SIMILAR PATTERNS OF AMINO ACIDS FOR 2YGN_A_PCFA1179_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE


(Thermotoga
maritima)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 LEU A 150
ILE A  95
LEU A  40
MET A  22
VAL A 298
None
1.10A 2ygnA-1a5zA:
undetectable
2ygnA-1a5zA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa)
PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target)
5 LEU A  49
ILE A  66
ARG A 154
ILE A 167
MET A  47
None
None
CL  A 701 (-4.1A)
None
None
1.12A 2ygnA-1ikpA:
0.0
2ygnA-1ikpA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1klp MEROMYCOLATE
EXTENSION ACYL
CARRIER PROTEIN


(Mycobacterium
tuberculosis)
PF00550
(PP-binding)
5 ILE A  16
LEU A  37
ILE A  27
MET A  44
VAL A  57
None
1.01A 2ygnA-1klpA:
undetectable
2ygnA-1klpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus)
PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N)
5 ILE X 494
ILE X 526
MET X 423
VAL X 479
VAL X 482
None
1.08A 2ygnA-1ogoX:
0.0
2ygnA-1ogoX:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi)
PF00544
(Pec_lyase_C)
5 LEU A 361
ILE A 123
ILE A 162
ILE A 106
VAL A 116
None
1.04A 2ygnA-1pe9A:
undetectable
2ygnA-1pe9A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5


(Mycobacterium
tuberculosis)
PF00668
(Condensation)
PF16911
(PapA_C)
5 LEU A 285
ILE A 307
LEU A 303
ARG A 253
ILE A 300
None
1.13A 2ygnA-1q9jA:
0.0
2ygnA-1q9jA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhv PROTEIN (ADENOVIRUS
FIBRE)


(Human
mastadenovirus
C)
PF00541
(Adeno_knob)
5 ILE A 534
LEU A 536
ILE A 516
MET A 553
PHE A 555
None
1.07A 2ygnA-1qhvA:
0.0
2ygnA-1qhvA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus)
PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small)
5 ILE A 266
LEU A 224
ARG A 189
ILE A 183
VAL A 327
None
1.11A 2ygnA-1qvrA:
undetectable
2ygnA-1qvrA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Vibrio cholerae)
PF12727
(PBP_like)
5 ILE A 126
LEU A 118
ILE A 131
ILE A 216
VAL A 194
None
1.07A 2ygnA-1twyA:
undetectable
2ygnA-1twyA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT


(Bos taurus)
PF04045
(P34-Arc)
5 LEU D 207
ILE D 223
LEU D 251
MET D 182
PHE D 200
None
1.10A 2ygnA-1u2vD:
0.0
2ygnA-1u2vD:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus)
PF09231
(RDV-p3)
5 LEU A 118
ILE A 706
LEU A 710
ILE A 754
VAL A 761
None
0.95A 2ygnA-1uf2A:
undetectable
2ygnA-1uf2A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul7 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3


(Mus musculus)
PF02149
(KA1)
5 LEU A  32
ILE A  92
ILE A  28
MET A  64
PHE A  79
None
1.13A 2ygnA-1ul7A:
undetectable
2ygnA-1ul7A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdq BACTERIAL SULFITE
OXIDASE


(Escherichia
coli)
PF00174
(Oxidored_molyb)
5 ILE A 212
LEU A 214
ILE A  72
PHE A 135
VAL A 197
None
1.12A 2ygnA-1xdqA:
undetectable
2ygnA-1xdqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major)
PF01008
(IF-2B)
5 LEU A  98
ILE A  51
LEU A  30
ILE A  21
VAL A 148
None
1.07A 2ygnA-2a0uA:
undetectable
2ygnA-2a0uA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bj0 ACETYLCHOLINE-BINDIN
G PROTEIN


(Bulinus
truncatus)
PF02931
(Neur_chan_LBD)
5 ILE A 137
LEU A  33
ILE A 196
ILE A  36
PHE A 120
None
1.14A 2ygnA-2bj0A:
undetectable
2ygnA-2bj0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50


(Rattus
norvegicus)
PF00928
(Adap_comp_sub)
6 LEU M 206
ILE M 263
ILE M 243
MET M 216
PHE M 214
VAL M 177
None
1.46A 2ygnA-2bp5M:
undetectable
2ygnA-2bp5M:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus)
PF02645
(DegV)
5 LEU A  28
ILE A  88
PHE A  69
VAL A 112
VAL A 110
None
0.93A 2ygnA-2dt8A:
undetectable
2ygnA-2dt8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC


(Lactococcus
lactis)
PF05147
(LANC_like)
5 ILE A 290
LEU A 293
ILE A 313
ILE A 241
VAL A 272
None
1.05A 2ygnA-2g02A:
undetectable
2ygnA-2g02A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4r MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN


(Mycobacterium
tuberculosis)
PF00994
(MoCF_biosynth)
5 ILE A  67
LEU A 128
ILE A  28
ILE A  99
VAL A 145
None
1.15A 2ygnA-2g4rA:
undetectable
2ygnA-2g4rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR


(Streptococcus
pneumoniae)
PF04198
(Sugar-bind)
5 ILE A 113
ILE A 205
ILE A 128
MET A 161
PHE A 115
None
1.01A 2ygnA-2gnpA:
undetectable
2ygnA-2gnpA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0e TRANSTHYRETIN-LIKE
PROTEIN PUCM


(Bacillus
subtilis)
PF00576
(Transthyretin)
5 ILE A  29
LEU A  54
MET A  67
PHE A  69
VAL A 117
None
0.98A 2ygnA-2h0eA:
undetectable
2ygnA-2h0eA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE


(Agrobacterium
tumefaciens)
PF01261
(AP_endonuc_2)
5 LEU A 182
ILE A 104
LEU A  93
ILE A  66
VAL A 170
LEU  A 182 ( 0.6A)
ILE  A 104 ( 0.7A)
LEU  A  93 ( 0.6A)
ILE  A  66 ( 0.7A)
VAL  A 170 ( 0.6A)
1.11A 2ygnA-2hk0A:
undetectable
2ygnA-2hk0A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC


(Saccharomyces
cerevisiae)
no annotation 5 LEU A 130
ILE A  84
ILE A  51
PHE A  85
VAL A  97
None
1.11A 2ygnA-2hsmA:
undetectable
2ygnA-2hsmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j43 SPYDX

(Streptococcus
pyogenes)
PF03714
(PUD)
5 ILE A  75
LEU A  16
MET A  47
VAL A  61
VAL A  33
None
1.14A 2ygnA-2j43A:
undetectable
2ygnA-2j43A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kii PUTATIVE
UNCHARACTERIZED
PROTEIN


(Shewanella
oneidensis)
PF07700
(HNOB)
5 ILE A 176
LEU A 130
ILE A 159
ILE A  98
PHE A  91
None
None
None
HEM  A 182 (-4.0A)
None
0.95A 2ygnA-2kiiA:
undetectable
2ygnA-2kiiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mdt PUTATIVE
UNCHARACTERIZED
PROTEIN


(Sulfolobus
solfataricus)
no annotation 5 LEU A  97
ILE A   5
LEU A  13
ILE A  84
ILE A  40
None
1.06A 2ygnA-2mdtA:
undetectable
2ygnA-2mdtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 LEU A 258
ILE A  14
LEU A  31
ILE A 263
VAL A  22
None
None
None
None
DP6  A 300 (-4.6A)
1.14A 2ygnA-2oi2A:
undetectable
2ygnA-2oi2A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Bacillus cereus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 122
ILE A 103
LEU A  66
ILE A  32
VAL A 301
None
1.08A 2ygnA-2p88A:
undetectable
2ygnA-2p88A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1


(Halothermothrix
orenii)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 LEU A  36
ILE A 195
ILE A 226
ARG A 450
ILE A 459
None
1.13A 2ygnA-2r66A:
undetectable
2ygnA-2r66A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1


(Saccharomyces
cerevisiae)
PF12697
(Abhydrolase_6)
5 LEU A 324
ILE A 142
ILE A 166
ILE A  86
PHE A  57
None
1.05A 2ygnA-2y6vA:
undetectable
2ygnA-2y6vA:
18.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygn WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
12 LEU A  36
ILE A  40
LEU A  48
ILE A  55
MET A  63
ARG A  76
MET A  77
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PCF  A1179 ( 4.0A)
None
PCF  A1179 (-4.1A)
PCF  A1179 ( 4.5A)
PCF  A1179 ( 4.1A)
MLY  A  72 (-4.5A)
PCF  A1179 (-4.0A)
None
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
PCF  A1179 (-4.4A)
PCF  A1179 ( 4.7A)
0.00A 2ygnA-2ygnA:
29.7
2ygnA-2ygnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
8 ILE A  40
ILE A  55
ARG A  76
MET A  77
ILE A  80
MET A  87
PHE A  89
VAL A 152
None
PCF  A1213 (-4.0A)
PCF  A1213 (-3.6A)
PCF  A1213 (-3.5A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 4.7A)
1.08A 2ygnA-2ygoA:
28.2
2ygnA-2ygoA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygo WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
11 LEU A  36
ILE A  40
LEU A  48
ILE A  55
MET A  63
MET A  77
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PCF  A1213 ( 4.2A)
None
PCF  A1213 (-4.3A)
PCF  A1213 (-4.0A)
PCF  A1213 ( 4.2A)
PCF  A1213 (-3.5A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 4.7A)
PCF  A1213 ( 4.7A)
0.13A 2ygnA-2ygoA:
28.2
2ygnA-2ygoA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
PF12661
(hEGF)
10 LEU A  36
ILE A  40
ILE A  55
MET A  63
MET A  77
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
None
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.1A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
0.42A 2ygnA-2ygqA:
26.1
2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
PF12661
(hEGF)
10 LEU A  36
ILE A  40
LEU A  48
ILE A  55
MET A  63
MET A  77
MET A  87
PHE A  89
VAL A 152
VAL A 154
None
None
PCF  A1275 (-4.6A)
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.1A)
PCF  A1275 (-3.2A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
0.69A 2ygnA-2ygqA:
26.1
2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
PF12661
(hEGF)
6 LEU A 165
ILE A  40
ILE A  55
ILE A  80
MET A  87
PHE A  89
None
None
PCF  A1275 ( 4.4A)
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
1.38A 2ygnA-2ygqA:
26.1
2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ygq WNT INHIBITORY
FACTOR 1


(Homo sapiens)
PF02019
(WIF)
PF12661
(hEGF)
6 LEU A 165
ILE A  40
ILE A  55
ILE A  84
MET A  87
PHE A  89
None
None
PCF  A1275 ( 4.4A)
None
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
1.33A 2ygnA-2ygqA:
26.1
2ygnA-2ygqA:
48.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Pyrococcus
horikoshii)
PF09488
(Osmo_MPGsynth)
5 LEU A  66
ILE A 112
LEU A 394
VAL A 181
VAL A 177
None
1.14A 2ygnA-2zu8A:
undetectable
2ygnA-2zu8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1


(Aeropyrum
pernix)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
5 LEU A 187
LEU A 325
ILE A  18
MET A 332
VAL A  58
None
1.02A 2ygnA-3a31A:
undetectable
2ygnA-3a31A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a45 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE


(Acanthamoeba
polyphaga
mimivirus)
PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
5 ILE A 206
LEU A 202
ILE A 179
ILE A 150
PHE A 139
None
1.09A 2ygnA-3a45A:
undetectable
2ygnA-3a45A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2


(Homo sapiens)
PF13532
(2OG-FeII_Oxy_2)
5 LEU A 178
ILE A 158
LEU A  85
ILE A  81
VAL A 145
None
1.15A 2ygnA-3btzA:
1.3
2ygnA-3btzA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb8 CYSTEINE
PROTEASE-LIKE VIRA


(Shigella
flexneri)
PF06872
(EspG)
5 LEU A 374
ILE A 186
ILE A 216
VAL A 344
VAL A 369
None
1.06A 2ygnA-3eb8A:
undetectable
2ygnA-3eb8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee1 EFFECTOR PROTEIN
VIRA


(Shigella
flexneri)
PF06872
(EspG)
5 LEU A 374
ILE A 186
ILE A 216
VAL A 344
VAL A 369
None
0.95A 2ygnA-3ee1A:
undetectable
2ygnA-3ee1A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY


(Deinococcus
geothermalis)
PF12897
(Aminotran_MocR)
5 LEU A 143
ILE A 175
ILE A 127
MET A 152
ILE A 189
None
1.11A 2ygnA-3ez1A:
undetectable
2ygnA-3ez1A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE


(Corynebacterium
diphtheriae)
PF00155
(Aminotran_1_2)
5 ILE A 313
LEU A 352
ILE A 302
PHE A 315
VAL A 372
None
1.15A 2ygnA-3fdbA:
undetectable
2ygnA-3fdbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flt SAP-LIKE PENTRAXIN

(Limulus
polyphemus)
PF00354
(Pentaxin)
5 ILE A 194
ILE A   4
PHE A 201
VAL A 209
VAL A 207
None
1.10A 2ygnA-3fltA:
undetectable
2ygnA-3fltA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfo COBALT IMPORT
ATP-BINDING PROTEIN
CBIO 1


(Clostridium
perfringens)
PF00005
(ABC_tran)
5 LEU A 207
LEU A  48
ILE A 196
ILE A  25
VAL A 229
None
1.12A 2ygnA-3gfoA:
undetectable
2ygnA-3gfoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
5 LEU A  69
LEU A 124
ILE A 114
PHE A  81
VAL A  48
None
1.04A 2ygnA-3l6aA:
undetectable
2ygnA-3l6aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE


(Exiguobacterium
sibiricum)
PF01593
(Amino_oxidase)
5 ILE A 284
LEU A 256
ILE A 259
VAL A 427
VAL A 423
FAD  A 500 (-3.7A)
FAD  A 500 (-4.9A)
None
None
None
1.12A 2ygnA-3lovA:
undetectable
2ygnA-3lovA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION


(Petromyzon
marinus)
PF13855
(LRR_8)
5 LEU A  63
LEU A 161
ILE A 145
VAL A 125
VAL A 101
None
1.10A 2ygnA-3m19A:
undetectable
2ygnA-3m19A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION


(Petromyzon
marinus)
PF13855
(LRR_8)
5 LEU A  65
LEU A 161
ILE A 145
VAL A 125
VAL A 101
None
1.00A 2ygnA-3m19A:
undetectable
2ygnA-3m19A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii)
PF02541
(Ppx-GppA)
5 LEU A 206
ILE A 198
ILE A 279
MET A 135
PHE A 144
None
1.10A 2ygnA-3mdqA:
undetectable
2ygnA-3mdqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2q SEX PHEROMONE
STAPH-CAM373


(Bacillus cereus)
PF07537
(CamS)
5 ILE A 252
LEU A 294
ILE A 261
PHE A 248
VAL A 312
None
1.07A 2ygnA-3n2qA:
undetectable
2ygnA-3n2qA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oce FUMARATE LYASE:DELTA
CRYSTALLIN


(Brucella
abortus)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ILE A 390
LEU A 294
ILE A 308
ARG A 185
ILE A 290
None
1.06A 2ygnA-3oceA:
undetectable
2ygnA-3oceA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 ILE A  78
LEU A 101
MET A 125
ILE A 133
VAL A 183
None
1.06A 2ygnA-3ojlA:
undetectable
2ygnA-3ojlA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo9 VARIABLE LYMPHOCYTE
RECEPTOR C


(Lethenteron
camtschaticum)
PF01462
(LRRNT)
PF13855
(LRR_8)
5 LEU A  73
LEU A 169
ILE A 153
VAL A 133
VAL A 109
None
1.09A 2ygnA-3wo9A:
undetectable
2ygnA-3wo9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4afr METACASPASE

(Trypanosoma
brucei)
PF00656
(Peptidase_C14)
5 LEU A 100
ILE A 255
LEU A 322
ILE A 328
MET A 253
None
0.97A 2ygnA-4afrA:
undetectable
2ygnA-4afrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ao7 ESTERASE

(unidentified)
PF12146
(Hydrolase_4)
5 LEU A 192
LEU A 126
ILE A 160
ILE A 129
VAL A  65
None
1.10A 2ygnA-4ao7A:
undetectable
2ygnA-4ao7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blp PACKAGING ENZYME P4

(Pseudomonas
phage phi13)
PF11602
(NTPase_P4)
5 ILE A 212
LEU A 253
ILE A 172
PHE A 215
VAL A  70
None
1.13A 2ygnA-4blpA:
undetectable
2ygnA-4blpA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dy0 GLIA-DERIVED NEXIN

(Homo sapiens)
PF00079
(Serpin)
5 ILE A 236
LEU A 274
ILE A 223
MET A 262
VAL A 370
None
1.06A 2ygnA-4dy0A:
undetectable
2ygnA-4dy0A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II


(Anaerococcus
prevotii)
PF00155
(Aminotran_1_2)
5 ILE A 375
LEU A 403
ILE A  37
ARG A 332
ILE A 358
None
1.12A 2ygnA-4emyA:
undetectable
2ygnA-4emyA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Haemophilus
influenzae)
PF01546
(Peptidase_M20)
5 ILE A  29
LEU A  12
ILE A 109
MET A 101
VAL A 145
None
None
None
ZN  A1001 ( 4.4A)
None
1.10A 2ygnA-4h2kA:
undetectable
2ygnA-4h2kA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae)
PF12706
(Lactamase_B_2)
5 LEU A 458
ILE A 303
LEU A 301
ILE A 319
VAL A 492
None
1.02A 2ygnA-4jo0A:
undetectable
2ygnA-4jo0A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1


(Rattus
norvegicus)
PF00245
(Alk_phosphatase)
5 LEU A 328
LEU A  38
ARG A 442
ILE A 458
VAL A 437
None
0.90A 2ygnA-4kjdA:
undetectable
2ygnA-4kjdA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
6 ILE A 674
LEU A 683
ILE A 670
MET A 661
MET A 677
PHE A 581
None
1.20A 2ygnA-4m7eA:
undetectable
2ygnA-4m7eA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN


(Paraburkholderia
graminis)
PF00043
(GST_C)
PF02798
(GST_N)
5 LEU A 161
ILE A 126
ILE A 205
VAL A 219
VAL A 224
None
1.08A 2ygnA-4mf6A:
undetectable
2ygnA-4mf6A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2


(Caldanaerobacter
subterraneus)
no annotation 5 LEU B 267
ILE B  38
LEU B  49
ILE B  26
MET B 217
None
1.15A 2ygnA-4mkiB:
undetectable
2ygnA-4mkiB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1


(Rattus
norvegicus)
PF00777
(Glyco_transf_29)
5 LEU A 395
MET A 375
ILE A 325
MET A 329
PHE A 398
None
0.93A 2ygnA-4mpsA:
undetectable
2ygnA-4mpsA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7l UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288


(Thermotoga
maritima)
PF00005
(ABC_tran)
5 ILE A 412
ILE A 419
ARG A 428
ILE A 544
PHE A 357
None
1.11A 2ygnA-4q7lA:
undetectable
2ygnA-4q7lA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7l UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288


(Thermotoga
maritima)
PF00005
(ABC_tran)
5 ILE A 412
ILE A 419
ARG A 428
ILE A 544
VAL A 370
None
1.15A 2ygnA-4q7lA:
undetectable
2ygnA-4q7lA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron)
PF08842
(Mfa2)
5 LEU A 284
ILE A 181
MET A 309
PHE A 311
VAL A 266
None
1.12A 2ygnA-4qdgA:
undetectable
2ygnA-4qdgA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I


(synthetic
construct)
PF12354
(Internalin_N)
PF13855
(LRR_8)
5 LEU A  67
LEU A 163
ILE A 147
VAL A 127
VAL A 103
None
1.14A 2ygnA-4r6fA:
undetectable
2ygnA-4r6fA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes)
PF04198
(Sugar-bind)
5 LEU A  68
ARG A 305
MET A 306
ILE A 300
VAL A 238
None
1.13A 2ygnA-4r9nA:
undetectable
2ygnA-4r9nA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN


(Sphingobium
chlorophenolicum)
PF03466
(LysR_substrate)
5 ILE A 101
LEU A 115
ILE A 299
MET A 111
VAL A 275
None
1.06A 2ygnA-4rnsA:
undetectable
2ygnA-4rnsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]


(Staphylococcus
aureus)
PF01380
(SIS)
5 ILE A 371
LEU A 389
ILE A 345
ILE A 267
VAL A 417
None
1.11A 2ygnA-4s1wA:
undetectable
2ygnA-4s1wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1


(Schizosaccharomyces
pombe)
PF01909
(NTP_transf_2)
PF03828
(PAP_assoc)
5 ILE A 328
LEU A 326
ILE A 350
VAL A 192
VAL A 189
None
1.04A 2ygnA-4ud4A:
undetectable
2ygnA-4ud4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica)
PF06100
(MCRA)
5 ILE A  67
ILE A 327
ILE A  82
PHE A  94
VAL A 270
None
1.06A 2ygnA-4uirA:
undetectable
2ygnA-4uirA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica)
PF00961
(LAGLIDADG_1)
5 LEU A 105
ILE A  86
LEU A  60
ILE A  56
PHE A  41
None
0.98A 2ygnA-4yisA:
undetectable
2ygnA-4yisA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae)
PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2)
5 LEU A 170
ILE A 134
LEU A 105
ILE A 221
PHE A 132
None
1.10A 2ygnA-4yw5A:
undetectable
2ygnA-4yw5A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE


(Sulfolobus
solfataricus)
PF00288
(GHMP_kinases_N)
5 LEU A 305
ILE A 182
LEU A  39
ILE A 311
ILE A  37
None
1.11A 2ygnA-4z7yA:
undetectable
2ygnA-4z7yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron)
PF15979
(Glyco_hydro_115)
6 LEU A 202
MET A 364
ILE A 373
MET A 418
PHE A 447
VAL A 434
None
1.26A 2ygnA-5by3A:
undetectable
2ygnA-5by3A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d55 HDAB,HDAA (ADHESIN),
HUS-ASSOCIATED
DIFFUSE ADHERENCE


(Escherichia
coli)
PF05775
(AfaD)
5 LEU A 130
ILE A   3
LEU A   5
ILE A  96
VAL A  83
None
1.09A 2ygnA-5d55A:
undetectable
2ygnA-5d55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME


(Enterococcus
faecium)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N)
5 LEU A 568
ILE A 505
ILE A 427
VAL A 650
VAL A 367
None
1.03A 2ygnA-5e31A:
undetectable
2ygnA-5e31A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5b FACT COMPLEX SUBUNIT
SPT16


(Homo sapiens)
PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob)
5 ILE A 247
LEU A 217
ILE A 205
MET A 266
VAL A 292
None
0.96A 2ygnA-5e5bA:
undetectable
2ygnA-5e5bA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL31

(Suid
alphaherpesvirus
1)
PF02718
(Herpes_UL31)
5 LEU A  65
LEU A 115
ILE A 118
VAL A 164
VAL A 180
None
1.13A 2ygnA-5e8cA:
undetectable
2ygnA-5e8cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE


(Pseudomonas
aeruginosa)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 LEU A 459
ILE A 487
MET A 492
PHE A 491
VAL A 542
None
1.04A 2ygnA-5im3A:
undetectable
2ygnA-5im3A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE


(Arabidopsis
thaliana)
PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase)
5 ILE A 287
LEU A 103
ILE A  99
MET A  73
VAL A 657
None
1.08A 2ygnA-5ksdA:
undetectable
2ygnA-5ksdA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbh CAIP

(Helicobacter
cinaedi)
PF00210
(Ferritin)
5 ILE A  77
ILE A  42
PHE A 101
VAL A  49
VAL A  53
None
1.15A 2ygnA-5lbhA:
undetectable
2ygnA-5lbhA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6p TYROCIDINE SYNTHASE
2


(Brevibacillus
parabrevis)
no annotation 5 LEU A3511
LEU A3550
ILE A3525
ILE A3553
VAL A3389
None
1.10A 2ygnA-5m6pA:
undetectable
2ygnA-5m6pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbo GLYCOSYL HYDROLASE
FAMILY 16


(Bacteroides
ovatus)
no annotation 5 ILE A 265
LEU A  84
ILE A 115
PHE A  41
VAL A  48
None
1.10A 2ygnA-5nboA:
undetectable
2ygnA-5nboA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk4 VARIABLE LYMPHOCYTE
RECEPTOR 39


(Petromyzon
marinus)
no annotation 5 LEU D  54
LEU D 152
ILE D 136
VAL D 116
VAL D  92
None
1.12A 2ygnA-5wk4D:
undetectable
2ygnA-5wk4D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk4 VARIABLE LYMPHOCYTE
RECEPTOR 39


(Petromyzon
marinus)
no annotation 5 LEU D  56
LEU D 152
ILE D 136
VAL D 116
VAL D  92
None
1.03A 2ygnA-5wk4D:
undetectable
2ygnA-5wk4D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrk AP-2 COMPLEX SUBUNIT
MU


(Rattus
norvegicus)
no annotation 5 ILE A 263
ILE A 220
MET A 216
PHE A 214
VAL A 177
None
1.08A 2ygnA-5wrkA:
2.0
2ygnA-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrl AP-2 COMPLEX SUBUNIT
MU


(Rattus
norvegicus)
no annotation 6 LEU A 206
ILE A 263
ILE A 243
MET A 216
PHE A 214
VAL A 177
None
1.33A 2ygnA-5wrlA:
undetectable
2ygnA-5wrlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9u DNA GYRASE, SUBUNIT
B:SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE


(Brucella
abortus)
no annotation 5 LEU A   4
MET A  22
ILE A  83
VAL A 183
VAL A 243
None
1.12A 2ygnA-6b9uA:
undetectable
2ygnA-6b9uA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA


(Escherichia
coli)
no annotation 5 ILE A 726
LEU A 722
ARG A 129
ILE A 784
PHE A 751
None
0.96A 2ygnA-6bogA:
undetectable
2ygnA-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2


(Petromyzon
marinus)
no annotation 5 LEU C  54
LEU C 152
ILE C 136
VAL C 116
VAL C  92
None
1.05A 2ygnA-6bxaC:
undetectable
2ygnA-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckb -

(-)
no annotation 5 LEU A 187
ILE A 219
ILE A 132
MET A 184
VAL A 197
None
0.92A 2ygnA-6ckbA:
undetectable
2ygnA-6ckbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egx STRUCTURAL PROTEIN
VP2


(Sacbrood virus)
no annotation 5 ILE B  64
ILE B 169
MET B 114
PHE B 116
VAL B 128
None
1.13A 2ygnA-6egxB:
undetectable
2ygnA-6egxB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni)
no annotation 5 LEU A 165
ILE A 114
LEU A 113
ILE A  92
ILE A 103
None
1.14A 2ygnA-6ejjA:
undetectable
2ygnA-6ejjA:
undetectable