SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7W_B_SALB1300
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1am5 | PEPSIN (Gadus morhua) |
PF00026(Asp) | 5 | GLY A 85GLY A 68HIS A 44PRO A 58ILE A 83 | None | 1.17A | 2y7wB-1am5A:0.0 | 2y7wB-1am5A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ciy | CRYIA(A) (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | THR A 360HIS A 319THR A 386PRO A 450ILE A 303 | None | 1.21A | 2y7wB-1ciyA:undetectable | 2y7wB-1ciyA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d6s | O-ACETYLSERINESULFHYDRYLASE (Salmonellaenterica) |
PF00291(PALP) | 5 | THR A 156ILE A 160GLY A 157GLY A 183THR A 180 | NoneNoneNoneNonePLP A 501 (-3.6A) | 1.16A | 2y7wB-1d6sA:undetectable | 2y7wB-1d6sA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3d | [NIFE] HYDROGENASELARGE SUBUNIT (Desulfovibriodesulfuricans) |
PF00374(NiFeSe_Hases) | 5 | THR B 515ILE B 38GLY B 514GLY B 281THR B 529 | None | 1.15A | 2y7wB-1e3dB:0.0 | 2y7wB-1e3dB:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyg | L-LACTATE/MALATEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 6GLY A 7GLY A 83THR A 122ILE A 102 | NoneNAP A 900 (-2.5A)NAP A 900 (-3.9A)NAP A 900 (-3.8A)NAP A 900 (-4.0A) | 1.41A | 2y7wB-1hygA:0.3 | 2y7wB-1hygA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kqj | A/G-SPECIFIC ADENINEGLYCOSYLASE (Escherichiacoli) |
PF00633(HHH)PF00730(HhH-GPD) | 5 | THR A 121ILE A 125GLY A 123PHE A 108GLY A 118 | None | 1.40A | 2y7wB-1kqjA:undetectable | 2y7wB-1kqjA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l2q | MONOMETHYLAMINEMETHYLTRANSFERASE (Methanosarcinabarkeri) |
PF05369(MtmB) | 5 | THR A 274GLY A 270GLY A 266HIS A 300ILE A 301 | None | 1.31A | 2y7wB-1l2qA:undetectable | 2y7wB-1l2qA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lvm | CATALYTIC DOMAIN OFTHE NUCLEARINCLUSION PROTEIN A(NIA) (Tobacco etchvirus) |
PF00863(Peptidase_C4) | 5 | ILE A 163PHE A 186THR A 17PRO A 154ILE A 42 | None | 1.14A | 2y7wB-1lvmA:undetectable | 2y7wB-1lvmA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mg5 | ALCOHOLDEHYDROGENASE (Drosophilamelanogaster) |
PF00106(adh_short) | 5 | ILE A 137GLY A 92GLY A 14THR A 22PRO A 182 | NAI A 850 (-4.1A)NAI A 850 (-4.6A)NoneNoneNAI A 850 (-3.8A) | 1.26A | 2y7wB-1mg5A:0.0 | 2y7wB-1mg5A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nnw | HYPOTHETICAL PROTEIN (Pyrococcusfuriosus) |
no annotation | 5 | PHE A 197GLY A 249HIS A 98PRO A 96ILE A 245 | None | 1.37A | 2y7wB-1nnwA:undetectable | 2y7wB-1nnwA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o12 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Thermotogamaritima) |
PF01979(Amidohydro_1) | 5 | THR A 151GLY A 116HIS A 51THR A 196HIS A 197 | NoneNoneNoneNone FE A 401 (-3.5A) | 1.18A | 2y7wB-1o12A:undetectable | 2y7wB-1o12A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1og0 | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Saccharomycescerevisiae) |
PF00793(DAHP_synth_1) | 5 | THR A 311ILE A 62GLY A 275GLY A 64PRO A 197 | None | 1.37A | 2y7wB-1og0A:undetectable | 2y7wB-1og0A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oi7 | SUCCINYL-COASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 5 | THR A 24ILE A 15GLY A 20PHE A 71ILE A 69 | None | 1.37A | 2y7wB-1oi7A:2.1 | 2y7wB-1oi7A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ovm | INDOLE-3-PYRUVATEDECARBOXYLASE (Enterobactercloacae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | THR A 433GLY A 434GLY A 411THR A 413ILE A 410 | NoneTPP A 600 (-3.2A)NoneNoneTPP A 600 (-4.0A) | 1.37A | 2y7wB-1ovmA:undetectable | 2y7wB-1ovmA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pfs | PF3 SINGLE-STRANDEDDNA BINDING PROTEIN (Pseudomonasvirus Pf3) |
no annotation | 5 | THR A 8GLY A 27GLY A 51HIS A 30PRO A 37 | None | 1.21A | 2y7wB-1pfsA:undetectable | 2y7wB-1pfsA:13.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pqu | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Haemophilusinfluenzae) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | THR A 72ILE A 7GLY A 8GLY A 75THR A 79 | NoneNoneNAP A1372 (-3.1A)NAP A1372 (-3.4A)None | 1.15A | 2y7wB-1pquA:undetectable | 2y7wB-1pquA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pss | PHOTOSYNTHETICREACTION CENTER (Rhodobactersphaeroides) |
PF00124(Photo_RC) | 5 | THR M 222ILE M 223GLY M 220HIS M 266ILE M 265 | U10 M 303 (-3.5A)NoneNone FE M 302 (-3.3A)U10 M 303 (-4.3A) | 1.08A | 2y7wB-1pssM:undetectable | 2y7wB-1pssM:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qr0 | 4'-PHOSPHOPANTETHEINYL TRANSFERASE SFP (Bacillussubtilis) |
PF01648(ACPS) | 5 | ILE A 3GLY A 97GLY A 105PRO A 212ILE A 104 | None | 0.98A | 2y7wB-1qr0A:undetectable | 2y7wB-1qr0A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wsv | AMINOMETHYLTRANSFERASE (Homo sapiens) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | THR A 92ILE A 98GLY A 97GLY A 276ILE A 280 | THR A 92 ( 0.8A)ILE A 98 ( 0.7A)GLY A 97 ( 0.0A)GLY A 276 ( 0.0A)ILE A 280 ( 0.7A) | 1.16A | 2y7wB-1wsvA:undetectable | 2y7wB-1wsvA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y56 | SARCOSINE OXIDASE (Pyrococcushorikoshii) |
PF01266(DAO) | 5 | THR B 187ILE B 192PHE B 175THR B 170ILE B 11 | None | 0.97A | 2y7wB-1y56B:undetectable | 2y7wB-1y56B:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z8l | GLUTAMATECARBOXYPEPTIDASE II (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | ILE A 292GLY A 224GLY A 168PRO A 290ILE A 346 | None | 1.37A | 2y7wB-1z8lA:undetectable | 2y7wB-1z8lA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bcc | UBIQUINOL CYTOCHROMEC OXIDOREDUCTASE (Gallus gallus) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | ILE A 255GLY A 321PHE A 320PRO A 420ILE A 415 | None | 1.40A | 2y7wB-2bccA:undetectable | 2y7wB-2bccA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7i | PUTATIVE LIPOATEPROTEIN LIGASE (Thermoplasmaacidophilum) |
PF03099(BPL_LplA_LipB) | 5 | GLY A 77HIS A 81THR A 74HIS A 161ILE A 46 | None | 1.26A | 2y7wB-2c7iA:undetectable | 2y7wB-2c7iA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpg | SUCCINYL-COA LIGASE[GDP-FORMING]ALPHA-CHAIN,MITOCHONDRIAL (Sus scrofa) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 5 | THR A 166GLY A 163GLY A 185HIS A 151PRO A 147 | NonePO4 A 401 (-3.4A)NoneNoneNone | 1.04A | 2y7wB-2fpgA:2.1 | 2y7wB-2fpgA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frv | PERIPLASMICHYDROGENASE (Desulfovibriogigas) |
no annotation | 5 | THR L 509ILE L 32GLY L 508GLY L 275THR L 523 | None | 1.01A | 2y7wB-2frvL:undetectable | 2y7wB-2frvL:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmh | ELECTRON TRANSFERFLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE (Sus scrofa) |
PF05187(ETF_QO)PF13450(NAD_binding_8) | 5 | ILE A 123GLY A 115PHE A 114GLY A 263THR A 118 | NoneNoneUQ5 A 612 (-4.1A)NoneNone | 1.18A | 2y7wB-2gmhA:0.9 | 2y7wB-2gmhA:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3e | G-RICH (Carassiusauratus) |
PF05881(CNPase) | 5 | THR A 167GLY A 168GLY A 113THR A 111ILE A 106 | None | 1.10A | 2y7wB-2i3eA:undetectable | 2y7wB-2i3eA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2np5 | TRANSCRIPTIONALREGULATOR (Rhodococcusjostii) |
PF00440(TetR_N)PF13977(TetR_C_6) | 5 | THR A 143ILE A 141GLY A 142GLY A 190PRO A 81 | None | 1.10A | 2y7wB-2np5A:undetectable | 2y7wB-2np5A:25.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph3 | 3-OXOACYL-[ACYLCARRIER PROTEIN]REDUCTASE (Thermusthermophilus) |
PF13561(adh_short_C2) | 5 | ILE A 175GLY A 174PHE A 131GLY A 229THR A 232 | None | 1.40A | 2y7wB-2ph3A:undetectable | 2y7wB-2ph3A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qck | FLAVIN REDUCTASEDOMAIN PROTEIN (Arthrobactersp. FB24) |
PF01613(Flavin_Reduct) | 5 | ILE A 109GLY A 103THR A 27HIS A 75ILE A 118 | None | 1.07A | 2y7wB-2qckA:undetectable | 2y7wB-2qckA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qio | ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 5 | ILE A 87GLY A 89GLY A 139THR A 137ILE A 183 | None | 1.37A | 2y7wB-2qioA:undetectable | 2y7wB-2qioA:21.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2uye | REGULATORY PROTEIN (Burkholderiacepacia) |
PF03466(LysR_substrate) | 6 | THR A 104GLY A 107GLY A 152HIS A 206PRO A 246ILE A 273 | SCN A1307 (-4.0A)SCN A1303 (-3.5A)SCN A1307 (-3.6A)SCN A1307 (-3.6A)NoneSCN A1303 (-4.1A) | 0.74A | 2y7wB-2uyeA:30.7 | 2y7wB-2uyeA:73.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2uye | REGULATORY PROTEIN (Burkholderiacepacia) |
PF03466(LysR_substrate) | 6 | THR A 104GLY A 107THR A 204HIS A 206PRO A 246ILE A 273 | SCN A1307 (-4.0A)SCN A1303 (-3.5A)SCN A1309 ( 4.7A)SCN A1307 (-3.6A)NoneSCN A1303 (-4.1A) | 0.90A | 2y7wB-2uyeA:30.7 | 2y7wB-2uyeA:73.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2uye | REGULATORY PROTEIN (Burkholderiacepacia) |
PF03466(LysR_substrate) | 6 | THR A 104ILE A 106GLY A 107GLY A 152PRO A 246ILE A 273 | SCN A1307 (-4.0A)SCN A1303 ( 4.9A)SCN A1303 (-3.5A)SCN A1307 (-3.6A)NoneSCN A1303 (-4.1A) | 0.33A | 2y7wB-2uyeA:30.7 | 2y7wB-2uyeA:73.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2uye | REGULATORY PROTEIN (Burkholderiacepacia) |
PF03466(LysR_substrate) | 6 | THR A 104ILE A 106GLY A 107THR A 204PRO A 246ILE A 273 | SCN A1307 (-4.0A)SCN A1303 ( 4.9A)SCN A1303 (-3.5A)SCN A1309 ( 4.7A)NoneSCN A1303 (-4.1A) | 0.56A | 2y7wB-2uyeA:30.7 | 2y7wB-2uyeA:73.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v84 | SPERMIDINE/PUTRESCINE ABC TRANSPORTER,PERIPLASMIC BINDINGPROTEIN (Treponemapallidum) |
PF13416(SBP_bac_8) | 5 | THR A 279ILE A 280PHE A 276GLY A 112PRO A 108 | None | 1.19A | 2y7wB-2v84A:8.6 | 2y7wB-2v84A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9i | RHAMNULOSE-1-PHOSPHATE ALDOLASE (Escherichiacoli) |
PF00596(Aldolase_II) | 5 | THR A 224GLY A 218GLY A 216HIS A 125ILE A 139 | None | 1.31A | 2y7wB-2v9iA:undetectable | 2y7wB-2v9iA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhl | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | THR A 176GLY A 137HIS A 65THR A 222HIS A 223 | NoneNone FE A1397 (-3.3A)None FE A1398 (-3.3A) | 1.19A | 2y7wB-2vhlA:undetectable | 2y7wB-2vhlA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vxy | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | THR A 160ILE A 162PHE A 100THR A 313ILE A 197 | None | 1.28A | 2y7wB-2vxyA:undetectable | 2y7wB-2vxyA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3g | TWO COMPONENT SENSORHISTIDINE KINASEDEVS (GAF FAMILYPROTEIN) (Mycobacteriumtuberculosis) |
PF13185(GAF_2) | 5 | ILE A 103PHE A 98GLY A 84HIS A 149PRO A 150 | HEM A 500 (-4.2A)HEM A 500 (-4.9A)HEM A 500 (-4.4A)HEM A 500 (-3.3A)None | 1.31A | 2y7wB-2w3gA:undetectable | 2y7wB-2w3gA:23.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y7r | LYSR-TYPE REGULATORYPROTEIN (Burkholderiasp. DNT) |
PF03466(LysR_substrate) | 7 | THR A 104GLY A 107PHE A 111GLY A 152HIS A 206PRO A 246ILE A 273 | None | 0.69A | 2y7wB-2y7rA:31.3 | 2y7wB-2y7rA:95.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y7r | LYSR-TYPE REGULATORYPROTEIN (Burkholderiasp. DNT) |
PF03466(LysR_substrate) | 7 | THR A 104GLY A 107PHE A 111THR A 204HIS A 206PRO A 246ILE A 273 | None | 0.88A | 2y7wB-2y7rA:31.3 | 2y7wB-2y7rA:95.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y7r | LYSR-TYPE REGULATORYPROTEIN (Burkholderiasp. DNT) |
PF03466(LysR_substrate) | 8 | THR A 104ILE A 106GLY A 107PHE A 111GLY A 152HIS A 169PRO A 246ILE A 273 | None | 0.53A | 2y7wB-2y7rA:31.3 | 2y7wB-2y7rA:95.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y7r | LYSR-TYPE REGULATORYPROTEIN (Burkholderiasp. DNT) |
PF03466(LysR_substrate) | 8 | THR A 104ILE A 106GLY A 107PHE A 111HIS A 169THR A 204PRO A 246ILE A 273 | None | 0.69A | 2y7wB-2y7rA:31.3 | 2y7wB-2y7rA:95.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrr | AMINOTRANSFERASE,CLASS V (Thermusthermophilus) |
PF00266(Aminotran_5) | 5 | THR A 320ILE A 317GLY A 318GLY A 83THR A 137 | None | 1.40A | 2y7wB-2yrrA:0.6 | 2y7wB-2yrrA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv2 | SUCCINYL-COASYNTHETASE ALPHACHAIN (Aeropyrumpernix) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 5 | ILE A 134GLY A 183THR A 164PRO A 136ILE A 182 | None | 1.38A | 2y7wB-2yv2A:1.8 | 2y7wB-2yv2A:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahi | XYLULOSE5-PHOSPHATE/FRUCTOSE6-PHOSPHATEPHOSPHOKETOLASE (Bifidobacteriumbreve) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 5 | THR A 298PHE A 247GLY A 250HIS A 260ILE A 259 | None | 1.21A | 2y7wB-3ahiA:0.3 | 2y7wB-3ahiA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 5 | THR A 298PHE A 247GLY A 250HIS A 260ILE A 259 | None | 1.23A | 2y7wB-3ai7A:undetectable | 2y7wB-3ai7A:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9f | 5'-NUCLEOTIDASE (Candidaalbicans) |
PF00149(Metallophos) | 5 | THR A 33GLY A 248GLY A 79HIS A 36PRO A 445 | NoneNoneNoneNoneFMT A 607 ( 4.6A) | 1.42A | 2y7wB-3c9fA:undetectable | 2y7wB-3c9fA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d4u | CARBOXYPEPTIDASE B2 (Bos taurus) |
PF00246(Peptidase_M14) | 5 | GLY A 253PHE A 147HIS A 69THR A 268ILE A 68 | NoneNone ZN A 309 ( 3.1A)NoneNone | 1.09A | 2y7wB-3d4uA:undetectable | 2y7wB-3d4uA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epm | THIAMINEBIOSYNTHESIS PROTEINTHIC (Caulobactervibrioides) |
PF01964(ThiC_Rad_SAM)PF13667(ThiC-associated) | 5 | THR A 470GLY A 466PHE A 468THR A 441ILE A 423 | None | 1.35A | 2y7wB-3epmA:undetectable | 2y7wB-3epmA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fai | BETA-LACTAMASE (Aeromonashydrophila) |
PF00753(Lactamase_B) | 5 | THR A 115ILE A 201GLY A 200GLY A 220ILE A 222 | NoneNone CL A 4 (-3.6A)None CL A 4 (-4.8A) | 1.39A | 2y7wB-3faiA:undetectable | 2y7wB-3faiA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gk3 | ACETOACETYL-COAREDUCTASE (Burkholderiapseudomallei) |
PF13561(adh_short_C2) | 5 | ILE A 177GLY A 176PHE A 133GLY A 232THR A 235 | None | 1.40A | 2y7wB-3gk3A:undetectable | 2y7wB-3gk3A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hig | AMILORIDE-SENSITIVEAMINE OXIDASE (Homo sapiens) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 5 | THR A 488ILE A 506GLY A 507GLY A 361THR A 363 | None | 1.34A | 2y7wB-3higA:undetectable | 2y7wB-3higA:15.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmj | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00109(ketoacyl-synt)PF01648(ACPS)PF02801(Ketoacyl-synt_C) | 5 | ILE A1573GLY A1537THR A1633PRO A1627ILE A1599 | None | 1.18A | 2y7wB-3hmjA:undetectable | 2y7wB-3hmjA:7.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvy | CYSTATHIONINEBETA-LYASE FAMILYPROTEIN, YNBBB.SUBTILIS ORTHOLOG (Clostridiumacetobutylicum) |
PF06838(Met_gamma_lyase) | 5 | THR A 101ILE A 104GLY A 105HIS A 180THR A 128 | LLP A 243 ( 3.3A)NoneNoneNoneLLP A 243 ( 4.8A) | 1.26A | 2y7wB-3hvyA:undetectable | 2y7wB-3hvyA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ohn | OUTER MEMBRANE USHERPROTEIN FIMD (Escherichiacoli) |
PF00577(Usher) | 5 | ILE A 259GLY A 258PHE A 285THR A 537ILE A 303 | None | 1.26A | 2y7wB-3ohnA:undetectable | 2y7wB-3ohnA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3osl | CARBOXYPEPTIDASE B2 (Bos taurus) |
PF00246(Peptidase_M14) | 5 | GLY A 368PHE A 259HIS A 181THR A 383ILE A 180 | NoneNone ZN A 999 (-3.1A)NoneNone | 1.09A | 2y7wB-3oslA:undetectable | 2y7wB-3oslA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgm | P-NITROPHENYLPHOSPHATASE (PHO2) (Archaeoglobusfulgidus) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 5 | THR A 163ILE A 167GLY A 164THR A 147PRO A 178 | None | 1.02A | 2y7wB-3qgmA:1.5 | 2y7wB-3qgmA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qtp | ENOLASE 1 (Entamoebahistolytica) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ILE A 351GLY A 352THR A 355PRO A 329ILE A 93 | None | 1.35A | 2y7wB-3qtpA:undetectable | 2y7wB-3qtpA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rj9 | ALCOHOLDEHYDROGENASE (Scaptodrosophilalebanonensis) |
PF00106(adh_short) | 5 | ILE A 17GLY A 18PHE A 10GLY A 91PRO A 181 | NAD A 850 (-4.0A)NoneNoneNAD A 850 (-4.7A)NAD A 850 (-3.9A) | 1.32A | 2y7wB-3rj9A:undetectable | 2y7wB-3rj9A:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v9e | LACCASE (Botrytis aclada) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | THR A 53GLY A 141PHE A 143GLY A 60PRO A 44 | None | 1.23A | 2y7wB-3v9eA:undetectable | 2y7wB-3v9eA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vbe | BETA-CYANOALNINESYNTHASE (Glycine max) |
PF00291(PALP) | 5 | THR A 210ILE A 214GLY A 211GLY A 237THR A 234 | NoneNoneNoneNonePLP A 500 (-3.7A) | 1.18A | 2y7wB-3vbeA:undetectable | 2y7wB-3vbeA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgk | CELL DIVISIONPROTEIN FTSZ (Staphylococcusaureus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | THR A 160ILE A 162PHE A 100THR A 311ILE A 197 | None | 1.23A | 2y7wB-3wgkA:undetectable | 2y7wB-3wgkA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 5 | THR A 495ILE A 499GLY A 496PHE A 543THR A 341 | None | 1.21A | 2y7wB-4a01A:undetectable | 2y7wB-4a01A:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4arx | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | THR A 361HIS A 319THR A 386PRO A 451ILE A 303 | None | 1.22A | 2y7wB-4arxA:undetectable | 2y7wB-4arxA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c60 | OCHRATOXINASE (Aspergillusniger) |
PF01979(Amidohydro_1) | 5 | THR A 408ILE A 404GLY A 106PRO A 440ILE A 434 | None | 1.32A | 2y7wB-4c60A:undetectable | 2y7wB-4c60A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgy | DNA TOPOISOMERASE3-ALPHA (Homo sapiens) |
PF01131(Topoisom_bac)PF01751(Toprim) | 5 | THR A 182GLY A 358THR A 420HIS A 418PRO A 415 | None | 1.35A | 2y7wB-4cgyA:undetectable | 2y7wB-4cgyA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hz8 | BETA-GLUCOSIDASE (unculturedbacterium) |
PF00232(Glyco_hydro_1) | 5 | ILE A 195GLY A 192GLY A 252HIS A 146PRO A 152 | None | 1.22A | 2y7wB-4hz8A:undetectable | 2y7wB-4hz8A:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3h | TOPOISOMERASE IVSUBUNIT B, DNATOPOISOMERASE 4SUBUNIT A CHIMERA (Streptococcuspneumoniae) |
PF00204(DNA_gyraseB)PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim)PF02518(HATPase_c) | 5 | ILE A1178GLY A1341HIS A1181PRO A1179ILE A1342 | None | 1.35A | 2y7wB-4i3hA:undetectable | 2y7wB-4i3hA:11.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhz | BETA-GLUCURONIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 5 | THR A 291GLY A 292PHE A 293GLY A 322ILE A 321 | None | 1.27A | 2y7wB-4jhzA:undetectable | 2y7wB-4jhzA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmp | ALANINEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 5 | ILE A 45GLY A 40THR A 310PRO A 20ILE A 5 | None | 1.32A | 2y7wB-4lmpA:undetectable | 2y7wB-4lmpA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhc | NUCLEOPORIN NUP157 (Saccharomycescerevisiae) |
PF08801(Nucleoporin_N) | 5 | ILE A 547GLY A 546PHE A 590GLY A 636HIS A 633 | None | 1.22A | 2y7wB-4mhcA:undetectable | 2y7wB-4mhcA:13.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8j | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | THR A 361HIS A 319THR A 386PRO A 451ILE A 303 | None | 1.25A | 2y7wB-4w8jA:undetectable | 2y7wB-4w8jA:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wky | BETA-KETOACYLSYNTHASE (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | THR A 50ILE A 78GLY A 77GLY A 48PRO A 80 | None | 1.36A | 2y7wB-4wkyA:undetectable | 2y7wB-4wkyA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xae | FERULOYL COAORTHO-HYDROXYLASE 1 (Arabidopsisthaliana) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | THR A 33ILE A 35GLY A 34GLY A 29PRO A 39 | None | 0.97A | 2y7wB-4xaeA:undetectable | 2y7wB-4xaeA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3o | DNA TOPOISOMERASE 4SUBUNITB,PARE30-PARC55FUSED TOPO IV FROMS. PNEUMONIAE (Streptococcuspneumoniae) |
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim) | 5 | ILE A1178GLY A1341HIS A1181PRO A1179ILE A1342 | None | 1.33A | 2y7wB-4z3oA:undetectable | 2y7wB-4z3oA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z64 | PHYTOSULFOKINERECEPTOR 1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | GLY A 161PHE A 184GLY A 139HIS A 166ILE A 140 | NoneNoneNoneNAG A 702 (-4.8A)None | 1.14A | 2y7wB-4z64A:undetectable | 2y7wB-4z64A:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a6s | ENDOLYSIN (Clostridiumphage phiCTP1) |
PF01183(Glyco_hydro_25) | 5 | GLY A 57PHE A 88GLY A 26THR A 49ILE A 55 | None | 1.42A | 2y7wB-5a6sA:undetectable | 2y7wB-5a6sA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cde | PROLINE DIPEPTIDASE (Xanthomonascampestris) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | THR A 220ILE A 337GLY A 253HIS A 376THR A 255 | None | 1.18A | 2y7wB-5cdeA:undetectable | 2y7wB-5cdeA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmh | UNCHARACTERIZEDPROTEIN CONSERVED INBACTERIA (Cupriavidusnecator) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | GLY A 414GLY A 371HIS A 155THR A 373PRO A 156 | ADP A 501 (-3.2A)ADP A 501 (-3.5A)ADP A 501 (-3.8A)ADP A 501 (-3.8A)ADP A 501 (-4.2A) | 1.37A | 2y7wB-5dmhA:1.7 | 2y7wB-5dmhA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmh | UNCHARACTERIZEDPROTEIN CONSERVED INBACTERIA (Cupriavidusnecator) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | THR A 277GLY A 414GLY A 271HIS A 155THR A 325 | NoneADP A 501 (-3.2A)ADP A 501 (-3.6A)ADP A 501 (-3.8A)None | 1.36A | 2y7wB-5dmhA:1.7 | 2y7wB-5dmhA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eb5 | HNL ISOENZYME 5 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | THR A 181ILE A 167GLY A 321GLY A 159ILE A 158 | None | 1.26A | 2y7wB-5eb5A:undetectable | 2y7wB-5eb5A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epo | 7-ALPHA-HYDROXYSTEROID DEYDROGENASE (Clostridiumsardiniense) |
PF13561(adh_short_C2) | 5 | THR A 193ILE A 191GLY A 192GLY A 17PRO A 188 | NAP A 301 (-2.9A)NAP A 301 (-3.9A)NoneNAP A 301 (-3.3A)NAP A 301 (-3.7A) | 1.36A | 2y7wB-5epoA:undetectable | 2y7wB-5epoA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f5n | MONOOXYGENASE (Micromonosporasp. TP-A0468) |
PF05368(NmrA) | 5 | ILE A 187GLY A 188GLY A 18THR A 16PRO A 148 | NoneNoneNoneNAD A 301 (-4.0A)NAD A 301 (-4.3A) | 1.12A | 2y7wB-5f5nA:undetectable | 2y7wB-5f5nA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjj | BETA-GLUCOSIDASE (Aspergillusoryzae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | THR A 401ILE A 583GLY A 397HIS A 550PRO A 463 | None | 1.17A | 2y7wB-5fjjA:undetectable | 2y7wB-5fjjA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITALPHA, PUTATIVE (Plasmodiumfalciparum) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | THR A 35GLY A 88GLY A 175PRO A 162ILE A 174 | None | 1.26A | 2y7wB-5fmgA:undetectable | 2y7wB-5fmgA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5t | FLAGELLARHOOK-ASSOCIATEDPROTEIN 2 (Salmonellaenterica) |
PF07195(FliD_C)PF07196(Flagellin_IN) | 5 | THR A 86ILE A 250GLY A 249GLY A 89THR A 73 | None | 1.37A | 2y7wB-5h5tA:undetectable | 2y7wB-5h5tA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvf | CARBOXYPEPTIDASE B2 (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 5 | GLY A 346PHE A 237HIS A 159THR A 361ILE A 158 | NoneNone ZN A 508 ( 3.2A)FLC A 509 ( 4.6A)None | 1.12A | 2y7wB-5hvfA:undetectable | 2y7wB-5hvfA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsm | FMN-DEPENDENTNITRONATEMONOOXYGENASE (Shewanellaoneidensis) |
PF03060(NMO) | 5 | THR A 265ILE A 279GLY A 278GLY A 180HIS A 253 | NoneNoneNoneFMN A 401 (-3.7A)None | 1.15A | 2y7wB-5lsmA:undetectable | 2y7wB-5lsmA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsm | FMN-DEPENDENTNITRONATEMONOOXYGENASE (Shewanellaoneidensis) |
PF03060(NMO) | 5 | THR A 265ILE A 279GLY A 278GLY A 325HIS A 253 | NoneNoneNoneFMN A 401 ( 4.1A)None | 1.25A | 2y7wB-5lsmA:undetectable | 2y7wB-5lsmA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mn5 | CELL DIVISIONPROTEIN FTSZ (Staphylococcusaureus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | THR A 160ILE A 162PHE A 100THR A 313ILE A 197 | None | 1.31A | 2y7wB-5mn5A:undetectable | 2y7wB-5mn5A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8u | LIPOATE-PROTEINLIGASE 1 (Plasmodiumfalciparum) |
PF03099(BPL_LplA_LipB)PF10437(Lip_prot_lig_C) | 5 | GLY A 107HIS A 111THR A 104HIS A 176ILE A 76 | LPA A 401 (-4.2A)LPA A 401 (-4.3A)NoneLPA A 401 (-3.6A)LPA A 401 ( 4.2A) | 1.26A | 2y7wB-5t8uA:undetectable | 2y7wB-5t8uA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ul4 | OXSB PROTEIN (Bacillusmegaterium) |
PF02310(B12-binding) | 5 | ILE A 298GLY A 296GLY A 349PRO A 134ILE A 354 | None | 1.33A | 2y7wB-5ul4A:1.2 | 2y7wB-5ul4A:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vqi | IMPORTIN SUBUNITALPHA (Neurosporacrassa) |
no annotation | 5 | THR B 328ILE B 331GLY B 323PRO B 295ILE B 286 | None | 1.40A | 2y7wB-5vqiB:undetectable | 2y7wB-5vqiB:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yo8 | TETRAPRENYL-BETA-CURCUMENE SYNTHASE (Bacillusalcalophilus) |
no annotation | 5 | GLY A 58PHE A 54GLY A 305HIS A 245ILE A 306 | None | 1.37A | 2y7wB-5yo8A:undetectable | 2y7wB-5yo8A:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ci9 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 5 | THR A 192ILE A 19GLY A 18GLY A 194PRO A 187 | NAP A 301 (-2.9A)NAP A 301 (-3.8A)NAP A 301 (-3.2A)NAP A 301 (-3.2A)NAP A 301 (-3.6A) | 1.39A | 2y7wB-6ci9A:undetectable | 2y7wB-6ci9A:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6etz | BETA-GALACTOSIDASE (Arthrobactersp. 32cB) |
no annotation | 5 | GLY A 569PHE A 572GLY A 554HIS A 959THR A 583 | None | 1.31A | 2y7wB-6etzA:undetectable | 2y7wB-6etzA:14.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fkh | ATP SYNTHASE EPSILONCHAIN, CHLOROPLASTIC (Spinaciaoleracea) |
no annotation | 5 | THR e 42ILE e 31THR e 40HIS e 37ILE e 74 | None | 1.28A | 2y7wB-6fkhe:undetectable | 2y7wB-6fkhe:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fv4 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Mycolicibacteriumsmegmatis) |
no annotation | 5 | THR A 162GLY A 123HIS A 58THR A 208HIS A 209 | NoneNone ZN A 401 ( 3.2A)None CD A 403 ( 3.7A) | 1.12A | 2y7wB-6fv4A:undetectable | 2y7wB-6fv4A:14.90 |