka9F:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 999
MET A 968
PRO A1001
VAL A 801
 None
 1.19A 2ygoA-1kcwA:
2.0		 2ygoA-1kcwA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 LEU A 464
ILE A 466
PRO A 478
VAL A 153
 None
 1.13A 2ygoA-1nr6A:
0.0		 2ygoA-1nr6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 4 LEU A  74
ILE A  78
PRO A 105
VAL A 141
 None
 1.18A 2ygoA-1qi9A:
0.0		 2ygoA-1qi9A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 LEU A 518
ILE A 515
PRO A 367
VAL A 645
 None
 1.17A 2ygoA-1uf2A:
undetectable		 2ygoA-1uf2A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjt LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		4 LEU A 182
ARG A  97
MET A 101
VAL A 157
 None
 1.19A 2ygoA-1xjtA:
undetectable		 2ygoA-1xjtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xju LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		4 LEU A 182
ARG A  97
MET A 101
VAL A 157
 None
 1.07A 2ygoA-1xjuA:
undetectable		 2ygoA-1xjuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		4 LEU A 297
ILE A 325
ARG A  73
VAL A 140
 None
 1.18A 2ygoA-1xknA:
undetectable		 2ygoA-1xknA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 LEU A  78
ILE A  81
PRO A 220
VAL A  39
 None
 1.16A 2ygoA-1yirA:
undetectable		 2ygoA-1yirA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A  36
ILE A  70
MET A   1
PRO A   0
 None
 1.12A 2ygoA-1yw6A:
undetectable		 2ygoA-1yw6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 770
ILE A 774
ARG A 530
VAL A 314
 None
 1.08A 2ygoA-1z1wA:
undetectable		 2ygoA-1z1wA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 LEU A 220
ILE A 279
MET A 272
VAL A 103
 None
 1.17A 2ygoA-1zg4A:
undetectable		 2ygoA-1zg4A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axc COLICIN E7

(Escherichia
coli) 		PF03515
(Cloacin) 		4 LEU A 131
ILE A 191
PRO A  88
VAL A 162
 None
 1.15A 2ygoA-2axcA:
undetectable		 2ygoA-2axcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b61 HOMOSERINE
O-ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00561
(Abhydrolase_1) 		4 LEU A 355
ILE A 351
MET A  69
VAL A  27
 None
 0.95A 2ygoA-2b61A:
undetectable		 2ygoA-2b61A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		4 ILE A 483
ARG A 247
PRO A 899
VAL A  61
 None
 1.02A 2ygoA-2btvA:
undetectable		 2ygoA-2btvA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LEU A  78
ILE A  73
PRO A 101
VAL A 274
 None
 1.03A 2ygoA-2c2yA:
undetectable		 2ygoA-2c2yA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egp TRIPARTITE
MOTIF-CONTAINING
PROTEIN 34

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 LEU A  34
ILE A  39
PRO A  57
VAL A  78
 None
 1.06A 2ygoA-2egpA:
undetectable		 2ygoA-2egpA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ius DNA TRANSLOCASE FTSK

(Escherichia
coli) 		PF01580
(FtsK_SpoIIIE) 		4 ILE A1172
MET A 984
PRO A 985
VAL A1227
 None
 1.05A 2ygoA-2iusA:
undetectable		 2ygoA-2iusA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 ILE A 646
MET A 459
PRO A 460
VAL A 701
 None
 1.19A 2ygoA-2iutA:
undetectable		 2ygoA-2iutA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 ILE A 646
MET A 459
PRO A 460
VAL A 701
 None
 1.14A 2ygoA-2iuuA:
undetectable		 2ygoA-2iuuA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		4 LEU A  73
ILE A  70
MET A  61
VAL A 155
 None
 1.14A 2ygoA-2jfwA:
undetectable		 2ygoA-2jfwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 ILE A 331
ARG A 385
PRO A 351
VAL A 295
 None
 0.99A 2ygoA-2jgdA:
undetectable		 2ygoA-2jgdA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p19 TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF07702
(UTRA) 		4 LEU A  78
ILE A 128
PRO A  58
VAL A  50
 None
 0.90A 2ygoA-2p19A:
undetectable		 2ygoA-2p19A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 160
ILE A 157
MET A 457
VAL A 365
 None
 1.12A 2ygoA-2pg6A:
undetectable		 2ygoA-2pg6A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		4 LEU A 585
ILE A 594
PRO A 558
VAL A 515
 None
 1.06A 2ygoA-2rkcA:
undetectable		 2ygoA-2rkcA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ILE A 441
MET A 431
PRO A 430
VAL A 608
 None
 1.13A 2ygoA-2v5dA:
undetectable		 2ygoA-2v5dA:
11.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygn WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		5 LEU A  48
ILE A  49
MET A  77
PRO A  78
VAL A 156
 PCF  A1179 (-4.1A)
PCF  A1179 (-4.8A)
PCF  A1179 (-4.0A)
PCF  A1179 (-4.3A)
None
 0.25A 2ygoA-2ygnA:
28.2		 2ygoA-2ygnA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		6 LEU A  48
ILE A  49
ARG A  76
MET A  77
PRO A  78
VAL A 156
 PCF  A1213 (-4.3A)
PCF  A1213 (-4.6A)
PCF  A1213 (-3.6A)
PCF  A1213 (-3.5A)
PCF  A1213 (-4.0A)
None
 0.00A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		4 LEU A  48
ILE A  49
PRO A  78
VAL A 127
 PCF  A1213 (-4.3A)
PCF  A1213 (-4.6A)
PCF  A1213 (-4.0A)
None
 1.12A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF)
PF12661
(hEGF) 		4 LEU A  48
ILE A  49
MET A  77
VAL A 156
 PCF  A1275 (-4.6A)
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
None
 0.95A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb3 PROSTAGLANDIN
REDUCTASE 2

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 LEU A 217
ARG A 280
MET A 244
VAL A 263
 None
 1.04A 2ygoA-2zb3A:
undetectable		 2ygoA-2zb3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 ILE A 416
MET A 421
PRO A 420
VAL A 482
 None
 1.12A 2ygoA-3d8bA:
undetectable		 2ygoA-3d8bA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		4 LEU B 292
ILE B 293
PRO B 297
VAL B 242
 None
 1.07A 2ygoA-3hrdB:
undetectable		 2ygoA-3hrdB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri;
Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF02738
(Ald_Xan_dh_C2) 		4 ILE B  15
ARG A 319
PRO B 290
VAL A 205
 None
NIO  B5661 (-4.3A)
None
None
 1.08A 2ygoA-3hrdB:
undetectable		 2ygoA-3hrdB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		4 LEU A 392
ILE A 402
MET A 465
VAL A 438
 None
 1.13A 2ygoA-3j4jA:
undetectable		 2ygoA-3j4jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		4 LEU X 257
ARG X 215
MET X 214
VAL X 229
 None
 1.04A 2ygoA-3o59X:
undetectable		 2ygoA-3o59X:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 LEU A 429
ILE A 417
MET A 410
VAL A 164
 None
 0.79A 2ygoA-3odmA:
undetectable		 2ygoA-3odmA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 160
ILE A 161
PRO A 164
VAL A 246
 None
 1.17A 2ygoA-3olzA:
undetectable		 2ygoA-3olzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		4 LEU A  71
ILE A  90
ARG A 125
VAL A 189
 None
 1.01A 2ygoA-3pmmA:
undetectable		 2ygoA-3pmmA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqy ALPHA CHAIN OF THE
6218-TCR

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 LEU D  89
ILE D  90
MET D  78
VAL D 174
 None
 0.99A 2ygoA-3pqyD:
undetectable		 2ygoA-3pqyD:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOA

(Methylocystis
sp. M) 		no annotation 4 ILE J 189
ARG J 195
PRO J 120
VAL J  98
 None
 1.17A 2ygoA-3rfrJ:
undetectable		 2ygoA-3rfrJ:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 LEU A 517
ILE A 386
PRO A 498
VAL A 403
 None
 0.95A 2ygoA-3sqlA:
undetectable		 2ygoA-3sqlA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE C1007
ARG C 880
PRO C1262
VAL C 764
 None
 1.10A 2ygoA-3sr6C:
undetectable		 2ygoA-3sr6C:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 LEU A  63
ILE A  67
MET A 289
VAL A 186
 None
 1.10A 2ygoA-3tsyA:
undetectable		 2ygoA-3tsyA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vaa SHIKIMATE KINASE

(Bacteroides
thetaiotaomicron) 		PF01202
(SKI) 		4 LEU A 156
ILE A 162
ARG A  23
VAL A  44
 None
 1.18A 2ygoA-3vaaA:
undetectable		 2ygoA-3vaaA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		4 LEU A  55
ILE A  53
PRO A  80
VAL A 187
 None
 1.11A 2ygoA-3w5iA:
undetectable		 2ygoA-3w5iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		4 LEU A 327
ILE A  48
PRO A  17
VAL A 252
 None
 1.15A 2ygoA-3wecA:
undetectable		 2ygoA-3wecA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 169
ILE A 172
PRO A 246
VAL A  38
 None
 1.11A 2ygoA-3wgkA:
undetectable		 2ygoA-3wgkA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 LEU A 220
ILE A 279
MET A 272
VAL A 103
 None
None
SO4  A1292 (-4.1A)
None
 1.03A 2ygoA-3zdjA:
undetectable		 2ygoA-3zdjA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 LEU A 441
ILE A 436
ARG A 274
VAL A 376
 None
 1.03A 2ygoA-4atqA:
undetectable		 2ygoA-4atqA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 165
ILE A 211
PRO A 182
VAL A 320
 None
 1.17A 2ygoA-4cvmA:
undetectable		 2ygoA-4cvmA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		4 LEU A 318
ILE A 319
PRO A 321
VAL A 111
 None
 1.02A 2ygoA-4d1iA:
undetectable		 2ygoA-4d1iA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 LEU A 449
ILE A 369
PRO A 433
VAL A  57
 None
 1.03A 2ygoA-4djiA:
undetectable		 2ygoA-4djiA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A  47
MET A  45
PRO A  44
VAL A 129
 None
 1.12A 2ygoA-4eqaA:
undetectable		 2ygoA-4eqaA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmr UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
vulgatus) 		PF14734
(DUF4469)
PF14848
(HU-DNA_bdg) 		4 ILE A  37
ARG A  51
MET A  42
VAL A  75
 None
 1.15A 2ygoA-4fmrA:
undetectable		 2ygoA-4fmrA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 LEU A  36
ARG A  46
MET A  45
VAL A 216
 None
 0.98A 2ygoA-4gtnA:
undetectable		 2ygoA-4gtnA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA
ARSB

(Sporomusa
ovata;
Sporomusa ovata) 		PF02277
(DBI_PRT)
PF02277
(DBI_PRT) 		4 LEU A  36
ARG B  83
PRO B  93
VAL B 291
 None
 1.17A 2ygoA-4hdsA:
undetectable		 2ygoA-4hdsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Mycobacterium
tuberculosis) 		PF00925
(GTP_cyclohydro2)
PF00926
(DHBP_synthase) 		4 ILE A  96
ARG A 110
MET A 109
VAL A 167
 None
 1.13A 2ygoA-4i14A:
undetectable		 2ygoA-4i14A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		4 ILE A  87
MET A 133
PRO A 132
VAL A  46
 None
 1.12A 2ygoA-4icqA:
undetectable		 2ygoA-4icqA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 LEU A  32
ILE A  55
ARG A  24
MET A  20
VAL A 134
 None
 1.36A 2ygoA-4inaA:
undetectable		 2ygoA-4inaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		4 ILE A 313
MET A 309
PRO A 310
VAL A 166
 None
 1.17A 2ygoA-4iqlA:
undetectable		 2ygoA-4iqlA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 111
ILE A  98
MET A 100
VAL A 299
 None
 1.02A 2ygoA-4l1fA:
undetectable		 2ygoA-4l1fA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 LEU B 395
ILE B 398
MET B 373
VAL B  81
 None
 1.01A 2ygoA-4mrmB:
undetectable		 2ygoA-4mrmB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 LEU A 276
ILE A 277
MET A 328
VAL A  70
 None
 1.15A 2ygoA-4n7tA:
undetectable		 2ygoA-4n7tA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 LEU A 405
ILE A 406
ARG A 247
VAL A  83
 None
 1.08A 2ygoA-4ofzA:
undetectable		 2ygoA-4ofzA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6g PYRROLYSINE--TRNA
LIGASE

(Methanosarcina
mazei) 		PF01409
(tRNA-synt_2d) 		4 LEU A 284
ILE A 278
PRO A 299
VAL A 377
 None
 1.16A 2ygoA-4q6gA:
undetectable		 2ygoA-4q6gA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_5) 		4 ILE C  58
MET A 880
PRO A 879
VAL A 421
 None
 1.10A 2ygoA-4qiwC:
undetectable		 2ygoA-4qiwC:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  80
ARG A 361
PRO A  28
VAL A 348
 None
 1.07A 2ygoA-4uzsA:
undetectable		 2ygoA-4uzsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF00155
(Aminotran_1_2) 		4 LEU A 359
ILE A 292
PRO A 364
VAL A 339
 None
 1.17A 2ygoA-4wbtA:
undetectable		 2ygoA-4wbtA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 LEU A 536
ILE A 210
ARG A 522
PRO A 529
 EDO  A1001 ( 4.8A)
None
None
None
 1.10A 2ygoA-4xprA:
undetectable		 2ygoA-4xprA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 LEU D 350
ILE D 347
ARG D 432
VAL D 217
 None
 1.19A 2ygoA-4yg7D:
undetectable		 2ygoA-4yg7D:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ILE A 441
MET A 431
PRO A 430
VAL A 608
 None
 1.17A 2ygoA-4zxlA:
undetectable		 2ygoA-4zxlA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 4 LEU A 307
ILE A 301
ARG A 322
VAL A 141
 None
 1.15A 2ygoA-5aa6A:
undetectable		 2ygoA-5aa6A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		4 LEU A 350
ILE A 407
MET A 400
VAL A 233
 None
 1.10A 2ygoA-5aqaA:
undetectable		 2ygoA-5aqaA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 LEU A 934
ILE A 935
ARG A1006
VAL A 364
 None
 1.17A 2ygoA-5aw4A:
undetectable		 2ygoA-5aw4A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A  12
ILE A  13
ARG A  69
VAL A 314
 None
 1.02A 2ygoA-5c70A:
undetectable		 2ygoA-5c70A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 454
ILE A 471
ARG A 532
VAL A   5
 None
 1.02A 2ygoA-5e6sA:
undetectable		 2ygoA-5e6sA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  76
ARG A 355
PRO A  22
VAL A 342
 None
 1.16A 2ygoA-5e9aA:
undetectable		 2ygoA-5e9aA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 LEU A 265
ILE A 178
PRO A  98
VAL A 135
 None
 1.13A 2ygoA-5gslA:
undetectable		 2ygoA-5gslA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A 352
ILE A 366
PRO A 292
VAL A  96
 None
 1.17A 2ygoA-5h1kA:
undetectable		 2ygoA-5h1kA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 LEU A 514
ILE A 517
MET A 536
VAL A 624
 None
 1.10A 2ygoA-5h2vA:
undetectable		 2ygoA-5h2vA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 LEU A  94
ILE A  92
MET A  85
VAL A 189
 None
 1.19A 2ygoA-5husA:
undetectable		 2ygoA-5husA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgy ALDOSE REDUCTASE,
AKR4C13

(Zea mays) 		PF00248
(Aldo_ket_red) 		4 LEU A 141
ARG A 148
PRO A  95
VAL A 210
 None
 1.10A 2ygoA-5jgyA:
undetectable		 2ygoA-5jgyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Homo sapiens) 		PF00076
(RRM_1)
PF08662
(eIF2A) 		4 LEU B 346
ILE B 370
ARG B 395
PRO B 387
 None
 1.17A 2ygoA-5k1hB:
undetectable		 2ygoA-5k1hB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o00 GLUTATHIONE
TRANSFERASE URE2P5

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  78
ILE A 168
MET A  23
VAL A 185
 None
 1.19A 2ygoA-5o00A:
undetectable		 2ygoA-5o00A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5

(Homo sapiens) 		no annotation 4 LEU A  79
ILE A  77
PRO A 120
VAL A 111
 None
 1.17A 2ygoA-5o8fA:
undetectable		 2ygoA-5o8fA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		4 ARG A  27
MET A  26
PRO A  25
VAL A 138
 CL  A 404 (-4.5A)
None
None
None
 1.15A 2ygoA-5trwA:
undetectable		 2ygoA-5trwA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE

(Homo sapiens) 		no annotation 4 LEU A 107
ILE A 104
PRO A 116
VAL A 223
 None
 1.03A 2ygoA-5wy0A:
undetectable		 2ygoA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		4 LEU F  68
ILE F  72
MET F 103
PRO F 105
 None
 1.07A 2ygoA-5x5yF:
undetectable		 2ygoA-5x5yF:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 4 ILE U  66
ARG U  40
MET U 145
VAL U 111
 None
 0.96A 2ygoA-5zvtU:
undetectable		 2ygoA-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 4 LEU A 240
ILE A 239
ARG A 227
VAL A 278
 None
None
EDO  A 502 ( 4.6A)
CL  A 503 ( 4.5A)
 1.14A 2ygoA-6bqlA:
undetectable		 2ygoA-6bqlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 4 LEU A  23
ARG A  76
PRO A  91
VAL A 285
 None
 1.03A 2ygoA-6dawA:
undetectable		 2ygoA-6dawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 4 LEU E  79
ILE E  77
PRO E 120
VAL E 111
 None
 1.12A 2ygoA-6dw1E:
undetectable		 2ygoA-6dw1E:
undetectable