SIMILAR PATTERNS OF AMINO ACIDS FOR 2YFB_B_ACTB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4e CATALASE A

(Saccharomyces
cerevisiae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASP A  88
VAL A 310
ARG A 308
ILE A 278
 None
 1.22A 2yfbB-1a4eA:
undetectable		 2yfbB-1a4eA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		4 ASP A 146
VAL A 118
ARG A 119
ILE A 122
 None
 1.14A 2yfbB-1g67A:
undetectable		 2yfbB-1g67A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ARG A 344
ARG A 303
ILE A 261
TYR A 352
 None
SO4  A 500 (-3.3A)
None
None
 1.23A 2yfbB-1hkwA:
undetectable		 2yfbB-1hkwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm7 PENTALENENE SYNTHASE

(Streptomyces
exfoliatus) 		no annotation 4 ARG A 294
VAL A 298
ARG A 299
ILE A 302
 None
 1.00A 2yfbB-1hm7A:
undetectable		 2yfbB-1hm7A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 ASP A 258
VAL A 470
ARG A 466
ILE A 467
 None
 1.11A 2yfbB-1hn0A:
undetectable		 2yfbB-1hn0A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		4 ASP B 280
ARG B 533
VAL B  19
ILE B  17
 None
 0.95A 2yfbB-1k5sB:
undetectable		 2yfbB-1k5sB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 ARG A 637
VAL A 638
ILE A 705
TYR A 743
 None
 1.19A 2yfbB-1ku1A:
undetectable		 2yfbB-1ku1A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovy 50S RIBOSOMAL
PROTEIN L18

(Geobacillus
stearothermophilus) 		PF00861
(Ribosomal_L18p) 		4 VAL A 106
ARG A 105
ILE A  71
TYR A 100
 None
 1.17A 2yfbB-1ovyA:
undetectable		 2yfbB-1ovyA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		4 ASP A 547
VAL A 544
ARG A 586
ILE A 570
 None
 1.04A 2yfbB-1qafA:
undetectable		 2yfbB-1qafA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 ASP A1412
ARG A1278
VAL A1425
ILE A1424
 None
 1.18A 2yfbB-1qhmA:
3.3		 2yfbB-1qhmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwg (2R)-PHOSPHO-3-SULFO
LACTATE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF02679
(ComA) 		4 ASP A 231
VAL A  18
ILE A 228
TYR A  31
 None
 1.10A 2yfbB-1qwgA:
undetectable		 2yfbB-1qwgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shx EPHRIN-A5

(Mus musculus) 		PF00812
(Ephrin) 		4 ARG A 138
VAL A 163
ILE A  58
TYR A 140
 None
 1.08A 2yfbB-1shxA:
undetectable		 2yfbB-1shxA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		4 VAL A 252
ARG A 278
ILE A 250
TYR A 222
 None
 1.06A 2yfbB-1sr8A:
undetectable		 2yfbB-1sr8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Thermus
thermophilus) 		PF02219
(MTHFR) 		4 ASP A 175
VAL A 131
ARG A 135
ILE A 134
 None
 1.12A 2yfbB-1v93A:
undetectable		 2yfbB-1v93A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		4 ASP A 315
VAL A 138
ARG A 136
ILE A 157
 CA  A1006 (-2.9A)
None
ICT  A1002 (-3.0A)
None
 1.05A 2yfbB-1xkdA:
undetectable		 2yfbB-1xkdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 ASP A 293
ARG A 262
ARG A 210
ILE A 206
 None
 1.18A 2yfbB-1xzqA:
2.0		 2yfbB-1xzqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ARG A 812
VAL A 841
ILE A 856
TYR A 830
 None
 1.23A 2yfbB-1yq2A:
undetectable		 2yfbB-1yq2A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ASP A  92
VAL A  98
ILE A  95
TYR A 146
 None
 1.12A 2yfbB-1zczA:
undetectable		 2yfbB-1zczA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 ASP A 271
ARG A  89
ILE A 245
TYR A 202
 MTV  A1479 ( 4.5A)
MTV  A1479 (-4.8A)
MTV  A1479 (-3.6A)
MTV  A1479 (-3.7A)
 1.22A 2yfbB-2bihA:
undetectable		 2yfbB-2bihA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 ASP A 311
VAL A 260
ARG A 261
ILE A 264
 None
 0.99A 2yfbB-2bs9A:
undetectable		 2yfbB-2bs9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cff 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)
METHYLIDENEAMINO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		4 ARG A  16
ARG A 224
ILE A 230
TYR A  28
 None
 1.23A 2yfbB-2cffA:
undetectable		 2yfbB-2cffA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cp6 RESTIN

(Homo sapiens) 		PF01302
(CAP_GLY) 		4 ASP A  74
VAL A  45
ARG A  44
ILE A 108
 None
 1.22A 2yfbB-2cp6A:
undetectable		 2yfbB-2cp6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		4 ASP A 324
VAL A 131
ARG A 129
ILE A 151
 None
None
FLC  A3001 (-3.4A)
None
 1.13A 2yfbB-2d4vA:
undetectable		 2yfbB-2d4vA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 ASP A  84
VAL A 129
ARG A 130
ILE A 140
 None
 1.22A 2yfbB-2d5wA:
undetectable		 2yfbB-2d5wA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfk COLLYBISTIN II

(Rattus
norvegicus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ASP A 213
ARG A  51
VAL A  54
ILE A  58
 None
 1.12A 2yfbB-2dfkA:
3.0		 2yfbB-2dfkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ASP A 244
VAL A 251
ARG A 250
TYR A 130
 None
 1.11A 2yfbB-2fgeA:
undetectable		 2yfbB-2fgeA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ASP A 433
ARG A 236
ARG A  66
ILE A 270
 None
None
None
CL  A 997 ( 4.2A)
 1.05A 2yfbB-2fgeA:
undetectable		 2yfbB-2fgeA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 4 ASP L 119
VAL L  11
ILE L  14
TYR L 174
 None
 1.17A 2yfbB-2frvL:
4.3		 2yfbB-2frvL:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		4 ASP A 305
VAL A 127
ARG A 125
ILE A 147
 ZN  A1415 (-2.5A)
None
None
None
 0.87A 2yfbB-2iv0A:
undetectable		 2yfbB-2iv0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ASP A1171
ARG A1175
ILE A1096
TYR A1107
 None
 1.12A 2yfbB-2nz9A:
3.2		 2yfbB-2nz9A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 215
VAL A 343
ARG A 129
TYR A 243
 None
 1.11A 2yfbB-2o56A:
undetectable		 2yfbB-2o56A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 VAL A  89
ARG A  86
ILE A  90
TYR A  51
 None
 1.18A 2yfbB-2o8rA:
4.6		 2yfbB-2o8rA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 ASP A 278
ARG A 282
ARG A 363
ILE A 354
 None
 1.09A 2yfbB-2punA:
undetectable		 2yfbB-2punA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 ASP A 447
ARG A 285
VAL A 288
ILE A 292
 None
 1.10A 2yfbB-2pz1A:
4.8		 2yfbB-2pz1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 ARG A 126
VAL A 115
ILE A 104
TYR A 128
 EIC  A 601 (-4.5A)
EIC  A 601 (-4.3A)
EIC  A 601 ( 4.5A)
EIC  A 601 (-4.7A)
 1.13A 2yfbB-2q9sA:
undetectable		 2yfbB-2q9sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 4 ASP A 191
VAL A 150
ARG A 151
ILE A 154
 None
 0.91A 2yfbB-2wjfA:
undetectable		 2yfbB-2wjfA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x11 EPHRIN-A5

(Homo sapiens) 		PF00812
(Ephrin) 		4 ARG B 138
VAL B 163
ILE B  58
TYR B 140
 None
 1.09A 2yfbB-2x11B:
undetectable		 2yfbB-2x11B:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER

(Pseudomonas
putida) 		PF16591
(HBM) 		6 ASP A 138
ARG A 183
VAL A 186
ARG A 187
ILE A 190
TYR A 236
 ACT  A 501 (-3.9A)
ACT  A 501 (-3.9A)
ACT  A 501 (-4.4A)
ACT  A 501 (-3.7A)
None
ACT  A 501 (-4.5A)
 0.24A 2yfbB-2yfbA:
30.5		 2yfbB-2yfbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ASP A 180
ARG A 173
VAL A 169
ILE A 167
 None
 1.18A 2yfbB-3a31A:
undetectable		 2yfbB-3a31A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6u KINESIN-LIKE PROTEIN
KIF3B

(Homo sapiens) 		PF00225
(Kinesin) 		4 ARG A  78
VAL A  81
ILE A 126
TYR A  73
 None
 1.14A 2yfbB-3b6uA:
undetectable		 2yfbB-3b6uA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h79 THIOREDOXIN-LIKE
PROTEIN

(Trypanosoma
cruzi) 		PF00085
(Thioredoxin) 		4 ARG A  97
VAL A  38
ILE A  76
TYR A  99
 None
 0.88A 2yfbB-3h79A:
undetectable		 2yfbB-3h79A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 470
ARG A 454
ILE A 450
TYR A 247
 None
 1.05A 2yfbB-3hdxA:
1.8		 2yfbB-3hdxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 174
VAL A 171
ILE A 451
TYR A 112
 None
 1.17A 2yfbB-3l22A:
undetectable		 2yfbB-3l22A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		4 ASP A 440
VAL A 404
ARG A 405
ILE A 410
 None
 1.21A 2yfbB-3l6yA:
undetectable		 2yfbB-3l6yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ASP A 268
VAL A 238
ARG A 239
ILE A 242
 None
 1.20A 2yfbB-3m07A:
undetectable		 2yfbB-3m07A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		4 ASP B1449
VAL B1242
ARG B1243
ILE B1246
 None
 0.99A 2yfbB-3myrB:
2.2		 2yfbB-3myrB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		4 ASP A 214
ARG A 160
VAL A 237
ILE A 221
 None
 1.23A 2yfbB-3o3pA:
undetectable		 2yfbB-3o3pA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Legionella
pneumophila) 		PF00440
(TetR_N) 		4 ASP A  90
VAL A 179
ARG A 180
ILE A 183
 None
 0.77A 2yfbB-3on4A:
2.1		 2yfbB-3on4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2

(Homo sapiens;
Homo sapiens) 		no annotation
PF07815
(Abi_HHR) 		4 ASP F  98
VAL E  68
ARG E  67
ILE E  64
 None
 1.11A 2yfbB-3p8cF:
3.1		 2yfbB-3p8cF:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pru PHYCOBILISOME 32.1
KDA LINKER
POLYPEPTIDE,
PHYCOCYANIN-ASSOCIAT
ED, ROD 1

(Synechocystis
sp. PCC 6803) 		no annotation 5 ASP C 135
ARG C  70
VAL C  73
ARG C  74
TYR C 139
 None
 1.30A 2yfbB-3pruC:
undetectable		 2yfbB-3pruC:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ARG A 180
ARG A 250
ILE A 255
TYR A 261
 None
 1.12A 2yfbB-3rp9A:
2.7		 2yfbB-3rp9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sra ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 VAL A  74
ARG A  77
ILE A  73
TYR A  83
 EDO  A   4 ( 4.8A)
EDO  A   5 (-3.8A)
EDO  A   4 (-4.0A)
None
 1.15A 2yfbB-3sraA:
undetectable		 2yfbB-3sraA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00180
(Iso_dh) 		4 ASP A 260
VAL A 109
ARG A 107
ILE A 124
 GOL  A 366 (-3.4A)
None
GOL  A 366 ( 4.7A)
None
 1.22A 2yfbB-3ty4A:
undetectable		 2yfbB-3ty4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A  66
VAL A 416
ARG A 415
ILE A 438
 None
 1.24A 2yfbB-3u9sA:
undetectable		 2yfbB-3u9sA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 4 ARG A 292
VAL A  83
ILE A 186
TYR A 294
 None
 1.13A 2yfbB-3wdyA:
undetectable		 2yfbB-3wdyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		4 ASP A 181
ARG A 154
ILE A 150
TYR A  54
 None
 1.17A 2yfbB-3zrpA:
undetectable		 2yfbB-3zrpA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ARG A 265
ARG A 120
ILE A  74
TYR A 266
 None
 1.20A 2yfbB-4bc5A:
undetectable		 2yfbB-4bc5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 ASP A 117
ARG A 403
VAL A 412
TYR A 116
 None
 1.08A 2yfbB-4c30A:
undetectable		 2yfbB-4c30A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e22 CYTIDYLATE KINASE

(Yersinia
pseudotuberculosis) 		PF02224
(Cytidylate_kin) 		4 ARG A  32
VAL A  72
ARG A  70
ILE A  81
 None
 1.12A 2yfbB-4e22A:
undetectable		 2yfbB-4e22A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2p CYTOCHROME P450
107B1 (P450CVIIB1)

(Streptomyces
himastatinicus) 		PF00067
(p450) 		4 ARG A 263
VAL A 262
ARG A 266
ILE A 269
 None
 1.10A 2yfbB-4e2pA:
undetectable		 2yfbB-4e2pA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2) 		4 ARG C 577
VAL C 477
ILE C 480
TYR C 579
 None
 1.19A 2yfbB-4gnxC:
undetectable		 2yfbB-4gnxC:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h08 PUTATIVE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF00657
(Lipase_GDSL) 		4 ARG A 160
VAL A 163
ARG A 164
ILE A 167
 None
 0.64A 2yfbB-4h08A:
undetectable		 2yfbB-4h08A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf3 ENVELOPE
GLYCOPROTEIN

(Mason-Pfizer
monkey virus) 		PF00429
(TLV_coat) 		4 ASP A 448
VAL A 492
ARG A 493
ILE A 496
 None
 1.23A 2yfbB-4jf3A:
2.8		 2yfbB-4jf3A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ARG A  48
VAL A  25
ARG A  35
ILE A  23
 None
 0.90A 2yfbB-4lcyA:
undetectable		 2yfbB-4lcyA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk4 VESB PROTEASE

(Vibrio cholerae) 		PF00089
(Trypsin) 		4 ASP A 241
VAL A 159
ILE A 164
TYR A 253
 None
 1.11A 2yfbB-4lk4A:
undetectable		 2yfbB-4lk4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ARG A 296
VAL A  32
ILE A  35
TYR A 196
 None
 1.21A 2yfbB-4lxlA:
undetectable		 2yfbB-4lxlA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtn TRANSCRIPTION
TERMINATION FACTOR
NUSA

(Planctopirus
limnophila) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
PF14520
(HHH_5) 		4 ASP A 218
ARG A 247
VAL A 210
ILE A 193
 None
 1.24A 2yfbB-4mtnA:
undetectable		 2yfbB-4mtnA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN

(Methanopyrus
kandleri) 		PF03787
(RAMPs) 		4 ARG A 150
VAL A  76
ILE A  72
TYR A 151
 None
 1.17A 2yfbB-4n0lA:
undetectable		 2yfbB-4n0lA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 ASP A 175
ARG A 217
VAL A 232
ARG A 174
 046  A 401 (-4.4A)
None
None
None
 1.20A 2yfbB-4o2zA:
2.2		 2yfbB-4o2zA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		4 ASP B 280
ARG B 533
VAL B  19
ILE B  17
 None
 1.07A 2yfbB-4pelB:
undetectable		 2yfbB-4pelB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1

(Populus tremula
x Populus
tremuloides) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ASP A 181
VAL A 137
ILE A 133
TYR A 184
 None
 1.11A 2yfbB-4ri6A:
2.2		 2yfbB-4ri6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		4 ASP Q 126
VAL Q  18
ILE Q  21
TYR Q 183
 None
 1.16A 2yfbB-4upeQ:
2.8		 2yfbB-4upeQ:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urj PROTEIN FAM83A

(Homo sapiens) 		PF07894
(DUF1669) 		4 ARG A 148
VAL A 151
ILE A 155
TYR A 257
 None
EDO  A1305 ( 4.3A)
None
None
 0.94A 2yfbB-4urjA:
undetectable		 2yfbB-4urjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urj PROTEIN FAM83A

(Homo sapiens) 		PF07894
(DUF1669) 		4 ASP A 171
ARG A 148
VAL A 151
TYR A 257
 None
None
EDO  A1305 ( 4.3A)
None
 1.17A 2yfbB-4urjA:
undetectable		 2yfbB-4urjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urj PROTEIN FAM83A

(Homo sapiens) 		PF07894
(DUF1669) 		4 VAL A 151
ARG A 152
ILE A 155
TYR A 257
 EDO  A1305 ( 4.3A)
None
None
None
 1.13A 2yfbB-4urjA:
undetectable		 2yfbB-4urjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ARG A 327
ARG A 328
ILE A 238
TYR A 347
 None
 1.19A 2yfbB-4xeeA:
5.2		 2yfbB-4xeeA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae) 		no annotation 4 ASP L 318
VAL L 374
ARG L 358
TYR L 291
 None
 1.10A 2yfbB-4xr7L:
3.4		 2yfbB-4xr7L:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ASP A1139
ARG A1143
ILE A1071
TYR A1082
 None
 0.97A 2yfbB-4zktA:
2.4		 2yfbB-4zktA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp)
PF01740
(STAS) 		4 ASP A 428
ARG A 407
VAL A 436
TYR A 409
 None
 1.23A 2yfbB-5da0A:
undetectable		 2yfbB-5da0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL31

(Suid
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		4 ASP A 156
ARG A 160
VAL A 162
ARG A 155
 None
 1.01A 2yfbB-5e8cA:
undetectable		 2yfbB-5e8cA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ASP A 219
ARG A  50
VAL A  53
ILE A  57
 None
 1.13A 2yfbB-5fi0A:
4.0		 2yfbB-5fi0A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ARG C 402
ARG C 388
ILE C 350
TYR C 406
 None
SO4  C1588 ( 3.9A)
HQE  C1583 ( 4.9A)
None
 1.15A 2yfbB-5fseC:
undetectable		 2yfbB-5fseC:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 4 ASP B1301
ARG B1312
VAL B1315
ILE B1319
 None
 0.76A 2yfbB-5hb0B:
4.7		 2yfbB-5hb0B:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		4 ASP A 219
VAL A  50
ARG A  52
ILE A  38
 GDP  A 401 (-2.6A)
GDP  A 401 (-4.6A)
GDP  A 401 (-4.5A)
GDP  A 401 (-4.2A)
 0.98A 2yfbB-5igpA:
undetectable		 2yfbB-5igpA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 ASP A4038
ARG A4081
VAL A4064
ILE A3845
 None
 1.07A 2yfbB-5ii5A:
undetectable		 2yfbB-5ii5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 ASP A 442
ARG A 475
ARG A 471
ILE A 468
 None
 0.98A 2yfbB-5itgA:
undetectable		 2yfbB-5itgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp6 PUTATIVE
POLYSACCHARIDE
DEACETYLASE

(Bdellovibrio
bacteriovorus) 		PF01522
(Polysacc_deac_1) 		4 ASP A 118
ARG A 339
ARG A  98
ILE A  97
 None
 0.98A 2yfbB-5jp6A:
undetectable		 2yfbB-5jp6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1

(Homo sapiens) 		PF13895
(Ig_2) 		4 ARG D 173
VAL D  15
ILE D  16
TYR D 175
 None
 1.11A 2yfbB-5knmD:
undetectable		 2yfbB-5knmD:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF01392
(Fz)
PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		4 ASP A 209
ARG A 485
VAL A 488
TYR A 207
 None
 1.09A 2yfbB-5l7dA:
undetectable		 2yfbB-5l7dA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4a NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 382
ARG A 328
VAL A 331
ILE A 335
 None
 0.90A 2yfbB-5m4aA:
undetectable		 2yfbB-5m4aA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		4 ARG A  59
VAL A 322
ILE A 321
TYR A  61
 None
 1.17A 2yfbB-5nv6A:
undetectable		 2yfbB-5nv6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ASP A 177
VAL A 184
ARG A 182
TYR A 152
 None
 1.09A 2yfbB-5t88A:
undetectable		 2yfbB-5t88A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 VAL A 600
ARG A 603
ILE A 599
TYR A 609
 None
 1.16A 2yfbB-5ubkA:
undetectable		 2yfbB-5ubkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v38 HCHA

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ASP A1163
ARG A1167
ILE A1088
TYR A1099
 None
 1.04A 2yfbB-5v38A:
undetectable		 2yfbB-5v38A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 4 ARG A 343
ARG A 302
ILE A 260
TYR A 351
 LYS  A 505 (-4.3A)
LYS  A 505 ( 3.8A)
None
None
 1.15A 2yfbB-5x7nA:
undetectable		 2yfbB-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xna SAHS1

(Ramazzottius
varieornatus) 		no annotation 4 ASP A 139
VAL A  96
ILE A  85
TYR A 117
 EDO  A 208 (-3.2A)
None
None
EDO  A 207 (-4.6A)
 1.10A 2yfbB-5xnaA:
undetectable		 2yfbB-5xnaA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 4 ASP A 219
VAL A 244
ARG A 243
ILE A 245
 None
 1.18A 2yfbB-5zqeA:
undetectable		 2yfbB-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 ASP K 520
ARG K 789
ILE K 813
TYR K 801
 None
 1.01A 2yfbB-6d6qK:
undetectable		 2yfbB-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 4 ARG D 413
VAL D 416
ILE D 349
TYR D 386
 None
 1.21A 2yfbB-6f5dD:
undetectable		 2yfbB-6f5dD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 4 ASP A 223
VAL A 179
ARG A 183
ILE A 182
 None
 1.10A 2yfbB-6fcxA:
undetectable		 2yfbB-6fcxA:
undetectable