SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7K_A_SALA1302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 GLY A  85
GLY A  68
HIS A  44
PRO A  58
ILE A  83
 None
 1.41A 2y7kA-1am5A:
0.0		 2y7kA-1am5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ILE A 389
GLY A 396
TYR A 385
PHE A 395
PHE A 374
 None
 1.24A 2y7kA-1aorA:
undetectable		 2y7kA-1aorA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLY B 279
GLY B 281
PHE B 334
HIS B 322
HIS B 221
 HAE  B 800 ( 4.5A)
None
None
None
KCX  B 219 (-4.0A)
 1.44A 2y7kA-1e9yB:
0.0		 2y7kA-1e9yB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A

(Robinia
pseudoacacia) 		PF00139
(Lectin_legB) 		5 THR A 213
GLY A  48
GLY A 108
PHE A  92
ILE A 109
 None
 1.43A 2y7kA-1fnzA:
0.0		 2y7kA-1fnzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		5 ILE A 285
PHE A 332
GLY A 253
PRO A 287
ILE A 281
 None
None
None
HEM  A 410 ( 4.8A)
None
 1.15A 2y7kA-1jioA:
undetectable		 2y7kA-1jioA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 162
ILE A 118
GLY A 115
TYR A 122
PHE A 133
 2HP  A 698 ( 4.1A)
None
2HP  A 698 (-3.6A)
None
None
 1.45A 2y7kA-1jscA:
0.8		 2y7kA-1jscA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		5 THR A 121
ILE A 125
GLY A 123
PHE A 108
GLY A 118
 None
 1.46A 2y7kA-1kqjA:
undetectable		 2y7kA-1kqjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		5 THR A 274
GLY A 270
GLY A 266
HIS A 300
ILE A 301
 None
 1.28A 2y7kA-1l2qA:
undetectable		 2y7kA-1l2qA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME

(Eisenia fetida) 		PF00089
(Trypsin) 		5 THR A 188
ILE A 160
GLY A 189
GLY A 186
PRO A 161
 None
 1.28A 2y7kA-1m9uA:
undetectable		 2y7kA-1m9uA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 ILE A  18
GLY A  19
PHE A  11
GLY A  92
PRO A 182
 NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.6A)
NAI  A 850 (-3.8A)
 1.02A 2y7kA-1mg5A:
1.1		 2y7kA-1mg5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 PHE A 197
GLY A 250
HIS A  98
PRO A  96
ILE A 245
 None
 1.29A 2y7kA-1nnwA:
undetectable		 2y7kA-1nnwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A1145
GLY A1066
GLY A1044
PHE A1357
ILE A1045
 None
 1.26A 2y7kA-1p0cA:
undetectable		 2y7kA-1p0cA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		5 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.29A 2y7kA-1pssM:
undetectable		 2y7kA-1pssM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Plasmodium
falciparum) 		PF00160
(Pro_isomerase) 		5 ILE A  74
GLY A  72
PHE A 119
PHE A   9
ILE A 165
 None
 1.29A 2y7kA-1qnhA:
undetectable		 2y7kA-1qnhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 THR A 154
GLY A 151
PHE A 330
PHE A 371
HIS A 480
 None
SO4  A 593 (-3.4A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.43A 2y7kA-1qonA:
undetectable		 2y7kA-1qonA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		5 THR A 239
GLY A 183
GLY A 236
PHE A  56
PRO A 151
 None
PLP  A 350 (-3.3A)
PLP  A 350 (-4.7A)
PLP  A 350 (-4.7A)
None
 0.97A 2y7kA-1v71A:
undetectable		 2y7kA-1v71A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 THR A 235
GLY A 178
GLY A 232
PHE A  50
PRO A 142
 None
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.7A)
PLP  A 413 (-4.6A)
None
 0.93A 2y7kA-1ve5A:
undetectable		 2y7kA-1ve5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  11
GLY A  10
PHE A 283
HIS A  22
ILE A  98
 None
 1.44A 2y7kA-1zh8A:
undetectable		 2y7kA-1zh8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		5 ILE A 326
GLY A 367
PHE A 348
PRO A 260
ILE A 352
 None
 1.34A 2y7kA-1zy9A:
undetectable		 2y7kA-1zy9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		5 THR A  52
ILE A  54
GLY A  55
TYR A  58
PHE A  59
 None
 1.00A 2y7kA-2aeuA:
undetectable		 2y7kA-2aeuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 ILE A 225
GLY A 208
GLY A 204
PRO A 232
ILE A 406
 None
 1.13A 2y7kA-2bmoA:
undetectable		 2y7kA-2bmoA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		5 GLY A 131
PHE A  42
PHE A 204
HIS A 203
ILE A 209
 None
 1.30A 2y7kA-2bszA:
undetectable		 2y7kA-2bszA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		5 THR A 228
GLY A 225
GLY A 219
PHE A  41
ILE A  38
 None
 1.27A 2y7kA-2nlyA:
undetectable		 2y7kA-2nlyA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		5 GLY A  82
GLY A  85
HIS A  97
PRO A 215
ILE A  79
 None
 1.22A 2y7kA-2psfA:
undetectable		 2y7kA-2psfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 THR A 316
ILE A 313
GLY A 271
PHE A 293
ILE A 272
 None
 1.28A 2y7kA-2qk4A:
undetectable		 2y7kA-2qk4A:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		7 THR A 104
GLY A 107
GLY A 152
PHE A 167
HIS A 206
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.92A 2y7kA-2uyeA:
30.2		 2y7kA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		7 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
None
SCN  A1303 (-4.1A)
 0.86A 2y7kA-2uyeA:
30.2		 2y7kA-2uyeA:
70.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2t TRANSCRIPTION FACTOR
RELB

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		5 ILE A 246
GLY A 204
PHE A 118
PRO A 111
ILE A 205
 None
 1.47A 2y7kA-2v2tA:
undetectable		 2y7kA-2v2tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 THR A 224
GLY A 218
GLY A 216
HIS A 125
ILE A 139
 None
 1.42A 2y7kA-2v9iA:
undetectable		 2y7kA-2v9iA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)

(Mycobacterium
tuberculosis) 		PF13185
(GAF_2) 		5 ILE A 103
PHE A  98
GLY A  84
HIS A 149
PRO A 150
 HEM  A 500 (-4.2A)
HEM  A 500 (-4.9A)
HEM  A 500 (-4.4A)
HEM  A 500 (-3.3A)
None
 1.42A 2y7kA-2w3gA:
undetectable		 2y7kA-2w3gA:
24.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN

(Burkholderia
sp. DNT) 		PF03466
(LysR_substrate) 		10 THR A 104
GLY A 107
TYR A 110
PHE A 111
GLY A 152
PHE A 167
HIS A 169
HIS A 206
PRO A 246
ILE A 273
 None
 0.84A 2y7kA-2y7rA:
30.6		 2y7kA-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7r LYSR-TYPE REGULATORY
PROTEIN

(Burkholderia
sp. DNT) 		PF03466
(LysR_substrate) 		10 THR A 104
ILE A 106
GLY A 107
TYR A 110
PHE A 111
GLY A 152
PHE A 167
HIS A 169
PRO A 246
ILE A 273
 None
 0.77A 2y7kA-2y7rA:
30.6		 2y7kA-2y7rA:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		5 ILE A 259
GLY A 177
TYR A 181
PHE A 172
GLY A 254
 None
 1.31A 2y7kA-2yysA:
undetectable		 2y7kA-2yysA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 5 GLY X   6
GLY X  53
PHE X 277
PRO X  12
ILE X 258
 None
 1.05A 2y7kA-2z22X:
5.7		 2y7kA-2z22X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 GLY A 345
PHE A 298
HIS A  64
HIS A 347
ILE A  11
 None
None
None
ZN  A 414 (-3.5A)
None
 1.41A 2y7kA-2zktA:
undetectable		 2y7kA-2zktA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		5 GLY A  67
GLY A  70
HIS A  81
PRO A 209
ILE A  64
 None
 1.30A 2y7kA-3a2lA:
undetectable		 2y7kA-3a2lA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		5 ILE A 100
GLY A  99
TYR A  95
PHE A 125
GLY A 122
 None
 1.11A 2y7kA-3adfA:
undetectable		 2y7kA-3adfA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 PHE B  51
GLY B 204
PHE B 199
HIS B 317
ILE B 203
 None
 1.34A 2y7kA-3aqcB:
undetectable		 2y7kA-3aqcB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b49 LIN2189 PROTEIN

(Listeria
innocua) 		PF06445
(GyrI-like) 		5 ILE A 186
GLY A  83
PHE A  32
PRO A  80
ILE A 104
 None
 1.24A 2y7kA-3b49A:
undetectable		 2y7kA-3b49A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		5 THR A 401
ILE A 422
GLY A 421
GLY A 367
PRO A 434
 None
 1.22A 2y7kA-3clqA:
undetectable		 2y7kA-3clqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 THR A 391
ILE A 370
GLY A 386
TYR A 385
GLY A 365
 None
 1.00A 2y7kA-3d1jA:
undetectable		 2y7kA-3d1jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezl ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF00106
(adh_short) 		5 THR A 190
ILE A 188
GLY A 189
GLY A  16
PRO A 185
 None
 1.43A 2y7kA-3ezlA:
undetectable		 2y7kA-3ezlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		5 ILE A  84
GLY A 238
TYR A 237
GLY A  87
PHE A 224
 None
 1.42A 2y7kA-3getA:
undetectable		 2y7kA-3getA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE B1101
GLY B1068
PHE A  72
PRO B1111
ILE B1067
 None
 1.14A 2y7kA-3hkzB:
undetectable		 2y7kA-3hkzB:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis) 		PF13649
(Methyltransf_25) 		5 THR A  73
ILE A 101
GLY A  74
PRO A 109
ILE A  53
 None
 1.36A 2y7kA-3kkzA:
undetectable		 2y7kA-3kkzA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksk TYPE-2 RESTRICTION
ENZYME PVUII

(Proteus hauseri) 		PF09225
(Endonuc-PvuII) 		5 ILE A  16
TYR A  19
GLY A 197
PHE A 192
ILE A 191
 None
 1.41A 2y7kA-3kskA:
undetectable		 2y7kA-3kskA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 5 THR B 376
ILE B 316
GLY B 312
GLY B 346
PRO B 343
 None
 1.36A 2y7kA-3kx2B:
undetectable		 2y7kA-3kx2B:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 125
PHE A 401
PHE A 379
HIS A 170
ILE A 385
 None
 1.46A 2y7kA-3l84A:
undetectable		 2y7kA-3l84A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		5 ILE A 413
GLY A 412
TYR A 424
GLY A 427
PRO A 436
 CL  A  23 (-3.9A)
GOL  A   8 (-4.0A)
GOL  A  10 (-3.5A)
None
None
 1.46A 2y7kA-3m1uA:
undetectable		 2y7kA-3m1uA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA

(Vibrio cholerae) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 THR B 153
ILE B 129
PHE B 208
PRO B 201
ILE B 207
 None
 1.19A 2y7kA-3o8qB:
3.1		 2y7kA-3o8qB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvd CAPSID

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 THR A 275
GLY A 321
GLY A 324
PHE A 286
PRO A 403
 None
 1.43A 2y7kA-3pvdA:
undetectable		 2y7kA-3pvdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE (INO1)

(Archaeoglobus
fulgidus) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 THR A  14
ILE A  11
GLY A  10
TYR A 260
HIS A  77
 None
NAD  A 396 (-4.4A)
NAD  A 396 (-3.2A)
NAD  A 396 (-3.9A)
None
 1.42A 2y7kA-3qw2A:
undetectable		 2y7kA-3qw2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE

(Scaptodrosophila
lebanonensis) 		PF00106
(adh_short) 		5 ILE A  17
GLY A  18
PHE A  10
GLY A  91
PRO A 181
 NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.7A)
NAD  A 850 (-3.9A)
 1.03A 2y7kA-3rj9A:
undetectable		 2y7kA-3rj9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 THR A1490
GLY A1517
PHE A1544
HIS A1170
ILE A1549
 None
 1.27A 2y7kA-3topA:
undetectable		 2y7kA-3topA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 GLY A 251
TYR A 247
PHE A 277
GLY A 274
ILE A 253
 None
 1.12A 2y7kA-3u0kA:
undetectable		 2y7kA-3u0kA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0n MRUBY

(Entacmaea
quadricolor) 		PF01353
(GFP) 		5 GLY A 100
TYR A  96
PHE A 126
GLY A 123
ILE A 102
 None
 1.14A 2y7kA-3u0nA:
undetectable		 2y7kA-3u0nA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
None
None
URE  A1902 (-4.3A)
None
 0.99A 2y7kA-3va7A:
undetectable		 2y7kA-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
 None
None
None
URE  A1902 (-4.3A)
None
 1.42A 2y7kA-3va7A:
undetectable		 2y7kA-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		5 ILE A 170
GLY A 145
GLY A  77
HIS A 300
PRO A 299
 None
 1.33A 2y7kA-3w04A:
undetectable		 2y7kA-3w04A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 THR A 226
GLY A 228
PHE A 166
HIS A 240
ILE A 146
 None
None
BGC  A 605 ( 3.8A)
None
None
 1.17A 2y7kA-3wy2A:
undetectable		 2y7kA-3wy2A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3r DUAL SPECIFICITY
PROTEIN PHOSPHATASE
19

(Homo sapiens) 		PF00782
(DSPc) 		5 ILE A 162
GLY A 163
PHE A 129
PRO A 189
ILE A 125
 None
 1.29A 2y7kA-4d3rA:
undetectable		 2y7kA-4d3rA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		5 ILE A 332
GLY A 239
GLY A 229
PRO A 184
ILE A 230
 None
 1.42A 2y7kA-4ddqA:
undetectable		 2y7kA-4ddqA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 THR A 214
ILE A  40
GLY A  39
GLY A 216
PRO A 208
 NAP  A 401 (-3.0A)
NAP  A 401 (-4.0A)
NAP  A 401 (-3.2A)
NAP  A 401 (-3.2A)
NAP  A 401 (-4.0A)
 1.24A 2y7kA-4fc7A:
undetectable		 2y7kA-4fc7A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 ILE A 180
PHE A 151
GLY A 159
PHE A 163
ILE A 162
 None
 1.37A 2y7kA-4h09A:
undetectable		 2y7kA-4h09A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		5 ILE A1178
GLY A1341
HIS A1181
PRO A1179
ILE A1342
 None
 1.38A 2y7kA-4i3hA:
undetectable		 2y7kA-4i3hA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9y E3 SUMO-PROTEIN
LIGASE RANBP2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 ILE A  67
GLY A  65
PHE A 112
PHE A   8
ILE A 158
 None
 1.33A 2y7kA-4i9yA:
undetectable		 2y7kA-4i9yA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imi SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		5 ILE A 130
GLY A 128
TYR A 131
PHE A 180
ILE A 158
 None
 1.22A 2y7kA-4imiA:
undetectable		 2y7kA-4imiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE

([Oscillatoria]
sp. PCC 6506) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 370
GLY A 366
GLY A 133
PHE A 237
ILE A 136
 None
FAD  A 400 ( 4.8A)
FAD  A 400 (-3.5A)
None
None
 1.16A 2y7kA-4irnA:
undetectable		 2y7kA-4irnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 THR A 291
GLY A 292
PHE A 293
GLY A 322
ILE A 321
 None
 1.25A 2y7kA-4jhzA:
undetectable		 2y7kA-4jhzA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		5 THR A 137
ILE A 121
GLY A 211
PHE A 214
HIS A 110
 None
 1.25A 2y7kA-4jisA:
undetectable		 2y7kA-4jisA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		5 GLY A 460
GLY A 428
PHE A 374
HIS A 305
HIS A 258
 None
None
None
FE  A 601 ( 3.4A)
ACT  A 604 (-4.5A)
 1.28A 2y7kA-4jo0A:
undetectable		 2y7kA-4jo0A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT

(Cupriavidus
necator) 		PF03480
(DctP) 		5 ILE A 245
PHE A 111
GLY A 132
PRO A 146
ILE A 135
 None
 1.36A 2y7kA-4p8bA:
8.3		 2y7kA-4p8bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE

(Cupriavidus
necator) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 THR A 159
GLY A 156
GLY A 138
PHE A 187
ILE A 154
 None
 1.39A 2y7kA-4pzcA:
undetectable		 2y7kA-4pzcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 THR A 267
ILE A 222
GLY A 266
HIS A 255
ILE A 262
 BLA  A 900 (-3.3A)
None
None
BLA  A 900 (-3.3A)
None
 1.23A 2y7kA-4r6lA:
undetectable		 2y7kA-4r6lA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes) 		PF04198
(Sugar-bind) 		5 THR A 217
ILE A 221
TYR A 223
GLY A 117
HIS A 152
 None
 1.31A 2y7kA-4r9nA:
undetectable		 2y7kA-4r9nA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Chloroflexus
aurantiacus) 		PF13407
(Peripla_BP_4) 		5 ILE A 135
TYR A 137
GLY A  54
PHE A  72
ILE A  55
 None
 1.21A 2y7kA-4rxuA:
3.7		 2y7kA-4rxuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF13561
(adh_short_C2) 		5 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
 None
 1.22A 2y7kA-4rzhA:
undetectable		 2y7kA-4rzhA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 5 THR E 113
ILE E 143
PHE E 154
HIS E 212
HIS E 273
 None
 1.24A 2y7kA-4whbE:
undetectable		 2y7kA-4whbE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 THR A  50
ILE A  78
GLY A  77
GLY A  48
PRO A  80
 None
 1.37A 2y7kA-4wkyA:
undetectable		 2y7kA-4wkyA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 GLY A 161
PHE A 184
GLY A 139
HIS A 166
ILE A 140
 None
None
None
NAG  A 702 (-4.8A)
None
 1.06A 2y7kA-4z64A:
undetectable		 2y7kA-4z64A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		5 THR A 108
ILE A 163
GLY A 107
PHE A 106
ILE A 152
 None
A  C  23 ( 4.4A)
None
None
None
 1.42A 2y7kA-4z7lA:
undetectable		 2y7kA-4z7lA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab) 		5 THR B 113
ILE B 115
GLY B 114
PHE B 383
PRO B 316
 None
 1.37A 2y7kA-5bn4B:
undetectable		 2y7kA-5bn4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		5 ILE A 289
GLY A 286
GLY A 291
HIS A 329
PRO A 420
 None
 1.16A 2y7kA-5c2iA:
undetectable		 2y7kA-5c2iA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		5 THR A 184
GLY A 243
PHE A 280
PRO A 188
ILE A 279
 None
 1.12A 2y7kA-5cg0A:
undetectable		 2y7kA-5cg0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE

(Clostridium
sardiniense) 		PF13561
(adh_short_C2) 		5 THR A 193
ILE A 191
GLY A 192
GLY A  17
PRO A 188
 NAP  A 301 (-2.9A)
NAP  A 301 (-3.9A)
None
NAP  A 301 (-3.3A)
NAP  A 301 (-3.7A)
 1.25A 2y7kA-5epoA:
undetectable		 2y7kA-5epoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 ILE A 176
PHE A 217
PHE A 270
PRO A 177
ILE A 234
 None
 1.31A 2y7kA-5g4iA:
undetectable		 2y7kA-5g4iA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
 None
None
None
None
GOL  A 403 ( 4.0A)
 0.97A 2y7kA-5hctA:
undetectable		 2y7kA-5hctA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
 0.99A 2y7kA-5i8iA:
2.3		 2y7kA-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
 None
 1.40A 2y7kA-5i8iA:
2.3		 2y7kA-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 5 THR B 139
GLY B 140
PHE B 141
GLY B 196
PHE B  40
 None
 1.30A 2y7kA-5lhsB:
undetectable		 2y7kA-5lhsB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 TYR A   9
PHE A  35
GLY A  56
PHE A  58
PRO A  12
 None
None
FMT  A 303 ( 4.4A)
None
None
 1.29A 2y7kA-5mrtA:
undetectable		 2y7kA-5mrtA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
 None
 0.95A 2y7kA-5p60A:
undetectable		 2y7kA-5p60A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		5 ILE A 198
GLY A 196
GLY A 170
HIS A 210
ILE A 178
 None
 1.12A 2y7kA-5vc2A:
undetectable		 2y7kA-5vc2A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8x LIPID-A-DISACCHARIDE
SYNTHASE

(Escherichia
coli) 		no annotation 5 THR A 140
ILE A 136
GLY A 137
HIS A 119
PRO A 123
 None
 1.22A 2y7kA-5w8xA:
2.2		 2y7kA-5w8xA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER

(Roseiflexus
castenholzii) 		no annotation 5 THR M 545
ILE M 546
GLY M 543
HIS M 589
ILE M 588
 MQE  M 701 (-4.0A)
None
None
FE  L1005 (-3.2A)
MQE  M 701 (-4.4A)
 1.29A 2y7kA-5yq7M:
undetectable		 2y7kA-5yq7M:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 ILE A 119
GLY A  94
GLY A  26
HIS A 249
PRO A 248
 None
 1.25A 2y7kA-6ap6A:
undetectable		 2y7kA-6ap6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 5 GLY A 314
TYR A 317
PHE A 358
GLY A 269
HIS A 266
 None
LOP  A 402 ( 3.7A)
LOP  A 402 ( 4.6A)
None
CO3  A 401 (-4.0A)
 1.16A 2y7kA-6bqcA:
undetectable		 2y7kA-6bqcA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE

(Campylobacter
jejuni) 		no annotation 5 THR A 470
ILE A 467
GLY A 468
GLY A 465
HIS A 445
 None
 1.00A 2y7kA-6cf8A:
undetectable		 2y7kA-6cf8A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cim V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 5 ILE B 185
GLY B 153
HIS B  94
PRO B 134
ILE B 142
 None
 1.43A 2y7kA-6cimB:
undetectable		 2y7kA-6cimB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11

(Mus musculus) 		no annotation 5 ILE Y  91
GLY Y  92
TYR Y  89
PHE Y  69
GLY Y 118
 None
 1.37A 2y7kA-6g72Y:
undetectable		 2y7kA-6g72Y:
17.92