SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7K_D_SALD1300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 GLY A  85
GLY A  68
HIS A  44
PRO A  58
ILE A  83
 None
 1.22A 2y7kD-1am5A:
0.0		 2y7kD-1am5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 THR A  53
ILE A   6
TYR A   9
GLY A  49
LEU A 124
 None
 1.10A 2y7kD-1gjuA:
undetectable		 2y7kD-1gjuA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 GLY A 359
LEU A 366
PHE A 376
HIS A 203
PRO A 201
 None
 1.15A 2y7kD-1i2dA:
2.1		 2y7kD-1i2dA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 ILE A 802
TYR A 775
GLY A 712
LEU A 716
PHE A 697
 None
 1.20A 2y7kD-1kz7A:
undetectable		 2y7kD-1kz7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE

(Pseudomonas sp.
CBS3) 		no annotation 5 ILE A  56
GLY A  58
LEU A  44
PHE A  92
PRO A 133
 None
BCA  A 170 ( 3.9A)
None
None
None
 1.11A 2y7kD-1lo9A:
undetectable		 2y7kD-1lo9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		5 GLY A 447
TYR A 446
GLY A 125
LEU A 124
ILE A 126
 None
 1.13A 2y7kD-1m0wA:
undetectable		 2y7kD-1m0wA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 ILE A  18
GLY A  19
PHE A  11
GLY A  92
PRO A 182
 NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.6A)
NAI  A 850 (-3.8A)
 1.13A 2y7kD-1mg5A:
0.4		 2y7kD-1mg5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		5 ILE A  12
PHE A 130
LEU A  97
PHE A 137
ILE A 169
 None
 1.12A 2y7kD-1ntgA:
undetectable		 2y7kD-1ntgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		5 GLY A 476
LEU A 537
HIS A 459
PRO A 465
ILE A 482
 None
 1.02A 2y7kD-1pixA:
undetectable		 2y7kD-1pixA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		5 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.18A 2y7kD-1pssM:
undetectable		 2y7kD-1pssM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Plasmodium
falciparum) 		PF00160
(Pro_isomerase) 		5 ILE A  74
GLY A  72
PHE A 119
PHE A   9
ILE A 165
 None
 1.22A 2y7kD-1qnhA:
undetectable		 2y7kD-1qnhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  62
GLY A  39
LEU A 325
HIS A 311
ILE A  40
 None
 1.22A 2y7kD-1qorA:
undetectable		 2y7kD-1qorA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  40
GLY A  39
GLY A  62
LEU A  61
HIS A 311
 None
 1.11A 2y7kD-1qorA:
undetectable		 2y7kD-1qorA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 GLY A 358
LEU A 365
PHE A 375
HIS A 201
PRO A 199
 None
 1.03A 2y7kD-1r6xA:
undetectable		 2y7kD-1r6xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		5 GLY A 150
LEU A 190
PHE A 139
PRO A 205
ILE A 149
 None
 0.99A 2y7kD-1sjiA:
undetectable		 2y7kD-1sjiA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		5 THR A 239
GLY A 183
GLY A 236
PHE A  56
PRO A 151
 None
PLP  A 350 (-3.3A)
PLP  A 350 (-4.7A)
PLP  A 350 (-4.7A)
None
 1.10A 2y7kD-1v71A:
undetectable		 2y7kD-1v71A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 THR A 235
GLY A 178
GLY A 232
PHE A  50
PRO A 142
 None
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.7A)
PLP  A 413 (-4.6A)
None
 1.00A 2y7kD-1ve5A:
undetectable		 2y7kD-1ve5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		5 ILE A 141
TYR A 139
LEU A 164
PHE A 197
PRO A 154
 None
 1.17A 2y7kD-1y3nA:
4.1		 2y7kD-1y3nA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		5 THR A  52
ILE A  54
GLY A  55
TYR A  58
PHE A  59
 None
 1.10A 2y7kD-2aeuA:
undetectable		 2y7kD-2aeuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 GLY A 328
GLY A 111
LEU A 106
HIS A 185
ILE A 112
 ACT  A1501 (-3.5A)
None
None
None
ACT  A1501 (-4.5A)
 1.07A 2y7kD-2bb0A:
undetectable		 2y7kD-2bb0A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A   4
GLY A  11
GLY A 361
LEU A 364
ILE A 335
 None
 1.00A 2y7kD-2e5vA:
undetectable		 2y7kD-2e5vA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 5 PHE A 197
GLY A 250
HIS A  98
PRO A  96
ILE A 245
 None
 1.22A 2y7kD-2gjuA:
undetectable		 2y7kD-2gjuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		5 TYR A 243
PHE A 343
LEU A 301
PHE A 196
ILE A 304
 None
 1.21A 2y7kD-2icyA:
1.0		 2y7kD-2icyA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 THR A  74
ILE A 119
GLY A 118
PHE A 117
LEU A 184
 None
 1.11A 2y7kD-2iukA:
undetectable		 2y7kD-2iukA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbe ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		5 ILE A 107
GLY A 106
TYR A 108
LEU A  99
PRO A 115
 None
 1.14A 2y7kD-2kbeA:
undetectable		 2y7kD-2kbeA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhs CBP21

(Serratia
marcescens) 		PF03067
(LPMO_10) 		5 ILE A 164
PHE A  79
LEU A 168
PHE A 117
ILE A 137
 None
 1.15A 2y7kD-2lhsA:
undetectable		 2y7kD-2lhsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np5 TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 THR A 143
ILE A 141
GLY A 142
GLY A 190
PRO A  81
 None
 1.10A 2y7kD-2np5A:
undetectable		 2y7kD-2np5A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 266
TYR A 265
GLY A 281
LEU A 776
ILE A 263
 None
 1.10A 2y7kD-2nyaA:
undetectable		 2y7kD-2nyaA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odf HYPOTHETICAL PROTEIN
ATU2144

(Agrobacterium
fabrum) 		PF05013
(FGase) 		5 ILE A  38
GLY A  43
TYR A  42
GLY A  46
LEU A  47
 None
 0.98A 2y7kD-2odfA:
undetectable		 2y7kD-2odfA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 THR A 382
ILE A 378
GLY A 379
LEU A 409
ILE A 421
 None
None
COA  A2000 ( 4.5A)
None
None
 1.18A 2y7kD-2oi6A:
undetectable		 2y7kD-2oi6A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 THR A 157
ILE A 159
PHE A  97
LEU A 258
ILE A 194
 None
 1.10A 2y7kD-2q1yA:
undetectable		 2y7kD-2q1yA:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		5 GLY A 152
PHE A 167
HIS A 169
PRO A 246
ILE A 273
 SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.4A)
None
SCN  A1303 (-4.1A)
 1.23A 2y7kD-2uyeA:
31.6		 2y7kD-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		8 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
HIS A 206
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.71A 2y7kD-2uyeA:
31.6		 2y7kD-2uyeA:
70.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v84 SPERMIDINE/PUTRESCIN
E ABC TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN

(Treponema
pallidum) 		PF13416
(SBP_bac_8) 		5 THR A 279
ILE A 280
PHE A 276
GLY A 112
PRO A 108
 None
 1.22A 2y7kD-2v84A:
8.8		 2y7kD-2v84A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 GLY A 259
GLY A 271
LEU A 272
HIS A 305
PRO A 353
 None
 1.08A 2y7kD-2wghA:
undetectable		 2y7kD-2wghA:
16.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN

(Burkholderia
sp. DNT) 		PF03466
(LysR_substrate) 		11 THR A 104
ILE A 106
GLY A 107
TYR A 110
PHE A 111
GLY A 152
PHE A 167
HIS A 169
HIS A 206
PRO A 246
ILE A 273
 None
 0.60A 2y7kD-2y7rA:
31.8		 2y7kD-2y7rA:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 5 GLY X   6
GLY X  53
PHE X 277
PRO X  12
ILE X 258
 None
 1.12A 2y7kD-2z22X:
4.9		 2y7kD-2z22X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 THR A 249
PHE A 216
LEU A 169
HIS A  78
PRO A 119
 None
 1.20A 2y7kD-2zzgA:
undetectable		 2y7kD-2zzgA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bry TBUX

(Ralstonia
pickettii) 		PF03349
(Toluene_X) 		5 THR A  55
ILE A  57
GLY A  71
GLY A 107
LEU A 106
 None
 1.22A 2y7kD-3bryA:
undetectable		 2y7kD-3bryA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
 None
 0.95A 2y7kD-3d1jA:
undetectable		 2y7kD-3d1jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9y PROFILIN

(Schizosaccharomyces
pombe) 		PF00235
(Profilin) 		5 ILE A  87
GLY A  80
TYR A  79
LEU A  46
ILE A  78
 None
 1.11A 2y7kD-3d9yA:
undetectable		 2y7kD-3d9yA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcf TRANSCRIPTIONAL
REGULATOR OF THE
TETR/ACRR FAMILY

(Thermobifida
fusca) 		PF00440
(TetR_N) 		5 ILE A 118
TYR A 187
GLY A 181
LEU A 180
HIS A 114
 None
 1.04A 2y7kD-3dcfA:
undetectable		 2y7kD-3dcfA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 ILE A 178
GLY A 135
GLY A  87
LEU A  88
ILE A  85
 None
 1.16A 2y7kD-3edmA:
undetectable		 2y7kD-3edmA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg9 PROTEIN OF UNIVERSAL
STRESS PROTEIN USPA
FAMILY

(Lactobacillus
plantarum) 		PF00582
(Usp) 		5 GLY A 123
GLY A 138
LEU A 141
PHE A 128
ILE A 137
 None
 1.11A 2y7kD-3fg9A:
2.1		 2y7kD-3fg9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ILE C 199
GLY C 221
GLY C 202
LEU C 282
PHE C 230
 None
 1.20A 2y7kD-3hrdC:
undetectable		 2y7kD-3hrdC:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		5 ILE A   6
GLY A  86
LEU A 103
PHE A  96
ILE A 100
 None
 1.16A 2y7kD-3lupA:
undetectable		 2y7kD-3lupA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ILE A 453
GLY A 450
TYR A 454
GLY A 504
PHE A 489
 None
 1.23A 2y7kD-3q60A:
undetectable		 2y7kD-3q60A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 319
TYR A 280
GLY A 325
LEU A 237
ILE A 324
 None
 1.22A 2y7kD-3q6dA:
undetectable		 2y7kD-3q6dA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE

(Scaptodrosophila
lebanonensis) 		PF00106
(adh_short) 		5 ILE A  17
GLY A  18
PHE A  10
GLY A  91
PRO A 181
 NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.7A)
NAD  A 850 (-3.9A)
 1.12A 2y7kD-3rj9A:
undetectable		 2y7kD-3rj9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		5 THR A 109
ILE A 106
GLY A 105
GLY A 181
LEU A 182
 None
 1.06A 2y7kD-3rmtA:
undetectable		 2y7kD-3rmtA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnr STAGE II SPORULATION
E FAMILY PROTEIN

(Thermanaerovibrio
acidaminovorans) 		PF07228
(SpoIIE) 		5 THR A  67
GLY A  68
PHE A 133
GLY A  65
LEU A  64
 None
 1.10A 2y7kD-3rnrA:
undetectable		 2y7kD-3rnrA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tej ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00550
(PP-binding)
PF00975
(Thioesterase) 		5 GLY A1076
GLY A1140
LEU A1143
HIS A1119
PRO A1105
 None
 1.16A 2y7kD-3tejA:
undetectable		 2y7kD-3tejA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tej ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00550
(PP-binding)
PF00975
(Thioesterase) 		5 ILE A1097
PHE A1081
GLY A1140
LEU A1143
HIS A1119
 None
 1.18A 2y7kD-3tejA:
undetectable		 2y7kD-3tejA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trp CALSEQUESTRIN-1

(Oryctolagus
cuniculus) 		PF01216
(Calsequestrin) 		5 GLY A 150
LEU A 190
PHE A 139
PRO A 205
ILE A 149
 None
 1.12A 2y7kD-3trpA:
undetectable		 2y7kD-3trpA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
None
None
URE  A1902 (-4.3A)
None
 1.09A 2y7kD-3va7A:
undetectable		 2y7kD-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 ILE A 372
GLY A 267
GLY A 240
LEU A 334
ILE A 239
 None
 1.08A 2y7kD-3vlaA:
undetectable		 2y7kD-3vlaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta) 		PF04261
(Dyp_perox) 		6 GLY A 119
PHE A  29
GLY A  75
LEU A  76
PHE A  37
PRO A 431
 None
 1.36A 2y7kD-3vxiA:
undetectable		 2y7kD-3vxiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 THR A1011
ILE A 909
GLY A 907
GLY A1007
PHE A 926
 None
 0.98A 2y7kD-3w9iA:
undetectable		 2y7kD-3w9iA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		6 THR A 253
GLY A 468
GLY A 502
LEU A 501
PHE A 190
PRO A 193
 None
 1.24A 2y7kD-4b9yA:
undetectable		 2y7kD-4b9yA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		5 THR A 102
ILE A  94
GLY A  57
PHE A  73
ILE A 324
 None
 0.99A 2y7kD-4be3A:
undetectable		 2y7kD-4be3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		5 GLY A 176
LEU A 148
PHE A 204
HIS A 188
PRO A 218
 None
 1.22A 2y7kD-4dn7A:
undetectable		 2y7kD-4dn7A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)

(Pseudomonas
stutzeri) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 156
GLY A 157
GLY A 152
LEU A 208
PRO A 235
 NAD  A 401 (-3.6A)
None
NAD  A 401 (-3.3A)
NAD  A 401 (-4.5A)
None
 1.22A 2y7kD-4e5kA:
undetectable		 2y7kD-4e5kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 ILE A 313
GLY A 312
GLY A 102
LEU A  35
ILE A  50
 None
 1.03A 2y7kD-4eygA:
undetectable		 2y7kD-4eygA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ILE A 167
GLY A 191
LEU A 246
PHE A 239
ILE A 243
 None
 1.08A 2y7kD-4fp4A:
undetectable		 2y7kD-4fp4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		5 ILE A 327
GLY A 328
PHE A 323
LEU A 231
ILE A 304
 ATP  A 405 (-4.6A)
None
None
None
None
 1.22A 2y7kD-4fwmA:
undetectable		 2y7kD-4fwmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		5 PHE A 372
GLY A 327
LEU A 328
PHE A 390
ILE A 349
 None
 1.21A 2y7kD-4gl3A:
undetectable		 2y7kD-4gl3A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		5 ILE A 637
GLY A 791
GLY A 538
LEU A 537
HIS A 533
 None
 1.19A 2y7kD-4h6xA:
undetectable		 2y7kD-4h6xA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpz DTALE2

(Xanthomonas) 		PF03377
(TAL_effector) 		5 ILE A 263
GLY A 267
GLY A 303
LEU A 307
HIS A 275
 None
 1.15A 2y7kD-4hpzA:
undetectable		 2y7kD-4hpzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		5 ILE A 229
GLY A 209
GLY A 211
LEU A 212
ILE A 200
 GOL  A 502 (-4.0A)
PO4  A 501 (-3.5A)
K  A 507 ( 4.3A)
None
None
 1.13A 2y7kD-4ijaA:
undetectable		 2y7kD-4ijaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE

([Oscillatoria]
sp. PCC 6506) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 370
GLY A 366
GLY A 133
PHE A 237
ILE A 136
 None
FAD  A 400 ( 4.8A)
FAD  A 400 (-3.5A)
None
None
 1.15A 2y7kD-4irnA:
undetectable		 2y7kD-4irnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		5 ILE A  77
GLY A  78
GLY A 151
LEU A 153
PRO A 170
 None
 0.87A 2y7kD-4iu4A:
undetectable		 2y7kD-4iu4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites virus) 		PF01768
(Birna_VP4) 		5 ILE A 665
GLY A 656
GLY A 637
LEU A 640
PHE A 598
 None
 1.22A 2y7kD-4izkA:
undetectable		 2y7kD-4izkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 5 ILE E  17
GLY E  24
GLY E 350
LEU E 353
ILE E 332
 None
 0.94A 2y7kD-4kprE:
undetectable		 2y7kD-4kprE:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Archaeoglobus
fulgidus) 		PF00215
(OMPdecase) 		5 THR A 131
ILE A 162
LEU A 171
PRO A 186
ILE A 183
 None
BMP  A 301 ( 4.9A)
None
BMP  A 301 (-4.3A)
None
 1.14A 2y7kD-4muzA:
undetectable		 2y7kD-4muzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Archaeoglobus
fulgidus) 		PF00215
(OMPdecase) 		5 THR A 131
ILE A 162
TYR A 128
PRO A 186
ILE A 183
 None
BMP  A 301 ( 4.9A)
None
BMP  A 301 (-4.3A)
None
 1.08A 2y7kD-4muzA:
undetectable		 2y7kD-4muzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7q INTERFERON-INDUCIBLE
PROTEIN AIM2

(Homo sapiens) 		PF02758
(PYRIN) 		5 THR A  65
ILE A  68
GLY A  13
LEU A  14
ILE A  17
 None
 1.20A 2y7kD-4o7qA:
undetectable		 2y7kD-4o7qA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 GLY A 285
GLY A 213
LEU A 215
PRO A 290
ILE A 212
 None
 1.18A 2y7kD-4r1pA:
undetectable		 2y7kD-4r1pA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE

(Bacillus
anthracis) 		PF03009
(GDPD) 		5 ILE A 262
GLY A 250
LEU A 211
PRO A 231
ILE A 249
 None
 1.18A 2y7kD-4r7oA:
undetectable		 2y7kD-4r7oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF13561
(adh_short_C2) 		5 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
 None
 1.21A 2y7kD-4rzhA:
undetectable		 2y7kD-4rzhA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6q GLUCOSYLTRANSFERASE

(Streptococcus
agalactiae) 		no annotation 5 THR A 196
GLY A 175
LEU A 202
PHE A 182
ILE A 183
 None
UDP  A 402 ( 4.8A)
None
None
None
 1.14A 2y7kD-4w6qA:
undetectable		 2y7kD-4w6qA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 THR A 403
GLY A 428
LEU A 495
PRO A 360
ILE A 499
 None
 1.00A 2y7kD-4woeA:
undetectable		 2y7kD-4woeA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx5 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAO

(Salmonella
enterica) 		PF01052
(FliMN_C)
no annotation 		5 ILE A  29
GLY B  50
LEU B  49
PHE B   9
ILE B  42
 None
 1.14A 2y7kD-4yx5A:
undetectable		 2y7kD-4yx5A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 GLY A 161
PHE A 184
GLY A 139
HIS A 166
ILE A 140
 None
None
None
NAG  A 702 (-4.8A)
None
 1.08A 2y7kD-4z64A:
undetectable		 2y7kD-4z64A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 THR e 119
GLY e 121
GLY e  87
LEU e  91
ILE e  61
 None
 1.16A 2y7kD-5gw5e:
undetectable		 2y7kD-5gw5e:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		5 ILE A 393
GLY A 394
PHE A 398
LEU A 427
ILE A 457
 None
 1.18A 2y7kD-5h0iA:
undetectable		 2y7kD-5h0iA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
 None
None
None
None
GOL  A 403 ( 4.0A)
 1.15A 2y7kD-5hctA:
undetectable		 2y7kD-5hctA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
 1.10A 2y7kD-5i8iA:
2.8		 2y7kD-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 5 THR A 977
ILE A 976
GLY A 991
LEU A 950
ILE A 922
 None
 1.08A 2y7kD-5id6A:
undetectable		 2y7kD-5id6A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 ILE A 103
TYR A  99
PHE A  98
LEU A  63
PRO A 113
 None
 1.12A 2y7kD-5ns8A:
undetectable		 2y7kD-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		5 ILE A 256
GLY A 255
TYR A 253
GLY A 379
LEU A 378
 None
 1.20A 2y7kD-5nsqA:
undetectable		 2y7kD-5nsqA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 ILE A 255
GLY A 254
TYR A 252
GLY A 378
LEU A 377
 None
 1.21A 2y7kD-5ntfA:
undetectable		 2y7kD-5ntfA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
 None
 1.12A 2y7kD-5p60A:
undetectable		 2y7kD-5p60A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		5 ILE A 298
GLY A 296
GLY A 349
LEU A 305
ILE A 354
 None
 1.20A 2y7kD-5ul4A:
undetectable		 2y7kD-5ul4A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 ILE A 114
GLY A 121
GLY A 448
LEU A 451
ILE A 430
 None
 0.99A 2y7kD-5w1jA:
0.8		 2y7kD-5w1jA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 ILE A 115
GLY A 228
GLY A 401
LEU A 402
ILE A 230
 FAD  A 601 (-4.7A)
FAD  A 601 (-3.8A)
None
None
None
 1.20A 2y7kD-5w1jA:
0.8		 2y7kD-5w1jA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE

(Campylobacter
jejuni) 		no annotation 5 THR A 470
ILE A 467
GLY A 468
GLY A 465
HIS A 445
 None
 1.05A 2y7kD-6cf8A:
undetectable		 2y7kD-6cf8A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dhi -

(-) 		no annotation 5 ILE A 388
GLY A 389
PHE A 393
LEU A 422
ILE A 452
 None
 1.22A 2y7kD-6dhiA:
undetectable		 2y7kD-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 5 ILE A 322
GLY A 577
TYR A 596
LEU A 580
ILE A 595
 None
 1.22A 2y7kD-6eksA:
undetectable		 2y7kD-6eksA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 5 THR A 560
ILE A 328
TYR A 329
HIS A 562
PRO A 347
 None
 1.17A 2y7kD-6fmqA:
undetectable		 2y7kD-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 5 ILE A  30
GLY A  32
PHE A 271
LEU A 398
ILE A 264
 None
 1.14A 2y7kD-6fv5A:
undetectable		 2y7kD-6fv5A:
18.14