SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7P_A_SALA1000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A


(Robinia
pseudoacacia)
PF00139
(Lectin_legB)
5 THR A 213
GLY A  48
GLY A 108
PHE A  92
ILE A 109
None
1.43A 2y7pA-1fnzA:
undetectable
2y7pA-1fnzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5


(Caenorhabditis
elegans)
PF00160
(Pro_isomerase)
5 GLY A  71
TYR A  72
GLY A  74
PHE A  32
ILE A 183
None
1.50A 2y7pA-1h0pA:
undetectable
2y7pA-1h0pA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE


(Neurospora
crassa)
PF10282
(Lactonase)
5 THR A   9
GLY A   8
GLY A  14
PHE A  65
ILE A  36
None
1.33A 2y7pA-1jofA:
undetectable
2y7pA-1jofA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE


(Saccharomyces
cerevisiae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 THR A 162
ILE A 118
GLY A 115
TYR A 122
PHE A 133
2HP  A 698 ( 4.1A)
None
2HP  A 698 (-3.6A)
None
None
1.47A 2y7pA-1jscA:
0.8
2y7pA-1jscA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE


(Methanosarcina
barkeri)
PF05369
(MtmB)
5 THR A 274
GLY A 270
GLY A 266
HIS A 300
ILE A 301
None
1.29A 2y7pA-1l2qA:
undetectable
2y7pA-1l2qA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME


(Eisenia fetida)
PF00089
(Trypsin)
5 THR A 188
ILE A 160
GLY A 189
GLY A 186
PRO A 161
None
1.36A 2y7pA-1m9uA:
undetectable
2y7pA-1m9uA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Pelophylax
perezi)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 THR A1145
GLY A1066
GLY A1044
PHE A1357
ILE A1045
None
1.26A 2y7pA-1p0cA:
0.0
2y7pA-1p0cA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER


(Rhodobacter
sphaeroides)
PF00124
(Photo_RC)
5 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
1.33A 2y7pA-1pssM:
undetectable
2y7pA-1pssM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans)
PF00232
(Glyco_hydro_1)
5 ILE A 291
GLY A 292
TYR A 352
GLY A 218
PRO A 349
None
1.39A 2y7pA-1qoxA:
0.0
2y7pA-1qoxA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus)
PF00232
(Glyco_hydro_1)
5 THR A 386
ILE A 261
TYR A 262
PHE A 290
ILE A 317
None
1.15A 2y7pA-1uwiA:
undetectable
2y7pA-1uwiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG


(Homo sapiens)
PF08423
(Rad51)
5 ILE A 335
GLY A 336
GLY A 333
PHE A 177
ILE A 173
None
1.39A 2y7pA-1v5wA:
undetectable
2y7pA-1v5wA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III


(Schizosaccharomyces
pombe)
PF00291
(PALP)
5 THR A 147
ILE A 148
HIS A  85
PRO A 150
ILE A  89
None
1.30A 2y7pA-1v71A:
undetectable
2y7pA-1v71A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III


(Schizosaccharomyces
pombe)
PF00291
(PALP)
5 THR A 239
GLY A 183
GLY A 236
PHE A  56
PRO A 151
None
PLP  A 350 (-3.3A)
PLP  A 350 (-4.7A)
PLP  A 350 (-4.7A)
None
1.02A 2y7pA-1v71A:
undetectable
2y7pA-1v71A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus)
PF00291
(PALP)
5 THR A 235
GLY A 178
GLY A 232
PHE A  50
PRO A 142
None
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.7A)
PLP  A 413 (-4.6A)
None
0.97A 2y7pA-1ve5A:
undetectable
2y7pA-1ve5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE


(Homo sapiens)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 THR A  92
ILE A  98
GLY A  97
GLY A 276
ILE A 280
THR  A  92 ( 0.8A)
ILE  A  98 ( 0.7A)
GLY  A  97 ( 0.0A)
GLY  A 276 ( 0.0A)
ILE  A 280 ( 0.7A)
1.25A 2y7pA-1wsvA:
undetectable
2y7pA-1wsvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE


(Homo sapiens)
PF13561
(adh_short_C2)
5 THR A  28
ILE A  30
GLY A  31
GLY A 108
PRO A 201
None
0.98A 2y7pA-1yxmA:
undetectable
2y7pA-1yxmA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 ILE A  11
GLY A  10
PHE A 283
HIS A  22
ILE A  98
None
1.43A 2y7pA-1zh8A:
undetectable
2y7pA-1zh8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1


(Homo sapiens)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
5 ILE A 211
GLY A 218
GLY A 203
HIS A 178
ILE A  84
None
None
None
SF4  A1000 (-4.5A)
None
1.34A 2y7pA-2b3xA:
undetectable
2y7pA-2b3xA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 THR A 463
GLY A 464
TYR A 465
GLY A 586
PRO A 594
None
1.30A 2y7pA-2gv9A:
undetectable
2y7pA-2gv9A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np5 TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF00440
(TetR_N)
PF13977
(TetR_C_6)
5 THR A 143
ILE A 141
GLY A 142
GLY A 190
PRO A  81
None
1.23A 2y7pA-2np5A:
undetectable
2y7pA-2np5A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE


(Renilla
reniformis)
PF00561
(Abhydrolase_1)
5 GLY A  82
GLY A  85
HIS A  97
PRO A 215
ILE A  79
None
1.27A 2y7pA-2psfA:
undetectable
2y7pA-2psfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3


(Homo sapiens)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 THR A 316
ILE A 313
GLY A 271
PHE A 293
ILE A 272
None
1.28A 2y7pA-2qk4A:
undetectable
2y7pA-2qk4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens)
PF00431
(CUB)
PF00754
(F5_F8_type_C)
5 GLY A 436
GLY A 241
PHE A 217
PRO A 222
ILE A 242
None
None
NAG  A 613 ( 4.7A)
None
None
1.37A 2y7pA-2qqmA:
undetectable
2y7pA-2qqmA:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia)
PF03466
(LysR_substrate)
5 GLY A 152
PHE A 167
HIS A 169
PRO A 246
ILE A 273
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.4A)
None
SCN  A1303 (-4.1A)
1.31A 2y7pA-2uyeA:
30.1
2y7pA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia)
PF03466
(LysR_substrate)
7 THR A 104
GLY A 107
GLY A 152
PHE A 167
HIS A 206
PRO A 246
ILE A 273
SCN  A1307 (-4.0A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
0.94A 2y7pA-2uyeA:
30.1
2y7pA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia)
PF03466
(LysR_substrate)
7 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
PRO A 246
ILE A 273
SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
None
SCN  A1303 (-4.1A)
0.92A 2y7pA-2uyeA:
30.1
2y7pA-2uyeA:
70.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE


(Escherichia
coli)
PF00596
(Aldolase_II)
5 THR A 224
GLY A 218
GLY A 216
HIS A 125
ILE A 139
None
1.48A 2y7pA-2v9iA:
undetectable
2y7pA-2v9iA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN


(Burkholderia
sp. DNT)
PF03466
(LysR_substrate)
9 THR A 104
GLY A 107
TYR A 110
GLY A 152
PHE A 167
HIS A 169
HIS A 206
PRO A 246
ILE A 273
None
0.96A 2y7pA-2y7rA:
30.2
2y7pA-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN


(Burkholderia
sp. DNT)
PF03466
(LysR_substrate)
8 THR A 104
ILE A 106
GLY A 107
TYR A 110
GLY A 152
PHE A 167
PRO A 246
ILE A 273
None
0.82A 2y7pA-2y7rA:
30.2
2y7pA-2y7rA:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN


(Yersinia pestis)
no annotation 5 GLY X   6
GLY X  53
PHE X 277
PRO X  12
ILE X 258
None
1.00A 2y7pA-2z22X:
10.3
2y7pA-2z22X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE


(Bradyrhizobium
japonicum)
PF00561
(Abhydrolase_1)
5 GLY A  67
GLY A  70
HIS A  81
PRO A 209
ILE A  64
None
1.34A 2y7pA-3a2lA:
undetectable
2y7pA-3a2lA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN


(Enterococcus
faecalis)
PF06545
(DUF1116)
5 THR A 401
ILE A 422
GLY A 421
GLY A 367
PRO A 434
None
1.28A 2y7pA-3clqA:
undetectable
2y7pA-3clqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
None
0.93A 2y7pA-3d1jA:
undetectable
2y7pA-3d1jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezl ACETOACETYL-COA
REDUCTASE


(Burkholderia
pseudomallei)
PF00106
(adh_short)
5 THR A 190
ILE A 188
GLY A 189
GLY A  16
PRO A 185
None
1.46A 2y7pA-3ezlA:
undetectable
2y7pA-3ezlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fle SE_1780 PROTEIN

(Staphylococcus
epidermidis)
PF06028
(DUF915)
5 ILE A 172
GLY A 142
GLY A  53
HIS A 269
HIS A 273
None
1.35A 2y7pA-3fleA:
undetectable
2y7pA-3fleA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43


(Saccharomyces
cerevisiae)
no annotation 5 THR B 376
ILE B 316
GLY B 312
GLY B 346
PRO B 343
None
1.38A 2y7pA-3kx2B:
undetectable
2y7pA-3kx2B:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083


(Pyrococcus
furiosus)
PF01593
(Amino_oxidase)
5 THR A 289
ILE A 294
GLY A 296
PHE A 341
ILE A 340
None
1.45A 2y7pA-3nrnA:
undetectable
2y7pA-3nrnA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA


(Vibrio cholerae)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 THR B 153
ILE B 129
PHE B 208
PRO B 201
ILE B 207
None
1.24A 2y7pA-3o8qB:
3.1
2y7pA-3o8qB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Paenibacillus
sp. Y412MC10)
PF13378
(MR_MLE_C)
5 ILE A 286
GLY A 318
TYR A 317
GLY A 323
PHE A 365
None
1.35A 2y7pA-3opsA:
undetectable
2y7pA-3opsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvd CAPSID

(Norwalk virus)
PF08435
(Calici_coat_C)
5 THR A 275
GLY A 321
GLY A 324
PHE A 286
PRO A 403
None
1.48A 2y7pA-3pvdA:
undetectable
2y7pA-3pvdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii)
PF14531
(Kinase-like)
5 ILE A 453
GLY A 450
TYR A 454
GLY A 504
PHE A 489
None
1.07A 2y7pA-3q60A:
undetectable
2y7pA-3q60A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL


(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
5 THR A1490
GLY A1517
PHE A1544
HIS A1170
ILE A1549
None
1.25A 2y7pA-3topA:
undetectable
2y7pA-3topA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
None
None
None
URE  A1902 (-4.3A)
None
1.04A 2y7pA-3va7A:
undetectable
2y7pA-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa)
PF12697
(Abhydrolase_6)
5 ILE A 170
GLY A 145
GLY A  77
HIS A 297
HIS A 300
None
1.41A 2y7pA-3w04A:
undetectable
2y7pA-3w04A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa)
PF12697
(Abhydrolase_6)
5 ILE A 170
GLY A 145
GLY A  77
HIS A 300
PRO A 299
None
1.37A 2y7pA-3w04A:
undetectable
2y7pA-3w04A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB


(Pseudomonas
aeruginosa)
PF00873
(ACR_tran)
5 THR A1011
ILE A 909
GLY A 907
GLY A1007
PHE A 926
None
1.04A 2y7pA-3w9iA:
undetectable
2y7pA-3w9iA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus)
PF00141
(peroxidase)
5 ILE A 436
GLY A 484
GLY A 481
PHE A 565
PRO A 416
None
1.11A 2y7pA-3wxoA:
undetectable
2y7pA-3wxoA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
5 THR A 226
GLY A 228
PHE A 166
HIS A 240
ILE A 146
None
None
BGC  A 605 ( 3.8A)
None
None
1.14A 2y7pA-3wy2A:
undetectable
2y7pA-3wy2A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1


(Methanococcus
maripaludis)
PF02517
(Abi)
5 THR C  26
ILE C  43
GLY C  27
TYR C  40
PRO C  46
None
1.41A 2y7pA-4cadC:
undetectable
2y7pA-4cadC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis)
PF00521
(DNA_topoisoIV)
5 ILE A 332
GLY A 239
GLY A 229
PRO A 184
ILE A 230
None
1.49A 2y7pA-4ddqA:
undetectable
2y7pA-4ddqA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Synechococcus
elongatus)
PF13561
(adh_short_C2)
5 ILE A 191
GLY A 214
TYR A 213
GLY A 244
ILE A 208
None
1.31A 2y7pA-4dmmA:
undetectable
2y7pA-4dmmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE


(Homo sapiens)
PF13561
(adh_short_C2)
5 THR A 214
ILE A  40
GLY A  39
GLY A 216
PRO A 208
NAP  A 401 (-3.0A)
NAP  A 401 (-4.0A)
NAP  A 401 (-3.2A)
NAP  A 401 (-3.2A)
NAP  A 401 (-4.0A)
1.22A 2y7pA-4fc7A:
undetectable
2y7pA-4fc7A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans)
PF00232
(Glyco_hydro_1)
5 THR A 384
ILE A 263
TYR A 264
PHE A 292
ILE A 315
None
1.16A 2y7pA-4ha4A:
undetectable
2y7pA-4ha4A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA


(Streptococcus
pneumoniae)
PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c)
5 ILE A1178
GLY A1341
HIS A1181
PRO A1179
ILE A1342
None
1.47A 2y7pA-4i3hA:
undetectable
2y7pA-4i3hA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE


([Oscillatoria]
sp. PCC 6506)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 ILE A 370
GLY A 366
GLY A 133
PHE A 237
ILE A 136
None
FAD  A 400 ( 4.8A)
FAD  A 400 (-3.5A)
None
None
1.18A 2y7pA-4irnA:
undetectable
2y7pA-4irnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jro FABG PROTEIN

(Listeria
monocytogenes)
PF13561
(adh_short_C2)
5 ILE A 188
GLY A 214
TYR A 213
GLY A 243
ILE A 208
None
1.30A 2y7pA-4jroA:
undetectable
2y7pA-4jroA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE


(Cupriavidus
necator)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 THR A 159
GLY A 156
GLY A 138
PHE A 187
ILE A 154
None
1.38A 2y7pA-4pzcA:
undetectable
2y7pA-4pzcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1


(Rhodopseudomonas
palustris)
PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2)
5 THR A 267
ILE A 222
GLY A 266
HIS A 255
ILE A 262
BLA  A 900 (-3.3A)
None
None
BLA  A 900 (-3.3A)
None
1.25A 2y7pA-4r6lA:
undetectable
2y7pA-4r6lA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes)
PF04198
(Sugar-bind)
5 THR A 217
ILE A 221
TYR A 223
GLY A 117
HIS A 152
None
1.24A 2y7pA-4r9nA:
undetectable
2y7pA-4r9nA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN


(Chloroflexus
aurantiacus)
PF13407
(Peripla_BP_4)
5 ILE A 135
TYR A 137
GLY A  54
PHE A  72
ILE A  55
None
1.24A 2y7pA-4rxuA:
3.8
2y7pA-4rxuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE


(Synechocystis
sp. PCC 6803)
PF13561
(adh_short_C2)
5 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
None
1.23A 2y7pA-4rzhA:
undetectable
2y7pA-4rzhA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT


(Methylococcus
capsulatus)
no annotation 5 THR B 369
GLY B 370
TYR B 322
HIS B 247
PRO B 246
None
1.36A 2y7pA-4tqoB:
undetectable
2y7pA-4tqoB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B


(Mycolicibacterium
brisbanense)
no annotation 5 THR E 113
ILE E 143
PHE E 154
HIS E 212
HIS E 273
None
1.24A 2y7pA-4whbE:
undetectable
2y7pA-4whbE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfj ARGININOSUCCINATE
SYNTHASE


(Mycolicibacterium
thermoresistibile)
PF00764
(Arginosuc_synth)
5 THR A  26
ILE A  22
GLY A  23
PHE A 158
PRO A 144
None
1.30A 2y7pA-4xfjA:
undetectable
2y7pA-4xfjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01


(Homo sapiens)
no annotation 5 THR H  58
TYR L  96
GLY H  49
PHE H 100
ILE H  35
None
1.50A 2y7pA-4ydjH:
undetectable
2y7pA-4ydjH:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH


(Synechocystis
sp. PCC 6803)
PF02514
(CobN-Mg_chel)
PF11965
(DUF3479)
5 ILE A 948
GLY A 994
TYR A 993
PRO A 945
ILE A 990
None
1.25A 2y7pA-4zhjA:
2.2
2y7pA-4zhjA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans)
PF00006
(ATP-synt_ab)
5 THR B 113
ILE B 115
GLY B 114
PHE B 383
PRO B 316
None
1.44A 2y7pA-5bn4B:
undetectable
2y7pA-5bn4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda)
PF00232
(Glyco_hydro_1)
5 THR A 184
GLY A 243
PHE A 280
PRO A 188
ILE A 279
None
1.15A 2y7pA-5cg0A:
undetectable
2y7pA-5cg0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE


(Clostridium
sardiniense)
PF13561
(adh_short_C2)
5 THR A 193
ILE A 191
GLY A 192
GLY A  17
PRO A 188
NAP  A 301 (-2.9A)
NAP  A 301 (-3.9A)
None
NAP  A 301 (-3.3A)
NAP  A 301 (-3.7A)
1.29A 2y7pA-5epoA:
undetectable
2y7pA-5epoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
None
None
None
None
GOL  A 403 ( 4.0A)
1.02A 2y7pA-5hctA:
undetectable
2y7pA-5hctA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
None
1.05A 2y7pA-5i8iA:
3.0
2y7pA-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkp PSEUDOURIDYLATE
SYNTHASE 7


(Homo sapiens)
PF01142
(TruD)
5 ILE A 476
GLY A 391
TYR A 475
PHE A 464
HIS A 563
None
1.03A 2y7pA-5kkpA:
undetectable
2y7pA-5kkpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE


(Anabaena)
no annotation 5 THR B  81
ILE B  77
GLY B  83
HIS B 359
PRO B 348
None
1.45A 2y7pA-5ltmB:
undetectable
2y7pA-5ltmB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
None
1.02A 2y7pA-5p60A:
undetectable
2y7pA-5p60A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB


(Shigella
flexneri)
PF00006
(ATP-synt_ab)
5 THR A 138
ILE A 140
GLY A 139
PHE A 407
PRO A 340
None
1.50A 2y7pA-5swjA:
undetectable
2y7pA-5swjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Bacillus
anthracis)
PF00496
(SBP_bac_5)
5 THR A 330
GLY A 491
HIS A 494
PRO A 509
ILE A 492
None
1.42A 2y7pA-5u4oA:
4.3
2y7pA-5u4oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue7 PHOSPHOMANNOMUTASE

(Candida
albicans)
PF03332
(PMM)
5 ILE A  95
GLY A  96
TYR A 100
PHE A 126
PRO A 188
None
1.11A 2y7pA-5ue7A:
undetectable
2y7pA-5ue7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Burkholderia
multivorans)
PF00171
(Aldedh)
5 ILE A 390
GLY A 391
TYR A 338
PRO A 431
ILE A 393
None
1.38A 2y7pA-5ujuA:
undetectable
2y7pA-5ujuA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8x LIPID-A-DISACCHARIDE
SYNTHASE


(Escherichia
coli)
no annotation 5 THR A 140
ILE A 136
GLY A 137
HIS A 119
PRO A 123
None
1.29A 2y7pA-5w8xA:
2.6
2y7pA-5w8xA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER


(Roseiflexus
castenholzii)
no annotation 5 THR M 545
ILE M 546
GLY M 543
HIS M 589
ILE M 588
MQE  M 701 (-4.0A)
None
None
FE  L1005 (-3.2A)
MQE  M 701 (-4.4A)
1.28A 2y7pA-5yq7M:
undetectable
2y7pA-5yq7M:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2


(Petunia x
hybrida)
no annotation 5 ILE A 119
GLY A  94
GLY A  26
HIS A 249
PRO A 248
None
1.27A 2y7pA-6ap6A:
undetectable
2y7pA-6ap6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5


(Homo sapiens)
no annotation 5 TYR D 172
GLY D 363
PHE D 317
PRO D 750
ILE D 362
None
1.24A 2y7pA-6cetD:
0.8
2y7pA-6cetD:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE


(Campylobacter
jejuni)
no annotation 5 THR A 470
ILE A 467
GLY A 468
GLY A 465
HIS A 445
None
0.97A 2y7pA-6cf8A:
undetectable
2y7pA-6cf8A:
15.35