SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7W_A_SALA1300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 162
GLY A 158
TYR A 159
GLY A 186
PHE A 336
 None
None
FAD  A 448 (-4.8A)
None
None
 1.38A 2y7wA-1f8wA:
undetectable		 2y7wA-1f8wA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 ILE A 237
GLY A 236
TYR A 235
GLY A 201
PHE A 129
 None
None
None
EDO  A1713 ( 4.3A)
None
 1.41A 2y7wA-1gqjA:
0.1		 2y7wA-1gqjA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		5 ILE A 159
TYR A 163
GLY A 226
PHE A 184
ILE A 229
 None
 1.23A 2y7wA-1hxjA:
0.0		 2y7wA-1hxjA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		5 THR A 274
GLY A 270
GLY A 266
HIS A 300
ILE A 301
 None
 1.31A 2y7wA-1l2qA:
undetectable		 2y7wA-1l2qA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A1145
GLY A1066
GLY A1044
PHE A1357
ILE A1045
 None
 1.28A 2y7wA-1p0cA:
0.0		 2y7wA-1p0cA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		5 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.09A 2y7wA-1pssM:
undetectable		 2y7wA-1pssM:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		5 THR A  58
ILE A  69
GLY A  55
PHE A 428
ILE A  54
 None
 1.32A 2y7wA-1qhbA:
undetectable		 2y7wA-1qhbA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		5 THR A 156
GLY A 154
GLY A 244
ARG A 176
ILE A 243
 NAP  A 481 (-3.5A)
NAP  A 481 ( 3.9A)
NAP  A 481 (-3.4A)
NAP  A 481 (-3.6A)
NAP  A 481 (-3.8A)
 1.45A 2y7wA-1tdfA:
undetectable		 2y7wA-1tdfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 THR A  92
ILE A  98
GLY A  97
GLY A 276
ILE A 280
 THR  A  92 ( 0.8A)
ILE  A  98 ( 0.7A)
GLY  A  97 ( 0.0A)
GLY  A 276 ( 0.0A)
ILE  A 280 ( 0.7A)
 1.16A 2y7wA-1wsvA:
0.0		 2y7wA-1wsvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq1 GLUTATHIONE
S-TRANSFERASE

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ILE A 196
GLY A 195
TYR A 193
GLY A  26
PHE A  78
 None
 1.27A 2y7wA-1yq1A:
1.1		 2y7wA-1yq1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE

(Escherichia
coli) 		PF14437
(MafB19-deam) 		5 ILE A 110
GLY A 103
HIS A 139
ARG A 109
ILE A 106
 None
 1.32A 2y7wA-1z3aA:
undetectable		 2y7wA-1z3aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afg ACIDIC FIBROBLAST
GROWTH FACTOR

(Homo sapiens) 		PF00167
(FGF) 		5 THR A 123
ILE A 130
TYR A 125
ARG A  88
ILE A  98
 None
 1.47A 2y7wA-2afgA:
undetectable		 2y7wA-2afgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 5 THR A 257
ILE A 346
GLY A 173
PHE A 253
ILE A 174
 None
 1.39A 2y7wA-2e5aA:
undetectable		 2y7wA-2e5aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		5 ILE A  51
GLY A  68
TYR A  50
GLY A  43
ARG A  49
 None
UTP  A1227 (-3.2A)
None
UTP  A1227 (-3.6A)
None
 1.36A 2y7wA-2j4lA:
undetectable		 2y7wA-2j4lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		5 ILE A  51
GLY A  68
TYR A  50
GLY A  44
ARG A  49
 None
UTP  A1227 (-3.2A)
None
None
None
 1.20A 2y7wA-2j4lA:
undetectable		 2y7wA-2j4lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		5 THR A 228
GLY A 225
GLY A 219
PHE A  41
ILE A  38
 None
 1.25A 2y7wA-2nlyA:
undetectable		 2y7wA-2nlyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 THR A 316
ILE A 313
GLY A 271
PHE A 293
ILE A 272
 None
 1.28A 2y7wA-2qk4A:
2.0		 2y7wA-2qk4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 THR A 331
GLY A 313
GLY A 286
PHE A 353
ILE A 285
 None
None
None
EDO  A 478 (-4.7A)
None
 1.43A 2y7wA-2qneA:
undetectable		 2y7wA-2qneA:
15.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		6 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.1A)
 0.59A 2y7wA-2uyeA:
20.4		 2y7wA-2uyeA:
73.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 THR A 224
GLY A 218
GLY A 216
HIS A 125
ILE A 139
 None
 1.31A 2y7wA-2v9iA:
undetectable		 2y7wA-2v9iA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wse LHCA3

(Glycine max) 		PF00504
(Chloroa_b-bind) 		5 GLY 3  62
TYR 3  64
GLY 3  57
ARG 3 188
ILE 3  60
 None
CLA  31222 ( 2.6A)
None
CLA  31223 ( 4.0A)
None
 1.40A 2y7wA-2wse3:
undetectable		 2y7wA-2wse3:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN

(Burkholderia
sp. DNT) 		PF03466
(LysR_substrate) 		9 THR A 104
ILE A 106
GLY A 107
TYR A 110
GLY A 152
PHE A 167
HIS A 169
ARG A 248
ILE A 273
 None
 0.53A 2y7wA-2y7rA:
31.0		 2y7wA-2y7rA:
95.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a58 GTP-BINDING PROTEIN
RHO1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 THR B 159
ILE B 118
GLY B 160
TYR B 161
GLY B 157
 None
 1.20A 2y7wA-3a58B:
undetectable		 2y7wA-3a58B:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		5 ILE A 164
TYR A 168
GLY A 231
PHE A 189
ILE A 234
 None
 1.26A 2y7wA-3aivA:
undetectable		 2y7wA-3aivA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 THR A  94
ILE A  65
GLY A 126
ARG A 116
ILE A 119
 None
 1.34A 2y7wA-3be7A:
undetectable		 2y7wA-3be7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
 None
 0.86A 2y7wA-3d1jA:
undetectable		 2y7wA-3d1jA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evt PHOSPHOGLYCERATE
DEHYDROGENASE

(Lactobacillus
plantarum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 142
GLY A 144
TYR A 143
GLY A 227
PHE A 209
 None
 1.06A 2y7wA-3evtA:
1.2		 2y7wA-3evtA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila) 		PF00753
(Lactamase_B) 		5 THR A 115
ILE A 201
GLY A 200
GLY A 220
ILE A 222
 None
None
CL  A   4 (-3.6A)
None
CL  A   4 (-4.8A)
 1.39A 2y7wA-3faiA:
undetectable		 2y7wA-3faiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 THR A 341
ILE A 245
GLY A 338
GLY A 336
ARG A 244
 None
None
None
None
SEP  A 101 ( 4.1A)
 1.42A 2y7wA-3i3wA:
2.0		 2y7wA-3i3wA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		5 ILE A  44
GLY A  45
PHE A 222
HIS A 189
ILE A 220
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.0A)
None
None
None
 1.05A 2y7wA-3nixA:
undetectable		 2y7wA-3nixA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		5 THR A 353
GLY A 138
GLY A 357
ARG A  96
ILE A 116
 None
 1.45A 2y7wA-3oqbA:
2.6		 2y7wA-3oqbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE

(Thermoplasma
acidophilum) 		PF01494
(FAD_binding_3) 		5 ILE A 288
GLY A 295
GLY A 282
PHE A 335
HIS A 339
 FAD  A 501 ( 4.8A)
FAD  A 501 (-3.0A)
FAD  A 501 (-3.5A)
None
None
 1.34A 2y7wA-3oz2A:
undetectable		 2y7wA-3oz2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvd CAPSID

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 THR A 442
ILE A 388
GLY A 437
GLY A 440
ARG A 351
 None
 1.27A 2y7wA-3pvdA:
undetectable		 2y7wA-3pvdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A  53
ILE A  54
GLY A  24
PHE A  19
ILE A  21
 None
None
None
DAL  A2472 (-4.8A)
ALA  A2473 ( 4.8A)
 1.41A 2y7wA-3q4dA:
undetectable		 2y7wA-3q4dA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ILE A 453
GLY A 450
TYR A 454
GLY A 504
PHE A 489
 None
 1.23A 2y7wA-3q60A:
undetectable		 2y7wA-3q60A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 GLY A1050
TYR A1049
GLY A1047
HIS A 133
ILE A 239
 None
None
None
ZN  A1194 (-4.0A)
None
 1.39A 2y7wA-3s5kA:
undetectable		 2y7wA-3s5kA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 THR A1104
ILE A1101
TYR A1100
PHE A1149
ILE A1029
 None
 1.32A 2y7wA-3s5kA:
undetectable		 2y7wA-3s5kA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbd NETRIN-G2

(Homo sapiens) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		5 THR A  43
ILE A  42
GLY A  41
GLY A  45
ARG A  97
 None
 1.35A 2y7wA-3tbdA:
undetectable		 2y7wA-3tbdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
None
None
URE  A1902 (-4.3A)
None
 1.13A 2y7wA-3va7A:
2.0		 2y7wA-3va7A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 THR A1011
ILE A 909
GLY A 907
GLY A1007
PHE A 926
 None
 0.99A 2y7wA-3w9iA:
undetectable		 2y7wA-3w9iA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2

(Homo sapiens) 		PF00018
(SH3_1)
PF12796
(Ank_2) 		5 ILE B1086
GLY B1055
GLY B1115
PHE B1019
ARG B1111
 None
 1.07A 2y7wA-4a63B:
undetectable		 2y7wA-4a63B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Synechococcus
elongatus) 		PF13561
(adh_short_C2) 		5 ILE A 191
GLY A 214
TYR A 213
GLY A 244
ILE A 208
 None
 1.32A 2y7wA-4dmmA:
undetectable		 2y7wA-4dmmA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnq THIOREDOXIN
REDUCTASE

(Brucella
melitensis) 		PF07992
(Pyr_redox_2) 		5 THR A 157
GLY A 155
GLY A 247
ARG A 177
ILE A 246
 None
 1.41A 2y7wA-4jnqA:
undetectable		 2y7wA-4jnqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jro FABG PROTEIN

(Listeria
monocytogenes) 		PF13561
(adh_short_C2) 		5 ILE A 188
GLY A 214
TYR A 213
GLY A 243
ILE A 208
 None
 1.25A 2y7wA-4jroA:
undetectable		 2y7wA-4jroA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw6 PEROXIREDOXIN-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA) 		5 THR A 140
ILE A 139
PHE A 160
ARG A 137
ILE A 129
 None
 1.47A 2y7wA-4kw6A:
undetectable		 2y7wA-4kw6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 THR A 324
ILE A 119
GLY A 333
GLY A 326
PHE A 356
 SAL  A 602 ( 3.7A)
None
None
SAL  A 602 ( 3.6A)
None
 1.46A 2y7wA-4l39A:
undetectable		 2y7wA-4l39A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		5 THR A 625
ILE A 624
GLY A 631
PHE A 755
ILE A 634
 None
 1.27A 2y7wA-4n9nA:
undetectable		 2y7wA-4n9nA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE

(Cupriavidus
necator) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 THR A 159
GLY A 156
GLY A 138
PHE A 187
ILE A 154
 None
 1.35A 2y7wA-4pzcA:
2.0		 2y7wA-4pzcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
uniformis) 		PF10282
(Lactonase) 		5 THR A 137
ILE A 173
GLY A 136
TYR A 133
GLY A 115
 None
 1.43A 2y7wA-4qrjA:
undetectable		 2y7wA-4qrjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Chloroflexus
aurantiacus) 		PF13407
(Peripla_BP_4) 		5 ILE A 135
TYR A 137
GLY A  54
PHE A  72
ILE A  55
 None
 1.22A 2y7wA-4rxuA:
2.5		 2y7wA-4rxuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF13561
(adh_short_C2) 		5 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
 None
 1.19A 2y7wA-4rzhA:
undetectable		 2y7wA-4rzhA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 THR A 410
ILE A 414
GLY A 409
PHE A 380
ILE A 375
 None
 1.26A 2y7wA-4uadA:
undetectable		 2y7wA-4uadA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		5 THR A 140
ILE A 113
GLY A 144
PHE A  97
ILE A 101
 None
None
NA  A 401 (-3.9A)
None
None
 1.36A 2y7wA-4w5zA:
undetectable		 2y7wA-4w5zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 THR A 181
ILE A 167
GLY A 321
GLY A 159
ILE A 158
 None
 1.28A 2y7wA-5eb5A:
undetectable		 2y7wA-5eb5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
 1.14A 2y7wA-5i8iA:
2.8		 2y7wA-5i8iA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 THR A 885
GLY A 888
TYR A 893
GLY A 676
PHE A 724
 None
 1.29A 2y7wA-5ldnA:
undetectable		 2y7wA-5ldnA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE

(Shewanella
oneidensis) 		PF03060
(NMO) 		5 THR A 265
ILE A 279
GLY A 278
GLY A 180
HIS A 253
 None
None
None
FMN  A 401 (-3.7A)
None
 1.15A 2y7wA-5lsmA:
undetectable		 2y7wA-5lsmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE

(Shewanella
oneidensis) 		PF03060
(NMO) 		5 THR A 265
ILE A 279
GLY A 278
GLY A 325
HIS A 253
 None
None
None
FMN  A 401 ( 4.1A)
None
 1.26A 2y7wA-5lsmA:
undetectable		 2y7wA-5lsmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npa LOQUACIOUS

(Drosophila
melanogaster) 		PF00035
(dsrm) 		5 ILE A  41
GLY A  52
GLY A  54
ARG A  62
ILE A  59
 None
 1.18A 2y7wA-5npaA:
undetectable		 2y7wA-5npaA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npa LOQUACIOUS

(Drosophila
melanogaster) 		PF00035
(dsrm) 		5 THR A  40
ILE A  41
GLY A  52
GLY A  54
ARG A  62
 None
 1.35A 2y7wA-5npaA:
undetectable		 2y7wA-5npaA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT II

(Synechocystis
sp. PCC 6803) 		no annotation 5 THR 4  33
ILE 4  80
TYR 4  83
PHE 4 104
ARG 4  73
 None
 1.44A 2y7wA-5oy04:
undetectable		 2y7wA-5oy04:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 5 ILE D 844
GLY D 827
PHE D 813
HIS D 822
ARG D 834
 None
 1.20A 2y7wA-5t4yD:
undetectable		 2y7wA-5t4yD:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1w P2X PURINOCEPTOR

(Ailuropoda
melanoleuca) 		PF00864
(P2X_receptor) 		5 THR A 106
ILE A 315
GLY A 314
TYR A 291
ARG A 316
 None
 1.29A 2y7wA-5u1wA:
undetectable		 2y7wA-5u1wA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 THR A 280
ILE A 279
GLY A 330
GLY A 357
ARG A  75
 None
 1.50A 2y7wA-5uqcA:
undetectable		 2y7wA-5uqcA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 5 ILE C 233
GLY C 266
GLY C 247
ARG C 234
ILE C 246
 None
 1.18A 2y7wA-5w4tC:
undetectable		 2y7wA-5w4tC:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 5 THR A 199
ILE A  48
GLY A  32
GLY A  30
ARG A  92
 None
 1.20A 2y7wA-5wl7A:
undetectable		 2y7wA-5wl7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yve P2X PURINOCEPTOR 3

(Homo sapiens) 		no annotation 5 THR A  94
ILE A 303
GLY A 302
TYR A 278
ARG A 304
 None
 1.31A 2y7wA-5yveA:
undetectable		 2y7wA-5yveA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 5 THR A  92
ILE A 219
GLY A  89
TYR A  86
ARG A 218
 None
 1.14A 2y7wA-6cc4A:
undetectable		 2y7wA-6cc4A:
17.82