SIMILAR PATTERNS OF AMINO ACIDS FOR 2YFB_B_ACTB501_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a4e | CATALASE A (Saccharomycescerevisiae) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | ASP A 88VAL A 310ARG A 308ILE A 278 | None | 1.22A | 2yfbB-1a4eA:undetectable | 2yfbB-1a4eA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g67 | THIAMIN PHOSPHATESYNTHASE (Bacillussubtilis) |
PF02581(TMP-TENI) | 4 | ASP A 146VAL A 118ARG A 119ILE A 122 | None | 1.14A | 2yfbB-1g67A:undetectable | 2yfbB-1g67A:26.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hkw | DIAMINOPIMELATEDECARBOXYLASE (Mycobacteriumtuberculosis) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 4 | ARG A 344ARG A 303ILE A 261TYR A 352 | NoneSO4 A 500 (-3.3A)NoneNone | 1.23A | 2yfbB-1hkwA:undetectable | 2yfbB-1hkwA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hm7 | PENTALENENE SYNTHASE (Streptomycesexfoliatus) |
no annotation | 4 | ARG A 294VAL A 298ARG A 299ILE A 302 | None | 1.00A | 2yfbB-1hm7A:undetectable | 2yfbB-1hm7A:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hn0 | CHONDROITIN ABCLYASE I (Proteusvulgaris) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF09092(Lyase_N)PF09093(Lyase_catalyt) | 4 | ASP A 258VAL A 470ARG A 466ILE A 467 | None | 1.11A | 2yfbB-1hn0A:undetectable | 2yfbB-1hn0A:13.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k5s | PENICILLIN G ACYLASEBETA SUBUNIT (Escherichiacoli) |
PF01804(Penicil_amidase) | 4 | ASP B 280ARG B 533VAL B 19ILE B 17 | None | 0.95A | 2yfbB-1k5sB:undetectable | 2yfbB-1k5sB:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ku1 | ARFGUANINE-NUCLEOTIDEEXCHANGE FACTOR 2 (Saccharomycescerevisiae) |
PF01369(Sec7) | 4 | ARG A 637VAL A 638ILE A 705TYR A 743 | None | 1.19A | 2yfbB-1ku1A:undetectable | 2yfbB-1ku1A:27.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ovy | 50S RIBOSOMALPROTEIN L18 (Geobacillusstearothermophilus) |
PF00861(Ribosomal_L18p) | 4 | VAL A 106ARG A 105ILE A 71TYR A 100 | None | 1.17A | 2yfbB-1ovyA:undetectable | 2yfbB-1ovyA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qaf | PROTEIN (COPPERAMINE OXIDASE) (Escherichiacoli) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3)PF07833(Cu_amine_oxidN1) | 4 | ASP A 547VAL A 544ARG A 586ILE A 570 | None | 1.04A | 2yfbB-1qafA:undetectable | 2yfbB-1qafA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhm | PYRUVATEFORMATE-LYASE (Escherichiacoli) |
PF02901(PFL-like) | 4 | ASP A1412ARG A1278VAL A1425ILE A1424 | None | 1.18A | 2yfbB-1qhmA:3.3 | 2yfbB-1qhmA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwg | (2R)-PHOSPHO-3-SULFOLACTATE SYNTHASE (Methanocaldococcusjannaschii) |
PF02679(ComA) | 4 | ASP A 231VAL A 18ILE A 228TYR A 31 | None | 1.10A | 2yfbB-1qwgA:undetectable | 2yfbB-1qwgA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1shx | EPHRIN-A5 (Mus musculus) |
PF00812(Ephrin) | 4 | ARG A 138VAL A 163ILE A 58TYR A 140 | None | 1.08A | 2yfbB-1shxA:undetectable | 2yfbB-1shxA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sr8 | COBALAMINBIOSYNTHESIS PROTEIN(CBID) (Archaeoglobusfulgidus) |
PF01888(CbiD) | 4 | VAL A 252ARG A 278ILE A 250TYR A 222 | None | 1.06A | 2yfbB-1sr8A:undetectable | 2yfbB-1sr8A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v93 | 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (Thermusthermophilus) |
PF02219(MTHFR) | 4 | ASP A 175VAL A 131ARG A 135ILE A 134 | None | 1.12A | 2yfbB-1v93A:undetectable | 2yfbB-1v93A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkd | ISOCITRATEDEHYDROGENASE (Aeropyrumpernix) |
PF00180(Iso_dh) | 4 | ASP A 315VAL A 138ARG A 136ILE A 157 | CA A1006 (-2.9A)NoneICT A1002 (-3.0A)None | 1.05A | 2yfbB-1xkdA:undetectable | 2yfbB-1xkdA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xzq | PROBABLE TRNAMODIFICATION GTPASETRME (Thermotogamaritima) |
PF01926(MMR_HSR1)PF10396(TrmE_N)PF12631(MnmE_helical) | 4 | ASP A 293ARG A 262ARG A 210ILE A 206 | None | 1.18A | 2yfbB-1xzqA:2.0 | 2yfbB-1xzqA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yq2 | BETA-GALACTOSIDASE (Arthrobactersp. C2-2) |
PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | ARG A 812VAL A 841ILE A 856TYR A 830 | None | 1.23A | 2yfbB-1yq2A:undetectable | 2yfbB-1yq2A:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zcz | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Thermotogamaritima) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 4 | ASP A 92VAL A 98ILE A 95TYR A 146 | None | 1.12A | 2yfbB-1zczA:undetectable | 2yfbB-1zczA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bih | NITRATE REDUCTASE[NADPH] (Ogataea angusta) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 4 | ASP A 271ARG A 89ILE A 245TYR A 202 | MTV A1479 ( 4.5A)MTV A1479 (-4.8A)MTV A1479 (-3.6A)MTV A1479 (-3.7A) | 1.22A | 2yfbB-2bihA:undetectable | 2yfbB-2bihA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bs9 | BETA-XYLOSIDASE (Geobacillusstearothermophilus) |
PF01229(Glyco_hydro_39) | 4 | ASP A 311VAL A 260ARG A 261ILE A 264 | None | 0.99A | 2yfbB-2bs9A:undetectable | 2yfbB-2bs9A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cff | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO]IMIDAZOLE-4-CARBOXAMIDE ISOMERASE (Thermotogamaritima) |
PF00977(His_biosynth) | 4 | ARG A 16ARG A 224ILE A 230TYR A 28 | None | 1.23A | 2yfbB-2cffA:undetectable | 2yfbB-2cffA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cp6 | RESTIN (Homo sapiens) |
PF01302(CAP_GLY) | 4 | ASP A 74VAL A 45ARG A 44ILE A 108 | None | 1.22A | 2yfbB-2cp6A:undetectable | 2yfbB-2cp6A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4v | ISOCITRATEDEHYDROGENASE (Acidithiobacillusthiooxidans) |
PF00180(Iso_dh) | 4 | ASP A 324VAL A 131ARG A 129ILE A 151 | NoneNoneFLC A3001 (-3.4A)None | 1.13A | 2yfbB-2d4vA:undetectable | 2yfbB-2d4vA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d5w | PEPTIDE ABCTRANSPORTER,PEPTIDE-BINDINGPROTEIN (Thermusthermophilus) |
PF00496(SBP_bac_5) | 4 | ASP A 84VAL A 129ARG A 130ILE A 140 | None | 1.22A | 2yfbB-2d5wA:undetectable | 2yfbB-2d5wA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfk | COLLYBISTIN II (Rattusnorvegicus) |
PF00169(PH)PF00621(RhoGEF) | 4 | ASP A 213ARG A 51VAL A 54ILE A 58 | None | 1.12A | 2yfbB-2dfkA:3.0 | 2yfbB-2dfkA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 4 | ASP A 244VAL A 251ARG A 250TYR A 130 | None | 1.11A | 2yfbB-2fgeA:undetectable | 2yfbB-2fgeA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 4 | ASP A 433ARG A 236ARG A 66ILE A 270 | NoneNoneNone CL A 997 ( 4.2A) | 1.05A | 2yfbB-2fgeA:undetectable | 2yfbB-2fgeA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frv | PERIPLASMICHYDROGENASE (Desulfovibriogigas) |
no annotation | 4 | ASP L 119VAL L 11ILE L 14TYR L 174 | None | 1.17A | 2yfbB-2frvL:4.3 | 2yfbB-2frvL:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iv0 | ISOCITRATEDEHYDROGENASE (Archaeoglobusfulgidus) |
PF00180(Iso_dh) | 4 | ASP A 305VAL A 127ARG A 125ILE A 147 | ZN A1415 (-2.5A)NoneNoneNone | 0.87A | 2yfbB-2iv0A:undetectable | 2yfbB-2iv0A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nz9 | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 4 | ASP A1171ARG A1175ILE A1096TYR A1107 | None | 1.12A | 2yfbB-2nz9A:3.2 | 2yfbB-2nz9A:10.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o56 | PUTATIVE MANDELATERACEMASE (Salmonellaenterica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASP A 215VAL A 343ARG A 129TYR A 243 | None | 1.11A | 2yfbB-2o56A:undetectable | 2yfbB-2o56A:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o8r | POLYPHOSPHATE KINASE (Porphyromonasgingivalis) |
PF02503(PP_kinase)PF13089(PP_kinase_N)PF13090(PP_kinase_C) | 4 | VAL A 89ARG A 86ILE A 90TYR A 51 | None | 1.18A | 2yfbB-2o8rA:4.6 | 2yfbB-2o8rA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pun | METHYLTHIORIBOSEKINASE (Bacillussubtilis) |
PF01636(APH) | 4 | ASP A 278ARG A 282ARG A 363ILE A 354 | None | 1.09A | 2yfbB-2punA:undetectable | 2yfbB-2punA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pz1 | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 4 (Homo sapiens) |
PF00018(SH3_1)PF00169(PH)PF00621(RhoGEF) | 4 | ASP A 447ARG A 285VAL A 288ILE A 292 | None | 1.10A | 2yfbB-2pz1A:4.8 | 2yfbB-2pz1A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9s | FATTY ACID-BINDINGPROTEIN (Mus musculus) |
PF00061(Lipocalin) | 4 | ARG A 126VAL A 115ILE A 104TYR A 128 | EIC A 601 (-4.5A)EIC A 601 (-4.3A)EIC A 601 ( 4.5A)EIC A 601 (-4.7A) | 1.13A | 2yfbB-2q9sA:undetectable | 2yfbB-2q9sA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wjf | TYROSINE-PROTEINPHOSPHATASE CPSB (Streptococcuspneumoniae) |
no annotation | 4 | ASP A 191VAL A 150ARG A 151ILE A 154 | None | 0.91A | 2yfbB-2wjfA:undetectable | 2yfbB-2wjfA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x11 | EPHRIN-A5 (Homo sapiens) |
PF00812(Ephrin) | 4 | ARG B 138VAL B 163ILE B 58TYR B 140 | None | 1.09A | 2yfbB-2x11B:undetectable | 2yfbB-2x11B:18.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yfb | METHYL-ACCEPTINGCHEMOTAXISTRANSDUCER (Pseudomonasputida) |
PF16591(HBM) | 6 | ASP A 138ARG A 183VAL A 186ARG A 187ILE A 190TYR A 236 | ACT A 501 (-3.9A)ACT A 501 (-3.9A)ACT A 501 (-4.4A)ACT A 501 (-3.7A)NoneACT A 501 (-4.5A) | 0.24A | 2yfbB-2yfbA:30.5 | 2yfbB-2yfbA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a31 | PROBABLETHREONYL-TRNASYNTHETASE 1 (Aeropyrumpernix) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 4 | ASP A 180ARG A 173VAL A 169ILE A 167 | None | 1.18A | 2yfbB-3a31A:undetectable | 2yfbB-3a31A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b6u | KINESIN-LIKE PROTEINKIF3B (Homo sapiens) |
PF00225(Kinesin) | 4 | ARG A 78VAL A 81ILE A 126TYR A 73 | None | 1.14A | 2yfbB-3b6uA:undetectable | 2yfbB-3b6uA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h79 | THIOREDOXIN-LIKEPROTEIN (Trypanosomacruzi) |
PF00085(Thioredoxin) | 4 | ARG A 97VAL A 38ILE A 76TYR A 99 | None | 0.88A | 2yfbB-3h79A:undetectable | 2yfbB-3h79A:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdx | SUSD SUPERFAMILYPROTEIN (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | ARG A 470ARG A 454ILE A 450TYR A 247 | None | 1.05A | 2yfbB-3hdxA:1.8 | 2yfbB-3hdxA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l22 | SUSD SUPERFAMILYPROTEIN (Bacteroidesfragilis) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | ARG A 174VAL A 171ILE A 451TYR A 112 | None | 1.17A | 2yfbB-3l22A:undetectable | 2yfbB-3l22A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6y | CATENIN DELTA-1 (Homo sapiens) |
PF00514(Arm) | 4 | ASP A 440VAL A 404ARG A 405ILE A 410 | None | 1.21A | 2yfbB-3l6yA:undetectable | 2yfbB-3l6yA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m07 | PUTATIVE ALPHAAMYLASE (Salmonellaenterica) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | ASP A 268VAL A 238ARG A 239ILE A 242 | None | 1.20A | 2yfbB-3m07A:undetectable | 2yfbB-3m07A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myr | NICKEL-DEPENDENTHYDROGENASE LARGESUBUNIT (Allochromatiumvinosum) |
PF00374(NiFeSe_Hases) | 4 | ASP B1449VAL B1242ARG B1243ILE B1246 | None | 0.99A | 2yfbB-3myrB:2.2 | 2yfbB-3myrB:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o3p | MANNOSYL-3-PHOSPHOGLYCERATE SYNTHASE (Rubrobacterxylanophilus) |
PF00535(Glycos_transf_2) | 4 | ASP A 214ARG A 160VAL A 237ILE A 221 | None | 1.23A | 2yfbB-3o3pA:undetectable | 2yfbB-3o3pA:25.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3on4 | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Legionellapneumophila) |
PF00440(TetR_N) | 4 | ASP A 90VAL A 179ARG A 180ILE A 183 | None | 0.77A | 2yfbB-3on4A:2.1 | 2yfbB-3on4A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8c | PROBABLE PROTEINBRICK1ABL INTERACTOR 2 (Homo sapiens;Homo sapiens) |
no annotationPF07815(Abi_HHR) | 4 | ASP F 98VAL E 68ARG E 67ILE E 64 | None | 1.11A | 2yfbB-3p8cF:3.1 | 2yfbB-3p8cF:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pru | PHYCOBILISOME 32.1KDA LINKERPOLYPEPTIDE,PHYCOCYANIN-ASSOCIATED, ROD 1 (Synechocystissp. PCC 6803) |
no annotation | 5 | ASP C 135ARG C 70VAL C 73ARG C 74TYR C 139 | None | 1.30A | 2yfbB-3pruC:undetectable | 2yfbB-3pruC:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rp9 | MITOGEN-ACTIVATEDPROTEIN KINASE (Toxoplasmagondii) |
PF00069(Pkinase) | 4 | ARG A 180ARG A 250ILE A 255TYR A 261 | None | 1.12A | 2yfbB-3rp9A:2.7 | 2yfbB-3rp9A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sra | ACYL-HOMOSERINELACTONE ACYLASE PVDQ (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | VAL A 74ARG A 77ILE A 73TYR A 83 | EDO A 4 ( 4.8A)EDO A 5 (-3.8A)EDO A 4 (-4.0A)None | 1.15A | 2yfbB-3sraA:undetectable | 2yfbB-3sraA:25.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty4 | PROBABLEHOMOISOCITRATEDEHYDROGENASE (Schizosaccharomycespombe) |
PF00180(Iso_dh) | 4 | ASP A 260VAL A 109ARG A 107ILE A 124 | GOL A 366 (-3.4A)NoneGOL A 366 ( 4.7A)None | 1.22A | 2yfbB-3ty4A:undetectable | 2yfbB-3ty4A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u9s | METHYLCROTONYL-COACARBOXYLASE,ALPHA-SUBUNIT (Pseudomonasaeruginosa) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 4 | ARG A 66VAL A 416ARG A 415ILE A 438 | None | 1.24A | 2yfbB-3u9sA:undetectable | 2yfbB-3u9sA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdy | BETA-1,3-1,4-GLUCANASE (Paecilomycessp.'thermophila') |
no annotation | 4 | ARG A 292VAL A 83ILE A 186TYR A 294 | None | 1.13A | 2yfbB-3wdyA:undetectable | 2yfbB-3wdyA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zrp | SERINE-PYRUVATEAMINOTRANSFERASE(AGXT) (Sulfolobussolfataricus) |
PF00266(Aminotran_5) | 4 | ASP A 181ARG A 154ILE A 150TYR A 54 | None | 1.17A | 2yfbB-3zrpA:undetectable | 2yfbB-3zrpA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc5 | XYLULOSE KINASE (Homo sapiens) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | ARG A 265ARG A 120ILE A 74TYR A 266 | None | 1.20A | 2yfbB-4bc5A:undetectable | 2yfbB-4bc5A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c30 | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 4 | ASP A 117ARG A 403VAL A 412TYR A 116 | None | 1.08A | 2yfbB-4c30A:undetectable | 2yfbB-4c30A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e22 | CYTIDYLATE KINASE (Yersiniapseudotuberculosis) |
PF02224(Cytidylate_kin) | 4 | ARG A 32VAL A 72ARG A 70ILE A 81 | None | 1.12A | 2yfbB-4e22A:undetectable | 2yfbB-4e22A:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2p | CYTOCHROME P450107B1 (P450CVIIB1) (Streptomyceshimastatinicus) |
PF00067(p450) | 4 | ARG A 263VAL A 262ARG A 266ILE A 269 | None | 1.10A | 2yfbB-4e2pA:undetectable | 2yfbB-4e2pA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gnx | PUTATIVEUNCHARACTERIZEDPROTEIN (Ustilago maydis) |
PF01336(tRNA_anti-codon)PF08646(Rep_fac-A_C)PF16900(REPA_OB_2) | 4 | ARG C 577VAL C 477ILE C 480TYR C 579 | None | 1.19A | 2yfbB-4gnxC:undetectable | 2yfbB-4gnxC:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h08 | PUTATIVE HYDROLASE (Bacteroidesthetaiotaomicron) |
PF00657(Lipase_GDSL) | 4 | ARG A 160VAL A 163ARG A 164ILE A 167 | None | 0.64A | 2yfbB-4h08A:undetectable | 2yfbB-4h08A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jf3 | ENVELOPEGLYCOPROTEIN (Mason-Pfizermonkey virus) |
PF00429(TLV_coat) | 4 | ASP A 448VAL A 492ARG A 493ILE A 496 | None | 1.23A | 2yfbB-4jf3A:2.8 | 2yfbB-4jf3A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lcy | HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-46 ALPHACHAIN (Homo sapiens) |
PF00129(MHC_I)PF07654(C1-set) | 4 | ARG A 48VAL A 25ARG A 35ILE A 23 | None | 0.90A | 2yfbB-4lcyA:undetectable | 2yfbB-4lcyA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lk4 | VESB PROTEASE (Vibrio cholerae) |
PF00089(Trypsin) | 4 | ASP A 241VAL A 159ILE A 164TYR A 253 | None | 1.11A | 2yfbB-4lk4A:undetectable | 2yfbB-4lk4A:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxl | LYSINE-SPECIFICDEMETHYLASE 4B (Homo sapiens) |
PF02373(JmjC)PF02375(JmjN) | 4 | ARG A 296VAL A 32ILE A 35TYR A 196 | None | 1.21A | 2yfbB-4lxlA:undetectable | 2yfbB-4lxlA:24.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mtn | TRANSCRIPTIONTERMINATION FACTORNUSA (Planctopiruslimnophila) |
PF00575(S1)PF08529(NusA_N)PF13184(KH_5)PF14520(HHH_5) | 4 | ASP A 218ARG A 247VAL A 210ILE A 193 | None | 1.24A | 2yfbB-4mtnA:undetectable | 2yfbB-4mtnA:25.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0l | PREDICTED COMPONENTOF ATHERMOPHILE-SPECIFICDNA REPAIR SYSTEM,CONTAINS A RAMPDOMAIN (Methanopyruskandleri) |
PF03787(RAMPs) | 4 | ARG A 150VAL A 76ILE A 72TYR A 151 | None | 1.17A | 2yfbB-4n0lA:undetectable | 2yfbB-4n0lA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o2z | MITOGEN-ACTIVATEDPROTEIN KINASE 3,PUTATIVE (Leishmaniadonovani) |
PF00069(Pkinase) | 4 | ASP A 175ARG A 217VAL A 232ARG A 174 | 046 A 401 (-4.4A)NoneNoneNone | 1.20A | 2yfbB-4o2zA:2.2 | 2yfbB-4o2zA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pel | PENICILLIN G ACYLASESUBUNIT BETA (Kluyveracryocrescens) |
PF01804(Penicil_amidase) | 4 | ASP B 280ARG B 533VAL B 19ILE B 17 | None | 1.07A | 2yfbB-4pelB:undetectable | 2yfbB-4pelB:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ri6 | PHI CLASSGLUTATHIONETRANSFERASE GSTF1 (Populus tremulax Populustremuloides) |
PF00043(GST_C)PF02798(GST_N) | 4 | ASP A 181VAL A 137ILE A 133TYR A 184 | None | 1.11A | 2yfbB-4ri6A:2.2 | 2yfbB-4ri6A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upe | NICKEL-DEPENDENTHYDROGENASE LARGESUBUNIT (Desulfovibriofructosivorans) |
PF00374(NiFeSe_Hases) | 4 | ASP Q 126VAL Q 18ILE Q 21TYR Q 183 | None | 1.16A | 2yfbB-4upeQ:2.8 | 2yfbB-4upeQ:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4urj | PROTEIN FAM83A (Homo sapiens) |
PF07894(DUF1669) | 4 | ARG A 148VAL A 151ILE A 155TYR A 257 | NoneEDO A1305 ( 4.3A)NoneNone | 0.94A | 2yfbB-4urjA:undetectable | 2yfbB-4urjA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4urj | PROTEIN FAM83A (Homo sapiens) |
PF07894(DUF1669) | 4 | ASP A 171ARG A 148VAL A 151TYR A 257 | NoneNoneEDO A1305 ( 4.3A)None | 1.17A | 2yfbB-4urjA:undetectable | 2yfbB-4urjA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4urj | PROTEIN FAM83A (Homo sapiens) |
PF07894(DUF1669) | 4 | VAL A 151ARG A 152ILE A 155TYR A 257 | EDO A1305 ( 4.3A)NoneNoneNone | 1.13A | 2yfbB-4urjA:undetectable | 2yfbB-4urjA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xee | NEUROTENSIN RECEPTORTYPE 1, ENDOLYSINCHIMERA (Rattusnorvegicus;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 4 | ARG A 327ARG A 328ILE A 238TYR A 347 | None | 1.19A | 2yfbB-4xeeA:5.2 | 2yfbB-4xeeA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xr7 | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN3 (Saccharomycescerevisiae) |
no annotation | 4 | ASP L 318VAL L 374ARG L 358TYR L 291 | None | 1.10A | 2yfbB-4xr7L:3.4 | 2yfbB-4xr7L:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zkt | BONTOXILYSIN A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 4 | ASP A1139ARG A1143ILE A1071TYR A1082 | None | 0.97A | 2yfbB-4zktA:2.4 | 2yfbB-4zktA:10.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp)PF01740(STAS) | 4 | ASP A 428ARG A 407VAL A 436TYR A 409 | None | 1.23A | 2yfbB-5da0A:undetectable | 2yfbB-5da0A:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8c | UL31 (Suidalphaherpesvirus1) |
PF02718(Herpes_UL31) | 4 | ASP A 156ARG A 160VAL A 162ARG A 155 | None | 1.01A | 2yfbB-5e8cA:undetectable | 2yfbB-5e8cA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fi0 | PHOSPHATIDYLINOSITOL3,4,5-TRISPHOSPHATE-DEPENDENT RACEXCHANGER 1PROTEIN,PHOSPHATIDYLINOSITOL3,4,5-TRISPHOSPHATE-DEPENDENT RACEXCHANGER 1 PROTEIN (Homo sapiens) |
PF00169(PH)PF00621(RhoGEF) | 4 | ASP A 219ARG A 50VAL A 53ILE A 57 | None | 1.13A | 2yfbB-5fi0A:4.0 | 2yfbB-5fi0A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fse | UREASE SUBUNIT ALPHA (Sporosarcinapasteurii) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | ARG C 402ARG C 388ILE C 350TYR C 406 | NoneSO4 C1588 ( 3.9A)HQE C1583 ( 4.9A)None | 1.15A | 2yfbB-5fseC:undetectable | 2yfbB-5fseC:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hb0 | NUCLEOPORIN NUP170 (Chaetomiumthermophilum) |
no annotation | 4 | ASP B1301ARG B1312VAL B1315ILE B1319 | None | 0.76A | 2yfbB-5hb0B:4.7 | 2yfbB-5hb0B:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5igp | MACROLIDE2'-PHOSPHOTRANSFERASE (Escherichiacoli) |
PF01636(APH) | 4 | ASP A 219VAL A 50ARG A 52ILE A 38 | GDP A 401 (-2.6A)GDP A 401 (-4.6A)GDP A 401 (-4.5A)GDP A 401 (-4.2A) | 0.98A | 2yfbB-5igpA:undetectable | 2yfbB-5igpA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ii5 | MALTOSE-BINDINGPERIPLASMICPROTEIN,VITELLINEENVELOPE SPERM LYSINRECEPTOR (Escherichiacoli;Haliotisrufescens) |
PF11386(VERL)PF13416(SBP_bac_8) | 4 | ASP A4038ARG A4081VAL A4064ILE A3845 | None | 1.07A | 2yfbB-5ii5A:undetectable | 2yfbB-5ii5A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5itg | SORBITOLDEHYDROGENASE (Gluconobacteroxydans) |
PF01232(Mannitol_dh)PF08125(Mannitol_dh_C) | 4 | ASP A 442ARG A 475ARG A 471ILE A 468 | None | 0.98A | 2yfbB-5itgA:undetectable | 2yfbB-5itgA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jp6 | PUTATIVEPOLYSACCHARIDEDEACETYLASE (Bdellovibriobacteriovorus) |
PF01522(Polysacc_deac_1) | 4 | ASP A 118ARG A 339ARG A 98ILE A 97 | None | 0.98A | 2yfbB-5jp6A:undetectable | 2yfbB-5jp6A:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5knm | LEUKOCYTEIMMUNOGLOBULIN-LIKERECEPTOR SUBFAMILY BMEMBER 1 (Homo sapiens) |
PF13895(Ig_2) | 4 | ARG D 173VAL D 15ILE D 16TYR D 175 | None | 1.11A | 2yfbB-5knmD:undetectable | 2yfbB-5knmD:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l7d | SMOOTHENEDHOMOLOG,SOLUBLECYTOCHROMEB562,SMOOTHENEDHOMOLOG (Escherichiacoli;Homo sapiens) |
PF01392(Fz)PF01534(Frizzled)PF07361(Cytochrom_B562) | 4 | ASP A 209ARG A 485VAL A 488TYR A 207 | None | 1.09A | 2yfbB-5l7dA:undetectable | 2yfbB-5l7dA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m4a | NEUTRAL TREHALASE (Saccharomycescerevisiae) |
no annotation | 4 | ASP A 382ARG A 328VAL A 331ILE A 335 | None | 0.90A | 2yfbB-5m4aA:undetectable | 2yfbB-5m4aA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nv6 | TRANSFORMING GROWTHFACTOR-BETA-INDUCEDPROTEIN IG-H3 (Homo sapiens) |
PF02469(Fasciclin) | 4 | ARG A 59VAL A 322ILE A 321TYR A 61 | None | 1.17A | 2yfbB-5nv6A:undetectable | 2yfbB-5nv6A:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t88 | PROLYL ENDOPEPTIDASE (Pyrococcusfuriosus) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 4 | ASP A 177VAL A 184ARG A 182TYR A 152 | None | 1.09A | 2yfbB-5t88A:undetectable | 2yfbB-5t88A:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubk | ACYL-HOMOSERINELACTONE ACYLASE PVDQ (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | VAL A 600ARG A 603ILE A 599TYR A 609 | None | 1.16A | 2yfbB-5ubkA:undetectable | 2yfbB-5ubkA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v38 | HCHA (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 4 | ASP A1163ARG A1167ILE A1088TYR A1099 | None | 1.04A | 2yfbB-5v38A:undetectable | 2yfbB-5v38A:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7n | DIAMINOPIMELATEDECARBOXYLASE (Corynebacteriumglutamicum) |
no annotation | 4 | ARG A 343ARG A 302ILE A 260TYR A 351 | LYS A 505 (-4.3A)LYS A 505 ( 3.8A)NoneNone | 1.15A | 2yfbB-5x7nA:undetectable | 2yfbB-5x7nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xna | SAHS1 (Ramazzottiusvarieornatus) |
no annotation | 4 | ASP A 139VAL A 96ILE A 85TYR A 117 | EDO A 208 (-3.2A)NoneNoneEDO A 207 (-4.6A) | 1.10A | 2yfbB-5xnaA:undetectable | 2yfbB-5xnaA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zqe | - (-) |
no annotation | 4 | ASP A 219VAL A 244ARG A 243ILE A 245 | None | 1.18A | 2yfbB-5zqeA:undetectable | 2yfbB-5zqeA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6q | EXOSOME COMPLEXEXONUCLEASE RRP44 (Homo sapiens) |
no annotation | 4 | ASP K 520ARG K 789ILE K 813TYR K 801 | None | 1.01A | 2yfbB-6d6qK:undetectable | 2yfbB-6d6qK:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5d | ATP SYNTHASE SUBUNITBETA (Trypanosomabrucei) |
no annotation | 4 | ARG D 413VAL D 416ILE D 349TYR D 386 | None | 1.21A | 2yfbB-6f5dD:undetectable | 2yfbB-6f5dD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fcx | METHYLENETETRAHYDROFOLATE REDUCTASE (Homo sapiens) |
no annotation | 4 | ASP A 223VAL A 179ARG A 183ILE A 182 | None | 1.10A | 2yfbB-6fcxA:undetectable | 2yfbB-6fcxA:undetectable |