SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7P_A_SALA1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 MET A 503
SER A 461
PRO A 406
GLY A 405
 None
 1.45A 2y7pA-1gqjA:
0.0		 2y7pA-1gqjA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 SER A 107
ARG A 162
PRO A 493
GLY A 494
 None
 1.41A 2y7pA-1hbzA:
0.0		 2y7pA-1hbzA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 SER A 229
ARG A 245
PRO A 283
GLY A 284
 DAN  A 700 ( 4.3A)
DAN  A 700 (-2.8A)
None
None
 1.49A 2y7pA-1ms8A:
0.0		 2y7pA-1ms8A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 ARG A 602
PRO A 585
GLY A 584
TRP A 633
 None
 1.43A 2y7pA-1obhA:
0.0		 2y7pA-1obhA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II

(Paracoccus
denitrificans) 		PF00115
(COX1)
PF00116
(COX2)
PF02790
(COX2_TM) 		4 MET A 308
PRO A 350
GLY A 352
TRP B  81
 None
None
HEA  A 602 ( 3.7A)
None
 1.17A 2y7pA-1qleA:
undetectable		 2y7pA-1qleA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT

(Thermus
thermophilus) 		PF00676
(E1_dh) 		4 SER A 134
PRO A  86
GLY A  87
TRP A  90
 None
 1.11A 2y7pA-1umbA:
0.4		 2y7pA-1umbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 SER A 974
PRO A 946
GLY A 977
TRP A 959
 None
 1.25A 2y7pA-1ux6A:
0.0		 2y7pA-1ux6A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 SER C 393
ARG C 306
GLY C 381
TRP C 379
 None
 0.94A 2y7pA-1zrtC:
0.0		 2y7pA-1zrtC:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a39 ENDOGLUCANASE I

(Humicola
insolens) 		PF00840
(Glyco_hydro_7) 		4 MET A  75
SER A  35
PRO A 162
GLY A 163
 PCA  A   1 ( 4.0A)
None
None
None
 1.42A 2y7pA-2a39A:
0.0		 2y7pA-2a39A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 349
PRO A 359
GLY A 355
TRP A 353
 None
 1.20A 2y7pA-2bucA:
undetectable		 2y7pA-2bucA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A

(Starkeya
novella) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 SER A 320
ARG A 322
PRO A 314
GLY A 315
 None
 1.42A 2y7pA-2ca4A:
undetectable		 2y7pA-2ca4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 SER A 547
ARG A 598
PRO A 556
GLY A 555
 None
 1.40A 2y7pA-2cvtA:
undetectable		 2y7pA-2cvtA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 MET A 465
SER A 215
ARG A 346
TRP A 481
 None
 1.49A 2y7pA-2dpgA:
1.7		 2y7pA-2dpgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 SER A 273
ARG A 276
PRO A 238
GLY A 210
 None
 1.37A 2y7pA-2dpyA:
undetectable		 2y7pA-2dpyA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8o SAM DOMAIN AND HD
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF07647
(SAM_2) 		4 SER A  37
ARG A  41
PRO A  19
GLY A  20
 None
 1.31A 2y7pA-2e8oA:
undetectable		 2y7pA-2e8oA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 349
PRO A 359
GLY A 355
TRP A 353
 None
 1.15A 2y7pA-2g5tA:
undetectable		 2y7pA-2g5tA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE

(Agrobacterium
tumefaciens) 		PF01261
(AP_endonuc_2) 		4 SER A 213
ARG A 216
GLY A 221
TRP A 225
 SER  A 213 ( 0.0A)
ARG  A 216 ( 0.6A)
GLY  A 221 ( 0.0A)
TRP  A 225 ( 0.5A)
 1.47A 2y7pA-2hk0A:
undetectable		 2y7pA-2hk0A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 MET A 289
SER A 489
ARG A 469
GLY A 309
 None
 1.40A 2y7pA-2iu3A:
undetectable		 2y7pA-2iu3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlp EXTRACELLULAR
SUPEROXIDE DISMUTASE
(CU-ZN)

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 ARG A 202
PRO A 197
GLY A 198
TRP A 200
 None
 1.48A 2y7pA-2jlpA:
undetectable		 2y7pA-2jlpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n24 O2_CONTRYPHAN_VC1

(Conus victoriae) 		no annotation 4 SER A  21
ARG A  22
PRO A   5
GLY A   6
 None
 1.31A 2y7pA-2n24A:
undetectable		 2y7pA-2n24A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 SER B 682
PRO B 623
GLY B 624
TRP B 628
 None
 1.47A 2y7pA-2o8eB:
undetectable		 2y7pA-2o8eB:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 347
PRO A 357
GLY A 353
TRP A 351
 None
 1.21A 2y7pA-2oaeA:
undetectable		 2y7pA-2oaeA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		4 MET A  89
SER A  31
PRO A  83
GLY A  82
 None
 1.37A 2y7pA-2ps3A:
undetectable		 2y7pA-2ps3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 MET A 413
SER A 440
PRO A 347
GLY A 407
 None
 1.41A 2y7pA-2r9zA:
undetectable		 2y7pA-2r9zA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 SER A 994
PRO A 966
GLY A 997
TRP A 979
 None
 1.23A 2y7pA-2rhpA:
undetectable		 2y7pA-2rhpA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvk YJHT

(Escherichia
coli) 		PF01344
(Kelch_1) 		4 SER A 266
ARG A 215
PRO A 212
GLY A 213
 None
 1.35A 2y7pA-2uvkA:
undetectable		 2y7pA-2uvkA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		5 SER A  95
ARG A  97
PRO A 285
GLY A 286
TRP A 289
 None
 0.38A 2y7pA-2uyeA:
20.9		 2y7pA-2uyeA:
70.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1

(Mycobacterium
tuberculosis) 		PF02391
(MoaE) 		4 SER A 106
ARG A  84
PRO A  32
GLY A  31
 None
 1.34A 2y7pA-2wp4A:
undetectable		 2y7pA-2wp4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		4 ARG A 285
PRO A 283
GLY A 281
TRP A 280
 None
 1.44A 2y7pA-2xfsA:
undetectable		 2y7pA-2xfsA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN

(Salmonella
enterica) 		PF01297
(ZnuA) 		4 MET A  89
SER A  31
PRO A  83
GLY A  82
 None
 1.35A 2y7pA-2xy4A:
undetectable		 2y7pA-2xy4A:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN

(Burkholderia
sp. DNT) 		PF03466
(LysR_substrate) 		5 SER A  95
ARG A  97
PRO A 285
GLY A 286
TRP A 289
 None
 0.34A 2y7pA-2y7rA:
21.9		 2y7pA-2y7rA:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		4 SER A  59
PRO A  86
GLY A  67
TRP A  64
 None
 1.11A 2y7pA-2zbaA:
undetectable		 2y7pA-2zbaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 SER A 658
PRO A 524
GLY A 632
TRP A 631
 None
WCC  A 811 (-4.8A)
None
None
 1.39A 2y7pA-3cf4A:
3.6		 2y7pA-3cf4A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
PHOSPHOTRANSFERASE
SUBUNIT DHAM

(Lactococcus
lactis) 		PF03610
(EIIA-man) 		4 SER C  45
ARG C  48
PRO C  12
GLY C  35
 None
 1.34A 2y7pA-3cr3C:
undetectable		 2y7pA-3cr3C:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 189
PRO A 148
GLY A 149
TRP A 142
 None
None
None
GOL  A 700 ( 4.9A)
 1.32A 2y7pA-3fcjA:
undetectable		 2y7pA-3fcjA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isl PURINE CATABOLISM
PROTEIN PUCG

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		4 MET A  17
SER A 372
PRO A  19
GLY A  20
 None
 1.49A 2y7pA-3islA:
undetectable		 2y7pA-3islA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j40 GP7

(Salmonella
virus Epsilon15) 		no annotation 4 SER A 229
ARG A 231
GLY A 181
TRP A 180
 None
 0.79A 2y7pA-3j40A:
undetectable		 2y7pA-3j40A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu CHLOROPHYLL A-B
BINDING PROTEIN 26
KD (CP26)

(Spinacia
oleracea) 		PF00504
(Chloroa_b-bind) 		4 ARG S 194
PRO S  54
GLY S  55
TRP S  26
 CLA  S 602 (-3.1A)
None
None
CLA  S 611 ( 3.9A)
 0.74A 2y7pA-3jcuS:
undetectable		 2y7pA-3jcuS:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00504
(Chloroa_b-bind) 		4 ARG G 185
PRO G  41
GLY G  42
TRP G  16
 CLA  G 602 (-3.2A)
None
CLA  G 602 (-4.4A)
CLA  G 611 ( 3.7A)
 0.82A 2y7pA-3jcuG:
undetectable		 2y7pA-3jcuG:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE

(Mus musculus) 		PF00266
(Aminotran_5) 		4 MET A 132
PRO A 375
GLY A 374
TRP A 130
 None
None
None
PLP  A 500 (-3.4A)
 1.16A 2y7pA-3kgwA:
undetectable		 2y7pA-3kgwA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		4 SER A 403
ARG A 360
PRO A  58
GLY A  57
 None
None
FAD  A 500 (-3.7A)
None
 1.46A 2y7pA-3lovA:
undetectable		 2y7pA-3lovA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		4 SER A  57
ARG A  35
PRO A 135
GLY A 136
 None
 1.19A 2y7pA-3mhpA:
undetectable		 2y7pA-3mhpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt2 INTERLEUKIN-5
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 SER A 108
ARG A 205
PRO A 102
GLY A 103
 None
 1.46A 2y7pA-3qt2A:
undetectable		 2y7pA-3qt2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		4 SER A 130
ARG A 132
PRO A  80
GLY A  81
 None
HM3  A 255 ( 4.2A)
None
None
 1.41A 2y7pA-3rhyA:
undetectable		 2y7pA-3rhyA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1b TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio cholerae) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 MET A 236
PRO A 193
GLY A 191
TRP A 197
 None
 1.25A 2y7pA-3t1bA:
9.4		 2y7pA-3t1bA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 SER A 157
ARG A 156
PRO A 106
GLY A 107
 None
 1.09A 2y7pA-3t57A:
undetectable		 2y7pA-3t57A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 MET A 335
SER A 373
PRO A 363
GLY A 365
 None
 1.41A 2y7pA-3ufbA:
undetectable		 2y7pA-3ufbA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A  85
PRO A 381
GLY A 104
TRP A 527
 None
 1.26A 2y7pA-3v9eA:
undetectable		 2y7pA-3v9eA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 MET A 128
SER A 316
GLY A 102
TRP A 290
 None
 1.24A 2y7pA-3wiqA:
undetectable		 2y7pA-3wiqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4d TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
11B

(Mus musculus) 		PF00020
(TNFR_c6) 		4 SER R  48
ARG R  78
PRO R  25
GLY R  26
 None
 1.19A 2y7pA-4e4dR:
undetectable		 2y7pA-4e4dR:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 MET A 269
SER A 299
PRO A 288
GLY A 293
 None
 1.49A 2y7pA-4g2rA:
undetectable		 2y7pA-4g2rA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grw NANOBODY 22E11

(Lama glama) 		PF07686
(V-set) 		4 SER H  54
ARG H  52
PRO H  58
GLY H  56
 None
 1.39A 2y7pA-4grwH:
undetectable		 2y7pA-4grwH:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		4 SER A  40
ARG A  37
PRO A  33
GLY A  34
 None
None
CL  A 205 (-3.3A)
None
 1.06A 2y7pA-4hc6A:
undetectable		 2y7pA-4hc6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 SER A 779
ARG A 788
PRO A 824
GLY A 822
 None
 1.32A 2y7pA-4iglA:
undetectable		 2y7pA-4iglA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 SER A  81
ARG A  92
PRO A  89
GLY A  90
 None
 1.03A 2y7pA-4j3qA:
undetectable		 2y7pA-4j3qA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE

(Cupriavidus
metallidurans) 		PF00378
(ECH_1) 		4 SER A 125
ARG A 127
PRO A  56
GLY A  57
 None
 1.05A 2y7pA-4jcsA:
undetectable		 2y7pA-4jcsA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lf3 GLUCAGON RECEPTOR

(Homo sapiens) 		PF02793
(HRM) 		4 SER C  66
ARG C 116
PRO C 114
TRP C 106
 None
 1.30A 2y7pA-4lf3C:
undetectable		 2y7pA-4lf3C:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 MET A  42
ARG A  44
PRO A  54
TRP A  52
 None
None
EDO  A 812 ( 4.6A)
None
 1.46A 2y7pA-4lgnA:
undetectable		 2y7pA-4lgnA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncc FAB FRAGMENT LIGHT

(Mus musculus) 		no annotation 4 SER L  75
ARG L  76
PRO L  15
GLY L  16
 None
 1.41A 2y7pA-4nccL:
undetectable		 2y7pA-4nccL:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0r CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Homo sapiens) 		PF02732
(ERCC4) 		4 SER B 542
ARG B 544
PRO B 547
GLY B 546
 None
 1.48A 2y7pA-4p0rB:
undetectable		 2y7pA-4p0rB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 SER A 235
ARG A 233
PRO A 232
GLY A 257
 None
 1.37A 2y7pA-4pbxA:
undetectable		 2y7pA-4pbxA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		4 SER A 200
PRO A  44
GLY A  43
TRP A  42
 None
 1.43A 2y7pA-4petA:
4.0		 2y7pA-4petA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		4 SER A 474
PRO A 128
GLY A 125
TRP A 123
 None
 1.47A 2y7pA-4pxbA:
undetectable		 2y7pA-4pxbA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		4 MET A 199
SER A 233
ARG A 230
GLY A 177
 None
None
SAH  A 501 (-2.9A)
SAH  A 501 ( 3.9A)
 1.28A 2y7pA-4r33A:
undetectable		 2y7pA-4r33A:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN

(Sphingobium
chlorophenolicum) 		PF03466
(LysR_substrate) 		5 SER A  95
ARG A  97
PRO A 287
GLY A 288
TRP A 291
 None
 0.63A 2y7pA-4rnsA:
18.2		 2y7pA-4rnsA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 SER A 238
ARG A 240
PRO A 215
GLY A 214
 None
 1.30A 2y7pA-4rsmA:
2.9		 2y7pA-4rsmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyu PROTEIN SCRIBBLE
HOMOLOG

(Homo sapiens) 		PF00595
(PDZ) 		4 SER A  60
ARG A  59
PRO A  53
GLY A  55
 None
 1.42A 2y7pA-4wyuA:
undetectable		 2y7pA-4wyuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yuf CORB

(Corallococcus
coralloides) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A  27
PRO A  38
GLY A  39
TRP A  40
 None
 1.33A 2y7pA-4yufA:
undetectable		 2y7pA-4yufA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 SER A 187
PRO A 162
GLY A 166
TRP A 174
 None
 1.42A 2y7pA-4zr5A:
undetectable		 2y7pA-4zr5A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		4 MET A 426
SER A 414
ARG A 411
GLY A 407
 None
 1.49A 2y7pA-5bs5A:
undetectable		 2y7pA-5bs5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 SER A 226
ARG A 215
PRO A 194
GLY A 193
 None
 1.34A 2y7pA-5c92A:
undetectable		 2y7pA-5c92A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff8 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		4 SER A 273
ARG A 275
PRO A 198
GLY A 199
 None
 1.29A 2y7pA-5ff8A:
undetectable		 2y7pA-5ff8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft1 GP37

(Pseudomonas
virus phiKZ) 		no annotation 4 SER A  76
ARG A  77
PRO A 132
GLY A 133
 None
 0.79A 2y7pA-5ft1A:
undetectable		 2y7pA-5ft1A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4g VCP-LIKE ATPASE

(Thermoplasma
acidophilum) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 MET A  73
SER A  22
ARG A 127
GLY A  20
 None
 1.39A 2y7pA-5g4gA:
undetectable		 2y7pA-5g4gA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq9 10E8V4 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER A  56
PRO A  52
GLY A  52
TRP A  33
 None
 1.45A 2y7pA-5iq9A:
undetectable		 2y7pA-5iq9A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 SER A 129
ARG A 126
PRO A 122
GLY A 123
 None
 1.24A 2y7pA-5iuwA:
0.9		 2y7pA-5iuwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 SER A 386
ARG A 412
PRO A 139
GLY A 140
 None
 1.29A 2y7pA-5li8A:
undetectable		 2y7pA-5li8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 SER B 331
PRO B 275
GLY B 276
TRP B 279
 None
 1.32A 2y7pA-5ltmB:
undetectable		 2y7pA-5ltmB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		4 ARG B 379
PRO B 581
GLY B 580
TRP B 595
 None
 1.48A 2y7pA-5m5xB:
undetectable		 2y7pA-5m5xB:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		4 SER A2567
ARG A2574
PRO A2618
GLY A2617
 None
 1.12A 2y7pA-5mc9A:
undetectable		 2y7pA-5mc9A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzv NANOBODY 22E11

(Lama glama) 		no annotation 4 SER D  54
ARG D  52
PRO D  58
GLY D  56
 None
 1.42A 2y7pA-5mzvD:
undetectable		 2y7pA-5mzvD:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 4 MET E 216
PRO E 190
GLY E 191
TRP E 192
 None
 1.25A 2y7pA-5n6yE:
undetectable		 2y7pA-5n6yE:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 4 SER A  81
ARG A  92
PRO A  89
GLY A  90
 None
 0.94A 2y7pA-5or4A:
undetectable		 2y7pA-5or4A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		4 MET A 207
ARG A 157
PRO A 229
GLY A 231
 None
 1.45A 2y7pA-5u8zA:
undetectable		 2y7pA-5u8zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uix DH576 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET H  78
SER H  21
ARG H  19
TRP H  36
 None
 1.42A 2y7pA-5uixH:
undetectable		 2y7pA-5uixH:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 MET A 176
SER A 214
ARG A 211
GLY A 204
 None
 1.46A 2y7pA-5utiA:
undetectable		 2y7pA-5utiA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 4 SER A  42
ARG A 270
PRO A 161
GLY A 162
 None
 1.05A 2y7pA-5wgcA:
undetectable		 2y7pA-5wgcA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaj FABHM14C10 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET A  78
SER A  21
ARG A  19
TRP A  36
 None
 1.34A 2y7pA-5xajA:
undetectable		 2y7pA-5xajA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB5, CP26

(Pisum sativum) 		no annotation 4 ARG S 194
PRO S  54
GLY S  55
TRP S  26
 CLA  S 602 (-4.2A)
None
CLA  S 602 (-4.7A)
CLA  S 611 ( 4.1A)
 0.84A 2y7pA-5xnlS:
undetectable		 2y7pA-5xnlS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 4 SER A 758
ARG A 787
PRO A 785
GLY A 783
 None
 1.37A 2y7pA-5y3jA:
undetectable		 2y7pA-5y3jA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Zea mays) 		no annotation 4 ARG Y 181
PRO Y  37
GLY Y  38
TRP Y  12
 CLA  Y 602 (-3.3A)
None
CLA  Y 602 (-4.5A)
CLA  Y 611 ( 4.6A)
 0.81A 2y7pA-5zjiY:
undetectable		 2y7pA-5zjiY:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE

(Helicobacter
pylori) 		no annotation 4 MET A  83
SER A 128
PRO A  47
GLY A  78
 None
 1.45A 2y7pA-6byqA:
undetectable		 2y7pA-6byqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY

(Thermobifida
fusca) 		no annotation 4 SER G 536
PRO G 520
GLY G 521
TRP G 522
 None
 0.98A 2y7pA-6c66G:
undetectable		 2y7pA-6c66G:
17.37