SIMILAR PATTERNS OF AMINO ACIDS FOR 2YFB_A_ACTA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a97 XANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		4 MET A 103
VAL A  58
ILE A  60
TYR A 104
 None
 0.93A 2yfbA-1a97A:
undetectable		 2yfbA-1a97A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 MET A 833
ARG A 138
ILE A 136
TYR A 452
 None
 1.03A 2yfbA-1dgjA:
undetectable		 2yfbA-1dgjA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		4 ASP A 146
VAL A 118
ARG A 119
ILE A 122
 None
 1.09A 2yfbA-1g67A:
undetectable		 2yfbA-1g67A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm7 PENTALENENE SYNTHASE

(Streptomyces
exfoliatus) 		no annotation 4 ARG A 294
VAL A 298
ARG A 299
ILE A 302
 None
 0.89A 2yfbA-1hm7A:
2.8		 2yfbA-1hm7A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 ASP A1053
VAL A 871
ARG A 874
ILE A1048
 None
 1.15A 2yfbA-1k32A:
undetectable		 2yfbA-1k32A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		4 ASP B 280
ARG B 533
VAL B  19
ILE B  17
 None
 0.92A 2yfbA-1k5sB:
0.5		 2yfbA-1k5sB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 MET N 141
ARG N 120
VAL N 101
ILE N  38
 None
 0.90A 2yfbA-1k7sN:
undetectable		 2yfbA-1k7sN:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 ASP A 203
VAL A 174
ARG A 175
ILE A 178
 None
 0.95A 2yfbA-1o4uA:
0.0		 2yfbA-1o4uA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		4 ASP A 547
VAL A 544
ARG A 586
ILE A 570
 None
 1.03A 2yfbA-1qafA:
undetectable		 2yfbA-1qafA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwg (2R)-PHOSPHO-3-SULFO
LACTATE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF02679
(ComA) 		4 ASP A 231
VAL A  18
ILE A 228
TYR A  31
 None
 1.07A 2yfbA-1qwgA:
undetectable		 2yfbA-1qwgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shx EPHRIN-A5

(Mus musculus) 		PF00812
(Ephrin) 		4 ARG A 138
VAL A 163
ILE A  58
TYR A 140
 None
 1.12A 2yfbA-1shxA:
undetectable		 2yfbA-1shxA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		4 VAL A 252
ARG A 278
ILE A 250
TYR A 222
 None
 1.15A 2yfbA-1sr8A:
undetectable		 2yfbA-1sr8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF02358
(Trehalose_PPase) 		4 ASP A 192
ARG A 166
ARG A 169
ILE A 176
 None
 1.15A 2yfbA-1u02A:
undetectable		 2yfbA-1u02A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xaj 3-DEHYDROQUINATE
SYNTHASE

(Staphylococcus
aureus) 		PF01761
(DHQ_synthase) 		4 MET A 210
ASP A 211
VAL A 179
ILE A 126
 None
 1.13A 2yfbA-1xajA:
undetectable		 2yfbA-1xajA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		4 ASP A 315
VAL A 138
ARG A 136
ILE A 157
 CA  A1006 (-2.9A)
None
ICT  A1002 (-3.0A)
None
 1.01A 2yfbA-1xkdA:
0.0		 2yfbA-1xkdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 MET A 346
ASP A 347
VAL A  19
ILE A 222
 None
 0.95A 2yfbA-1z1eA:
0.0		 2yfbA-1z1eA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ASP A  92
VAL A  98
ILE A  95
TYR A 146
 None
 1.08A 2yfbA-1zczA:
0.5		 2yfbA-1zczA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 ASP A 311
VAL A 260
ARG A 261
ILE A 264
 None
 0.98A 2yfbA-2bs9A:
0.0		 2yfbA-2bs9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfk COLLYBISTIN II

(Rattus
norvegicus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ASP A 213
ARG A  51
VAL A  54
ILE A  58
 None
 1.04A 2yfbA-2dfkA:
1.6		 2yfbA-2dfkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ASP A 244
VAL A 251
ARG A 250
TYR A 130
 None
 1.14A 2yfbA-2fgeA:
undetectable		 2yfbA-2fgeA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ASP A 433
ARG A 236
ARG A  66
ILE A 270
 None
None
None
CL  A 997 ( 4.2A)
 1.05A 2yfbA-2fgeA:
undetectable		 2yfbA-2fgeA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 MET A 115
VAL A 168
ILE A 167
TYR A  99
 None
 1.00A 2yfbA-2ggzA:
undetectable		 2yfbA-2ggzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		4 ASP A 305
VAL A 127
ARG A 125
ILE A 147
 ZN  A1415 (-2.5A)
None
None
None
 0.81A 2yfbA-2iv0A:
undetectable		 2yfbA-2iv0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3w PHYCOBILISOME ROD
LINKER POLYPEPTIDE

(Synechococcus
elongatus) 		PF00427
(PBS_linker_poly) 		4 ASP A 117
ARG A  52
VAL A  55
TYR A 121
 None
 0.89A 2yfbA-2l3wA:
undetectable		 2yfbA-2l3wA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 MET A 377
ASP A 378
VAL A 390
TYR A 259
 None
 0.90A 2yfbA-2nlxA:
undetectable		 2yfbA-2nlxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ASP A1171
ARG A1175
ILE A1096
TYR A1107
 None
 1.07A 2yfbA-2nz9A:
3.1		 2yfbA-2nz9A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 215
VAL A 343
ARG A 129
TYR A 243
 None
 1.08A 2yfbA-2o56A:
undetectable		 2yfbA-2o56A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 ASP A 278
ARG A 282
ARG A 363
ILE A 354
 None
 1.13A 2yfbA-2punA:
undetectable		 2yfbA-2punA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 ASP A 447
ARG A 285
VAL A 288
ILE A 292
 None
 1.03A 2yfbA-2pz1A:
2.2		 2yfbA-2pz1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 4 ASP A 191
VAL A 150
ARG A 151
ILE A 154
 None
 0.89A 2yfbA-2wjfA:
undetectable		 2yfbA-2wjfA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x11 EPHRIN-A5

(Homo sapiens) 		PF00812
(Ephrin) 		4 ARG B 138
VAL B 163
ILE B  58
TYR B 140
 None
 1.13A 2yfbA-2x11B:
undetectable		 2yfbA-2x11B:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER

(Pseudomonas
putida) 		PF16591
(HBM) 		7 MET A 137
ASP A 138
ARG A 183
VAL A 186
ARG A 187
ILE A 190
TYR A 236
 ACT  A 501 (-3.8A)
ACT  A 501 (-3.9A)
ACT  A 501 (-3.9A)
ACT  A 501 (-4.4A)
ACT  A 501 (-3.7A)
None
ACT  A 501 (-4.5A)
 0.01A 2yfbA-2yfbA:
33.1		 2yfbA-2yfbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 ASP A 150
ARG A 105
VAL A 107
ARG A 106
 None
 1.15A 2yfbA-3b89A:
undetectable		 2yfbA-3b89A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		4 ASP A  29
ARG A  70
VAL A  71
ILE A  39
 None
 1.14A 2yfbA-3fluA:
undetectable		 2yfbA-3fluA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7z CYTOTOXIC PROTEIN
CCDB
PROTEIN CCDA

(Escherichia
coli;
Escherichia
coli) 		PF01845
(CcdB)
PF07362
(CcdA) 		4 MET A  64
VAL C  55
ILE C  59
TYR A  51
 None
 1.06A 2yfbA-3g7zA:
undetectable		 2yfbA-3g7zA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h79 THIOREDOXIN-LIKE
PROTEIN

(Trypanosoma
cruzi) 		PF00085
(Thioredoxin) 		4 ARG A  97
VAL A  38
ILE A  76
TYR A  99
 None
 0.90A 2yfbA-3h79A:
undetectable		 2yfbA-3h79A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 470
ARG A 454
ILE A 450
TYR A 247
 None
 1.14A 2yfbA-3hdxA:
undetectable		 2yfbA-3hdxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrr INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 3

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		4 ARG A 171
VAL A 183
ILE A 221
TYR A 118
 None
 1.11A 2yfbA-3jrrA:
undetectable		 2yfbA-3jrrA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jts MHC CLASS I
MAMU-A*02

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ARG A  48
VAL A  25
ARG A  35
ILE A  23
 None
 0.98A 2yfbA-3jtsA:
undetectable		 2yfbA-3jtsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ASP A 186
VAL A 408
ARG A 409
ILE A 412
 None
 0.75A 2yfbA-3kdnA:
undetectable		 2yfbA-3kdnA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke2 UNCHARACTERIZED
PROTEIN YP_928783.1

(Shewanella
amazonensis) 		PF09904
(HTH_43) 		4 MET A  28
ASP A  29
VAL A  63
ILE A  61
 None
 0.93A 2yfbA-3ke2A:
undetectable		 2yfbA-3ke2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A1020
VAL A1065
ARG A1064
ILE A1061
 None
 1.06A 2yfbA-3kfoA:
undetectable		 2yfbA-3kfoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 174
VAL A 171
ILE A 451
TYR A 112
 None
 1.14A 2yfbA-3l22A:
undetectable		 2yfbA-3l22A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ASP A 268
VAL A 238
ARG A 239
ILE A 242
 None
 1.00A 2yfbA-3m07A:
undetectable		 2yfbA-3m07A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A 354
ASP A 363
VAL A 249
ILE A 245
 None
 1.05A 2yfbA-3my0A:
undetectable		 2yfbA-3my0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		4 ASP B1449
VAL B1242
ARG B1243
ILE B1246
 None
 0.88A 2yfbA-3myrB:
2.2		 2yfbA-3myrB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Legionella
pneumophila) 		PF00440
(TetR_N) 		4 ASP A  90
VAL A 179
ARG A 180
ILE A 183
 None
 0.82A 2yfbA-3on4A:
undetectable		 2yfbA-3on4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osj PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		PF00427
(PBS_linker_poly) 		4 ASP A 382
VAL A 320
ARG A 321
TYR A 386
 None
 1.10A 2yfbA-3osjA:
undetectable		 2yfbA-3osjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2

(Homo sapiens;
Homo sapiens) 		no annotation
PF07815
(Abi_HHR) 		4 ASP F  98
VAL E  68
ARG E  67
ILE E  64
 None
 1.06A 2yfbA-3p8cF:
3.2		 2yfbA-3p8cF:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pru PHYCOBILISOME 32.1
KDA LINKER
POLYPEPTIDE,
PHYCOCYANIN-ASSOCIAT
ED, ROD 1

(Synechocystis
sp. PCC 6803) 		no annotation 5 ASP C 135
ARG C  70
VAL C  73
ARG C  74
TYR C 139
 None
 1.27A 2yfbA-3pruC:
undetectable		 2yfbA-3pruC:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Clostridioides
difficile) 		PF12683
(DUF3798) 		4 MET A 330
VAL A 162
ARG A 167
ILE A 389
 None
 1.09A 2yfbA-3qi7A:
undetectable		 2yfbA-3qi7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qq3 MHC CLASS I ANTIGEN

(Sus scrofa) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ARG A  48
VAL A  25
ARG A  35
ILE A  23
 None
 0.77A 2yfbA-3qq3A:
undetectable		 2yfbA-3qq3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ARG A 180
ARG A 250
ILE A 255
TYR A 261
 None
 1.15A 2yfbA-3rp9A:
2.5		 2yfbA-3rp9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 MET A 334
VAL A 147
ILE A 119
TYR A 140
 None
 1.13A 2yfbA-3sthA:
undetectable		 2yfbA-3sthA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00180
(Iso_dh) 		4 ASP A 260
VAL A 109
ARG A 107
ILE A 124
 GOL  A 366 (-3.4A)
None
GOL  A 366 ( 4.7A)
None
 1.14A 2yfbA-3ty4A:
undetectable		 2yfbA-3ty4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		4 ASP A 250
VAL A 108
ARG A 106
ILE A 132
 None
 1.07A 2yfbA-3u1hA:
undetectable		 2yfbA-3u1hA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		4 ASP A 181
ARG A 154
ILE A 150
TYR A  54
 None
 1.15A 2yfbA-3zrpA:
undetectable		 2yfbA-3zrpA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A 286
VAL A 288
ARG A 293
ILE A 324
 None
 1.08A 2yfbA-4a0sA:
undetectable		 2yfbA-4a0sA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ARG A 265
ARG A 120
ILE A  74
TYR A 266
 None
 1.14A 2yfbA-4bc5A:
undetectable		 2yfbA-4bc5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqk BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 MET A 980
ASP A 983
VAL A 902
ILE A 900
 None
 1.14A 2yfbA-4dqkA:
undetectable		 2yfbA-4dqkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2p CYTOCHROME P450
107B1 (P450CVIIB1)

(Streptomyces
himastatinicus) 		PF00067
(p450) 		4 ARG A 263
VAL A 262
ARG A 266
ILE A 269
 None
 1.10A 2yfbA-4e2pA:
1.8		 2yfbA-4e2pA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h08 PUTATIVE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF00657
(Lipase_GDSL) 		4 ARG A 160
VAL A 163
ARG A 164
ILE A 167
 None
 0.48A 2yfbA-4h08A:
undetectable		 2yfbA-4h08A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf3 ENVELOPE
GLYCOPROTEIN

(Mason-Pfizer
monkey virus) 		PF00429
(TLV_coat) 		4 ASP A 448
VAL A 492
ARG A 493
ILE A 496
 None
 1.09A 2yfbA-4jf3A:
2.8		 2yfbA-4jf3A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkj TRANSCOBALAMIN-1

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 MET A 339
VAL A 405
ILE A 363
TYR A 315
 None
None
CBY  A 508 (-4.0A)
None
 1.05A 2yfbA-4kkjA:
undetectable		 2yfbA-4kkjA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ARG A  48
VAL A  25
ARG A  35
ILE A  23
 None
 0.86A 2yfbA-4lcyA:
undetectable		 2yfbA-4lcyA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk4 VESB PROTEASE

(Vibrio cholerae) 		PF00089
(Trypsin) 		4 ASP A 241
VAL A 159
ILE A 164
TYR A 253
 None
 1.14A 2yfbA-4lk4A:
undetectable		 2yfbA-4lk4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 MET O 328
VAL O 144
ILE O 117
TYR O 137
 None
 1.04A 2yfbA-4o59O:
undetectable		 2yfbA-4o59O:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		4 ASP B 280
ARG B 533
VAL B  19
ILE B  17
 None
 1.07A 2yfbA-4pelB:
undetectable		 2yfbA-4pelB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4l ATP SYNTHASE SUBUNIT
BETA 1

(Burkholderia
thailandensis) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ASP A 449
VAL A 377
ARG A 376
ILE A 373
 None
 1.10A 2yfbA-4q4lA:
undetectable		 2yfbA-4q4lA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uft NUCLEOPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap) 		4 MET B 233
VAL B 178
ARG B 230
ILE B 223
 None
 1.15A 2yfbA-4uftB:
undetectable		 2yfbA-4uftB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urj PROTEIN FAM83A

(Homo sapiens) 		PF07894
(DUF1669) 		4 ARG A 148
VAL A 151
ILE A 155
TYR A 257
 None
EDO  A1305 ( 4.3A)
None
None
 0.96A 2yfbA-4urjA:
undetectable		 2yfbA-4urjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urj PROTEIN FAM83A

(Homo sapiens) 		PF07894
(DUF1669) 		4 VAL A 151
ARG A 152
ILE A 155
TYR A 257
 EDO  A1305 ( 4.3A)
None
None
None
 1.05A 2yfbA-4urjA:
undetectable		 2yfbA-4urjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae) 		no annotation 4 ASP L 318
VAL L 374
ARG L 358
TYR L 291
 None
 1.14A 2yfbA-4xr7L:
undetectable		 2yfbA-4xr7L:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ASP A1139
ARG A1143
ILE A1071
TYR A1082
 None
 0.96A 2yfbA-4zktA:
1.9		 2yfbA-4zktA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Thermoplasma
acidophilum) 		PF01884
(PcrB) 		4 MET A  60
ASP A  61
VAL A  49
ILE A  77
 None
 0.92A 2yfbA-5b69A:
undetectable		 2yfbA-5b69A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxd PUTATIVE
BETA-GLUCANASE

(Mycobacteroides
abscessus) 		PF00722
(Glyco_hydro_16) 		4 MET A 195
VAL A 173
ILE A 175
TYR A 204
 None
 1.12A 2yfbA-5dxdA:
undetectable		 2yfbA-5dxdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL31

(Suid
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		4 ASP A 156
ARG A 160
VAL A 162
ARG A 155
 None
 1.03A 2yfbA-5e8cA:
undetectable		 2yfbA-5e8cA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ASP A 219
ARG A  50
VAL A  53
ILE A  57
 None
 1.05A 2yfbA-5fi0A:
3.4		 2yfbA-5fi0A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA

(Lactobacillus
plantarum) 		PF09861
(DUF2088) 		4 MET A 399
VAL A 412
ILE A 281
TYR A 403
 None
 1.15A 2yfbA-5huqA:
undetectable		 2yfbA-5huqA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 MET A1005
ASP A1023
VAL A1040
TYR A1007
 None
 1.00A 2yfbA-5hy7A:
undetectable		 2yfbA-5hy7A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		4 ASP A 219
VAL A  50
ARG A  52
ILE A  38
 GDP  A 401 (-2.6A)
GDP  A 401 (-4.6A)
GDP  A 401 (-4.5A)
GDP  A 401 (-4.2A)
 0.95A 2yfbA-5igpA:
undetectable		 2yfbA-5igpA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 ASP A4038
ARG A4081
VAL A4064
ILE A3845
 None
 1.03A 2yfbA-5ii5A:
undetectable		 2yfbA-5ii5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASP A 632
ARG A 664
VAL A 626
ILE A 629
 None
 1.04A 2yfbA-5iudA:
2.8		 2yfbA-5iudA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp6 PUTATIVE
POLYSACCHARIDE
DEACETYLASE

(Bdellovibrio
bacteriovorus) 		PF01522
(Polysacc_deac_1) 		4 ASP A 118
ARG A 339
ARG A  98
ILE A  97
 None
 0.83A 2yfbA-5jp6A:
undetectable		 2yfbA-5jp6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1

(Homo sapiens) 		PF13895
(Ig_2) 		4 ARG D 173
VAL D  15
ILE D  16
TYR D 175
 None
 1.15A 2yfbA-5knmD:
undetectable		 2yfbA-5knmD:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF01392
(Fz)
PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		4 ASP A 209
ARG A 485
VAL A 488
TYR A 207
 None
 1.08A 2yfbA-5l7dA:
5.8		 2yfbA-5l7dA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		4 MET A 316
VAL A 400
ILE A 416
TYR A 285
 None
 1.10A 2yfbA-5mtzA:
undetectable		 2yfbA-5mtzA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ASP A 177
VAL A 184
ARG A 182
TYR A 152
 None
 1.13A 2yfbA-5t88A:
undetectable		 2yfbA-5t88A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpc BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ASP A1171
ARG A1175
ILE A1096
TYR A1107
 None
 1.04A 2yfbA-5tpcA:
undetectable		 2yfbA-5tpcA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v38 HCHA

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ASP A1163
ARG A1167
ILE A1088
TYR A1099
 None
 1.01A 2yfbA-5v38A:
undetectable		 2yfbA-5v38A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xna SAHS1

(Ramazzottius
varieornatus) 		no annotation 4 ASP A 139
VAL A  96
ILE A  85
TYR A 117
 EDO  A 208 (-3.2A)
None
None
EDO  A 207 (-4.6A)
 1.09A 2yfbA-5xnaA:
undetectable		 2yfbA-5xnaA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtk XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		no annotation 4 MET A 103
VAL A  58
ILE A  60
TYR A 104
 None
 1.12A 2yfbA-5xtkA:
undetectable		 2yfbA-5xtkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 MET C2473
ASP C2437
VAL C2459
TYR C2474
 None
 1.11A 2yfbA-5y3rC:
undetectable		 2yfbA-5y3rC:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 4 ASP A 219
VAL A 244
ARG A 243
ILE A 245
 None
 1.13A 2yfbA-5zqeA:
undetectable		 2yfbA-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 4 ASP A 193
VAL A 216
ARG A 217
ILE A 220
 None
 1.12A 2yfbA-6b5fA:
undetectable		 2yfbA-6b5fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f PROTEASOME-INTERACTI
NG PROTEIN CIC1

(Saccharomyces
cerevisiae) 		no annotation 4 ASP K 261
VAL K  37
ARG K  34
ILE K  38
 None
 1.03A 2yfbA-6c0fK:
undetectable		 2yfbA-6c0fK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 ASP K 520
ARG K 789
ILE K 813
TYR K 801
 None
 0.93A 2yfbA-6d6qK:
undetectable		 2yfbA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Acropora
millepora) 		no annotation 4 MET A 330
VAL A 146
ILE A 118
TYR A 138
 None
 0.98A 2yfbA-6dfzA:
undetectable		 2yfbA-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f7s SERRATE RNA EFFECTOR
MOLECULE
HOMOLOG,SERRATE RNA
EFFECTOR MOLECULE
HOMOLOG

(Homo sapiens) 		no annotation 4 ASP C 609
ARG C 645
ILE C 520
TYR C 624
 None
 1.06A 2yfbA-6f7sC:
undetectable		 2yfbA-6f7sC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 4 ASP A 223
VAL A 179
ARG A 183
ILE A 182
 None
 1.12A 2yfbA-6fcxA:
undetectable		 2yfbA-6fcxA:
undetectable