SIMILAR PATTERNS OF AMINO ACIDS FOR 2YFB_A_ACTA501_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a97 | XANTHINE-GUANINEPHOSPHORIBOSYLTRANSFERASE (Escherichiacoli) |
PF00156(Pribosyltran) | 4 | MET A 103VAL A 58ILE A 60TYR A 104 | None | 0.93A | 2yfbA-1a97A:undetectable | 2yfbA-1a97A:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgj | ALDEHYDEOXIDOREDUCTASE (Desulfovibriodesulfuricans) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 4 | MET A 833ARG A 138ILE A 136TYR A 452 | None | 1.03A | 2yfbA-1dgjA:undetectable | 2yfbA-1dgjA:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g67 | THIAMIN PHOSPHATESYNTHASE (Bacillussubtilis) |
PF02581(TMP-TENI) | 4 | ASP A 146VAL A 118ARG A 119ILE A 122 | None | 1.09A | 2yfbA-1g67A:undetectable | 2yfbA-1g67A:26.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hm7 | PENTALENENE SYNTHASE (Streptomycesexfoliatus) |
no annotation | 4 | ARG A 294VAL A 298ARG A 299ILE A 302 | None | 0.89A | 2yfbA-1hm7A:2.8 | 2yfbA-1hm7A:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k32 | TRICORN PROTEASE (Thermoplasmaacidophilum) |
PF03572(Peptidase_S41)PF07676(PD40)PF14684(Tricorn_C1)PF14685(Tricorn_PDZ) | 4 | ASP A1053VAL A 871ARG A 874ILE A1048 | None | 1.15A | 2yfbA-1k32A:undetectable | 2yfbA-1k32A:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k5s | PENICILLIN G ACYLASEBETA SUBUNIT (Escherichiacoli) |
PF01804(Penicil_amidase) | 4 | ASP B 280ARG B 533VAL B 19ILE B 17 | None | 0.92A | 2yfbA-1k5sB:0.5 | 2yfbA-1k5sB:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k7s | FERRICHROME-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF01497(Peripla_BP_2) | 4 | MET N 141ARG N 120VAL N 101ILE N 38 | None | 0.90A | 2yfbA-1k7sN:undetectable | 2yfbA-1k7sN:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o4u | TYPE II QUINOLICACIDPHOSPHORIBOSYLTRANSFERASE (Thermotogamaritima) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 4 | ASP A 203VAL A 174ARG A 175ILE A 178 | None | 0.95A | 2yfbA-1o4uA:0.0 | 2yfbA-1o4uA:26.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qaf | PROTEIN (COPPERAMINE OXIDASE) (Escherichiacoli) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3)PF07833(Cu_amine_oxidN1) | 4 | ASP A 547VAL A 544ARG A 586ILE A 570 | None | 1.03A | 2yfbA-1qafA:undetectable | 2yfbA-1qafA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwg | (2R)-PHOSPHO-3-SULFOLACTATE SYNTHASE (Methanocaldococcusjannaschii) |
PF02679(ComA) | 4 | ASP A 231VAL A 18ILE A 228TYR A 31 | None | 1.07A | 2yfbA-1qwgA:undetectable | 2yfbA-1qwgA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1shx | EPHRIN-A5 (Mus musculus) |
PF00812(Ephrin) | 4 | ARG A 138VAL A 163ILE A 58TYR A 140 | None | 1.12A | 2yfbA-1shxA:undetectable | 2yfbA-1shxA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sr8 | COBALAMINBIOSYNTHESIS PROTEIN(CBID) (Archaeoglobusfulgidus) |
PF01888(CbiD) | 4 | VAL A 252ARG A 278ILE A 250TYR A 222 | None | 1.15A | 2yfbA-1sr8A:undetectable | 2yfbA-1sr8A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u02 | TREHALOSE-6-PHOSPHATE PHOSPHATASERELATED PROTEIN (Thermoplasmaacidophilum) |
PF02358(Trehalose_PPase) | 4 | ASP A 192ARG A 166ARG A 169ILE A 176 | None | 1.15A | 2yfbA-1u02A:undetectable | 2yfbA-1u02A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xaj | 3-DEHYDROQUINATESYNTHASE (Staphylococcusaureus) |
PF01761(DHQ_synthase) | 4 | MET A 210ASP A 211VAL A 179ILE A 126 | None | 1.13A | 2yfbA-1xajA:undetectable | 2yfbA-1xajA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkd | ISOCITRATEDEHYDROGENASE (Aeropyrumpernix) |
PF00180(Iso_dh) | 4 | ASP A 315VAL A 138ARG A 136ILE A 157 | CA A1006 (-2.9A)NoneICT A1002 (-3.0A)None | 1.01A | 2yfbA-1xkdA:0.0 | 2yfbA-1xkdA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z1e | STILBENE SYNTHASE (Arachishypogaea) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 4 | MET A 346ASP A 347VAL A 19ILE A 222 | None | 0.95A | 2yfbA-1z1eA:0.0 | 2yfbA-1z1eA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zcz | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Thermotogamaritima) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 4 | ASP A 92VAL A 98ILE A 95TYR A 146 | None | 1.08A | 2yfbA-1zczA:0.5 | 2yfbA-1zczA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bs9 | BETA-XYLOSIDASE (Geobacillusstearothermophilus) |
PF01229(Glyco_hydro_39) | 4 | ASP A 311VAL A 260ARG A 261ILE A 264 | None | 0.98A | 2yfbA-2bs9A:0.0 | 2yfbA-2bs9A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfk | COLLYBISTIN II (Rattusnorvegicus) |
PF00169(PH)PF00621(RhoGEF) | 4 | ASP A 213ARG A 51VAL A 54ILE A 58 | None | 1.04A | 2yfbA-2dfkA:1.6 | 2yfbA-2dfkA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 4 | ASP A 244VAL A 251ARG A 250TYR A 130 | None | 1.14A | 2yfbA-2fgeA:undetectable | 2yfbA-2fgeA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 4 | ASP A 433ARG A 236ARG A 66ILE A 270 | NoneNoneNone CL A 997 ( 4.2A) | 1.05A | 2yfbA-2fgeA:undetectable | 2yfbA-2fgeA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggz | GUANYLYLCYCLASE-ACTIVATINGPROTEIN 3 (Homo sapiens) |
PF13202(EF-hand_5)PF13499(EF-hand_7) | 4 | MET A 115VAL A 168ILE A 167TYR A 99 | None | 1.00A | 2yfbA-2ggzA:undetectable | 2yfbA-2ggzA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iv0 | ISOCITRATEDEHYDROGENASE (Archaeoglobusfulgidus) |
PF00180(Iso_dh) | 4 | ASP A 305VAL A 127ARG A 125ILE A 147 | ZN A1415 (-2.5A)NoneNoneNone | 0.81A | 2yfbA-2iv0A:undetectable | 2yfbA-2iv0A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l3w | PHYCOBILISOME RODLINKER POLYPEPTIDE (Synechococcuselongatus) |
PF00427(PBS_linker_poly) | 4 | ASP A 117ARG A 52VAL A 55TYR A 121 | None | 0.89A | 2yfbA-2l3wA:undetectable | 2yfbA-2l3wA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nlx | XYLULOSE KINASE (Escherichiacoli) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | MET A 377ASP A 378VAL A 390TYR A 259 | None | 0.90A | 2yfbA-2nlxA:undetectable | 2yfbA-2nlxA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nz9 | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 4 | ASP A1171ARG A1175ILE A1096TYR A1107 | None | 1.07A | 2yfbA-2nz9A:3.1 | 2yfbA-2nz9A:10.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o56 | PUTATIVE MANDELATERACEMASE (Salmonellaenterica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASP A 215VAL A 343ARG A 129TYR A 243 | None | 1.08A | 2yfbA-2o56A:undetectable | 2yfbA-2o56A:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pun | METHYLTHIORIBOSEKINASE (Bacillussubtilis) |
PF01636(APH) | 4 | ASP A 278ARG A 282ARG A 363ILE A 354 | None | 1.13A | 2yfbA-2punA:undetectable | 2yfbA-2punA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pz1 | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 4 (Homo sapiens) |
PF00018(SH3_1)PF00169(PH)PF00621(RhoGEF) | 4 | ASP A 447ARG A 285VAL A 288ILE A 292 | None | 1.03A | 2yfbA-2pz1A:2.2 | 2yfbA-2pz1A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wjf | TYROSINE-PROTEINPHOSPHATASE CPSB (Streptococcuspneumoniae) |
no annotation | 4 | ASP A 191VAL A 150ARG A 151ILE A 154 | None | 0.89A | 2yfbA-2wjfA:undetectable | 2yfbA-2wjfA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x11 | EPHRIN-A5 (Homo sapiens) |
PF00812(Ephrin) | 4 | ARG B 138VAL B 163ILE B 58TYR B 140 | None | 1.13A | 2yfbA-2x11B:undetectable | 2yfbA-2x11B:18.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yfb | METHYL-ACCEPTINGCHEMOTAXISTRANSDUCER (Pseudomonasputida) |
PF16591(HBM) | 7 | MET A 137ASP A 138ARG A 183VAL A 186ARG A 187ILE A 190TYR A 236 | ACT A 501 (-3.8A)ACT A 501 (-3.9A)ACT A 501 (-3.9A)ACT A 501 (-4.4A)ACT A 501 (-3.7A)NoneACT A 501 (-4.5A) | 0.01A | 2yfbA-2yfbA:33.1 | 2yfbA-2yfbA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b89 | 16S RRNA METHYLASE (Escherichiacoli) |
PF07091(FmrO) | 4 | ASP A 150ARG A 105VAL A 107ARG A 106 | None | 1.15A | 2yfbA-3b89A:undetectable | 2yfbA-3b89A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3flu | DIHYDRODIPICOLINATESYNTHASE (Neisseriameningitidis) |
PF00701(DHDPS) | 4 | ASP A 29ARG A 70VAL A 71ILE A 39 | None | 1.14A | 2yfbA-3fluA:undetectable | 2yfbA-3fluA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7z | CYTOTOXIC PROTEINCCDBPROTEIN CCDA (Escherichiacoli;Escherichiacoli) |
PF01845(CcdB)PF07362(CcdA) | 4 | MET A 64VAL C 55ILE C 59TYR A 51 | None | 1.06A | 2yfbA-3g7zA:undetectable | 2yfbA-3g7zA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h79 | THIOREDOXIN-LIKEPROTEIN (Trypanosomacruzi) |
PF00085(Thioredoxin) | 4 | ARG A 97VAL A 38ILE A 76TYR A 99 | None | 0.90A | 2yfbA-3h79A:undetectable | 2yfbA-3h79A:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdx | SUSD SUPERFAMILYPROTEIN (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | ARG A 470ARG A 454ILE A 450TYR A 247 | None | 1.14A | 2yfbA-3hdxA:undetectable | 2yfbA-3hdxA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jrr | INOSITOL1,4,5-TRISPHOSPHATERECEPTOR TYPE 3 (Mus musculus) |
PF08709(Ins145_P3_rec) | 4 | ARG A 171VAL A 183ILE A 221TYR A 118 | None | 1.11A | 2yfbA-3jrrA:undetectable | 2yfbA-3jrrA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jts | MHC CLASS IMAMU-A*02 (Macaca mulatta) |
PF00129(MHC_I)PF07654(C1-set) | 4 | ARG A 48VAL A 25ARG A 35ILE A 23 | None | 0.98A | 2yfbA-3jtsA:undetectable | 2yfbA-3jtsA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kdn | RIBULOSEBISPHOSPHATECARBOXYLASE (Thermococcuskodakarensis) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 4 | ASP A 186VAL A 408ARG A 409ILE A 412 | None | 0.75A | 2yfbA-3kdnA:undetectable | 2yfbA-3kdnA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ke2 | UNCHARACTERIZEDPROTEIN YP_928783.1 (Shewanellaamazonensis) |
PF09904(HTH_43) | 4 | MET A 28ASP A 29VAL A 63ILE A 61 | None | 0.93A | 2yfbA-3ke2A:undetectable | 2yfbA-3ke2A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfo | NUCLEOPORIN NUP133 (Saccharomycescerevisiae) |
no annotation | 4 | ARG A1020VAL A1065ARG A1064ILE A1061 | None | 1.06A | 2yfbA-3kfoA:undetectable | 2yfbA-3kfoA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l22 | SUSD SUPERFAMILYPROTEIN (Bacteroidesfragilis) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | ARG A 174VAL A 171ILE A 451TYR A 112 | None | 1.14A | 2yfbA-3l22A:undetectable | 2yfbA-3l22A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m07 | PUTATIVE ALPHAAMYLASE (Salmonellaenterica) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | ASP A 268VAL A 238ARG A 239ILE A 242 | None | 1.00A | 2yfbA-3m07A:undetectable | 2yfbA-3m07A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my0 | SERINE/THREONINE-PROTEIN KINASE RECEPTORR3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | MET A 354ASP A 363VAL A 249ILE A 245 | None | 1.05A | 2yfbA-3my0A:undetectable | 2yfbA-3my0A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myr | NICKEL-DEPENDENTHYDROGENASE LARGESUBUNIT (Allochromatiumvinosum) |
PF00374(NiFeSe_Hases) | 4 | ASP B1449VAL B1242ARG B1243ILE B1246 | None | 0.88A | 2yfbA-3myrB:2.2 | 2yfbA-3myrB:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3on4 | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Legionellapneumophila) |
PF00440(TetR_N) | 4 | ASP A 90VAL A 179ARG A 180ILE A 183 | None | 0.82A | 2yfbA-3on4A:undetectable | 2yfbA-3on4A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3osj | PHYCOBILISOME LCMCORE-MEMBRANE LINKERPOLYPEPTIDE (Synechocystissp. PCC 6803) |
PF00427(PBS_linker_poly) | 4 | ASP A 382VAL A 320ARG A 321TYR A 386 | None | 1.10A | 2yfbA-3osjA:undetectable | 2yfbA-3osjA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8c | PROBABLE PROTEINBRICK1ABL INTERACTOR 2 (Homo sapiens;Homo sapiens) |
no annotationPF07815(Abi_HHR) | 4 | ASP F 98VAL E 68ARG E 67ILE E 64 | None | 1.06A | 2yfbA-3p8cF:3.2 | 2yfbA-3p8cF:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pru | PHYCOBILISOME 32.1KDA LINKERPOLYPEPTIDE,PHYCOCYANIN-ASSOCIATED, ROD 1 (Synechocystissp. PCC 6803) |
no annotation | 5 | ASP C 135ARG C 70VAL C 73ARG C 74TYR C 139 | None | 1.27A | 2yfbA-3pruC:undetectable | 2yfbA-3pruC:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qi7 | PUTATIVETRANSCRIPTIONALREGULATOR (Clostridioidesdifficile) |
PF12683(DUF3798) | 4 | MET A 330VAL A 162ARG A 167ILE A 389 | None | 1.09A | 2yfbA-3qi7A:undetectable | 2yfbA-3qi7A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qq3 | MHC CLASS I ANTIGEN (Sus scrofa) |
PF00129(MHC_I)PF07654(C1-set) | 4 | ARG A 48VAL A 25ARG A 35ILE A 23 | None | 0.77A | 2yfbA-3qq3A:undetectable | 2yfbA-3qq3A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rp9 | MITOGEN-ACTIVATEDPROTEIN KINASE (Toxoplasmagondii) |
PF00069(Pkinase) | 4 | ARG A 180ARG A 250ILE A 255TYR A 261 | None | 1.15A | 2yfbA-3rp9A:2.5 | 2yfbA-3rp9A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sth | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Toxoplasmagondii) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | MET A 334VAL A 147ILE A 119TYR A 140 | None | 1.13A | 2yfbA-3sthA:undetectable | 2yfbA-3sthA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty4 | PROBABLEHOMOISOCITRATEDEHYDROGENASE (Schizosaccharomycespombe) |
PF00180(Iso_dh) | 4 | ASP A 260VAL A 109ARG A 107ILE A 124 | GOL A 366 (-3.4A)NoneGOL A 366 ( 4.7A)None | 1.14A | 2yfbA-3ty4A:undetectable | 2yfbA-3ty4A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1h | 3-ISOPROPYLMALATEDEHYDROGENASE (Bacillus sp.(in: Bacteria)) |
PF00180(Iso_dh) | 4 | ASP A 250VAL A 108ARG A 106ILE A 132 | None | 1.07A | 2yfbA-3u1hA:undetectable | 2yfbA-3u1hA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zrp | SERINE-PYRUVATEAMINOTRANSFERASE(AGXT) (Sulfolobussolfataricus) |
PF00266(Aminotran_5) | 4 | ASP A 181ARG A 154ILE A 150TYR A 54 | None | 1.15A | 2yfbA-3zrpA:undetectable | 2yfbA-3zrpA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0s | OCTENOYL-COAREDUCTASE/CARBOXYLASE (Streptomycescinnabarigriseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ARG A 286VAL A 288ARG A 293ILE A 324 | None | 1.08A | 2yfbA-4a0sA:undetectable | 2yfbA-4a0sA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc5 | XYLULOSE KINASE (Homo sapiens) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | ARG A 265ARG A 120ILE A 74TYR A 266 | None | 1.14A | 2yfbA-4bc5A:undetectable | 2yfbA-4bc5A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqk | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | MET A 980ASP A 983VAL A 902ILE A 900 | None | 1.14A | 2yfbA-4dqkA:undetectable | 2yfbA-4dqkA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2p | CYTOCHROME P450107B1 (P450CVIIB1) (Streptomyceshimastatinicus) |
PF00067(p450) | 4 | ARG A 263VAL A 262ARG A 266ILE A 269 | None | 1.10A | 2yfbA-4e2pA:1.8 | 2yfbA-4e2pA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h08 | PUTATIVE HYDROLASE (Bacteroidesthetaiotaomicron) |
PF00657(Lipase_GDSL) | 4 | ARG A 160VAL A 163ARG A 164ILE A 167 | None | 0.48A | 2yfbA-4h08A:undetectable | 2yfbA-4h08A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jf3 | ENVELOPEGLYCOPROTEIN (Mason-Pfizermonkey virus) |
PF00429(TLV_coat) | 4 | ASP A 448VAL A 492ARG A 493ILE A 496 | None | 1.09A | 2yfbA-4jf3A:2.8 | 2yfbA-4jf3A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kkj | TRANSCOBALAMIN-1 (Homo sapiens) |
PF01122(Cobalamin_bind)PF14478(DUF4430) | 4 | MET A 339VAL A 405ILE A 363TYR A 315 | NoneNoneCBY A 508 (-4.0A)None | 1.05A | 2yfbA-4kkjA:undetectable | 2yfbA-4kkjA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lcy | HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-46 ALPHACHAIN (Homo sapiens) |
PF00129(MHC_I)PF07654(C1-set) | 4 | ARG A 48VAL A 25ARG A 35ILE A 23 | None | 0.86A | 2yfbA-4lcyA:undetectable | 2yfbA-4lcyA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lk4 | VESB PROTEASE (Vibrio cholerae) |
PF00089(Trypsin) | 4 | ASP A 241VAL A 159ILE A 164TYR A 253 | None | 1.14A | 2yfbA-4lk4A:undetectable | 2yfbA-4lk4A:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o59 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Bos taurus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | MET O 328VAL O 144ILE O 117TYR O 137 | None | 1.04A | 2yfbA-4o59O:undetectable | 2yfbA-4o59O:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pel | PENICILLIN G ACYLASESUBUNIT BETA (Kluyveracryocrescens) |
PF01804(Penicil_amidase) | 4 | ASP B 280ARG B 533VAL B 19ILE B 17 | None | 1.07A | 2yfbA-4pelB:undetectable | 2yfbA-4pelB:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q4l | ATP SYNTHASE SUBUNITBETA 1 (Burkholderiathailandensis) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 4 | ASP A 449VAL A 377ARG A 376ILE A 373 | None | 1.10A | 2yfbA-4q4lA:undetectable | 2yfbA-4q4lA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uft | NUCLEOPROTEIN (Measlesmorbillivirus) |
PF00973(Paramyxo_ncap) | 4 | MET B 233VAL B 178ARG B 230ILE B 223 | None | 1.15A | 2yfbA-4uftB:undetectable | 2yfbA-4uftB:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4urj | PROTEIN FAM83A (Homo sapiens) |
PF07894(DUF1669) | 4 | ARG A 148VAL A 151ILE A 155TYR A 257 | NoneEDO A1305 ( 4.3A)NoneNone | 0.96A | 2yfbA-4urjA:undetectable | 2yfbA-4urjA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4urj | PROTEIN FAM83A (Homo sapiens) |
PF07894(DUF1669) | 4 | VAL A 151ARG A 152ILE A 155TYR A 257 | EDO A1305 ( 4.3A)NoneNoneNone | 1.05A | 2yfbA-4urjA:undetectable | 2yfbA-4urjA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xr7 | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN3 (Saccharomycescerevisiae) |
no annotation | 4 | ASP L 318VAL L 374ARG L 358TYR L 291 | None | 1.14A | 2yfbA-4xr7L:undetectable | 2yfbA-4xr7L:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zkt | BONTOXILYSIN A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 4 | ASP A1139ARG A1143ILE A1071TYR A1082 | None | 0.96A | 2yfbA-4zktA:1.9 | 2yfbA-4zktA:10.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b69 | GERANYLGERANYLGLYCERYL PHOSPHATESYNTHASE (Thermoplasmaacidophilum) |
PF01884(PcrB) | 4 | MET A 60ASP A 61VAL A 49ILE A 77 | None | 0.92A | 2yfbA-5b69A:undetectable | 2yfbA-5b69A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxd | PUTATIVEBETA-GLUCANASE (Mycobacteroidesabscessus) |
PF00722(Glyco_hydro_16) | 4 | MET A 195VAL A 173ILE A 175TYR A 204 | None | 1.12A | 2yfbA-5dxdA:undetectable | 2yfbA-5dxdA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8c | UL31 (Suidalphaherpesvirus1) |
PF02718(Herpes_UL31) | 4 | ASP A 156ARG A 160VAL A 162ARG A 155 | None | 1.03A | 2yfbA-5e8cA:undetectable | 2yfbA-5e8cA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fi0 | PHOSPHATIDYLINOSITOL3,4,5-TRISPHOSPHATE-DEPENDENT RACEXCHANGER 1PROTEIN,PHOSPHATIDYLINOSITOL3,4,5-TRISPHOSPHATE-DEPENDENT RACEXCHANGER 1 PROTEIN (Homo sapiens) |
PF00169(PH)PF00621(RhoGEF) | 4 | ASP A 219ARG A 50VAL A 53ILE A 57 | None | 1.05A | 2yfbA-5fi0A:3.4 | 2yfbA-5fi0A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huq | LACTATE RACEMIZATIONOPERON PROTEIN LARA (Lactobacillusplantarum) |
PF09861(DUF2088) | 4 | MET A 399VAL A 412ILE A 281TYR A 403 | None | 1.15A | 2yfbA-5huqA:undetectable | 2yfbA-5huqA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hy7 | PUTATIVE PRE-MRNASPLICING PROTEIN (Chaetomiumthermophilum) |
PF03178(CPSF_A)PF10433(MMS1_N) | 4 | MET A1005ASP A1023VAL A1040TYR A1007 | None | 1.00A | 2yfbA-5hy7A:undetectable | 2yfbA-5hy7A:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5igp | MACROLIDE2'-PHOSPHOTRANSFERASE (Escherichiacoli) |
PF01636(APH) | 4 | ASP A 219VAL A 50ARG A 52ILE A 38 | GDP A 401 (-2.6A)GDP A 401 (-4.6A)GDP A 401 (-4.5A)GDP A 401 (-4.2A) | 0.95A | 2yfbA-5igpA:undetectable | 2yfbA-5igpA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ii5 | MALTOSE-BINDINGPERIPLASMICPROTEIN,VITELLINEENVELOPE SPERM LYSINRECEPTOR (Escherichiacoli;Haliotisrufescens) |
PF11386(VERL)PF13416(SBP_bac_8) | 4 | ASP A4038ARG A4081VAL A4064ILE A3845 | None | 1.03A | 2yfbA-5ii5A:undetectable | 2yfbA-5ii5A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iud | DNA POLYMERASE ALPHACATALYTIC SUBUNIT (Homo sapiens) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | ASP A 632ARG A 664VAL A 626ILE A 629 | None | 1.04A | 2yfbA-5iudA:2.8 | 2yfbA-5iudA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jp6 | PUTATIVEPOLYSACCHARIDEDEACETYLASE (Bdellovibriobacteriovorus) |
PF01522(Polysacc_deac_1) | 4 | ASP A 118ARG A 339ARG A 98ILE A 97 | None | 0.83A | 2yfbA-5jp6A:undetectable | 2yfbA-5jp6A:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5knm | LEUKOCYTEIMMUNOGLOBULIN-LIKERECEPTOR SUBFAMILY BMEMBER 1 (Homo sapiens) |
PF13895(Ig_2) | 4 | ARG D 173VAL D 15ILE D 16TYR D 175 | None | 1.15A | 2yfbA-5knmD:undetectable | 2yfbA-5knmD:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l7d | SMOOTHENEDHOMOLOG,SOLUBLECYTOCHROMEB562,SMOOTHENEDHOMOLOG (Escherichiacoli;Homo sapiens) |
PF01392(Fz)PF01534(Frizzled)PF07361(Cytochrom_B562) | 4 | ASP A 209ARG A 485VAL A 488TYR A 207 | None | 1.08A | 2yfbA-5l7dA:5.8 | 2yfbA-5l7dA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mtz | RIBONUCLEASE Z (Saccharomycescerevisiae) |
PF13691(Lactamase_B_4) | 4 | MET A 316VAL A 400ILE A 416TYR A 285 | None | 1.10A | 2yfbA-5mtzA:undetectable | 2yfbA-5mtzA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t88 | PROLYL ENDOPEPTIDASE (Pyrococcusfuriosus) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 4 | ASP A 177VAL A 184ARG A 182TYR A 152 | None | 1.13A | 2yfbA-5t88A:undetectable | 2yfbA-5t88A:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tpc | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 4 | ASP A1171ARG A1175ILE A1096TYR A1107 | None | 1.04A | 2yfbA-5tpcA:undetectable | 2yfbA-5tpcA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v38 | HCHA (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 4 | ASP A1163ARG A1167ILE A1088TYR A1099 | None | 1.01A | 2yfbA-5v38A:undetectable | 2yfbA-5v38A:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xna | SAHS1 (Ramazzottiusvarieornatus) |
no annotation | 4 | ASP A 139VAL A 96ILE A 85TYR A 117 | EDO A 208 (-3.2A)NoneNoneEDO A 207 (-4.6A) | 1.09A | 2yfbA-5xnaA:undetectable | 2yfbA-5xnaA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtk | XANTHINEPHOSPHORIBOSYLTRANSFERASE (Yersinia pestis) |
no annotation | 4 | MET A 103VAL A 58ILE A 60TYR A 104 | None | 1.12A | 2yfbA-5xtkA:undetectable | 2yfbA-5xtkA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 4 | MET C2473ASP C2437VAL C2459TYR C2474 | None | 1.11A | 2yfbA-5y3rC:undetectable | 2yfbA-5y3rC:4.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zqe | - (-) |
no annotation | 4 | ASP A 219VAL A 244ARG A 243ILE A 245 | None | 1.13A | 2yfbA-5zqeA:undetectable | 2yfbA-5zqeA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b5f | NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE (Yersiniaenterocolitica) |
no annotation | 4 | ASP A 193VAL A 216ARG A 217ILE A 220 | None | 1.12A | 2yfbA-6b5fA:undetectable | 2yfbA-6b5fA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c0f | PROTEASOME-INTERACTING PROTEIN CIC1 (Saccharomycescerevisiae) |
no annotation | 4 | ASP K 261VAL K 37ARG K 34ILE K 38 | None | 1.03A | 2yfbA-6c0fK:undetectable | 2yfbA-6c0fK:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6q | EXOSOME COMPLEXEXONUCLEASE RRP44 (Homo sapiens) |
no annotation | 4 | ASP K 520ARG K 789ILE K 813TYR K 801 | None | 0.93A | 2yfbA-6d6qK:undetectable | 2yfbA-6d6qK:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dfz | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Acroporamillepora) |
no annotation | 4 | MET A 330VAL A 146ILE A 118TYR A 138 | None | 0.98A | 2yfbA-6dfzA:undetectable | 2yfbA-6dfzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f7s | SERRATE RNA EFFECTORMOLECULEHOMOLOG,SERRATE RNAEFFECTOR MOLECULEHOMOLOG (Homo sapiens) |
no annotation | 4 | ASP C 609ARG C 645ILE C 520TYR C 624 | None | 1.06A | 2yfbA-6f7sC:undetectable | 2yfbA-6f7sC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fcx | METHYLENETETRAHYDROFOLATE REDUCTASE (Homo sapiens) |
no annotation | 4 | ASP A 223VAL A 179ARG A 183ILE A 182 | None | 1.12A | 2yfbA-6fcxA:undetectable | 2yfbA-6fcxA:undetectable |