SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7K_C_SALC1302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua)
PF00026
(Asp)
5 GLY A  85
GLY A  68
HIS A  44
PRO A  58
ILE A  83
None
1.22A 2y7kC-1am5A:
undetectable
2y7kC-1am5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
5 ILE A 389
GLY A 396
TYR A 385
PHE A 395
PHE A 374
None
1.25A 2y7kC-1aorA:
undetectable
2y7kC-1aorA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
5 ILE A 240
PHE A 243
PHE A 194
ARG A 311
ILE A 193
None
None
None
GAP  A1550 (-3.8A)
None
1.25A 2y7kC-1ggmA:
undetectable
2y7kC-1ggmA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
5 ILE A 243
GLY A 244
TYR A 247
PHE A 288
HIS A 182
None
None
10A  A 901 ( 4.3A)
10A  A 901 ( 4.9A)
CO3  A 902 (-3.8A)
1.22A 2y7kC-1kpiA:
undetectable
2y7kC-1kpiA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE


(Methanosarcina
barkeri)
PF05369
(MtmB)
5 THR A 274
GLY A 270
GLY A 266
HIS A 300
ILE A 301
None
1.28A 2y7kC-1l2qA:
undetectable
2y7kC-1l2qA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME


(Eisenia fetida)
PF00089
(Trypsin)
5 THR A 188
ILE A 160
GLY A 189
GLY A 186
PRO A 161
None
1.32A 2y7kC-1m9uA:
undetectable
2y7kC-1m9uA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE


(Drosophila
melanogaster)
PF00106
(adh_short)
5 ILE A  18
GLY A  19
PHE A  11
GLY A  92
PRO A 182
NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.6A)
NAI  A 850 (-3.8A)
1.12A 2y7kC-1mg5A:
undetectable
2y7kC-1mg5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus)
no annotation 5 PHE A 197
GLY A 250
HIS A  98
PRO A  96
ILE A 245
None
1.21A 2y7kC-1nnwA:
undetectable
2y7kC-1nnwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum)
PF05067
(Mn_catalase)
5 GLY A  38
GLY A  63
PHE A 185
HIS A 181
HIS A  69
None
None
None
MN3  A 268 ( 3.2A)
MN3  A 267 ( 3.3A)
1.24A 2y7kC-1o9iA:
undetectable
2y7kC-1o9iA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Pelophylax
perezi)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 THR A1145
GLY A1066
GLY A1044
PHE A1357
ILE A1045
None
1.32A 2y7kC-1p0cA:
undetectable
2y7kC-1p0cA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER


(Rhodobacter
sphaeroides)
PF00124
(Photo_RC)
5 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
1.21A 2y7kC-1pssM:
undetectable
2y7kC-1pssM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Plasmodium
falciparum)
PF00160
(Pro_isomerase)
5 ILE A  74
GLY A  72
PHE A 119
PHE A   9
ILE A 165
None
1.22A 2y7kC-1qnhA:
undetectable
2y7kC-1qnhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans)
PF00232
(Glyco_hydro_1)
5 ILE A 291
GLY A 292
TYR A 352
GLY A 218
PRO A 349
None
1.13A 2y7kC-1qoxA:
undetectable
2y7kC-1qoxA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ILE A 403
GLY A 373
PHE A 428
PHE A 364
ARG A 401
None
1.29A 2y7kC-1r9jA:
undetectable
2y7kC-1r9jA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III


(Schizosaccharomyces
pombe)
PF00291
(PALP)
5 THR A 239
GLY A 183
GLY A 236
PHE A  56
PRO A 151
None
PLP  A 350 (-3.3A)
PLP  A 350 (-4.7A)
PLP  A 350 (-4.7A)
None
1.10A 2y7kC-1v71A:
undetectable
2y7kC-1v71A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus)
PF00291
(PALP)
5 THR A 235
GLY A 178
GLY A 232
PHE A  50
PRO A 142
None
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.7A)
PLP  A 413 (-4.6A)
None
1.00A 2y7kC-1ve5A:
undetectable
2y7kC-1ve5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE


(Homo sapiens)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 THR A  92
ILE A  98
GLY A  97
GLY A 276
ILE A 280
THR  A  92 ( 0.8A)
ILE  A  98 ( 0.7A)
GLY  A  97 ( 0.0A)
GLY  A 276 ( 0.0A)
ILE  A 280 ( 0.7A)
1.26A 2y7kC-1wsvA:
undetectable
2y7kC-1wsvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima)
PF02065
(Melibiase)
5 ILE A 326
GLY A 367
PHE A 348
PRO A 260
ILE A 352
None
1.24A 2y7kC-1zy9A:
undetectable
2y7kC-1zy9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158


(Methanocaldococcus
jannaschii)
PF03841
(SelA)
5 THR A  52
ILE A  54
GLY A  55
TYR A  58
PHE A  59
None
1.06A 2y7kC-2aeuA:
undetectable
2y7kC-2aeuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1


(Homo sapiens)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
5 ILE A 211
GLY A 218
GLY A 203
ARG A 187
ILE A  84
None
1.28A 2y7kC-2b3xA:
undetectable
2y7kC-2b3xA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
no annotation 5 PHE A 197
GLY A 250
HIS A  98
PRO A  96
ILE A 245
None
1.18A 2y7kC-2gjuA:
undetectable
2y7kC-2gjuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np5 TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF00440
(TetR_N)
PF13977
(TetR_C_6)
5 THR A 143
ILE A 141
GLY A 142
GLY A 190
PRO A  81
None
1.10A 2y7kC-2np5A:
undetectable
2y7kC-2np5A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE


(Renilla
reniformis)
PF00561
(Abhydrolase_1)
5 GLY A  82
GLY A  85
HIS A  97
PRO A 215
ILE A  79
None
1.32A 2y7kC-2psfA:
undetectable
2y7kC-2psfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3


(Homo sapiens)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 THR A 316
ILE A 313
GLY A 271
PHE A 293
ILE A 272
None
1.27A 2y7kC-2qk4A:
undetectable
2y7kC-2qk4A:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia)
PF03466
(LysR_substrate)
5 GLY A 152
PHE A 167
HIS A 169
PRO A 246
ILE A 273
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.4A)
None
SCN  A1303 (-4.1A)
1.22A 2y7kC-2uyeA:
32.6
2y7kC-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia)
PF03466
(LysR_substrate)
8 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
HIS A 206
PRO A 246
ILE A 273
SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
0.77A 2y7kC-2uyeA:
32.6
2y7kC-2uyeA:
70.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v84 SPERMIDINE/PUTRESCIN
E ABC TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN


(Treponema
pallidum)
PF13416
(SBP_bac_8)
5 THR A 279
ILE A 280
PHE A 276
GLY A 112
PRO A 108
None
1.21A 2y7kC-2v84A:
3.3
2y7kC-2v84A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)


(Arabidopsis
thaliana)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 ILE A 683
GLY A 679
TYR A 682
GLY A 708
ARG A 686
None
1.34A 2y7kC-2wtbA:
undetectable
2y7kC-2wtbA:
15.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN


(Burkholderia
sp. DNT)
PF03466
(LysR_substrate)
12 THR A 104
ILE A 106
GLY A 107
TYR A 110
PHE A 111
GLY A 152
PHE A 167
HIS A 169
HIS A 206
PRO A 246
ARG A 248
ILE A 273
None
0.61A 2y7kC-2y7rA:
32.5
2y7kC-2y7rA:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN


(Yersinia pestis)
no annotation 5 GLY X   6
GLY X  53
PHE X 277
PRO X  12
ILE X 258
None
1.13A 2y7kC-2z22X:
10.2
2y7kC-2z22X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
5 ILE A 123
GLY A 122
TYR A 119
ARG A 117
ILE A 272
None
1.23A 2y7kC-3a24A:
undetectable
2y7kC-3a24A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 ILE A 140
GLY A 141
GLY A 145
HIS A  69
ARG A  45
None
0.71A 2y7kC-3aoeA:
undetectable
2y7kC-3aoeA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE


(Micrococcus
luteus)
PF00348
(polyprenyl_synt)
5 PHE B  51
GLY B 204
PHE B 199
HIS B 317
ILE B 203
None
1.34A 2y7kC-3aqcB:
undetectable
2y7kC-3aqcB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
None
0.95A 2y7kC-3d1jA:
undetectable
2y7kC-3d1jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB4
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7


(Schizosaccharomyces
pombe)
PF00575
(S1)
PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N)
5 THR G 153
ILE G 158
GLY G  41
PHE D  19
PRO G  82
None
1.34A 2y7kC-3h0gG:
undetectable
2y7kC-3h0gG:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis)
PF01266
(DAO)
5 ILE A 312
GLY A 313
PHE A 210
HIS A 327
PRO A 310
None
1.34A 2y7kC-3if9A:
undetectable
2y7kC-3if9A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083


(Pyrococcus
furiosus)
PF01593
(Amino_oxidase)
5 ILE A 294
GLY A 296
PHE A 297
PHE A 341
ILE A 340
None
1.31A 2y7kC-3nrnA:
undetectable
2y7kC-3nrnA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA


(Vibrio cholerae)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 THR B 153
ILE B 129
PHE B 208
PRO B 201
ILE B 207
None
1.25A 2y7kC-3o8qB:
3.5
2y7kC-3o8qB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvd CAPSID

(Norwalk virus)
PF08435
(Calici_coat_C)
5 THR A 275
GLY A 321
GLY A 324
PHE A 286
PRO A 403
None
1.32A 2y7kC-3pvdA:
undetectable
2y7kC-3pvdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvd CAPSID

(Norwalk virus)
PF08435
(Calici_coat_C)
5 THR A 442
ILE A 388
GLY A 437
GLY A 440
ARG A 351
None
1.18A 2y7kC-3pvdA:
undetectable
2y7kC-3pvdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii)
PF14531
(Kinase-like)
5 ILE A 453
GLY A 450
TYR A 454
GLY A 504
PHE A 489
None
1.12A 2y7kC-3q60A:
undetectable
2y7kC-3q60A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica)
PF13561
(adh_short_C2)
5 THR A 254
GLY A 251
PHE A 250
GLY A 230
ILE A 232
None
None
None
NAD  A 300 (-4.7A)
NAD  A 300 (-4.3A)
0.97A 2y7kC-3r3sA:
undetectable
2y7kC-3r3sA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE


(Scaptodrosophila
lebanonensis)
PF00106
(adh_short)
5 ILE A  17
GLY A  18
PHE A  10
GLY A  91
PRO A 181
NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.7A)
NAD  A 850 (-3.9A)
1.11A 2y7kC-3rj9A:
undetectable
2y7kC-3rj9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL


(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
5 THR A1490
GLY A1517
PHE A1544
HIS A1170
ILE A1549
None
1.28A 2y7kC-3topA:
undetectable
2y7kC-3topA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE


(Leptospirillum
rubarum)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 THR A 292
GLY A 303
GLY A 301
PHE A  -2
ARG A 327
None
1.32A 2y7kC-3ttgA:
undetectable
2y7kC-3ttgA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor)
PF01353
(GFP)
PF13499
(EF-hand_7)
5 GLY A 251
TYR A 247
PHE A 277
GLY A 274
ILE A 253
None
1.16A 2y7kC-3u0kA:
undetectable
2y7kC-3u0kA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
None
None
None
URE  A1902 (-4.3A)
None
1.02A 2y7kC-3va7A:
undetectable
2y7kC-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
None
None
None
URE  A1902 (-4.3A)
None
1.26A 2y7kC-3va7A:
undetectable
2y7kC-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa)
PF12697
(Abhydrolase_6)
5 ILE A 170
GLY A 145
GLY A  77
HIS A 300
PRO A 299
None
1.35A 2y7kC-3w04A:
undetectable
2y7kC-3w04A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB


(Pseudomonas
aeruginosa)
PF00873
(ACR_tran)
5 THR A1011
ILE A 909
GLY A 907
GLY A1007
PHE A 926
None
0.98A 2y7kC-3w9iA:
undetectable
2y7kC-3w9iA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
5 THR A 226
GLY A 228
PHE A 166
HIS A 240
ILE A 146
None
None
BGC  A 605 ( 3.8A)
None
None
1.22A 2y7kC-3wy2A:
undetectable
2y7kC-3wy2A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens)
PF00704
(Glyco_hydro_18)
5 TYR A 207
PHE A 180
GLY A 211
PHE A 235
PRO A 263
None
1.31A 2y7kC-4axnA:
undetectable
2y7kC-4axnA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7


(Zobellia
galactanivorans)
PF08787
(Alginate_lyase2)
5 THR A 102
ILE A  94
GLY A  57
PHE A  73
ILE A 324
None
1.00A 2y7kC-4be3A:
undetectable
2y7kC-4be3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Synechococcus
elongatus)
PF13561
(adh_short_C2)
5 ILE A 191
GLY A 214
TYR A 213
GLY A 244
ILE A 208
None
1.26A 2y7kC-4dmmA:
undetectable
2y7kC-4dmmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE


(Arabidopsis
thaliana)
PF02431
(Chalcone)
5 THR A 196
ILE A  45
GLY A  29
GLY A  27
ARG A  89
None
1.30A 2y7kC-4dokA:
undetectable
2y7kC-4dokA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE


(Homo sapiens)
PF13561
(adh_short_C2)
5 THR A 214
ILE A  40
GLY A  39
GLY A 216
PRO A 208
NAP  A 401 (-3.0A)
NAP  A 401 (-4.0A)
NAP  A 401 (-3.2A)
NAP  A 401 (-3.2A)
NAP  A 401 (-4.0A)
1.34A 2y7kC-4fc7A:
undetectable
2y7kC-4fc7A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9y E3 SUMO-PROTEIN
LIGASE RANBP2


(Homo sapiens)
PF00160
(Pro_isomerase)
5 ILE A  67
GLY A  65
PHE A 112
PHE A   8
ILE A 158
None
1.26A 2y7kC-4i9yA:
undetectable
2y7kC-4i9yA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imi SYMPLEKIN

(Drosophila
melanogaster)
PF11935
(DUF3453)
5 ILE A 130
GLY A 128
TYR A 131
PHE A 180
ILE A 158
None
1.27A 2y7kC-4imiA:
undetectable
2y7kC-4imiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE


([Oscillatoria]
sp. PCC 6506)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 ILE A 370
GLY A 366
GLY A 133
PHE A 237
ILE A 136
None
FAD  A 400 ( 4.8A)
FAD  A 400 (-3.5A)
None
None
1.18A 2y7kC-4irnA:
undetectable
2y7kC-4irnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
5 THR A 291
GLY A 292
PHE A 293
GLY A 322
ILE A 321
None
1.26A 2y7kC-4jhzA:
undetectable
2y7kC-4jhzA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jro FABG PROTEIN

(Listeria
monocytogenes)
PF13561
(adh_short_C2)
5 ILE A 188
GLY A 214
TYR A 213
GLY A 243
ILE A 208
None
1.23A 2y7kC-4jroA:
undetectable
2y7kC-4jroA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D


(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
5 THR A 168
GLY A 167
TYR A 192
PHE A 166
ARG A 191
None
1.25A 2y7kC-4jwyA:
8.2
2y7kC-4jwyA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Archaeoglobus
fulgidus)
PF00215
(OMPdecase)
5 THR A 131
ILE A 162
TYR A 128
PRO A 186
ILE A 183
None
BMP  A 301 ( 4.9A)
None
BMP  A 301 (-4.3A)
None
1.18A 2y7kC-4muzA:
undetectable
2y7kC-4muzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 GLY H  31
TYR H  32
GLY H  31
PRO H 100
ARG H  96
None
1.34A 2y7kC-4nzrH:
undetectable
2y7kC-4nzrH:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pde PROTEIN FDHD

(Escherichia
coli)
PF02634
(FdhD-NarQ)
5 GLY A 133
GLY A  74
HIS A  52
ARG A 112
ILE A  75
None
1.34A 2y7kC-4pdeA:
undetectable
2y7kC-4pdeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE


(Cupriavidus
necator)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 THR A 159
GLY A 156
GLY A 138
PHE A 187
ILE A 154
None
1.34A 2y7kC-4pzcA:
undetectable
2y7kC-4pzcA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN


(Sphingobium
chlorophenolicum)
PF03466
(LysR_substrate)
5 GLY A 107
GLY A 152
PHE A 167
PRO A 248
ARG A 250
None
0.73A 2y7kC-4rnsA:
24.6
2y7kC-4rnsA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN


(Sphingobium
chlorophenolicum)
PF03466
(LysR_substrate)
5 GLY A 107
PHE A 151
PHE A 167
PRO A 248
ARG A 250
None
1.20A 2y7kC-4rnsA:
24.6
2y7kC-4rnsA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)


(Mycobacterium
tuberculosis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A   5
PHE A  58
GLY A  61
HIS A 313
ARG A  48
None
1.17A 2y7kC-4rvsA:
undetectable
2y7kC-4rvsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN


(Chloroflexus
aurantiacus)
PF13407
(Peripla_BP_4)
5 ILE A 135
TYR A 137
GLY A  54
PHE A  72
ILE A  55
None
1.21A 2y7kC-4rxuA:
2.8
2y7kC-4rxuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE


(Synechocystis
sp. PCC 6803)
PF13561
(adh_short_C2)
5 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
None
1.17A 2y7kC-4rzhA:
undetectable
2y7kC-4rzhA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7


(Homo sapiens)
PF00514
(Arm)
PF16186
(Arm_3)
5 THR A 410
ILE A 414
GLY A 409
PHE A 380
ILE A 375
None
1.29A 2y7kC-4uadA:
undetectable
2y7kC-4uadA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v08 UL26

(Suid
alphaherpesvirus
1)
PF00716
(Peptidase_S21)
5 THR A 140
ILE A 141
GLY A 139
GLY A 135
ILE A 134
None
None
None
DFP  A 300 (-3.6A)
None
1.34A 2y7kC-4v08A:
undetectable
2y7kC-4v08A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE


(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 THR A  50
ILE A  78
GLY A  77
GLY A  48
PRO A  80
None
1.32A 2y7kC-4wkyA:
undetectable
2y7kC-4wkyA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 GLY A 161
PHE A 184
GLY A 139
HIS A 166
ILE A 140
None
None
None
NAG  A 702 (-4.8A)
None
1.06A 2y7kC-4z64A:
undetectable
2y7kC-4z64A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans)
PF00006
(ATP-synt_ab)
5 THR B 113
ILE B 115
GLY B 114
PHE B 383
PRO B 316
None
1.25A 2y7kC-5bn4B:
1.3
2y7kC-5bn4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda)
PF00232
(Glyco_hydro_1)
5 THR A 184
GLY A 243
PHE A 280
PRO A 188
ILE A 279
None
1.33A 2y7kC-5cg0A:
undetectable
2y7kC-5cg0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN


(Measles
morbillivirus)
PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT)
5 THR A  51
ILE A  16
GLY A  52
GLY A  47
HIS A  14
None
1.32A 2y7kC-5e4vA:
undetectable
2y7kC-5e4vA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 THR A 181
ILE A 167
GLY A 321
GLY A 159
ILE A 158
None
1.32A 2y7kC-5eb5A:
undetectable
2y7kC-5eb5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE


(Clostridium
sardiniense)
PF13561
(adh_short_C2)
5 THR A 193
ILE A 191
GLY A 192
GLY A  17
PRO A 188
NAP  A 301 (-2.9A)
NAP  A 301 (-3.9A)
None
NAP  A 301 (-3.3A)
NAP  A 301 (-3.7A)
1.32A 2y7kC-5epoA:
undetectable
2y7kC-5epoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA, PUTATIVE


(Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
5 THR A  35
GLY A  88
GLY A 175
PRO A 162
ILE A 174
None
1.32A 2y7kC-5fmgA:
undetectable
2y7kC-5fmgA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1


(Mus musculus)
PF01344
(Kelch_1)
5 THR A 560
ILE A 328
TYR A 329
HIS A 562
PRO A 347
None
1.26A 2y7kC-5fnuA:
undetectable
2y7kC-5fnuA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
None
None
None
None
GOL  A 403 ( 4.0A)
1.13A 2y7kC-5hctA:
undetectable
2y7kC-5hctA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
None
1.02A 2y7kC-5i8iA:
2.3
2y7kC-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
None
1.25A 2y7kC-5i8iA:
2.3
2y7kC-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldx NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11


(Bos taurus)
PF02466
(Tim17)
5 ILE Y  91
GLY Y  92
TYR Y  89
PHE Y  69
GLY Y 118
None
1.27A 2y7kC-5ldxY:
undetectable
2y7kC-5ldxY:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npa LOQUACIOUS

(Drosophila
melanogaster)
PF00035
(dsrm)
5 THR A  40
ILE A  41
GLY A  52
GLY A  54
ARG A  62
None
1.28A 2y7kC-5npaA:
undetectable
2y7kC-5npaA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okz EXOSOME COMPLEX
COMPONENT RRP4


(Saccharomyces
cerevisiae)
PF14382
(ECR1_N)
PF15985
(KH_6)
5 ILE H 128
GLY H 129
GLY H 229
PHE H 199
ARG H 115
None
None
None
None
CL  H 401 (-3.9A)
1.01A 2y7kC-5okzH:
undetectable
2y7kC-5okzH:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT II


(Synechocystis
sp. PCC 6803)
no annotation 5 THR 4  33
ILE 4  80
TYR 4  83
PHE 4 104
ARG 4  73
None
1.31A 2y7kC-5oy04:
undetectable
2y7kC-5oy04:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
None
1.09A 2y7kC-5p60A:
undetectable
2y7kC-5p60A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB


(Shigella
flexneri)
PF00006
(ATP-synt_ab)
5 THR A 138
ILE A 140
GLY A 139
PHE A 407
PRO A 340
None
1.31A 2y7kC-5swjA:
1.4
2y7kC-5swjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium)
PF02310
(B12-binding)
5 ILE A 298
GLY A 296
GLY A 349
ARG A 302
ILE A 354
None
1.24A 2y7kC-5ul4A:
undetectable
2y7kC-5ul4A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8x LIPID-A-DISACCHARIDE
SYNTHASE


(Escherichia
coli)
no annotation 6 THR A 140
ILE A 136
GLY A 137
HIS A 119
PRO A 123
ARG A 132
None
1.39A 2y7kC-5w8xA:
undetectable
2y7kC-5w8xA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*


(unidentified)
no annotation 5 THR A 199
ILE A  48
GLY A  32
GLY A  30
ARG A  92
None
1.25A 2y7kC-5wl7A:
undetectable
2y7kC-5wl7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER


(Roseiflexus
castenholzii)
no annotation 5 THR M 545
ILE M 546
GLY M 543
HIS M 589
ILE M 588
MQE  M 701 (-4.0A)
None
None
FE  L1005 (-3.2A)
MQE  M 701 (-4.4A)
1.20A 2y7kC-5yq7M:
undetectable
2y7kC-5yq7M:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bka NITRONATE
MONOOXYGENASE


(Cyberlindnera
mrakii)
no annotation 5 GLY A  47
PHE A 148
HIS A  81
PRO A 322
ARG A 296
None
1.26A 2y7kC-6bkaA:
undetectable
2y7kC-6bkaA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE


(Escherichia
coli)
no annotation 5 GLY A 314
TYR A 317
PHE A 358
GLY A 269
HIS A 266
None
LOP  A 402 ( 3.7A)
LOP  A 402 ( 4.6A)
None
CO3  A 401 (-4.0A)
1.25A 2y7kC-6bqcA:
undetectable
2y7kC-6bqcA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE


(Campylobacter
jejuni)
no annotation 5 THR A 470
ILE A 467
GLY A 468
GLY A 465
HIS A 445
None
1.07A 2y7kC-6cf8A:
undetectable
2y7kC-6cf8A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-)
no annotation 5 THR A 560
ILE A 328
TYR A 329
HIS A 562
PRO A 347
None
1.18A 2y7kC-6fmqA:
undetectable
2y7kC-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11


(Mus musculus)
no annotation 5 ILE Y  91
GLY Y  92
TYR Y  89
PHE Y  69
GLY Y 118
None
1.32A 2y7kC-6g72Y:
undetectable
2y7kC-6g72Y:
17.92