SIMILAR PATTERNS OF AMINO ACIDS FOR 2YA7_D_ZMRD1776_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ms8 | TRANS-SIALIDASE (Trypanosomacruzi) |
PF13385(Laminin_G_3)PF13859(BNR_3) | 6 | ARG A 35ASP A 51ASP A 96ARG A 245ARG A 314TYR A 342 | DAN A 700 (-3.0A)NoneDAN A 700 (-3.3A)DAN A 700 (-2.8A)DAN A 700 (-3.0A)DAN A 700 (-3.5A) | 0.98A | 2ya7D-1ms8A:39.5 | 2ya7D-1ms8A:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mz5 | SIALIDASE (Trypanosomarangeli) |
PF13385(Laminin_G_3)PF13859(BNR_3) | 7 | ARG A 36ILE A 37ASP A 52ASP A 97ARG A 246ARG A 315TYR A 343 | None | 0.44A | 2ya7D-1mz5A:39.9 | 2ya7D-1mz5A:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mz5 | SIALIDASE (Trypanosomarangeli) |
PF13385(Laminin_G_3)PF13859(BNR_3) | 6 | ARG A 36ILE A 37ASP A 52ILE A 64ARG A 315TYR A 343 | None | 1.38A | 2ya7D-1mz5A:39.9 | 2ya7D-1mz5A:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8o | BACTERIAL SIALIDASE (Micromonosporaviridifaciens) |
PF00754(F5_F8_type_C)PF10633(NPCBM_assoc)PF13088(BNR_2) | 7 | ARG A 68ILE A 69ASP A 85ASP A 131ARG A 276ARG A 342TYR A 370 | CIT A1649 ( 2.6A)NoneNoneGOL A1650 (-2.7A)CIT A1649 ( 2.7A)CIT A1649 ( 2.9A)CIT A1649 (-4.5A) | 0.38A | 2ya7D-1w8oA:46.9 | 2ya7D-1w8oA:24.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2bf6 | EXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF13088(BNR_2) | 5 | ARG A 266ILE A 267ASP A 283ILE A 297ARG A 615 | SIA A1692 (-2.7A)SIA A1692 (-4.5A)NoneNoneSIA A1692 (-3.1A) | 1.38A | 2ya7D-2bf6A:56.6 | 2ya7D-2bf6A:43.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2bf6 | EXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF13088(BNR_2) | 10 | ARG A 266ILE A 267ASP A 283ILE A 327ASP A 328TYR A 485GLN A 493ARG A 555ARG A 615TYR A 655 | SIA A1692 (-2.7A)SIA A1692 (-4.5A)NoneSIA A1692 (-4.5A)SIA A1692 (-2.9A)SIA A1692 (-4.7A)SIA A1692 (-3.0A)SIA A1692 (-2.9A)SIA A1692 (-3.1A)SIA A1692 (-4.2A) | 0.35A | 2ya7D-2bf6A:56.6 | 2ya7D-2bf6A:43.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2bf6 | EXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF13088(BNR_2) | 5 | ARG A 285ILE A 267ASP A 328TYR A 485GLN A 493 | SIA A1692 (-3.6A)SIA A1692 (-4.5A)SIA A1692 (-2.9A)SIA A1692 (-4.7A)SIA A1692 (-3.0A) | 1.20A | 2ya7D-2bf6A:56.6 | 2ya7D-2bf6A:43.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f28 | SIALIDASE 2 (Homo sapiens) |
PF13088(BNR_2) | 6 | ARG A 21ILE A 22TYR A 179ARG A 237ARG A 304TYR A 334 | None | 0.41A | 2ya7D-2f28A:43.0 | 2ya7D-2f28A:23.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w20 | SIALIDASE A (Streptococcuspneumoniae) |
PF13088(BNR_2) | 11 | ARG A 347ILE A 348ASP A 364ILE A 416ASP A 417ASP A 434TYR A 590GLN A 602ARG A 663ARG A 721TYR A 752 | None | 0.24A | 2ya7D-2w20A:67.7 | 2ya7D-2w20A:94.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w20 | SIALIDASE A (Streptococcuspneumoniae) |
PF13088(BNR_2) | 6 | ARG A 366ILE A 348ASP A 417PHE A 443TYR A 590GLN A 602 | None | 1.47A | 2ya7D-2w20A:67.7 | 2ya7D-2w20A:94.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w20 | SIALIDASE A (Streptococcuspneumoniae) |
PF13088(BNR_2) | 8 | ILE A 348ASP A 364ILE A 416ASP A 417ASP A 434PHE A 443TYR A 590GLN A 602 | None | 0.68A | 2ya7D-2w20A:67.7 | 2ya7D-2w20A:94.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w38 | SIALIDASE (Pseudomonasaeruginosa) |
PF13088(BNR_2) | 5 | ASP A 79TYR A 146ARG A 198ARG A 260TYR A 297 | None | 0.72A | 2ya7D-2w38A:33.1 | 2ya7D-2w38A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzi | EXTRACELLULARSIALIDASE/NEURAMINIDASE, PUTATIVE (Aspergillusfumigatus) |
PF13088(BNR_2) | 5 | ARG A 59ILE A 60ARG A 265ARG A 322TYR A 358 | KDM A 500 (-2.7A)NoneKDM A 500 (-2.7A)KDM A 500 ( 3.0A)KDM A 500 (-4.5A) | 0.29A | 2ya7D-2xziA:41.2 | 2ya7D-2xziA:26.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzi | EXTRACELLULARSIALIDASE/NEURAMINIDASE, PUTATIVE (Aspergillusfumigatus) |
PF13088(BNR_2) | 5 | ARG A 59ILE A 60ILE A 88ARG A 322TYR A 358 | KDM A 500 (-2.7A)NoneNoneKDM A 500 ( 3.0A)KDM A 500 (-4.5A) | 1.17A | 2ya7D-2xziA:41.2 | 2ya7D-2xziA:26.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eb7 | INSECTICIDALDELTA-ENDOTOXINCRY8EA1 (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | ILE A 238TYR A 293GLN A 513ARG A 567TYR A 604 | None | 1.30A | 2ya7D-3eb7A:undetectable | 2ya7D-3eb7A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sil | SIALIDASE (Salmonellaenterica) |
PF13859(BNR_3) | 7 | ARG A 37ILE A 38ASP A 54ASP A 100ARG A 246ARG A 309TYR A 342 | PO4 A 499 (-2.7A)NoneNoneGOL A 403 (-3.4A)PO4 A 499 (-2.7A)PO4 A 499 (-3.0A)PO4 A 499 (-4.6A) | 0.43A | 2ya7D-3silA:39.8 | 2ya7D-3silA:25.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bbw | SIALIDASE(NEURAMINIDASE) (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2)PF14873(BNR_assoc_N) | 7 | ARG A 204ILE A 205ASP A 221ASP A 272ARG A 415ARG A 479TYR A 510 | None | 0.51A | 2ya7D-4bbwA:45.4 | 2ya7D-4bbwA:26.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e0t | CYCLIC DIPEPTIDEN-PRENYLTRANSFERASE (Aspergillusfumigatus) |
PF11991(Trp_DMAT) | 5 | ARG A 284ASP A 276ASP A 210TYR A 431GLN A 122 | NoneNoneNone CL A 606 (-4.9A)None | 1.35A | 2ya7D-4e0tA:undetectable | 2ya7D-4e0tA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fj6 | GLYCOSIDE HYDROLASEFAMILY 33, CANDIDATESIALIDASE (Parabacteroidesdistasonis) |
PF13859(BNR_3)PF14873(BNR_assoc_N) | 7 | ARG A 200ILE A 201ASP A 217ASP A 268ARG A 411ARG A 475TYR A 506 | PO4 A 607 ( 2.6A)NoneNoneNonePO4 A 607 (-2.7A)PO4 A 607 (-2.8A)PO4 A 607 (-4.6A) | 0.32A | 2ya7D-4fj6A:45.9 | 2ya7D-4fj6A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzh | HEMAGGLUTININ-NEURAMINIDASE (Avianavulavirus 1) |
PF00423(HN) | 6 | ARG A 174ILE A 175TYR A 317ARG A 416ARG A 498TYR A 526 | None | 0.95A | 2ya7D-4fzhA:13.1 | 2ya7D-4fzhA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3c | BILIRUBIN-INDUCIBLEFLUORESCENT PROTEINUNAG (Anguillajaponica) |
PF00061(Lipocalin) | 5 | ILE A 24ASP A 81GLN A 57ARG A 112TYR A 99 | NoneNoneBLR A 200 (-2.7A)BLR A 200 (-3.6A)BLR A 200 ( 4.4A) | 1.45A | 2ya7D-4i3cA:2.4 | 2ya7D-4i3cA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jf7 | HEMAGGLUTININ-NEURAMINIDASE (Mammalianrubulavirus 5) |
no annotation | 6 | ARG D 163ILE D 164TYR D 306ARG D 405ARG D 495TYR D 523 | SO4 D 608 ( 4.1A)NoneNoneSO4 D 608 (-2.6A)SO4 D 608 (-3.3A)None | 0.71A | 2ya7D-4jf7D:13.2 | 2ya7D-4jf7D:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lnf | GLUTAMINE SYNTHETASE (Bacillussubtilis) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 5 | ILE A 96ASP A 107ASP A 95TYR A 344GLN A 212 | None | 1.42A | 2ya7D-4lnfA:undetectable | 2ya7D-4lnfA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4phs | PUTATIVEGLYCOSYLTRANSFERASE(GALT1) (Streptococcusparasanguinis) |
PF08759(GT-D) | 5 | ASP A 252ILE A 255TYR A 263GLN A 264ARG A 270 | None | 1.38A | 2ya7D-4phsA:undetectable | 2ya7D-4phsA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6k | BNR/ASP-BOX REPEATPROTEIN (Bacteroidescaccae) |
PF13088(BNR_2)PF14873(BNR_assoc_N) | 7 | ARG A 220ILE A 221ASP A 237ASP A 288ARG A 431ARG A 495TYR A 526 | EDO A 604 (-4.0A)NoneNoneEDO A 607 (-3.1A)NoneNoneNone | 0.31A | 2ya7D-4q6kA:45.6 | 2ya7D-4q6kA:25.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4sli | INTRAMOLECULARTRANS-SIALIDASE (Macrobdelladecora) |
PF02973(Sialidase)PF13088(BNR_2) | 5 | ARG A 293ILE A 294ASP A 310ILE A 323ARG A 673 | CNP A 760 (-3.0A)CNP A 760 (-4.5A)NoneNoneCNP A 760 (-3.0A) | 1.24A | 2ya7D-4sliA:45.1 | 2ya7D-4sliA:25.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4sli | INTRAMOLECULARTRANS-SIALIDASE (Macrobdelladecora) |
PF02973(Sialidase)PF13088(BNR_2) | 10 | ARG A 293ILE A 294ASP A 310ILE A 374ASP A 375ASP A 392TYR A 561ARG A 611ARG A 673TYR A 713 | CNP A 760 (-3.0A)CNP A 760 (-4.5A)NoneCNP A 760 ( 4.4A)CNP A 760 (-2.8A)CNP A 760 (-4.4A)NoneCNP A 760 (-3.0A)CNP A 760 (-3.0A)CNP A 760 (-4.0A) | 0.41A | 2ya7D-4sliA:45.1 | 2ya7D-4sliA:25.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4x6k | ANHYDROSIALIDASE ([Ruminococcus]gnavus) |
PF13088(BNR_2) | 5 | ARG A 257ILE A 258ASP A 274ILE A 287ARG A 637 | 3XR A 802 (-3.0A)NoneNoneNone3XR A 802 (-3.0A) | 1.43A | 2ya7D-4x6kA:40.8 | 2ya7D-4x6kA:31.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4x6k | ANHYDROSIALIDASE ([Ruminococcus]gnavus) |
PF13088(BNR_2) | 10 | ARG A 257ILE A 258ASP A 274ILE A 338ASP A 339ASP A 356TYR A 525ARG A 575ARG A 637TYR A 677 | 3XR A 802 (-3.0A)NoneNone3XR A 802 (-4.2A)3XR A 802 (-2.8A)3XR A 802 (-4.6A)None3XR A 802 (-2.6A)3XR A 802 (-3.0A)3XR A 802 (-4.2A) | 0.35A | 2ya7D-4x6kA:40.8 | 2ya7D-4x6kA:31.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhb | SIALIDASE B (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 5 | ARG A 245ILE A 246ASP A 262ILE A 275ARG A 619 | NHE A 702 (-2.7A)NoneNoneNoneNHE A 702 (-2.9A) | 1.44A | 2ya7D-4xhbA:18.0 | 2ya7D-4xhbA:24.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhb | SIALIDASE B (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 10 | ARG A 245ILE A 246ASP A 262ILE A 326ASP A 327ASP A 344TYR A 509ARG A 557ARG A 619TYR A 653 | NHE A 702 (-2.7A)NoneNoneNHE A 702 ( 4.8A)NHE A 702 (-3.6A)NoneNoneNHE A 702 (-2.8A)NHE A 702 (-2.9A)NHE A 702 (-4.8A) | 0.34A | 2ya7D-4xhbA:18.0 | 2ya7D-4xhbA:24.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yw5 | NEURAMINIDASE C (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 6 | ARG A 290ILE A 291ASP A 307ILE A 320ARG A 662TYR A 695 | G39 A 801 (-2.6A)NoneNoneNoneG39 A 801 (-2.9A)G39 A 801 (-4.4A) | 1.31A | 2ya7D-4yw5A:19.6 | 2ya7D-4yw5A:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yw5 | NEURAMINIDASE C (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 10 | ARG A 290ILE A 291ASP A 307ILE A 371ASP A 372ASP A 388TYR A 553ARG A 600ARG A 662TYR A 695 | G39 A 801 (-2.6A)NoneNoneNoneG39 A 801 (-2.6A)G39 A 801 ( 4.8A)NoneG39 A 801 (-2.9A)G39 A 801 (-2.9A)G39 A 801 (-4.4A) | 0.35A | 2ya7D-4yw5A:19.6 | 2ya7D-4yw5A:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yw5 | NEURAMINIDASE C (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 6 | ARG A 290ILE A 291ASP A 307ILE A 371ASP A 388PHE A 316 | G39 A 801 (-2.6A)NoneNoneNoneG39 A 801 ( 4.8A)GOL A 802 (-4.9A) | 0.78A | 2ya7D-4yw5A:19.6 | 2ya7D-4yw5A:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2d | HN PROTEIN (Mumpsrubulavirus) |
PF00423(HN) | 6 | ARG A 180ILE A 181TYR A 323ARG A 422ARG A 512TYR A 540 | SLT A 606 (-2.6A)NoneSLT A 606 (-4.6A)SLT A 606 (-3.0A)SLT A 606 (-2.8A)SLT A 606 (-4.7A) | 0.60A | 2ya7D-5b2dA:27.4 | 2ya7D-5b2dA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsr | D-ALANYL-D-ALANINECARBOXYPEPTIDASEDACD (Escherichiacoli) |
PF00768(Peptidase_S11)PF07943(PBP5_C) | 5 | ILE A 303ILE A 306ASP A 334PHE A 294GLN A 27 | None | 1.45A | 2ya7D-5fsrA:undetectable | 2ya7D-5fsrA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byw | GOXA (Pseudoalteromonasluteoviolacea) |
no annotation | 5 | ARG B 404ILE B 365ASP B 360TYR B 45TYR B 807 | NoneNone MG B 901 (-2.8A)NoneNone | 1.25A | 2ya7D-6bywB:undetectable | 2ya7D-6bywB:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccb | GLYCOPROTEIN 120 (Humanimmunodeficiencyvirus 1) |
no annotation | 5 | ARG C 298ILE C 420ASP C 180TYR C 435GLN C 203 | None | 1.46A | 2ya7D-6ccbC:undetectable | 2ya7D-6ccbC:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eks | SIALIDASE (Vibrio cholerae) |
no annotation | 6 | ARG A 250ILE A 251ASP A 318ARG A 661ARG A 738TYR A 766 | G39 A 908 (-2.8A)G39 A 908 (-4.7A)G39 A 908 ( 4.2A)G39 A 908 (-2.8A)G39 A 908 (-3.0A)G39 A 908 (-4.6A) | 0.83A | 2ya7D-6eksA:43.0 | 2ya7D-6eksA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fbt | LYTIC MUREINTRANSGLYCOSYLASE (Pseudomonasaeruginosa) |
no annotation | 5 | ARG A 438ILE A 442ASP A 439ARG A 392TYR A 466 | None | 1.21A | 2ya7D-6fbtA:undetectable | 2ya7D-6fbtA:10.43 |