SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7W_B_SALB1300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua)
PF00026
(Asp)
5 GLY A  85
GLY A  68
HIS A  44
PRO A  58
ILE A  83
None
1.17A 2y7wB-1am5A:
0.0
2y7wB-1am5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 THR A 360
HIS A 319
THR A 386
PRO A 450
ILE A 303
None
1.21A 2y7wB-1ciyA:
undetectable
2y7wB-1ciyA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE


(Salmonella
enterica)
PF00291
(PALP)
5 THR A 156
ILE A 160
GLY A 157
GLY A 183
THR A 180
None
None
None
None
PLP  A 501 (-3.6A)
1.16A 2y7wB-1d6sA:
undetectable
2y7wB-1d6sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT


(Desulfovibrio
desulfuricans)
PF00374
(NiFeSe_Hases)
5 THR B 515
ILE B  38
GLY B 514
GLY B 281
THR B 529
None
1.15A 2y7wB-1e3dB:
0.0
2y7wB-1e3dB:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A   6
GLY A   7
GLY A  83
THR A 122
ILE A 102
None
NAP  A 900 (-2.5A)
NAP  A 900 (-3.9A)
NAP  A 900 (-3.8A)
NAP  A 900 (-4.0A)
1.41A 2y7wB-1hygA:
0.3
2y7wB-1hygA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE


(Escherichia
coli)
PF00633
(HHH)
PF00730
(HhH-GPD)
5 THR A 121
ILE A 125
GLY A 123
PHE A 108
GLY A 118
None
1.40A 2y7wB-1kqjA:
undetectable
2y7wB-1kqjA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE


(Methanosarcina
barkeri)
PF05369
(MtmB)
5 THR A 274
GLY A 270
GLY A 266
HIS A 300
ILE A 301
None
1.31A 2y7wB-1l2qA:
undetectable
2y7wB-1l2qA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvm CATALYTIC DOMAIN OF
THE NUCLEAR
INCLUSION PROTEIN A
(NIA)


(Tobacco etch
virus)
PF00863
(Peptidase_C4)
5 ILE A 163
PHE A 186
THR A  17
PRO A 154
ILE A  42
None
1.14A 2y7wB-1lvmA:
undetectable
2y7wB-1lvmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE


(Drosophila
melanogaster)
PF00106
(adh_short)
5 ILE A 137
GLY A  92
GLY A  14
THR A  22
PRO A 182
NAI  A 850 (-4.1A)
NAI  A 850 (-4.6A)
None
None
NAI  A 850 (-3.8A)
1.26A 2y7wB-1mg5A:
0.0
2y7wB-1mg5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus)
no annotation 5 PHE A 197
GLY A 249
HIS A  98
PRO A  96
ILE A 245
None
1.37A 2y7wB-1nnwA:
undetectable
2y7wB-1nnwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Thermotoga
maritima)
PF01979
(Amidohydro_1)
5 THR A 151
GLY A 116
HIS A  51
THR A 196
HIS A 197
None
None
None
None
FE  A 401 (-3.5A)
1.18A 2y7wB-1o12A:
undetectable
2y7wB-1o12A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og0 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE


(Saccharomyces
cerevisiae)
PF00793
(DAHP_synth_1)
5 THR A 311
ILE A  62
GLY A 275
GLY A  64
PRO A 197
None
1.37A 2y7wB-1og0A:
undetectable
2y7wB-1og0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN


(Thermus
thermophilus)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
5 THR A  24
ILE A  15
GLY A  20
PHE A  71
ILE A  69
None
1.37A 2y7wB-1oi7A:
2.1
2y7wB-1oi7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE


(Enterobacter
cloacae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 THR A 433
GLY A 434
GLY A 411
THR A 413
ILE A 410
None
TPP  A 600 (-3.2A)
None
None
TPP  A 600 (-4.0A)
1.37A 2y7wB-1ovmA:
undetectable
2y7wB-1ovmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pfs PF3 SINGLE-STRANDED
DNA BINDING PROTEIN


(Pseudomonas
virus Pf3)
no annotation 5 THR A   8
GLY A  27
GLY A  51
HIS A  30
PRO A  37
None
1.21A 2y7wB-1pfsA:
undetectable
2y7wB-1pfsA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Haemophilus
influenzae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 THR A  72
ILE A   7
GLY A   8
GLY A  75
THR A  79
None
None
NAP  A1372 (-3.1A)
NAP  A1372 (-3.4A)
None
1.15A 2y7wB-1pquA:
undetectable
2y7wB-1pquA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER


(Rhodobacter
sphaeroides)
PF00124
(Photo_RC)
5 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
1.08A 2y7wB-1pssM:
undetectable
2y7wB-1pssM:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr0 4'-PHOSPHOPANTETHEIN
YL TRANSFERASE SFP


(Bacillus
subtilis)
PF01648
(ACPS)
5 ILE A   3
GLY A  97
GLY A 105
PRO A 212
ILE A 104
None
0.98A 2y7wB-1qr0A:
undetectable
2y7wB-1qr0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE


(Homo sapiens)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 THR A  92
ILE A  98
GLY A  97
GLY A 276
ILE A 280
THR  A  92 ( 0.8A)
ILE  A  98 ( 0.7A)
GLY  A  97 ( 0.0A)
GLY  A 276 ( 0.0A)
ILE  A 280 ( 0.7A)
1.16A 2y7wB-1wsvA:
undetectable
2y7wB-1wsvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii)
PF01266
(DAO)
5 THR B 187
ILE B 192
PHE B 175
THR B 170
ILE B  11
None
0.97A 2y7wB-1y56B:
undetectable
2y7wB-1y56B:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
5 ILE A 292
GLY A 224
GLY A 168
PRO A 290
ILE A 346
None
1.37A 2y7wB-1z8lA:
undetectable
2y7wB-1z8lA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE


(Gallus gallus)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 ILE A 255
GLY A 321
PHE A 320
PRO A 420
ILE A 415
None
1.40A 2y7wB-2bccA:
undetectable
2y7wB-2bccA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7i PUTATIVE LIPOATE
PROTEIN LIGASE


(Thermoplasma
acidophilum)
PF03099
(BPL_LplA_LipB)
5 GLY A  77
HIS A  81
THR A  74
HIS A 161
ILE A  46
None
1.26A 2y7wB-2c7iA:
undetectable
2y7wB-2c7iA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL


(Sus scrofa)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
5 THR A 166
GLY A 163
GLY A 185
HIS A 151
PRO A 147
None
PO4  A 401 (-3.4A)
None
None
None
1.04A 2y7wB-2fpgA:
2.1
2y7wB-2fpgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE


(Desulfovibrio
gigas)
no annotation 5 THR L 509
ILE L  32
GLY L 508
GLY L 275
THR L 523
None
1.01A 2y7wB-2frvL:
undetectable
2y7wB-2frvL:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
5 ILE A 123
GLY A 115
PHE A 114
GLY A 263
THR A 118
None
None
UQ5  A 612 (-4.1A)
None
None
1.18A 2y7wB-2gmhA:
0.9
2y7wB-2gmhA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3e G-RICH

(Carassius
auratus)
PF05881
(CNPase)
5 THR A 167
GLY A 168
GLY A 113
THR A 111
ILE A 106
None
1.10A 2y7wB-2i3eA:
undetectable
2y7wB-2i3eA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np5 TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF00440
(TetR_N)
PF13977
(TetR_C_6)
5 THR A 143
ILE A 141
GLY A 142
GLY A 190
PRO A  81
None
1.10A 2y7wB-2np5A:
undetectable
2y7wB-2np5A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
5 ILE A 175
GLY A 174
PHE A 131
GLY A 229
THR A 232
None
1.40A 2y7wB-2ph3A:
undetectable
2y7wB-2ph3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qck FLAVIN REDUCTASE
DOMAIN PROTEIN


(Arthrobacter
sp. FB24)
PF01613
(Flavin_Reduct)
5 ILE A 109
GLY A 103
THR A  27
HIS A  75
ILE A 118
None
1.07A 2y7wB-2qckA:
undetectable
2y7wB-2qckA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE


(Bacillus
anthracis)
PF13561
(adh_short_C2)
5 ILE A  87
GLY A  89
GLY A 139
THR A 137
ILE A 183
None
1.37A 2y7wB-2qioA:
undetectable
2y7wB-2qioA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia)
PF03466
(LysR_substrate)
6 THR A 104
GLY A 107
GLY A 152
HIS A 206
PRO A 246
ILE A 273
SCN  A1307 (-4.0A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
0.74A 2y7wB-2uyeA:
30.7
2y7wB-2uyeA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia)
PF03466
(LysR_substrate)
6 THR A 104
GLY A 107
THR A 204
HIS A 206
PRO A 246
ILE A 273
SCN  A1307 (-4.0A)
SCN  A1303 (-3.5A)
SCN  A1309 ( 4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
0.90A 2y7wB-2uyeA:
30.7
2y7wB-2uyeA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia)
PF03466
(LysR_substrate)
6 THR A 104
ILE A 106
GLY A 107
GLY A 152
PRO A 246
ILE A 273
SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
0.33A 2y7wB-2uyeA:
30.7
2y7wB-2uyeA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia)
PF03466
(LysR_substrate)
6 THR A 104
ILE A 106
GLY A 107
THR A 204
PRO A 246
ILE A 273
SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1309 ( 4.7A)
None
SCN  A1303 (-4.1A)
0.56A 2y7wB-2uyeA:
30.7
2y7wB-2uyeA:
73.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v84 SPERMIDINE/PUTRESCIN
E ABC TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN


(Treponema
pallidum)
PF13416
(SBP_bac_8)
5 THR A 279
ILE A 280
PHE A 276
GLY A 112
PRO A 108
None
1.19A 2y7wB-2v84A:
8.6
2y7wB-2v84A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE


(Escherichia
coli)
PF00596
(Aldolase_II)
5 THR A 224
GLY A 218
GLY A 216
HIS A 125
ILE A 139
None
1.31A 2y7wB-2v9iA:
undetectable
2y7wB-2v9iA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
5 THR A 176
GLY A 137
HIS A  65
THR A 222
HIS A 223
None
None
FE  A1397 (-3.3A)
None
FE  A1398 (-3.3A)
1.19A 2y7wB-2vhlA:
undetectable
2y7wB-2vhlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 THR A 160
ILE A 162
PHE A 100
THR A 313
ILE A 197
None
1.28A 2y7wB-2vxyA:
undetectable
2y7wB-2vxyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)


(Mycobacterium
tuberculosis)
PF13185
(GAF_2)
5 ILE A 103
PHE A  98
GLY A  84
HIS A 149
PRO A 150
HEM  A 500 (-4.2A)
HEM  A 500 (-4.9A)
HEM  A 500 (-4.4A)
HEM  A 500 (-3.3A)
None
1.31A 2y7wB-2w3gA:
undetectable
2y7wB-2w3gA:
23.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN


(Burkholderia
sp. DNT)
PF03466
(LysR_substrate)
7 THR A 104
GLY A 107
PHE A 111
GLY A 152
HIS A 206
PRO A 246
ILE A 273
None
0.69A 2y7wB-2y7rA:
31.3
2y7wB-2y7rA:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN


(Burkholderia
sp. DNT)
PF03466
(LysR_substrate)
7 THR A 104
GLY A 107
PHE A 111
THR A 204
HIS A 206
PRO A 246
ILE A 273
None
0.88A 2y7wB-2y7rA:
31.3
2y7wB-2y7rA:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN


(Burkholderia
sp. DNT)
PF03466
(LysR_substrate)
8 THR A 104
ILE A 106
GLY A 107
PHE A 111
GLY A 152
HIS A 169
PRO A 246
ILE A 273
None
0.53A 2y7wB-2y7rA:
31.3
2y7wB-2y7rA:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN


(Burkholderia
sp. DNT)
PF03466
(LysR_substrate)
8 THR A 104
ILE A 106
GLY A 107
PHE A 111
HIS A 169
THR A 204
PRO A 246
ILE A 273
None
0.69A 2y7wB-2y7rA:
31.3
2y7wB-2y7rA:
95.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V


(Thermus
thermophilus)
PF00266
(Aminotran_5)
5 THR A 320
ILE A 317
GLY A 318
GLY A  83
THR A 137
None
1.40A 2y7wB-2yrrA:
0.6
2y7wB-2yrrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN


(Aeropyrum
pernix)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
5 ILE A 134
GLY A 183
THR A 164
PRO A 136
ILE A 182
None
1.38A 2y7wB-2yv2A:
1.8
2y7wB-2yv2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE


(Bifidobacterium
breve)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
5 THR A 298
PHE A 247
GLY A 250
HIS A 260
ILE A 259
None
1.21A 2y7wB-3ahiA:
0.3
2y7wB-3ahiA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
5 THR A 298
PHE A 247
GLY A 250
HIS A 260
ILE A 259
None
1.23A 2y7wB-3ai7A:
undetectable
2y7wB-3ai7A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans)
PF00149
(Metallophos)
5 THR A  33
GLY A 248
GLY A  79
HIS A  36
PRO A 445
None
None
None
None
FMT  A 607 ( 4.6A)
1.42A 2y7wB-3c9fA:
undetectable
2y7wB-3c9fA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2

(Bos taurus)
PF00246
(Peptidase_M14)
5 GLY A 253
PHE A 147
HIS A  69
THR A 268
ILE A  68
None
None
ZN  A 309 ( 3.1A)
None
None
1.09A 2y7wB-3d4uA:
undetectable
2y7wB-3d4uA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC


(Caulobacter
vibrioides)
PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated)
5 THR A 470
GLY A 466
PHE A 468
THR A 441
ILE A 423
None
1.35A 2y7wB-3epmA:
undetectable
2y7wB-3epmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila)
PF00753
(Lactamase_B)
5 THR A 115
ILE A 201
GLY A 200
GLY A 220
ILE A 222
None
None
CL  A   4 (-3.6A)
None
CL  A   4 (-4.8A)
1.39A 2y7wB-3faiA:
undetectable
2y7wB-3faiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk3 ACETOACETYL-COA
REDUCTASE


(Burkholderia
pseudomallei)
PF13561
(adh_short_C2)
5 ILE A 177
GLY A 176
PHE A 133
GLY A 232
THR A 235
None
1.40A 2y7wB-3gk3A:
undetectable
2y7wB-3gk3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE


(Homo sapiens)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
5 THR A 488
ILE A 506
GLY A 507
GLY A 361
THR A 363
None
1.34A 2y7wB-3higA:
undetectable
2y7wB-3higA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
5 ILE A1573
GLY A1537
THR A1633
PRO A1627
ILE A1599
None
1.18A 2y7wB-3hmjA:
undetectable
2y7wB-3hmjA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG


(Clostridium
acetobutylicum)
PF06838
(Met_gamma_lyase)
5 THR A 101
ILE A 104
GLY A 105
HIS A 180
THR A 128
LLP  A 243 ( 3.3A)
None
None
None
LLP  A 243 ( 4.8A)
1.26A 2y7wB-3hvyA:
undetectable
2y7wB-3hvyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD


(Escherichia
coli)
PF00577
(Usher)
5 ILE A 259
GLY A 258
PHE A 285
THR A 537
ILE A 303
None
1.26A 2y7wB-3ohnA:
undetectable
2y7wB-3ohnA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osl CARBOXYPEPTIDASE B2

(Bos taurus)
PF00246
(Peptidase_M14)
5 GLY A 368
PHE A 259
HIS A 181
THR A 383
ILE A 180
None
None
ZN  A 999 (-3.1A)
None
None
1.09A 2y7wB-3oslA:
undetectable
2y7wB-3oslA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgm P-NITROPHENYL
PHOSPHATASE (PHO2)


(Archaeoglobus
fulgidus)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
5 THR A 163
ILE A 167
GLY A 164
THR A 147
PRO A 178
None
1.02A 2y7wB-3qgmA:
1.5
2y7wB-3qgmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ILE A 351
GLY A 352
THR A 355
PRO A 329
ILE A  93
None
1.35A 2y7wB-3qtpA:
undetectable
2y7wB-3qtpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE


(Scaptodrosophila
lebanonensis)
PF00106
(adh_short)
5 ILE A  17
GLY A  18
PHE A  10
GLY A  91
PRO A 181
NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.7A)
NAD  A 850 (-3.9A)
1.32A 2y7wB-3rj9A:
undetectable
2y7wB-3rj9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 THR A  53
GLY A 141
PHE A 143
GLY A  60
PRO A  44
None
1.23A 2y7wB-3v9eA:
undetectable
2y7wB-3v9eA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE


(Glycine max)
PF00291
(PALP)
5 THR A 210
ILE A 214
GLY A 211
GLY A 237
THR A 234
None
None
None
None
PLP  A 500 (-3.7A)
1.18A 2y7wB-3vbeA:
undetectable
2y7wB-3vbeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ


(Staphylococcus
aureus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 THR A 160
ILE A 162
PHE A 100
THR A 311
ILE A 197
None
1.23A 2y7wB-3wgkA:
undetectable
2y7wB-3wgkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
5 THR A 495
ILE A 499
GLY A 496
PHE A 543
THR A 341
None
1.21A 2y7wB-4a01A:
undetectable
2y7wB-4a01A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 THR A 361
HIS A 319
THR A 386
PRO A 451
ILE A 303
None
1.22A 2y7wB-4arxA:
undetectable
2y7wB-4arxA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger)
PF01979
(Amidohydro_1)
5 THR A 408
ILE A 404
GLY A 106
PRO A 440
ILE A 434
None
1.32A 2y7wB-4c60A:
undetectable
2y7wB-4c60A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA


(Homo sapiens)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
5 THR A 182
GLY A 358
THR A 420
HIS A 418
PRO A 415
None
1.35A 2y7wB-4cgyA:
undetectable
2y7wB-4cgyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium)
PF00232
(Glyco_hydro_1)
5 ILE A 195
GLY A 192
GLY A 252
HIS A 146
PRO A 152
None
1.22A 2y7wB-4hz8A:
undetectable
2y7wB-4hz8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA


(Streptococcus
pneumoniae)
PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c)
5 ILE A1178
GLY A1341
HIS A1181
PRO A1179
ILE A1342
None
1.35A 2y7wB-4i3hA:
undetectable
2y7wB-4i3hA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
5 THR A 291
GLY A 292
PHE A 293
GLY A 322
ILE A 321
None
1.27A 2y7wB-4jhzA:
undetectable
2y7wB-4jhzA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
5 ILE A  45
GLY A  40
THR A 310
PRO A  20
ILE A   5
None
1.32A 2y7wB-4lmpA:
undetectable
2y7wB-4lmpA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae)
PF08801
(Nucleoporin_N)
5 ILE A 547
GLY A 546
PHE A 590
GLY A 636
HIS A 633
None
1.22A 2y7wB-4mhcA:
undetectable
2y7wB-4mhcA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 THR A 361
HIS A 319
THR A 386
PRO A 451
ILE A 303
None
1.25A 2y7wB-4w8jA:
undetectable
2y7wB-4w8jA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE


(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 THR A  50
ILE A  78
GLY A  77
GLY A  48
PRO A  80
None
1.36A 2y7wB-4wkyA:
undetectable
2y7wB-4wkyA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1


(Arabidopsis
thaliana)
PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N)
5 THR A  33
ILE A  35
GLY A  34
GLY A  29
PRO A  39
None
0.97A 2y7wB-4xaeA:
undetectable
2y7wB-4xaeA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE


(Streptococcus
pneumoniae)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
5 ILE A1178
GLY A1341
HIS A1181
PRO A1179
ILE A1342
None
1.33A 2y7wB-4z3oA:
undetectable
2y7wB-4z3oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 GLY A 161
PHE A 184
GLY A 139
HIS A 166
ILE A 140
None
None
None
NAG  A 702 (-4.8A)
None
1.14A 2y7wB-4z64A:
undetectable
2y7wB-4z64A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6s ENDOLYSIN

(Clostridium
phage phiCTP1)
PF01183
(Glyco_hydro_25)
5 GLY A  57
PHE A  88
GLY A  26
THR A  49
ILE A  55
None
1.42A 2y7wB-5a6sA:
undetectable
2y7wB-5a6sA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 THR A 220
ILE A 337
GLY A 253
HIS A 376
THR A 255
None
1.18A 2y7wB-5cdeA:
undetectable
2y7wB-5cdeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA


(Cupriavidus
necator)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 GLY A 414
GLY A 371
HIS A 155
THR A 373
PRO A 156
ADP  A 501 (-3.2A)
ADP  A 501 (-3.5A)
ADP  A 501 (-3.8A)
ADP  A 501 (-3.8A)
ADP  A 501 (-4.2A)
1.37A 2y7wB-5dmhA:
1.7
2y7wB-5dmhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA


(Cupriavidus
necator)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 THR A 277
GLY A 414
GLY A 271
HIS A 155
THR A 325
None
ADP  A 501 (-3.2A)
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
None
1.36A 2y7wB-5dmhA:
1.7
2y7wB-5dmhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 THR A 181
ILE A 167
GLY A 321
GLY A 159
ILE A 158
None
1.26A 2y7wB-5eb5A:
undetectable
2y7wB-5eb5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE


(Clostridium
sardiniense)
PF13561
(adh_short_C2)
5 THR A 193
ILE A 191
GLY A 192
GLY A  17
PRO A 188
NAP  A 301 (-2.9A)
NAP  A 301 (-3.9A)
None
NAP  A 301 (-3.3A)
NAP  A 301 (-3.7A)
1.36A 2y7wB-5epoA:
undetectable
2y7wB-5epoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5n MONOOXYGENASE

(Micromonospora
sp. TP-A0468)
PF05368
(NmrA)
5 ILE A 187
GLY A 188
GLY A  18
THR A  16
PRO A 148
None
None
None
NAD  A 301 (-4.0A)
NAD  A 301 (-4.3A)
1.12A 2y7wB-5f5nA:
undetectable
2y7wB-5f5nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 THR A 401
ILE A 583
GLY A 397
HIS A 550
PRO A 463
None
1.17A 2y7wB-5fjjA:
undetectable
2y7wB-5fjjA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA, PUTATIVE


(Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
5 THR A  35
GLY A  88
GLY A 175
PRO A 162
ILE A 174
None
1.26A 2y7wB-5fmgA:
undetectable
2y7wB-5fmgA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5t FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2


(Salmonella
enterica)
PF07195
(FliD_C)
PF07196
(Flagellin_IN)
5 THR A  86
ILE A 250
GLY A 249
GLY A  89
THR A  73
None
1.37A 2y7wB-5h5tA:
undetectable
2y7wB-5h5tA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvf CARBOXYPEPTIDASE B2

(Homo sapiens)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
5 GLY A 346
PHE A 237
HIS A 159
THR A 361
ILE A 158
None
None
ZN  A 508 ( 3.2A)
FLC  A 509 ( 4.6A)
None
1.12A 2y7wB-5hvfA:
undetectable
2y7wB-5hvfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE


(Shewanella
oneidensis)
PF03060
(NMO)
5 THR A 265
ILE A 279
GLY A 278
GLY A 180
HIS A 253
None
None
None
FMN  A 401 (-3.7A)
None
1.15A 2y7wB-5lsmA:
undetectable
2y7wB-5lsmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE


(Shewanella
oneidensis)
PF03060
(NMO)
5 THR A 265
ILE A 279
GLY A 278
GLY A 325
HIS A 253
None
None
None
FMN  A 401 ( 4.1A)
None
1.25A 2y7wB-5lsmA:
undetectable
2y7wB-5lsmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mn5 CELL DIVISION
PROTEIN FTSZ


(Staphylococcus
aureus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 THR A 160
ILE A 162
PHE A 100
THR A 313
ILE A 197
None
1.31A 2y7wB-5mn5A:
undetectable
2y7wB-5mn5A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8u LIPOATE-PROTEIN
LIGASE 1


(Plasmodium
falciparum)
PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C)
5 GLY A 107
HIS A 111
THR A 104
HIS A 176
ILE A  76
LPA  A 401 (-4.2A)
LPA  A 401 (-4.3A)
None
LPA  A 401 (-3.6A)
LPA  A 401 ( 4.2A)
1.26A 2y7wB-5t8uA:
undetectable
2y7wB-5t8uA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium)
PF02310
(B12-binding)
5 ILE A 298
GLY A 296
GLY A 349
PRO A 134
ILE A 354
None
1.33A 2y7wB-5ul4A:
1.2
2y7wB-5ul4A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA


(Neurospora
crassa)
no annotation 5 THR B 328
ILE B 331
GLY B 323
PRO B 295
ILE B 286
None
1.40A 2y7wB-5vqiB:
undetectable
2y7wB-5vqiB:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE


(Bacillus
alcalophilus)
no annotation 5 GLY A  58
PHE A  54
GLY A 305
HIS A 245
ILE A 306
None
1.37A 2y7wB-5yo8A:
undetectable
2y7wB-5yo8A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Mycolicibacterium
smegmatis)
no annotation 5 THR A 192
ILE A  19
GLY A  18
GLY A 194
PRO A 187
NAP  A 301 (-2.9A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.2A)
NAP  A 301 (-3.2A)
NAP  A 301 (-3.6A)
1.39A 2y7wB-6ci9A:
undetectable
2y7wB-6ci9A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB)
no annotation 5 GLY A 569
PHE A 572
GLY A 554
HIS A 959
THR A 583
None
1.31A 2y7wB-6etzA:
undetectable
2y7wB-6etzA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE EPSILON
CHAIN, CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 5 THR e  42
ILE e  31
THR e  40
HIS e  37
ILE e  74
None
1.28A 2y7wB-6fkhe:
undetectable
2y7wB-6fkhe:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Mycolicibacterium
smegmatis)
no annotation 5 THR A 162
GLY A 123
HIS A  58
THR A 208
HIS A 209
None
None
ZN  A 401 ( 3.2A)
None
CD  A 403 ( 3.7A)
1.12A 2y7wB-6fv4A:
undetectable
2y7wB-6fv4A:
14.90