SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7W_C_SALC1300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)

(Thermobifida
fusca) 		PF00150
(Cellulase) 		4 THR A 294
ILE A 291
GLY A 290
PHE A 226
 None
 0.88A 2y7wC-1bqcA:
0.0		 2y7wC-1bqcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gui LAMINARINASE 16A

(Thermotoga
maritima) 		PF02018
(CBM_4_9) 		4 ILE A   4
GLY A   7
PHE A   9
PHE A  65
 None
GOL  A 300 (-4.0A)
None
None
 0.83A 2y7wC-1guiA:
undetectable		 2y7wC-1guiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4u NIDOGEN-1

(Mus musculus) 		PF07474
(G2F) 		4 ILE A 460
GLY A 461
PHE A 507
ILE A 518
 None
 0.65A 2y7wC-1h4uA:
undetectable		 2y7wC-1h4uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 ILE A 174
GLY A 170
PHE A 200
ILE A 181
 None
 0.84A 2y7wC-1jhzA:
1.0		 2y7wC-1jhzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		4 THR A 479
GLY A 480
HIS A  95
ILE A 572
 None
WCC  A 800 ( 4.4A)
None
None
 0.87A 2y7wC-1jqkA:
2.9		 2y7wC-1jqkA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 ILE A 150
PHE A  79
PHE A  97
ILE A  95
 None
 0.74A 2y7wC-1nhcA:
undetectable		 2y7wC-1nhcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 THR B  79
ILE B  10
GLY B  11
ILE B  38
 NAD  B3501 (-4.1A)
NAD  B3501 (-4.9A)
NAD  B3501 (-3.2A)
NAD  B3501 (-4.2A)
 0.70A 2y7wC-1nvmB:
1.6		 2y7wC-1nvmB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 THR A  24
ILE A  15
GLY A  20
PHE A  71
ILE A  69
 None
 1.37A 2y7wC-1oi7A:
2.2		 2y7wC-1oi7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		4 GLY A  13
PHE A  53
PHE A 109
HIS A 105
 None
 0.71A 2y7wC-1otkA:
undetectable		 2y7wC-1otkA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		5 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.09A 2y7wC-1pssM:
undetectable		 2y7wC-1pssM:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 THR A 273
ILE A 271
GLY A 280
PHE A 221
 NAG  A 803 (-2.6A)
None
None
None
 0.00A 2y7wC-1q5aA:
undetectable		 2y7wC-1q5aA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Plasmodium
falciparum) 		PF00160
(Pro_isomerase) 		5 ILE A  74
GLY A  72
PHE A 119
PHE A   9
ILE A 165
 None
 1.16A 2y7wC-1qnhA:
undetectable		 2y7wC-1qnhA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 THR A 154
GLY A 151
PHE A 330
PHE A 371
HIS A 480
 None
SO4  A 593 (-3.4A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.17A 2y7wC-1qonA:
undetectable		 2y7wC-1qonA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwi OSMOTICALLY
INDUCIBLE PROTEIN

(Escherichia
coli) 		PF02566
(OsmC) 		4 THR A  80
ILE A  78
PHE A 114
ILE A 118
 None
 0.87A 2y7wC-1qwiA:
undetectable		 2y7wC-1qwiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 THR A  22
ILE A  11
GLY A  19
ILE A 146
 None
 0.81A 2y7wC-1spxA:
undetectable		 2y7wC-1spxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		4 THR A 204
ILE A 303
GLY A 304
ILE A 449
 None
 0.80A 2y7wC-1t8wA:
undetectable		 2y7wC-1t8wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7s HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 2 229
GLY 2 228
PHE 2 130
PHE 2 157
 None
 0.87A 2y7wC-1z7s2:
undetectable		 2y7wC-1z7s2:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		4 THR A  52
ILE A  54
GLY A  55
PHE A  59
 None
 0.79A 2y7wC-2aeuA:
undetectable		 2y7wC-2aeuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		5 GLY A 131
PHE A  42
PHE A 204
HIS A 203
ILE A 209
 None
 1.31A 2y7wC-2bszA:
undetectable		 2y7wC-2bszA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2g THREONINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 THR A 397
GLY A 398
HIS A 153
ILE A 401
 None
 0.88A 2y7wC-2c2gA:
undetectable		 2y7wC-2c2gA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4i HYPOTHETICAL PROTEIN
TM0957

(Thermotoga
maritima) 		PF10054
(DUF2291) 		4 THR A 138
ILE A 140
GLY A 139
PHE A 152
 None
MLY  A  51 ( 4.9A)
None
MLY  A 142 ( 4.3A)
 0.84A 2y7wC-2f4iA:
undetectable		 2y7wC-2f4iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsn HYPOTHETICAL PROTEIN
TA0583

(Thermoplasma
acidophilum) 		no annotation 4 THR A 182
ILE A 204
GLY A 205
ILE A 290
 None
 0.81A 2y7wC-2fsnA:
undetectable		 2y7wC-2fsnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A  96
PHE A 135
HIS A 139
ILE A 136
 None
 0.86A 2y7wC-2ix5A:
undetectable		 2y7wC-2ix5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 THR A 178
ILE A 182
GLY A 179
PHE A 188
 None
 0.85A 2y7wC-2nyfA:
undetectable		 2y7wC-2nyfA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 THR A 157
ILE A 159
PHE A  97
ILE A 194
 None
 0.79A 2y7wC-2q1yA:
undetectable		 2y7wC-2q1yA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		5 THR A 104
ILE A 106
GLY A 107
PHE A 167
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.1A)
 0.64A 2y7wC-2uyeA:
30.7		 2y7wC-2uyeA:
73.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vm6 BCL-2-RELATED
PROTEIN A1

(Homo sapiens) 		PF00452
(Bcl-2) 		4 THR A 130
ILE A 134
GLY A 131
ILE A   9
 None
 0.79A 2y7wC-2vm6A:
undetectable		 2y7wC-2vm6A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdt UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE L3

(Plasmodium
falciparum) 		PF01088
(Peptidase_C12) 		4 THR A 200
ILE A 204
GLY A 201
ILE A  34
 None
 0.75A 2y7wC-2wdtA:
undetectable		 2y7wC-2wdtA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 THR A  84
PHE A  19
PHE A 253
ILE A 257
 None
 0.66A 2y7wC-2xmzA:
undetectable		 2y7wC-2xmzA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN

(Burkholderia
sp. DNT) 		PF03466
(LysR_substrate) 		7 THR A 104
ILE A 106
GLY A 107
PHE A 111
PHE A 167
HIS A 169
ILE A 273
 None
 0.54A 2y7wC-2y7rA:
31.1		 2y7wC-2y7rA:
95.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		4 ILE A 681
GLY A 680
PHE A 529
HIS A 512
 None
 0.81A 2y7wC-3dpuA:
undetectable		 2y7wC-3dpuA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e81 ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		4 THR A   9
ILE A  52
GLY A  51
ILE A  40
 None
 0.82A 2y7wC-3e81A:
1.3		 2y7wC-3e81A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		4 ILE A 242
GLY A 243
PHE A 199
ILE A 162
 None
 0.75A 2y7wC-3efbA:
undetectable		 2y7wC-3efbA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A 274
ILE A 298
GLY A 299
HIS A 352
 None
NAD  A 439 (-4.6A)
NAD  A 439 (-3.4A)
ADN  A 438 ( 3.6A)
 0.84A 2y7wC-3g1uA:
undetectable		 2y7wC-3g1uA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdi PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus musculus) 		PF08447
(PAS_3) 		4 THR A 410
PHE A 391
HIS A 380
ILE A 379
 None
 0.78A 2y7wC-3gdiA:
undetectable		 2y7wC-3gdiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A 690
PHE A 682
PHE A 553
ILE A 549
 None
 0.85A 2y7wC-3hhdA:
undetectable		 2y7wC-3hhdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		4 THR A 107
PHE A 286
PHE A 116
ILE A 114
 None
 0.82A 2y7wC-3i5tA:
undetectable		 2y7wC-3i5tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ILE A 117
PHE A 110
PHE A 145
ILE A  24
 None
 0.84A 2y7wC-3ig4A:
undetectable		 2y7wC-3ig4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A 311
ILE A 335
GLY A 336
HIS A 387
 None
NAD  A 550 (-4.3A)
NAD  A 550 (-3.4A)
ADN  A 500 (-3.4A)
 0.81A 2y7wC-3n58A:
undetectable		 2y7wC-3n58A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		5 ILE A  44
GLY A  45
PHE A 222
HIS A 189
ILE A 220
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.0A)
None
None
None
 1.06A 2y7wC-3nixA:
undetectable		 2y7wC-3nixA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A 324
ILE A 348
GLY A 349
HIS A 404
 None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.5A)
ADE  A 506 (-3.4A)
 0.85A 2y7wC-3oneA:
undetectable		 2y7wC-3oneA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0s CAPSID PROTEIN VP

(Lepidopteran
iteradensovirus
1) 		PF01057
(Parvo_NS1) 		4 ILE A 367
GLY A 368
PHE A 369
ILE A  73
 None
 0.81A 2y7wC-3p0sA:
undetectable		 2y7wC-3p0sA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 THR A  82
ILE A  59
GLY A  58
HIS A  93
 None
 0.84A 2y7wC-3pkjA:
undetectable		 2y7wC-3pkjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3w 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Campylobacter
jejuni) 		PF00694
(Aconitase_C) 		4 ILE A  19
GLY A  80
PHE A 109
ILE A 100
 None
 0.80A 2y7wC-3q3wA:
undetectable		 2y7wC-3q3wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdf 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Mycobacterium
marinum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 ILE A 124
GLY A 125
PHE A  37
ILE A  58
 None
 0.87A 2y7wC-3qdfA:
undetectable		 2y7wC-3qdfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		4 GLY A 110
PHE A 120
PHE A 100
ILE A 106
 None
 0.88A 2y7wC-3rc3A:
undetectable		 2y7wC-3rc3A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6d PHOTOSYNTHETIC
REACTION CENTER
M-SUBUNIT

(Blastochloris
viridis) 		PF00124
(Photo_RC) 		4 THR M 220
ILE M 221
GLY M 218
HIS M 264
 MQ9  M 501 (-3.5A)
None
None
FE2  M 500 (-3.4A)
 0.83A 2y7wC-3t6dM:
undetectable		 2y7wC-3t6dM:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdp FORMATE/NITRITE
TRANSPORTER

(Clostridioides
difficile) 		PF01226
(Form_Nir_trans) 		4 ILE A  42
GLY A  41
PHE A 194
ILE A 195
 None
 0.80A 2y7wC-3tdpA:
undetectable		 2y7wC-3tdpA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9l 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 THR A  19
ILE A   8
GLY A  16
ILE A 144
 None
 0.85A 2y7wC-3u9lA:
undetectable		 2y7wC-3u9lA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdo MFS TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 THR A 182
ILE A 179
GLY A 178
ILE A 116
 None
 0.86A 2y7wC-3wdoA:
undetectable		 2y7wC-3wdoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 THR A  82
ILE A  59
GLY A  58
HIS A  93
 None
 0.82A 2y7wC-3zg6A:
undetectable		 2y7wC-3zg6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyp CIP1

(Trichoderma
reesei) 		no annotation 4 THR A  59
GLY A  58
PHE A  57
ILE A 208
 None
PEG  A1223 (-4.5A)
None
None
 0.81A 2y7wC-3zypA:
undetectable		 2y7wC-3zypA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axz PUTATIVE ANTIGEN P35

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 THR A 185
ILE A 189
GLY A 186
PHE A 147
 None
 0.86A 2y7wC-4axzA:
undetectable		 2y7wC-4axzA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		4 THR A 350
GLY B 293
PHE A 356
PHE A 392
 None
 0.81A 2y7wC-4cakA:
undetectable		 2y7wC-4cakA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		4 THR B 296
GLY B 293
PHE A 356
PHE A 392
 None
 0.84A 2y7wC-4cakB:
undetectable		 2y7wC-4cakB:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN

(Plasmodium
berghei;
synthetic
construct) 		PF00022
(Actin) 		4 ILE A  35
GLY A  56
PHE A  32
ILE A  86
 None
 0.87A 2y7wC-4cbwA:
undetectable		 2y7wC-4cbwA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 THR A 157
ILE A 159
PHE A  97
ILE A 194
 None
 0.86A 2y7wC-4e6eA:
undetectable		 2y7wC-4e6eA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 267
ILE A 272
PHE A 245
ILE A 246
 None
None
FAD  A 501 (-3.7A)
None
 0.86A 2y7wC-4emwA:
undetectable		 2y7wC-4emwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		5 ILE A 232
GLY A 231
PHE A 222
PHE A 263
ILE A 278
 None
 1.36A 2y7wC-4femA:
undetectable		 2y7wC-4femA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		4 ILE A 167
GLY A 191
PHE A 239
ILE A 243
 None
 0.71A 2y7wC-4fp4A:
undetectable		 2y7wC-4fp4A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 ILE A 311
GLY A 310
PHE A 330
ILE A 343
 None
 0.82A 2y7wC-4gq1A:
undetectable		 2y7wC-4gq1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Archaeoglobus
fulgidus) 		PF02289
(MCH) 		4 THR A  53
ILE A  50
GLY A  49
ILE A 211
 None
 0.78A 2y7wC-4gvrA:
undetectable		 2y7wC-4gvrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9y E3 SUMO-PROTEIN
LIGASE RANBP2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 ILE A  67
GLY A  65
PHE A 112
PHE A   8
ILE A 158
 None
 1.20A 2y7wC-4i9yA:
undetectable		 2y7wC-4i9yA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idi ORYZA SATIVA
RURM1-RELATED

(Plasmodium
yoelii) 		PF09138
(Urm1) 		4 ILE A 116
PHE A   9
PHE A  54
ILE A  43
 None
 0.81A 2y7wC-4idiA:
undetectable		 2y7wC-4idiA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 209
GLY A 212
PHE A 216
ILE A 122
 None
None
None
EDO  A 502 (-4.9A)
 0.80A 2y7wC-4jgaA:
1.0		 2y7wC-4jgaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE

(Staphylococcus
aureus) 		PF01656
(CbiA) 		4 THR A1158
ILE A1156
GLY A1078
ILE A1135
 None
 0.62A 2y7wC-4jmpA:
undetectable		 2y7wC-4jmpA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 4 THR D 196
GLY D 199
PHE D 203
ILE D 109
 None
 0.82A 2y7wC-4jrmD:
0.7		 2y7wC-4jrmD:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Burkholderia
ambifaria) 		PF03480
(DctP) 		4 ILE A 129
GLY A 126
PHE A 111
ILE A 324
 None
 0.80A 2y7wC-4n17A:
5.1		 2y7wC-4n17A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT

(Brucella
abortus) 		PF00132
(Hexapep) 		4 THR A  58
ILE A  54
GLY A  55
ILE A  93
 None
 0.88A 2y7wC-4n27A:
undetectable		 2y7wC-4n27A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp. BTAi1) 		PF03480
(DctP) 		4 ILE A 125
GLY A 122
PHE A 107
ILE A 319
 None
 0.78A 2y7wC-4n8yA:
4.9		 2y7wC-4n8yA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Xanthobacter
autotrophicus) 		PF03480
(DctP) 		4 ILE A 128
GLY A 125
PHE A 110
ILE A 320
 None
 0.85A 2y7wC-4ovrA:
5.0		 2y7wC-4ovrA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 ILE A 139
GLY A 140
PHE A  55
ILE A  76
 None
 0.87A 2y7wC-4pfzA:
undetectable		 2y7wC-4pfzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 195
GLY A 198
PHE A 202
ILE A 108
 None
 0.84A 2y7wC-4r8eA:
undetectable		 2y7wC-4r8eA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 THR A 410
ILE A 414
GLY A 409
PHE A 380
ILE A 375
 None
 1.26A 2y7wC-4uadA:
undetectable		 2y7wC-4uadA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbj BLR1131 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF02630
(SCO1-SenC) 		4 ILE A  41
GLY A  42
PHE A  69
ILE A  67
 None
 0.80A 2y7wC-4wbjA:
undetectable		 2y7wC-4wbjA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xav GLIOMEDIN

(Mus musculus) 		PF02191
(OLF) 		4 ILE A 478
PHE A 473
PHE A 505
ILE A 301
 None
 0.84A 2y7wC-4xavA:
undetectable		 2y7wC-4xavA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 THR A 169
ILE A  94
GLY A  95
ILE A 119
 S4M  A 301 (-4.7A)
None
S4M  A 301 (-3.5A)
S4M  A 301 (-3.9A)
 0.70A 2y7wC-4yv2A:
undetectable		 2y7wC-4yv2A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		5 THR A 108
ILE A 163
GLY A 107
PHE A 106
ILE A 152
 None
A  C  23 ( 4.4A)
None
None
None
 1.48A 2y7wC-4z7lA:
undetectable		 2y7wC-4z7lA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		4 ILE A  74
GLY A  75
PHE A  79
ILE A 107
 PGT  A 309 ( 4.2A)
None
None
PGT  A 309 ( 4.8A)
 0.82A 2y7wC-5azbA:
undetectable		 2y7wC-5azbA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		4 ILE A 233
GLY A 234
PHE A 238
ILE A 213
 PGT  A 307 (-4.2A)
None
None
None
 0.84A 2y7wC-5azbA:
undetectable		 2y7wC-5azbA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ILE A 479
GLY A 480
PHE A 502
PHE A 513
 None
 0.83A 2y7wC-5gr8A:
undetectable		 2y7wC-5gr8A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		4 ILE A 393
GLY A 394
PHE A 398
ILE A 452
 None
 0.83A 2y7wC-5h0iA:
undetectable		 2y7wC-5h0iA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		4 THR A 992
ILE A 928
GLY A 927
ILE A 114
 None
 0.78A 2y7wC-5ijlA:
undetectable		 2y7wC-5ijlA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 THR B 178
ILE B 182
GLY B 179
PHE B 188
 None
 0.86A 2y7wC-5ltmB:
undetectable		 2y7wC-5ltmB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 ILE A  41
GLY A  38
PHE A 432
ILE A 448
 None
 0.87A 2y7wC-5muxA:
undetectable		 2y7wC-5muxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 THR A 548
ILE A 550
GLY A 551
HIS A 482
 MGD  A2001 (-4.5A)
None
None
None
 0.85A 2y7wC-5nqdA:
undetectable		 2y7wC-5nqdA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 THR A 241
ILE A 245
GLY A 242
ILE A  50
 None
 0.87A 2y7wC-5oynA:
undetectable		 2y7wC-5oynA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 THR A 930
ILE A 934
GLY A 931
PHE A 840
 None
 0.69A 2y7wC-5szsA:
undetectable		 2y7wC-5szsA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 THR A 639
ILE A 636
GLY A 637
ILE A 597
 None
 0.75A 2y7wC-5te1A:
undetectable		 2y7wC-5te1A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 THR B 639
ILE B 636
GLY B 637
ILE B 597
 None
 0.72A 2y7wC-5tetB:
undetectable		 2y7wC-5tetB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9c DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Yersinia
enterocolitica) 		PF04321
(RmlD_sub_bind) 		4 ILE A 229
GLY A 230
PHE A 235
ILE A 180
 None
 0.79A 2y7wC-5u9cA:
undetectable		 2y7wC-5u9cA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 ILE C 190
GLY C 191
PHE C 161
PHE C 177
 None
 0.83A 2y7wC-5uj7C:
undetectable		 2y7wC-5uj7C:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER

(Roseiflexus
castenholzii) 		no annotation 4 THR M 545
ILE M 546
GLY M 543
HIS M 589
 MQE  M 701 (-4.0A)
None
None
FE  L1005 (-3.2A)
 0.83A 2y7wC-5yq7M:
undetectable		 2y7wC-5yq7M:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yve P2X PURINOCEPTOR 3

(Homo sapiens) 		no annotation 4 ILE A 243
GLY A 244
PHE A 181
ILE A  56
 None
 0.86A 2y7wC-5yveA:
undetectable		 2y7wC-5yveA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum) 		no annotation 4 THR A 211
ILE A 192
GLY A 191
ILE A 139
 None
 0.88A 2y7wC-5zh5A:
undetectable		 2y7wC-5zh5A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 4 THR A 553
ILE A 557
GLY A 554
PHE A 535
 None
 0.58A 2y7wC-6a91A:
undetectable		 2y7wC-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A 280
ILE A 304
GLY A 305
HIS A 358
 None
NAD  A 500 (-4.4A)
NAD  A 500 (-3.4A)
ADN  A 501 ( 3.5A)
 0.86A 2y7wC-6aphA:
undetectable		 2y7wC-6aphA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv6 3-DEHYDROQUINATE
DEHYDRATASE

(Paraburkholderia
phymatum) 		no annotation 4 ILE A  10
GLY A   9
PHE A 117
ILE A  86
 None
 0.79A 2y7wC-6cv6A:
2.2		 2y7wC-6cv6A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2x PROTEIN TYROSINE
KINASE A

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A 164
GLY A 165
PHE A 202
ILE A 198
 None
 0.82A 2y7wC-6f2xA:
undetectable		 2y7wC-6f2xA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 4 THR B 297
ILE B 321
GLY B 322
HIS B 382
 None
NAD  B 501 (-4.4A)
NAD  B 501 (-3.4A)
ADN  B 502 (-3.4A)
 0.85A 2y7wC-6f3mB:
undetectable		 2y7wC-6f3mB:
undetectable