SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7P_A_SALA1000_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fnz | BARK AGGLUTININ I,POLYPEPTIDE A (Robiniapseudoacacia) |
PF00139(Lectin_legB) | 5 | THR A 213GLY A 48GLY A 108PHE A 92ILE A 109 | None | 1.43A | 2y7pA-1fnzA:undetectable | 2y7pA-1fnzA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0p | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE5 (Caenorhabditiselegans) |
PF00160(Pro_isomerase) | 5 | GLY A 71TYR A 72GLY A 74PHE A 32ILE A 183 | None | 1.50A | 2y7pA-1h0pA:undetectable | 2y7pA-1h0pA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jof | CARBOXY-CIS,CIS-MUCONATE CYCLASE (Neurosporacrassa) |
PF10282(Lactonase) | 5 | THR A 9GLY A 8GLY A 14PHE A 65ILE A 36 | None | 1.33A | 2y7pA-1jofA:undetectable | 2y7pA-1jofA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsc | ACETOHYDROXY-ACIDSYNTHASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | THR A 162ILE A 118GLY A 115TYR A 122PHE A 133 | 2HP A 698 ( 4.1A)None2HP A 698 (-3.6A)NoneNone | 1.47A | 2y7pA-1jscA:0.8 | 2y7pA-1jscA:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l2q | MONOMETHYLAMINEMETHYLTRANSFERASE (Methanosarcinabarkeri) |
PF05369(MtmB) | 5 | THR A 274GLY A 270GLY A 266HIS A 300ILE A 301 | None | 1.29A | 2y7pA-1l2qA:undetectable | 2y7pA-1l2qA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m9u | EARTHWORMFIBRINOLYTIC ENZYME (Eisenia fetida) |
PF00089(Trypsin) | 5 | THR A 188ILE A 160GLY A 189GLY A 186PRO A 161 | None | 1.36A | 2y7pA-1m9uA:undetectable | 2y7pA-1m9uA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p0c | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Pelophylaxperezi) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | THR A1145GLY A1066GLY A1044PHE A1357ILE A1045 | None | 1.26A | 2y7pA-1p0cA:0.0 | 2y7pA-1p0cA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pss | PHOTOSYNTHETICREACTION CENTER (Rhodobactersphaeroides) |
PF00124(Photo_RC) | 5 | THR M 222ILE M 223GLY M 220HIS M 266ILE M 265 | U10 M 303 (-3.5A)NoneNone FE M 302 (-3.3A)U10 M 303 (-4.3A) | 1.33A | 2y7pA-1pssM:undetectable | 2y7pA-1pssM:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qox | BETA-GLUCOSIDASE (Bacilluscirculans) |
PF00232(Glyco_hydro_1) | 5 | ILE A 291GLY A 292TYR A 352GLY A 218PRO A 349 | None | 1.39A | 2y7pA-1qoxA:0.0 | 2y7pA-1qoxA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uwi | BETA-GALACTOSIDASE (Sulfolobussolfataricus) |
PF00232(Glyco_hydro_1) | 5 | THR A 386ILE A 261TYR A 262PHE A 290ILE A 317 | None | 1.15A | 2y7pA-1uwiA:undetectable | 2y7pA-1uwiA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5w | MEIOTICRECOMBINATIONPROTEIN DMC1/LIM15HOMOLOG (Homo sapiens) |
PF08423(Rad51) | 5 | ILE A 335GLY A 336GLY A 333PHE A 177ILE A 173 | None | 1.39A | 2y7pA-1v5wA:undetectable | 2y7pA-1v5wA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v71 | HYPOTHETICAL PROTEINC320.14 INCHROMOSOME III (Schizosaccharomycespombe) |
PF00291(PALP) | 5 | THR A 147ILE A 148HIS A 85PRO A 150ILE A 89 | None | 1.30A | 2y7pA-1v71A:undetectable | 2y7pA-1v71A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v71 | HYPOTHETICAL PROTEINC320.14 INCHROMOSOME III (Schizosaccharomycespombe) |
PF00291(PALP) | 5 | THR A 239GLY A 183GLY A 236PHE A 56PRO A 151 | NonePLP A 350 (-3.3A)PLP A 350 (-4.7A)PLP A 350 (-4.7A)None | 1.02A | 2y7pA-1v71A:undetectable | 2y7pA-1v71A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve5 | THREONINE DEAMINASE (Thermusthermophilus) |
PF00291(PALP) | 5 | THR A 235GLY A 178GLY A 232PHE A 50PRO A 142 | NonePLP A 413 (-3.3A)PLP A 413 ( 4.7A)PLP A 413 (-4.6A)None | 0.97A | 2y7pA-1ve5A:undetectable | 2y7pA-1ve5A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wsv | AMINOMETHYLTRANSFERASE (Homo sapiens) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | THR A 92ILE A 98GLY A 97GLY A 276ILE A 280 | THR A 92 ( 0.8A)ILE A 98 ( 0.7A)GLY A 97 ( 0.0A)GLY A 276 ( 0.0A)ILE A 280 ( 0.7A) | 1.25A | 2y7pA-1wsvA:undetectable | 2y7pA-1wsvA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yxm | PEROXISOMAL TRANS2-ENOYL COAREDUCTASE (Homo sapiens) |
PF13561(adh_short_C2) | 5 | THR A 28ILE A 30GLY A 31GLY A 108PRO A 201 | None | 0.98A | 2y7pA-1yxmA:undetectable | 2y7pA-1yxmA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zh8 | OXIDOREDUCTASE (Thermotogamaritima) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ILE A 11GLY A 10PHE A 283HIS A 22ILE A 98 | None | 1.43A | 2y7pA-1zh8A:undetectable | 2y7pA-1zh8A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3x | IRON-RESPONSIVEELEMENT BINDINGPROTEIN 1 (Homo sapiens) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | ILE A 211GLY A 218GLY A 203HIS A 178ILE A 84 | NoneNoneNoneSF4 A1000 (-4.5A)None | 1.34A | 2y7pA-2b3xA:undetectable | 2y7pA-2b3xA:13.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gv9 | DNA POLYMERASE (Humanalphaherpesvirus1) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | THR A 463GLY A 464TYR A 465GLY A 586PRO A 594 | None | 1.30A | 2y7pA-2gv9A:undetectable | 2y7pA-2gv9A:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2np5 | TRANSCRIPTIONALREGULATOR (Rhodococcusjostii) |
PF00440(TetR_N)PF13977(TetR_C_6) | 5 | THR A 143ILE A 141GLY A 142GLY A 190PRO A 81 | None | 1.23A | 2y7pA-2np5A:undetectable | 2y7pA-2np5A:25.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2psf | RENILLA-LUCIFERIN2-MONOOXYGENASE (Renillareniformis) |
PF00561(Abhydrolase_1) | 5 | GLY A 82GLY A 85HIS A 97PRO A 215ILE A 79 | None | 1.27A | 2y7pA-2psfA:undetectable | 2y7pA-2psfA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qk4 | TRIFUNCTIONAL PURINEBIOSYNTHETIC PROTEINADENOSINE-3 (Homo sapiens) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | THR A 316ILE A 313GLY A 271PHE A 293ILE A 272 | None | 1.28A | 2y7pA-2qk4A:undetectable | 2y7pA-2qk4A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqm | NEUROPILIN-1 (Homo sapiens) |
PF00431(CUB)PF00754(F5_F8_type_C) | 5 | GLY A 436GLY A 241PHE A 217PRO A 222ILE A 242 | NoneNoneNAG A 613 ( 4.7A)NoneNone | 1.37A | 2y7pA-2qqmA:undetectable | 2y7pA-2qqmA:18.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2uye | REGULATORY PROTEIN (Burkholderiacepacia) |
PF03466(LysR_substrate) | 5 | GLY A 152PHE A 167HIS A 169PRO A 246ILE A 273 | SCN A1307 (-3.6A)SCN A1303 (-4.7A)SCN A1303 (-4.4A)NoneSCN A1303 (-4.1A) | 1.31A | 2y7pA-2uyeA:30.1 | 2y7pA-2uyeA:70.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2uye | REGULATORY PROTEIN (Burkholderiacepacia) |
PF03466(LysR_substrate) | 7 | THR A 104GLY A 107GLY A 152PHE A 167HIS A 206PRO A 246ILE A 273 | SCN A1307 (-4.0A)SCN A1303 (-3.5A)SCN A1307 (-3.6A)SCN A1303 (-4.7A)SCN A1307 (-3.6A)NoneSCN A1303 (-4.1A) | 0.94A | 2y7pA-2uyeA:30.1 | 2y7pA-2uyeA:70.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2uye | REGULATORY PROTEIN (Burkholderiacepacia) |
PF03466(LysR_substrate) | 7 | THR A 104ILE A 106GLY A 107GLY A 152PHE A 167PRO A 246ILE A 273 | SCN A1307 (-4.0A)SCN A1303 ( 4.9A)SCN A1303 (-3.5A)SCN A1307 (-3.6A)SCN A1303 (-4.7A)NoneSCN A1303 (-4.1A) | 0.92A | 2y7pA-2uyeA:30.1 | 2y7pA-2uyeA:70.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9i | RHAMNULOSE-1-PHOSPHATE ALDOLASE (Escherichiacoli) |
PF00596(Aldolase_II) | 5 | THR A 224GLY A 218GLY A 216HIS A 125ILE A 139 | None | 1.48A | 2y7pA-2v9iA:undetectable | 2y7pA-2v9iA:23.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y7r | LYSR-TYPE REGULATORYPROTEIN (Burkholderiasp. DNT) |
PF03466(LysR_substrate) | 9 | THR A 104GLY A 107TYR A 110GLY A 152PHE A 167HIS A 169HIS A 206PRO A 246ILE A 273 | None | 0.96A | 2y7pA-2y7rA:30.2 | 2y7pA-2y7rA:99.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y7r | LYSR-TYPE REGULATORYPROTEIN (Burkholderiasp. DNT) |
PF03466(LysR_substrate) | 8 | THR A 104ILE A 106GLY A 107TYR A 110GLY A 152PHE A 167PRO A 246ILE A 273 | None | 0.82A | 2y7pA-2y7rA:30.2 | 2y7pA-2y7rA:99.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z22 | PERIPLASMICPHOSPHATE-BINDINGPROTEIN (Yersinia pestis) |
no annotation | 5 | GLY X 6GLY X 53PHE X 277PRO X 12ILE X 258 | None | 1.00A | 2y7pA-2z22X:10.3 | 2y7pA-2z22X:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2l | HALOALKANEDEHALOGENASE (Bradyrhizobiumjaponicum) |
PF00561(Abhydrolase_1) | 5 | GLY A 67GLY A 70HIS A 81PRO A 209ILE A 64 | None | 1.34A | 2y7pA-3a2lA:undetectable | 2y7pA-3a2lA:24.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clq | UNCHARACTERIZEDPROTEIN (Enterococcusfaecalis) |
PF06545(DUF1116) | 5 | THR A 401ILE A 422GLY A 421GLY A 367PRO A 434 | None | 1.28A | 2y7pA-3clqA:undetectable | 2y7pA-3clqA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1j | GLYCOGEN SYNTHASE (Escherichiacoli) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 5 | THR A 391ILE A 370GLY A 386TYR A 385GLY A 365 | None | 0.93A | 2y7pA-3d1jA:undetectable | 2y7pA-3d1jA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ezl | ACETOACETYL-COAREDUCTASE (Burkholderiapseudomallei) |
PF00106(adh_short) | 5 | THR A 190ILE A 188GLY A 189GLY A 16PRO A 185 | None | 1.46A | 2y7pA-3ezlA:undetectable | 2y7pA-3ezlA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fle | SE_1780 PROTEIN (Staphylococcusepidermidis) |
PF06028(DUF915) | 5 | ILE A 172GLY A 142GLY A 53HIS A 269HIS A 273 | None | 1.35A | 2y7pA-3fleA:undetectable | 2y7pA-3fleA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kx2 | PRE-MRNA-SPLICINGFACTOR ATP-DEPENDENTRNA HELICASE PRP43 (Saccharomycescerevisiae) |
no annotation | 5 | THR B 376ILE B 316GLY B 312GLY B 346PRO B 343 | None | 1.38A | 2y7pA-3kx2B:undetectable | 2y7pA-3kx2B:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nrn | UNCHARACTERIZEDPROTEIN PF1083 (Pyrococcusfuriosus) |
PF01593(Amino_oxidase) | 5 | THR A 289ILE A 294GLY A 296PHE A 341ILE A 340 | None | 1.45A | 2y7pA-3nrnA:undetectable | 2y7pA-3nrnA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8q | SHIKIMATE5-DEHYDROGENASE IALPHA (Vibrio cholerae) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | THR B 153ILE B 129PHE B 208PRO B 201ILE B 207 | None | 1.24A | 2y7pA-3o8qB:3.1 | 2y7pA-3o8qB:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ops | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Paenibacillussp. Y412MC10) |
PF13378(MR_MLE_C) | 5 | ILE A 286GLY A 318TYR A 317GLY A 323PHE A 365 | None | 1.35A | 2y7pA-3opsA:undetectable | 2y7pA-3opsA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvd | CAPSID (Norwalk virus) |
PF08435(Calici_coat_C) | 5 | THR A 275GLY A 321GLY A 324PHE A 286PRO A 403 | None | 1.48A | 2y7pA-3pvdA:undetectable | 2y7pA-3pvdA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q60 | ROP5B (Toxoplasmagondii) |
PF14531(Kinase-like) | 5 | ILE A 453GLY A 450TYR A 454GLY A 504PHE A 489 | None | 1.07A | 2y7pA-3q60A:undetectable | 2y7pA-3q60A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3top | MALTASE-GLUCOAMYLASE, INTESTINAL (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 5 | THR A1490GLY A1517PHE A1544HIS A1170ILE A1549 | None | 1.25A | 2y7pA-3topA:undetectable | 2y7pA-3topA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va7 | KLLA0E08119P (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | THR A1643ILE A1627GLY A1616TYR A1628GLY A1641 | NoneNoneNoneURE A1902 (-4.3A)None | 1.04A | 2y7pA-3va7A:undetectable | 2y7pA-3va7A:10.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w04 | DWARF 88 ESTERASE (Oryza sativa) |
PF12697(Abhydrolase_6) | 5 | ILE A 170GLY A 145GLY A 77HIS A 297HIS A 300 | None | 1.41A | 2y7pA-3w04A:undetectable | 2y7pA-3w04A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w04 | DWARF 88 ESTERASE (Oryza sativa) |
PF12697(Abhydrolase_6) | 5 | ILE A 170GLY A 145GLY A 77HIS A 300PRO A 299 | None | 1.37A | 2y7pA-3w04A:undetectable | 2y7pA-3w04A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9i | MULTIDRUG RESISTANCEPROTEIN MEXB (Pseudomonasaeruginosa) |
PF00873(ACR_tran) | 5 | THR A1011ILE A 909GLY A 907GLY A1007PHE A 926 | None | 1.04A | 2y7pA-3w9iA:undetectable | 2y7pA-3w9iA:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxo | CATALASE-PEROXIDASE (Synechococcuselongatus) |
PF00141(peroxidase) | 5 | ILE A 436GLY A 484GLY A 481PHE A 565PRO A 416 | None | 1.11A | 2y7pA-3wxoA:undetectable | 2y7pA-3wxoA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wy2 | ALPHA-GLUCOSIDASE (Halomonas sp.H11) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | THR A 226GLY A 228PHE A 166HIS A 240ILE A 146 | NoneNoneBGC A 605 ( 3.8A)NoneNone | 1.14A | 2y7pA-3wy2A:undetectable | 2y7pA-3wy2A:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cad | RAS AND A-FACTORCONVERTING ENZYME 1,RCE1 (Methanococcusmaripaludis) |
PF02517(Abi) | 5 | THR C 26ILE C 43GLY C 27TYR C 40PRO C 46 | None | 1.41A | 2y7pA-4cadC:undetectable | 2y7pA-4cadC:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ddq | DNA GYRASE SUBUNIT A (Bacillussubtilis) |
PF00521(DNA_topoisoIV) | 5 | ILE A 332GLY A 239GLY A 229PRO A 184ILE A 230 | None | 1.49A | 2y7pA-4ddqA:undetectable | 2y7pA-4ddqA:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dmm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Synechococcuselongatus) |
PF13561(adh_short_C2) | 5 | ILE A 191GLY A 214TYR A 213GLY A 244ILE A 208 | None | 1.31A | 2y7pA-4dmmA:undetectable | 2y7pA-4dmmA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fc7 | PEROXISOMAL2,4-DIENOYL-COAREDUCTASE (Homo sapiens) |
PF13561(adh_short_C2) | 5 | THR A 214ILE A 40GLY A 39GLY A 216PRO A 208 | NAP A 401 (-3.0A)NAP A 401 (-4.0A)NAP A 401 (-3.2A)NAP A 401 (-3.2A)NAP A 401 (-4.0A) | 1.22A | 2y7pA-4fc7A:undetectable | 2y7pA-4fc7A:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha4 | BETA-GALACTOSIDASE (Acidilobussaccharovorans) |
PF00232(Glyco_hydro_1) | 5 | THR A 384ILE A 263TYR A 264PHE A 292ILE A 315 | None | 1.16A | 2y7pA-4ha4A:undetectable | 2y7pA-4ha4A:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3h | TOPOISOMERASE IVSUBUNIT B, DNATOPOISOMERASE 4SUBUNIT A CHIMERA (Streptococcuspneumoniae) |
PF00204(DNA_gyraseB)PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim)PF02518(HATPase_c) | 5 | ILE A1178GLY A1341HIS A1181PRO A1179ILE A1342 | None | 1.47A | 2y7pA-4i3hA:undetectable | 2y7pA-4i3hA:10.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4irn | PROLYL-ACPDEHYDROGENASE ([Oscillatoria]sp. PCC 6506) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ILE A 370GLY A 366GLY A 133PHE A 237ILE A 136 | NoneFAD A 400 ( 4.8A)FAD A 400 (-3.5A)NoneNone | 1.18A | 2y7pA-4irnA:undetectable | 2y7pA-4irnA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jro | FABG PROTEIN (Listeriamonocytogenes) |
PF13561(adh_short_C2) | 5 | ILE A 188GLY A 214TYR A 213GLY A 243ILE A 208 | None | 1.30A | 2y7pA-4jroA:undetectable | 2y7pA-4jroA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pzc | 3-HYDROXYACYL-COADEHYDROGENASE (Cupriavidusnecator) |
PF00725(3HCDH)PF02737(3HCDH_N) | 5 | THR A 159GLY A 156GLY A 138PHE A 187ILE A 154 | None | 1.38A | 2y7pA-4pzcA:undetectable | 2y7pA-4pzcA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r6l | BACTERIOPHYTOCHROME(LIGHT-REGULATEDSIGNAL TRANSDUCTIONHISTIDINE KINASE),PHYB1 (Rhodopseudomonaspalustris) |
PF00360(PHY)PF01590(GAF)PF08446(PAS_2) | 5 | THR A 267ILE A 222GLY A 266HIS A 255ILE A 262 | BLA A 900 (-3.3A)NoneNoneBLA A 900 (-3.3A)None | 1.25A | 2y7pA-4r6lA:undetectable | 2y7pA-4r6lA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9n | LMO0547 PROTEIN (Listeriamonocytogenes) |
PF04198(Sugar-bind) | 5 | THR A 217ILE A 221TYR A 223GLY A 117HIS A 152 | None | 1.24A | 2y7pA-4r9nA:undetectable | 2y7pA-4r9nA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rxu | PERIPLASMICSUGAR-BINDINGPROTEIN (Chloroflexusaurantiacus) |
PF13407(Peripla_BP_4) | 5 | ILE A 135TYR A 137GLY A 54PHE A 72ILE A 55 | None | 1.24A | 2y7pA-4rxuA:3.8 | 2y7pA-4rxuA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rzh | 3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Synechocystissp. PCC 6803) |
PF13561(adh_short_C2) | 5 | ILE A 189GLY A 212TYR A 211GLY A 242ILE A 206 | None | 1.23A | 2y7pA-4rzhA:undetectable | 2y7pA-4rzhA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqo | METHANOLDEHYDROGENASEPROTEIN, LARGESUBUNIT (Methylococcuscapsulatus) |
no annotation | 5 | THR B 369GLY B 370TYR B 322HIS B 247PRO B 246 | None | 1.36A | 2y7pA-4tqoB:undetectable | 2y7pA-4tqoB:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4whb | PHENYLUREA HYDROLASEB (Mycolicibacteriumbrisbanense) |
no annotation | 5 | THR E 113ILE E 143PHE E 154HIS E 212HIS E 273 | None | 1.24A | 2y7pA-4whbE:undetectable | 2y7pA-4whbE:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xfj | ARGININOSUCCINATESYNTHASE (Mycolicibacteriumthermoresistibile) |
PF00764(Arginosuc_synth) | 5 | THR A 26ILE A 22GLY A 23PHE A 158PRO A 144 | None | 1.30A | 2y7pA-4xfjA:undetectable | 2y7pA-4xfjA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydj | HEAVY CHAIN OFANTIBODY 44-VRC13.01LIGHT CHAIN OFANTIBODY 44-VRC13.01 (Homo sapiens) |
no annotation | 5 | THR H 58TYR L 96GLY H 49PHE H 100ILE H 35 | None | 1.50A | 2y7pA-4ydjH:undetectable | 2y7pA-4ydjH:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zhj | MG-CHELATASE SUBUNITCHLH (Synechocystissp. PCC 6803) |
PF02514(CobN-Mg_chel)PF11965(DUF3479) | 5 | ILE A 948GLY A 994TYR A 993PRO A 945ILE A 990 | None | 1.25A | 2y7pA-4zhjA:2.2 | 2y7pA-4zhjA:10.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bn4 | NEQ263 (Nanoarchaeumequitans) |
PF00006(ATP-synt_ab) | 5 | THR B 113ILE B 115GLY B 114PHE B 383PRO B 316 | None | 1.44A | 2y7pA-5bn4B:undetectable | 2y7pA-5bn4B:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cg0 | BETA-GLUCOSIDASE (Spodopterafrugiperda) |
PF00232(Glyco_hydro_1) | 5 | THR A 184GLY A 243PHE A 280PRO A 188ILE A 279 | None | 1.15A | 2y7pA-5cg0A:undetectable | 2y7pA-5cg0A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epo | 7-ALPHA-HYDROXYSTEROID DEYDROGENASE (Clostridiumsardiniense) |
PF13561(adh_short_C2) | 5 | THR A 193ILE A 191GLY A 192GLY A 17PRO A 188 | NAP A 301 (-2.9A)NAP A 301 (-3.9A)NoneNAP A 301 (-3.3A)NAP A 301 (-3.7A) | 1.29A | 2y7pA-5epoA:undetectable | 2y7pA-5epoA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hct | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 5 | THR A 212ILE A 214GLY A 201PHE A 262PRO A 228 | NoneNoneNoneNoneGOL A 403 ( 4.0A) | 1.02A | 2y7pA-5hctA:undetectable | 2y7pA-5hctA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8i | UREA AMIDOLYASE (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF01425(Amidase)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | THR A1643ILE A1627GLY A1616TYR A1628GLY A1641 | None | 1.05A | 2y7pA-5i8iA:3.0 | 2y7pA-5i8iA:7.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kkp | PSEUDOURIDYLATESYNTHASE 7 (Homo sapiens) |
PF01142(TruD) | 5 | ILE A 476GLY A 391TYR A 475PHE A 464HIS A 563 | None | 1.03A | 2y7pA-5kkpA:undetectable | 2y7pA-5kkpA:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltm | PHENYLALANINEAMMONIA LYASE (Anabaena) |
no annotation | 5 | THR B 81ILE B 77GLY B 83HIS B 359PRO B 348 | None | 1.45A | 2y7pA-5ltmB:undetectable | 2y7pA-5ltmB:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5p60 | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 5 | THR A 212ILE A 214GLY A 201PHE A 262PRO A 228 | None | 1.02A | 2y7pA-5p60A:undetectable | 2y7pA-5p60A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swj | PROBABLE ATPSYNTHASE SPAL/MXIB (Shigellaflexneri) |
PF00006(ATP-synt_ab) | 5 | THR A 138ILE A 140GLY A 139PHE A 407PRO A 340 | None | 1.50A | 2y7pA-5swjA:undetectable | 2y7pA-5swjA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4o | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Bacillusanthracis) |
PF00496(SBP_bac_5) | 5 | THR A 330GLY A 491HIS A 494PRO A 509ILE A 492 | None | 1.42A | 2y7pA-5u4oA:4.3 | 2y7pA-5u4oA:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ue7 | PHOSPHOMANNOMUTASE (Candidaalbicans) |
PF03332(PMM) | 5 | ILE A 95GLY A 96TYR A 100PHE A 126PRO A 188 | None | 1.11A | 2y7pA-5ue7A:undetectable | 2y7pA-5ue7A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uju | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Burkholderiamultivorans) |
PF00171(Aldedh) | 5 | ILE A 390GLY A 391TYR A 338PRO A 431ILE A 393 | None | 1.38A | 2y7pA-5ujuA:undetectable | 2y7pA-5ujuA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w8x | LIPID-A-DISACCHARIDESYNTHASE (Escherichiacoli) |
no annotation | 5 | THR A 140ILE A 136GLY A 137HIS A 119PRO A 123 | None | 1.29A | 2y7pA-5w8xA:2.6 | 2y7pA-5w8xA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yq7 | PRECURSOR FOR MSUBUNITS OFPHOTOSYNTHETICREACTION CENTER (Roseiflexuscastenholzii) |
no annotation | 5 | THR M 545ILE M 546GLY M 543HIS M 589ILE M 588 | MQE M 701 (-4.0A)NoneNone FE L1005 (-3.2A)MQE M 701 (-4.4A) | 1.28A | 2y7pA-5yq7M:undetectable | 2y7pA-5yq7M:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ap6 | PROBABLESTRIGOLACTONEESTERASE DAD2 (Petunia xhybrida) |
no annotation | 5 | ILE A 119GLY A 94GLY A 26HIS A 249PRO A 248 | None | 1.27A | 2y7pA-6ap6A:undetectable | 2y7pA-6ap6A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cet | GATOR COMPLEXPROTEIN DEPDC5 (Homo sapiens) |
no annotation | 5 | TYR D 172GLY D 363PHE D 317PRO D 750ILE D 362 | None | 1.24A | 2y7pA-6cetD:0.8 | 2y7pA-6cetD:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cf8 | LYTICTRANSGLYCOSYLASE (Campylobacterjejuni) |
no annotation | 5 | THR A 470ILE A 467GLY A 468GLY A 465HIS A 445 | None | 0.97A | 2y7pA-6cf8A:undetectable | 2y7pA-6cf8A:15.35 |