SIMILAR PATTERNS OF AMINO ACIDS FOR 2YFX_A_VGHA9000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		4 LEU A 129
ALA A   9
GLY A  57
ASP A  56
 None
 0.62A 2yfxA-1ahaA:
undetectable		 2yfxA-1ahaA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 LEU A 144
GLY A 113
LEU A  69
GLY A  71
ASP A 107
 None
GLC  A 997 (-3.3A)
None
None
None
 1.27A 2yfxA-1e4oA:
undetectable		 2yfxA-1e4oA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 186
ALA A 286
GLY A 283
LEU A 279
GLY A 275
 None
 1.40A 2yfxA-1f8fA:
undetectable		 2yfxA-1f8fA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 ALA A 536
MET A 511
LEU A 543
GLY A 502
 None
 0.51A 2yfxA-1gjuA:
undetectable		 2yfxA-1gjuA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		5 LEU A 429
ALA A 448
GLY A  25
LEU A  85
GLY A  84
 None
 1.30A 2yfxA-1gnxA:
undetectable		 2yfxA-1gnxA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 428
MET A 477
GLY A 480
LEU A 528
 None
 0.19A 2yfxA-1k2pA:
28.8		 2yfxA-1k2pA:
34.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.45A 2yfxA-1k9aA:
32.3		 2yfxA-1k9aA:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 ALA A 606
MET A 657
GLY A 660
LEU A 731
 None
 0.30A 2yfxA-1lufA:
26.7		 2yfxA-1lufA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 LEU A 208
ALA A 247
GLY A 210
LEU A 263
ASP A 202
 None
 1.28A 2yfxA-1ny5A:
undetectable		 2yfxA-1ny5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
ALA A 288
MET A 337
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.50A 2yfxA-1opkA:
30.6		 2yfxA-1opkA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A  53
ALA A  45
MET A  30
GLY A 211
ASP A 194
 None
 1.40A 2yfxA-1orfA:
undetectable		 2yfxA-1orfA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		5 ALA A 296
GLY A 257
LEU A 236
GLY A 235
ASP A 124
 None
None
None
None
MN  A 500 (-2.6A)
 1.50A 2yfxA-1p8rA:
undetectable		 2yfxA-1p8rA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 LEU A 161
GLY A 188
LEU A 144
GLY A 147
ASP A 151
 None
 1.32A 2yfxA-1pieA:
undetectable		 2yfxA-1pieA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 164
ALA A 185
LEU A 301
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.50A 2yfxA-1q8yA:
13.9		 2yfxA-1q8yA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		5 LEU A 141
MET A 135
GLY A 185
LEU A  88
ASP A  93
 None
 1.49A 2yfxA-1qfcA:
undetectable		 2yfxA-1qfcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 LEU A  59
ALA A  67
GLY A  61
LEU A 320
GLY A 317
 None
 1.23A 2yfxA-1qjmA:
undetectable		 2yfxA-1qjmA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz8 POLYPROTEIN 1AB

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF08710
(nsp9) 		4 LEU A  94
ALA A  43
GLY A 100
LEU A 103
 None
 0.64A 2yfxA-1qz8A:
undetectable		 2yfxA-1qz8A:
14.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
ALA A 642
GLY A 697
LEU A 818
 None
 0.58A 2yfxA-1rjbA:
29.3		 2yfxA-1rjbA:
36.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvv RIBOFLAVIN SYNTHASE

(Bacillus
subtilis) 		no annotation 5 ALA A 124
GLY A  79
LEU A  30
GLY A 136
ASP A 138
 None
 1.45A 2yfxA-1rvvA:
undetectable		 2yfxA-1rvvA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
ALA A  99
MET A 147
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.53A 2yfxA-1s9iA:
16.7		 2yfxA-1s9iA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT

(Deinococcus
radiodurans) 		PF03328
(HpcH_HpaI) 		5 LEU A 102
ALA A 126
GLY A 133
GLY A 152
ASP A 155
 None
None
None
OAA  A 285 ( 4.8A)
MG  A 286 ( 4.6A)
 1.35A 2yfxA-1sgjA:
undetectable		 2yfxA-1sgjA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siq GLUTARYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 130
ALA A  96
GLY A 127
LEU A  62
GLY A  63
 None
 1.31A 2yfxA-1siqA:
undetectable		 2yfxA-1siqA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 389
MET A 438
GLY A 441
LEU A 489
 None
 0.31A 2yfxA-1snxA:
30.2		 2yfxA-1snxA:
36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 LEU A  58
ALA A  30
GLY A  56
LEU A  53
GLY A  49
 None
None
None
None
EDO  A1223 (-3.5A)
 1.38A 2yfxA-1szsA:
undetectable		 2yfxA-1szsA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
ALA A 621
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.59A 2yfxA-1t46A:
25.3		 2yfxA-1t46A:
36.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
ALA A 367
MET A 414
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.88A 2yfxA-1u59A:
31.5		 2yfxA-1u59A:
33.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
MET A 105
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 None
 0.55A 2yfxA-1u5qA:
25.0		 2yfxA-1u5qA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  18
ALA A  39
MET A  94
LEU A 144
 ATP  A 381 (-4.4A)
ATP  A 381 (-3.6A)
None
None
 0.54A 2yfxA-1ua2A:
20.8		 2yfxA-1ua2A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw7 NSP9

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF08710
(nsp9) 		4 LEU A  94
ALA A  43
GLY A 100
LEU A 103
 None
 0.63A 2yfxA-1uw7A:
undetectable		 2yfxA-1uw7A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq7 50S RIBOSOMAL
PROTEIN L30P

(Haloarcula
marismortui) 		PF00327
(Ribosomal_L30) 		5 LEU W 138
ALA W  53
GLY W 136
GLY W 145
ASP W 142
 None
 1.47A 2yfxA-1vq7W:
undetectable		 2yfxA-1vq7W:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		4 ALA A  48
GLY A  32
GLY A  84
ASP A  85
 None
 0.65A 2yfxA-1xnyA:
undetectable		 2yfxA-1xnyA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg) 		5 LEU A  67
GLY A  37
LEU A  34
GLY A  58
ASP A  59
 None
 1.43A 2yfxA-1zh4A:
undetectable		 2yfxA-1zh4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
ALA A  36
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.79A 2yfxA-1zltA:
12.1		 2yfxA-1zltA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 605
ALA A 626
MET A 788
GLY A 852
 None
GOL  A 998 ( 3.7A)
GOL  A 998 ( 4.2A)
None
 0.55A 2yfxA-1zy4A:
19.4		 2yfxA-1zy4A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		5 LEU A 232
ALA A  50
GLY A 294
LEU A 297
GLY A 272
 None
 1.46A 2yfxA-2a8iA:
undetectable		 2yfxA-2a8iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 111
MET A 162
GLY A 165
LEU A 212
 None
 0.51A 2yfxA-2ac5A:
19.8		 2yfxA-2ac5A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 LEU A 206
ALA A  36
GLY A 335
GLY A 401
ASP A 404
 None
None
None
COA  A2600 ( 4.5A)
None
 1.37A 2yfxA-2ahwA:
undetectable		 2yfxA-2ahwA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 LEU A 561
ALA A 589
GLY A 559
GLY A 784
ASP A 781
 None
 1.35A 2yfxA-2b39A:
undetectable		 2yfxA-2b39A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9l PROPHENOLOXIDASE
ACTIVATING FACTOR

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		5 LEU A 183
ALA A 168
GLY A 289
LEU A 305
ASP A 220
 None
 1.29A 2yfxA-2b9lA:
undetectable		 2yfxA-2b9lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE

(Podophyllum
peltatum) 		PF13561
(adh_short_C2) 		5 ALA A  19
GLY A  40
LEU A  14
GLY A 245
ASP A 246
 None
 1.45A 2yfxA-2bgkA:
undetectable		 2yfxA-2bgkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  26
ALA A  47
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.77A 2yfxA-2bujA:
23.7		 2yfxA-2bujA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 LEU A 244
GLY A 113
LEU A  69
GLY A  71
ASP A 107
 None
PO4  A1794 (-3.5A)
None
None
None
 1.40A 2yfxA-2c4mA:
undetectable		 2yfxA-2c4mA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A  48
ALA A 139
GLY A  43
LEU A  60
ASP A  56
 None
None
CSX  A  42 ( 2.6A)
None
None
 1.31A 2yfxA-2cduA:
undetectable		 2yfxA-2cduA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cex PROTEIN HI0146

(Haemophilus
influenzae) 		PF03480
(DctP) 		5 ALA A 158
MET A 141
GLY A 143
LEU A 144
GLY A 184
 None
 1.30A 2yfxA-2cexA:
undetectable		 2yfxA-2cexA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 ALA A  89
GLY A  30
LEU A   7
GLY A 103
 None
 0.67A 2yfxA-2culA:
undetectable		 2yfxA-2culA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ALA A 222
LEU A 276
GLY A 320
ASP A 316
 None
 0.65A 2yfxA-2d5lA:
undetectable		 2yfxA-2d5lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195

(Thermus
thermophilus) 		PF03746
(LamB_YcsF) 		5 LEU A 103
ALA A  52
GLY A  60
LEU A  33
GLY A  10
 None
 1.36A 2yfxA-2dfaA:
undetectable		 2yfxA-2dfaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 MET A 442
GLY A 444
GLY A 220
ASP A 221
 None
 0.58A 2yfxA-2dpnA:
undetectable		 2yfxA-2dpnA:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
ALA X  37
MET X  85
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.71A 2yfxA-2dq7X:
31.1		 2yfxA-2dq7X:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 LEU A 622
ALA A 293
GLY A 285
LEU A 306
ASP A 583
 None
None
FAD  A1001 (-3.2A)
None
None
 1.45A 2yfxA-2dw4A:
undetectable		 2yfxA-2dw4A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3h RESTIN

(Homo sapiens) 		PF01302
(CAP_GLY) 		4 LEU A 219
GLY A 226
LEU A 246
GLY A 251
 None
 0.67A 2yfxA-2e3hA:
undetectable		 2yfxA-2e3hA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A  19
ALA A  40
MET A  96
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.64A 2yfxA-2f9gA:
13.9		 2yfxA-2f9gA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 LEU A 144
GLY A 168
LEU A 173
GLY A 155
ASP A   8
 None
 1.00A 2yfxA-2fi1A:
undetectable		 2yfxA-2fi1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fph YLMH

(Streptococcus
pneumoniae) 		no annotation 5 LEU X 122
GLY X 117
LEU X 116
GLY X 148
ASP X 147
 None
 1.47A 2yfxA-2fphX:
undetectable		 2yfxA-2fphX:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 5 LEU L 261
ALA L 412
GLY L 266
LEU L 397
GLY L 398
 None
 1.45A 2yfxA-2frvL:
undetectable		 2yfxA-2frvL:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
MET A 105
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 STU  A 400 (-3.2A)
STU  A 400 ( 3.7A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
None
STU  A 400 (-3.6A)
 0.55A 2yfxA-2gcdA:
18.4		 2yfxA-2gcdA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.67A 2yfxA-2h8hA:
29.8		 2yfxA-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		5 LEU A 283
ALA A 279
MET A 276
LEU A 184
ASP A 178
 None
 1.37A 2yfxA-2hb6A:
undetectable		 2yfxA-2hb6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.53A 2yfxA-2hckA:
28.8		 2yfxA-2hckA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ALA A 659
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.18A 2yfxA-2henA:
33.1		 2yfxA-2henA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 MET A 710
GLY A 713
LEU A 761
ASP A 772
 None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.60A 2yfxA-2henA:
33.1		 2yfxA-2henA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
ALA A 271
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.48A 2yfxA-2hk5A:
24.7		 2yfxA-2hk5A:
36.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 325
GLY A 356
LEU A  52
GLY A  51
ASP A 122
 None
 1.44A 2yfxA-2hneA:
undetectable		 2yfxA-2hneA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE

(Enterococcus
faecalis) 		PF02525
(Flavodoxin_2) 		5 LEU A  23
ALA A 101
LEU A 178
GLY A 177
ASP A 176
 None
 1.50A 2yfxA-2hpvA:
undetectable		 2yfxA-2hpvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  55
ALA A  76
GLY A 130
LEU A 177
 None
 0.53A 2yfxA-2hw6A:
19.8		 2yfxA-2hw6A:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
MET A 318
GLY A 321
LEU A 370
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
None
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
 0.83A 2yfxA-2hz0A:
30.6		 2yfxA-2hz0A:
37.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3d HYPOTHETICAL PROTEIN
ATU1826

(Agrobacterium
fabrum) 		PF02129
(Peptidase_S15) 		4 LEU A  61
ALA A  88
LEU A  31
GLY A 114
 None
 0.65A 2yfxA-2i3dA:
undetectable		 2yfxA-2i3dA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		5 ALA A 151
MET A 129
GLY A 121
LEU A 120
GLY A 117
 None
 1.21A 2yfxA-2imhA:
undetectable		 2yfxA-2imhA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN

(Ryegrass mottle
virus) 		PF00729
(Viral_coat) 		5 LEU A 151
ALA A 202
MET A 136
GLY A 156
LEU A 170
 None
 1.28A 2yfxA-2izwA:
undetectable		 2yfxA-2izwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ALA A 452
MET A 499
GLY A 505
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 0.72A 2yfxA-2j0jA:
32.3		 2yfxA-2j0jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 LEU A 501
GLY A 505
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 1.42A 2yfxA-2j0jA:
32.3		 2yfxA-2j0jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 ALA A 278
GLY A 153
LEU A 154
GLY A 138
 None
 0.63A 2yfxA-2jbmA:
undetectable		 2yfxA-2jbmA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1

(Rhodobacter
capsulatus) 		PF00072
(Response_reg) 		5 LEU A  44
ALA A  40
LEU A  67
GLY A  63
ASP A  65
 None
 1.36A 2yfxA-2jk1A:
undetectable		 2yfxA-2jk1A:
16.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 452
MET A 499
GLY A 505
LEU A 553
GLY A 563
 BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
BII  A1687 ( 3.9A)
 0.81A 2yfxA-2jkmA:
31.3		 2yfxA-2jkmA:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 452
MET A 499
LEU A 553
GLY A 563
ASP A 564
 BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-4.2A)
BII  A1687 ( 3.9A)
None
 0.98A 2yfxA-2jkmA:
31.3		 2yfxA-2jkmA:
37.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjl PEPTIDYL-TRNA
HYDROLASE

(Vibrio cholerae) 		PF01195
(Pept_tRNA_hydro) 		5 LEU A  65
ALA A  77
GLY A  11
LEU A  12
GLY A 119
 None
 1.41A 2yfxA-2mjlA:
undetectable		 2yfxA-2mjlA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		5 LEU 1 184
ALA 1 211
LEU 1 177
GLY 1 151
ASP 1 150
 None
 1.47A 2yfxA-2oap1:
undetectable		 2yfxA-2oap1:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		5 LEU A 163
ALA A 146
GLY A 165
GLY A 128
ASP A 132
 None
 1.48A 2yfxA-2oceA:
undetectable		 2yfxA-2oceA:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
ALA A 271
MET A 319
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.63A 2yfxA-2og8A:
30.0		 2yfxA-2og8A:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
ALA A 614
GLY A 669
LEU A 785
GLY A 795
ASP A 796
 None
 0.77A 2yfxA-2ogvA:
30.4		 2yfxA-2ogvA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omk HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF04263
(TPK_catalytic) 		5 LEU A 170
ALA A 188
LEU A 205
GLY A -10
ASP A -12
 None
 1.49A 2yfxA-2omkA:
undetectable		 2yfxA-2omkA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot9 HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF07152
(YaeQ) 		5 LEU A 137
ALA A 141
MET A 144
MET A  40
LEU A  44
 None
None
NA  A 181 (-4.4A)
NA  A 181 (-3.1A)
None
 1.33A 2yfxA-2ot9A:
undetectable		 2yfxA-2ot9A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LEU A 344
ALA A 367
MET A 414
GLY A 418
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
 1.34A 2yfxA-2ozoA:
24.5		 2yfxA-2ozoA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LEU A 344
ALA A 367
MET A 414
GLY A 419
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
None
ANP  A 615 (-4.7A)
 1.01A 2yfxA-2ozoA:
24.5		 2yfxA-2ozoA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LEU A 344
ALA A 367
MET A 414
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.59A 2yfxA-2ozoA:
24.5		 2yfxA-2ozoA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU X  70
ALA X  91
MET X 138
ASP X 207
 F10  X 401 (-3.9A)
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 (-3.4A)
 0.58A 2yfxA-2p3gX:
19.0		 2yfxA-2p3gX:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		5 LEU A 267
ALA A 265
GLY A  90
LEU A  89
GLY A 296
 None
 1.32A 2yfxA-2pb0A:
undetectable		 2yfxA-2pb0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
ALA A  46
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.62A 2yfxA-2phkA:
22.6		 2yfxA-2phkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.63A 2yfxA-2pmiA:
21.3		 2yfxA-2pmiA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU X  34
ALA X  53
MET X 120
LEU X 179
ASP X 190
 HMD  X 400 ( 4.3A)
HMD  X 400 (-3.5A)
None
HMD  X 400 (-4.7A)
HMD  X 400 (-3.7A)
 0.55A 2yfxA-2pmoX:
21.7		 2yfxA-2pmoX:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 487
ALA A 515
GLY A 570
LEU A 633
 None
 0.49A 2yfxA-2psqA:
31.6		 2yfxA-2psqA:
34.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pth PEPTIDYL-TRNA
HYDROLASE

(Escherichia
coli) 		PF01195
(Pept_tRNA_hydro) 		5 LEU A  61
ALA A  73
GLY A   7
LEU A   8
GLY A 115
 None
 1.14A 2yfxA-2pthA:
undetectable		 2yfxA-2pthA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 268
ALA A 252
GLY A 274
LEU A 238
GLY A 235
 None
 1.20A 2yfxA-2pwzA:
undetectable		 2yfxA-2pwzA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		5 ALA B  67
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.54A 2yfxA-2qkwB:
24.0		 2yfxA-2qkwB:
27.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.38A 2yfxA-2qobA:
33.8		 2yfxA-2qobA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		5 LEU A 327
ALA A 314
LEU A 306
GLY A 307
ASP A 218
 None
 1.48A 2yfxA-2qzwA:
undetectable		 2yfxA-2qzwA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 705
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 0.30A 2yfxA-2r2pA:
25.7		 2yfxA-2r2pA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 724
ALA A 749
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.55A 2yfxA-2r4bA:
29.9		 2yfxA-2r4bA:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A 799
GLY A 802
LEU A 850
ASP A 861
 None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.63A 2yfxA-2r4bA:
29.9		 2yfxA-2r4bA:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		5 MET A1131
GLY A1134
LEU A1155
GLY A1154
ASP A1153
 None
 1.26A 2yfxA-2ri8A:
undetectable		 2yfxA-2ri8A:
21.82