SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7K_B_SALB1305_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 SER A 334
ARG A 266
PRO A 236
GLY A 237
 None
 1.22A 2y7kB-1ethA:
0.0		 2y7kB-1ethA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		4 SER A  81
ARG A  79
PRO A  55
GLY A  56
 None
 1.02A 2y7kB-1i4wA:
0.8		 2y7kB-1i4wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 SER A 229
ARG A 245
PRO A 283
GLY A 284
 DAN  A 700 ( 4.3A)
DAN  A 700 (-2.8A)
None
None
 1.33A 2y7kB-1ms8A:
undetectable		 2y7kB-1ms8A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 ARG A 602
PRO A 585
GLY A 584
TRP A 633
 None
 1.49A 2y7kB-1obhA:
0.0		 2y7kB-1obhA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 SER A 974
PRO A 946
GLY A 977
TRP A 959
 None
 1.46A 2y7kB-1ux6A:
undetectable		 2y7kB-1ux6A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xty PEPTIDYL-TRNA
HYDROLASE

(Sulfolobus
solfataricus) 		PF01981
(PTH2) 		4 SER A  33
PRO A 104
GLY A 103
TRP A  42
 None
 1.05A 2y7kB-1xtyA:
undetectable		 2y7kB-1xtyA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 SER 1 597
ARG 1 248
GLY 1 245
TRP 1 246
 None
 1.36A 2y7kB-1y791:
0.0		 2y7kB-1y791:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 SER C 393
ARG C 306
GLY C 381
TRP C 379
 None
 0.98A 2y7kB-1zrtC:
undetectable		 2y7kB-1zrtC:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 349
PRO A 359
GLY A 355
TRP A 353
 None
 1.32A 2y7kB-2bucA:
0.0		 2y7kB-2bucA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 ARG A 230
PRO A  47
GLY A  46
TRP A  45
 None
 1.38A 2y7kB-2cfbA:
undetectable		 2y7kB-2cfbA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc5 GLUTATHIONE
S-TRANSFERASE, MU 7

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 SER A 146
ARG A 143
PRO A 139
GLY A 140
 None
 1.35A 2y7kB-2dc5A:
undetectable		 2y7kB-2dc5A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 SER A 499
ARG A 493
PRO A 171
GLY A 511
 None
 1.34A 2y7kB-2eidA:
undetectable		 2y7kB-2eidA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 349
PRO A 359
GLY A 355
TRP A 353
 None
 1.20A 2y7kB-2g5tA:
undetectable		 2y7kB-2g5tA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE

(Agrobacterium
tumefaciens) 		PF01261
(AP_endonuc_2) 		4 SER A 213
ARG A 216
GLY A 221
TRP A 225
 SER  A 213 ( 0.0A)
ARG  A 216 ( 0.6A)
GLY  A 221 ( 0.0A)
TRP  A 225 ( 0.5A)
 1.47A 2y7kB-2hk0A:
undetectable		 2y7kB-2hk0A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 347
PRO A 357
GLY A 353
TRP A 351
 None
 1.27A 2y7kB-2oaeA:
undetectable		 2y7kB-2oaeA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzd COMPLEMENT
DECAY-ACCELERATING
FACTOR

(Homo sapiens) 		PF00084
(Sushi) 		4 SER A1232
PRO A1247
GLY A1246
TRP A1244
 None
 1.30A 2y7kB-2qzdA:
undetectable		 2y7kB-2qzdA:
14.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		5 SER A  95
ARG A  97
PRO A 285
GLY A 286
TRP A 289
 None
 0.36A 2y7kB-2uyeA:
30.5		 2y7kB-2uyeA:
70.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1

(Mycobacterium
tuberculosis) 		PF02391
(MoaE) 		4 SER A 106
ARG A  84
PRO A  32
GLY A  31
 None
 1.29A 2y7kB-2wp4A:
undetectable		 2y7kB-2wp4A:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN

(Burkholderia
sp. DNT) 		PF03466
(LysR_substrate) 		5 SER A  95
ARG A  97
PRO A 285
GLY A 286
TRP A 289
 None
 0.35A 2y7kB-2y7rA:
30.7		 2y7kB-2y7rA:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		4 SER A  59
PRO A  86
GLY A  67
TRP A  64
 None
 1.29A 2y7kB-2zbaA:
undetectable		 2y7kB-2zbaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		4 SER A 356
ARG A 355
GLY A 391
TRP A 495
 None
 1.46A 2y7kB-3axiA:
undetectable		 2y7kB-3axiA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
PHOSPHOTRANSFERASE
SUBUNIT DHAM

(Lactococcus
lactis) 		PF03610
(EIIA-man) 		4 SER C  45
ARG C  48
PRO C  12
GLY C  35
 None
 1.10A 2y7kB-3cr3C:
undetectable		 2y7kB-3cr3C:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 189
PRO A 148
GLY A 149
TRP A 142
 None
None
None
GOL  A 700 ( 4.9A)
 1.45A 2y7kB-3fcjA:
undetectable		 2y7kB-3fcjA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcg PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB

(Neisseria
meningitidis) 		PF01641
(SelR) 		4 SER A 444
ARG A 493
PRO A 486
GLY A 485
 None
 1.38A 2y7kB-3hcgA:
undetectable		 2y7kB-3hcgA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 SER A 231
ARG A 258
PRO A 293
GLY A 180
 None
SO4  A 378 (-2.9A)
None
None
 1.42A 2y7kB-3ic1A:
undetectable		 2y7kB-3ic1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j40 GP7

(Salmonella
virus Epsilon15) 		no annotation 4 SER A 229
ARG A 231
GLY A 181
TRP A 180
 None
 0.90A 2y7kB-3j40A:
undetectable		 2y7kB-3j40A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 ARG A 247
PRO A  64
GLY A  63
TRP A  62
 None
 1.35A 2y7kB-3k28A:
undetectable		 2y7kB-3k28A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		4 SER A  57
ARG A  35
PRO A 135
GLY A 136
 None
 1.29A 2y7kB-3mhpA:
0.6		 2y7kB-3mhpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A  92
PRO A 387
GLY A 111
TRP A 384
 None
 1.36A 2y7kB-3ppsA:
undetectable		 2y7kB-3ppsA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		4 SER A 130
ARG A 132
PRO A  80
GLY A  81
 None
HM3  A 255 ( 4.2A)
None
None
 1.36A 2y7kB-3rhyA:
undetectable		 2y7kB-3rhyA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 SER A 157
ARG A 156
PRO A 106
GLY A 107
 None
 1.15A 2y7kB-3t57A:
undetectable		 2y7kB-3t57A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 SER A 465
ARG A 464
GLY A 462
TRP A 463
 None
 1.37A 2y7kB-3zdnA:
undetectable		 2y7kB-3zdnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 SER A 335
ARG A 366
PRO A 327
GLY A 326
 None
 1.32A 2y7kB-4a7kA:
undetectable		 2y7kB-4a7kA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		4 SER A  40
ARG A  37
PRO A  33
GLY A  34
 None
None
CL  A 205 (-3.3A)
None
 1.13A 2y7kB-4hc6A:
undetectable		 2y7kB-4hc6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ARG A 224
PRO A 245
GLY A 244
TRP A 218
 G39  A 509 (-4.7A)
None
None
None
 1.33A 2y7kB-4hzzA:
undetectable		 2y7kB-4hzzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE

(Cupriavidus
metallidurans) 		PF00378
(ECH_1) 		4 SER A 125
ARG A 127
PRO A  56
GLY A  57
 None
 1.00A 2y7kB-4jcsA:
undetectable		 2y7kB-4jcsA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l11 AGAP007709-PA

(Anopheles
gambiae) 		PF00027
(cNMP_binding) 		4 SER A 622
ARG A 619
PRO A 615
GLY A 616
 None
 1.30A 2y7kB-4l11A:
undetectable		 2y7kB-4l11A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lf3 GLUCAGON RECEPTOR

(Homo sapiens) 		PF02793
(HRM) 		4 SER C  66
ARG C 116
PRO C 114
TRP C 106
 None
 1.12A 2y7kB-4lf3C:
undetectable		 2y7kB-4lf3C:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncc FAB FRAGMENT LIGHT

(Mus musculus) 		no annotation 4 SER L  75
ARG L  76
PRO L  15
GLY L  16
 None
 1.48A 2y7kB-4nccL:
undetectable		 2y7kB-4nccL:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0r CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Homo sapiens) 		PF02732
(ERCC4) 		4 SER B 542
ARG B 544
PRO B 547
GLY B 546
 None
 1.25A 2y7kB-4p0rB:
undetectable		 2y7kB-4p0rB:
20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN

(Sphingobium
chlorophenolicum) 		PF03466
(LysR_substrate) 		5 SER A  95
ARG A  97
PRO A 287
GLY A 288
TRP A 291
 None
 0.56A 2y7kB-4rnsA:
25.4		 2y7kB-4rnsA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 SER A 238
ARG A 240
PRO A 215
GLY A 214
 None
 1.29A 2y7kB-4rsmA:
2.5		 2y7kB-4rsmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF04069
(OpuAC) 		4 ARG A 184
PRO A 239
GLY A 262
TRP A 241
 None
 1.39A 2y7kB-4xz6A:
9.6		 2y7kB-4xz6A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN

(Homo sapiens) 		PF00533
(BRCT) 		4 SER A1755
ARG A1751
PRO A1749
GLY A1748
 None
 1.48A 2y7kB-4y18A:
undetectable		 2y7kB-4y18A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yuf CORB

(Corallococcus
coralloides) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A  27
PRO A  38
GLY A  39
TRP A  40
 None
 1.44A 2y7kB-4yufA:
undetectable		 2y7kB-4yufA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft1 GP37

(Pseudomonas
virus phiKZ) 		no annotation 4 SER A  76
ARG A  77
PRO A 132
GLY A 133
 None
 0.76A 2y7kB-5ft1A:
undetectable		 2y7kB-5ft1A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 SER F 352
ARG F1056
PRO F1059
GLY F1058
 None
 1.36A 2y7kB-5gjwF:
undetectable		 2y7kB-5gjwF:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdm GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3) 		4 ARG A 253
PRO A  70
GLY A  69
TRP A  68
 None
 1.29A 2y7kB-5hdmA:
undetectable		 2y7kB-5hdmA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 ARG A 244
PRO A  61
GLY A  60
TRP A  59
 None
 1.28A 2y7kB-5i92A:
undetectable		 2y7kB-5i92A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 SER A 129
ARG A 126
PRO A 122
GLY A 123
 None
 1.18A 2y7kB-5iuwA:
1.4		 2y7kB-5iuwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		4 SER A  56
ARG A  57
PRO A  53
GLY A  54
 None
 1.48A 2y7kB-5jrmA:
undetectable		 2y7kB-5jrmA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 SER A 386
ARG A 412
PRO A 139
GLY A 140
 None
 1.32A 2y7kB-5li8A:
undetectable		 2y7kB-5li8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 SER B 331
PRO B 275
GLY B 276
TRP B 279
 None
 1.28A 2y7kB-5ltmB:
undetectable		 2y7kB-5ltmB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		4 ARG B 379
PRO B 581
GLY B 580
TRP B 595
 None
 1.37A 2y7kB-5m5xB:
undetectable		 2y7kB-5m5xB:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00504
(Chloroa_b-bind) 		4 SER 4 232
ARG 4 233
PRO 4  78
GLY 4  79
 None
CLA  4 302 (-3.3A)
None
CLA  4 302 (-4.4A)
 1.46A 2y7kB-5mdx4:
undetectable		 2y7kB-5mdx4:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L28

(Mycolicibacterium
smegmatis) 		PF00830
(Ribosomal_L28) 		4 SER Y  26
PRO Y  12
GLY Y  13
TRP Y  29
 G  A 188 ( 2.6A)
A  A1480 ( 4.5A)
G  A 483 ( 3.4A)
G  A 483 ( 3.4A)
 0.97A 2y7kB-5o60Y:
undetectable		 2y7kB-5o60Y:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB5, CP26

(Pisum sativum) 		no annotation 4 ARG S 194
PRO S  54
GLY S  55
TRP S  26
 CLA  S 602 (-4.2A)
None
CLA  S 602 (-4.7A)
CLA  S 611 ( 4.1A)
 0.80A 2y7kB-5xnlS:
undetectable		 2y7kB-5xnlS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 SER C3579
ARG C3734
PRO C3677
GLY C3678
 None
 1.23A 2y7kB-5y3rC:
undetectable		 2y7kB-5y3rC:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Zea mays) 		no annotation 4 ARG Y 181
PRO Y  37
GLY Y  38
TRP Y  12
 CLA  Y 602 (-3.3A)
None
CLA  Y 602 (-4.5A)
CLA  Y 611 ( 4.6A)
 0.94A 2y7kB-5zjiY:
undetectable		 2y7kB-5zjiY:
16.83