SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7J_D_B49D1294_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ILE A 201
VAL A 209
ALA A 220
MET A 269
GLY A 272
ASP A 276
LEU A 321
 None
 0.56A 2y7jD-1k9aA:
26.1		 2y7jD-1k9aA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 580
VAL A 588
ALA A 606
PHE A 654
MET A 657
GLY A 660
LEU A 731
 None
 0.94A 2y7jD-1lufA:
24.3		 2y7jD-1lufA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ILE A 211
VAL A 219
ALA A 230
GLY A 286
ASP A 290
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-4.4A)
 0.57A 2y7jD-1py5A:
18.7		 2y7jD-1py5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 369
VAL A 377
ALA A 389
PHE A 435
MET A 438
GLY A 441
ASP A 445
LEU A 489
 None
 0.65A 2y7jD-1snxA:
18.0		 2y7jD-1snxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
ALA A  55
ILE A  89
GLY A 110
LEU A 158
 None
 0.58A 2y7jD-1u5qA:
29.6		 2y7jD-1u5qA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  26
ALA A  39
ILE A  75
PHE A  91
MET A  94
LEU A 144
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
 0.54A 2y7jD-1ua2A:
23.2		 2y7jD-1ua2A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  98
ALA A 111
PHE A 159
MET A 162
GLY A 165
LEU A 212
 None
 0.64A 2y7jD-2ac5A:
27.0		 2y7jD-2ac5A:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL X  25
ALA X  37
MET X  85
GLY X  88
ASP X  92
LEU X 137
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
None
STU  X 902 (-4.4A)
 0.53A 2y7jD-2dq7X:
27.8		 2y7jD-2dq7X:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
ILE A  72
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.25A 2y7jD-2f9gA:
20.6		 2y7jD-2f9gA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
ALA A  55
ILE A  89
GLY A 110
LEU A 158
 STU  A 400 (-4.2A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
 0.60A 2y7jD-2gcdA:
30.7		 2y7jD-2gcdA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
 0.25A 2y7jD-2h8hA:
24.4		 2y7jD-2h8hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
 0.51A 2y7jD-2hckA:
24.2		 2y7jD-2hckA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 635
VAL A 643
ALA A 659
ILE A 691
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.60A 2y7jD-2henA:
19.9		 2y7jD-2henA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 259
ALA A 271
MET A 319
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.32A 2y7jD-2hk5A:
21.2		 2y7jD-2hk5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		6 ILE A 190
VAL A 258
ALA A 254
LEU A 245
GLY A 239
LEU A 309
 None
 1.00A 2y7jD-2incA:
undetectable		 2y7jD-2incA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ILE A 428
VAL A 436
ALA A 452
LEU A 501
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.62A 2y7jD-2j0jA:
24.4		 2y7jD-2j0jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
VAL A 436
ALA A 452
LEU A 501
GLY A 505
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.4A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.69A 2y7jD-2jkmA:
24.2		 2y7jD-2jkmA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		9 VAL A  33
ALA A  46
ILE A  87
PHE A 103
LEU A 105
MET A 106
GLY A 109
ASP A 113
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
None
None
ATP  A 381 ( 4.8A)
 0.48A 2y7jD-2phkA:
37.7		 2y7jD-2phkA:
53.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
 None
 0.41A 2y7jD-2qkwB:
17.7		 2y7jD-2qkwB:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.57A 2y7jD-2qobA:
25.9		 2y7jD-2qobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 681
VAL A 689
ALA A 705
ILE A 737
MET A 756
GLY A 759
LEU A 807
 None
 0.74A 2y7jD-2r2pA:
27.0		 2y7jD-2r2pA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 732
ALA A 749
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.57A 2y7jD-2r4bA:
23.1		 2y7jD-2r4bA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 ILE A 490
VAL A 498
ALA A 509
ILE A 557
PHE A 605
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
5ID  A1800 (-4.5A)
 0.53A 2y7jD-2vuwA:
18.9		 2y7jD-2vuwA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
GLY A 307
ASP A 311
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.42A 2y7jD-2xk9A:
29.5		 2y7jD-2xk9A:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 627
VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.9A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.53A 2y7jD-2xyuA:
9.8		 2y7jD-2xyuA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 261
ALA A 273
MET A 322
GLY A 325
ASP A 329
LEU A 374
 None
 0.42A 2y7jD-2zv7A:
27.1		 2y7jD-2zv7A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
 3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
 0.83A 2y7jD-3c0iA:
32.5		 2y7jD-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 201
VAL A 209
ALA A 220
MET A 269
GLY A 272
ASP A 276
LEU A 321
 None
 0.56A 2y7jD-3d7uA:
26.9		 2y7jD-3d7uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  23
VAL A  31
ALA A  44
LEU A  94
ASP A 102
LEU A 153
 ANP  A   1 (-4.2A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
None
 0.91A 2y7jD-3dakA:
24.5		 2y7jD-3dakA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 639
VAL A 647
ALA A 663
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.61A 2y7jD-3dkoA:
23.2		 2y7jD-3dkoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 150
VAL A 158
ALA A 169
ILE A 204
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.36A 2y7jD-3dtcA:
23.6		 2y7jD-3dtcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  32
VAL A  40
ALA A  53
ILE A  86
LEU A 110
MET A 111
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
35F  A   1 (-4.5A)
None
 0.38A 2y7jD-3e7oA:
24.2		 2y7jD-3e7oA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
ALA A  55
ILE A  86
LEU A 104
LEU A 155
 DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
DRK  A   1 (-4.6A)
 0.63A 2y7jD-3f3zA:
30.4		 2y7jD-3f3zA:
27.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 ALA A 247
ILE A 286
LEU A 303
MET A 304
GLY A 307
ASP A 311
LEU A 354
 None
 0.79A 2y7jD-3i6uA:
27.9		 2y7jD-3i6uA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		6 VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
LEU A 354
 None
 0.85A 2y7jD-3i6uA:
27.9		 2y7jD-3i6uA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
ILE A 697
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
 0.72A 2y7jD-3kulA:
27.2		 2y7jD-3kulA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 VAL A 689
ALA A 700
ILE A 729
LEU A 747
ASP A 754
LEU A 804
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 ( 4.9A)
ADP  A2101 (-4.4A)
 0.57A 2y7jD-3lj0A:
28.1		 2y7jD-3lj0A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ILE A 210
VAL A 218
ALA A 229
GLY A 285
ASP A 289
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.3A)
LDN  A   1 (-3.7A)
LDN  A   1 (-4.5A)
 0.68A 2y7jD-3mdyA:
24.5		 2y7jD-3mdyA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 VAL A 200
ALA A 213
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.41A 2y7jD-3nyoA:
30.2		 2y7jD-3nyoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 734
ALA A 751
LEU A 800
MET A 801
GLY A 804
ASP A 808
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
 0.43A 2y7jD-3pp0A:
25.4		 2y7jD-3pp0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 552
ALA A 570
PHE A 617
MET A 620
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.38A 2y7jD-3v5qA:
23.4		 2y7jD-3v5qA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1959
ALA A1978
LEU A2028
MET A2029
GLY A2032
LEU A2086
 None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.35A 2y7jD-3zbfA:
25.9		 2y7jD-3zbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 625
VAL A 633
ALA A 649
ILE A 681
MET A 700
GLY A 703
LEU A 751
 None
 0.37A 2y7jD-3zfxA:
26.6		 2y7jD-3zfxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 568
ALA A 586
PHE A 633
MET A 636
GLY A 639
LEU A 699
 None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.44A 2y7jD-4at3A:
23.7		 2y7jD-4at3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A  97
VAL A 105
ALA A 121
ILE A 153
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.45A 2y7jD-4aw5A:
25.1		 2y7jD-4aw5A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 (-4.0A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.69A 2y7jD-4b99A:
26.7		 2y7jD-4b99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.55A 2y7jD-4e93A:
20.3		 2y7jD-4e93A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 523
ALA A 541
PHE A 588
MET A 591
GLY A 594
LEU A 656
 None
 0.39A 2y7jD-4f0iA:
17.1		 2y7jD-4f0iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1130
ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.23A 2y7jD-4fodA:
24.1		 2y7jD-4fodA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  29
VAL A  37
ALA A  50
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.61A 2y7jD-4fr4A:
29.4		 2y7jD-4fr4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 VAL A 140
ALA A 156
ILE A 190
GLY A 211
ASP A 215
LEU A 259
 None
 0.66A 2y7jD-4hzsA:
22.4		 2y7jD-4hzsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 VAL A 140
ALA A 156
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 None
 0.58A 2y7jD-4hzsA:
22.4		 2y7jD-4hzsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 140
ALA A 156
ILE A 190
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.59A 2y7jD-4id7A:
27.6		 2y7jD-4id7A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 140
ALA A 156
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.53A 2y7jD-4id7A:
27.6		 2y7jD-4id7A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-4.5A)
 0.30A 2y7jD-4k11A:
24.1		 2y7jD-4k11A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 413
VAL A 421
ALA A 434
GLY A 487
ASP A 491
LEU A 533
 B49  A 701 (-4.2A)
None
B49  A 701 (-3.2A)
B49  A 701 ( 3.7A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.5A)
 0.45A 2y7jD-4ks8A:
30.6		 2y7jD-4ks8A:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
 0.32A 2y7jD-4lggA:
23.8		 2y7jD-4lggA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.90A 2y7jD-4mk0A:
30.4		 2y7jD-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		6 ILE A 197
VAL A 205
ALA A 218
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
None
29X  A 702 (-4.6A)
 0.79A 2y7jD-4mk0A:
30.4		 2y7jD-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  86
ALA A  99
ILE A 212
LEU A 148
GLY A 151
LEU A 199
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 1.02A 2y7jD-4mvfA:
25.9		 2y7jD-4mvfA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		6 ILE A 190
VAL A 258
ALA A 254
LEU A 245
GLY A 239
LEU A 309
 None
 0.98A 2y7jD-4p1cA:
undetectable		 2y7jD-4p1cA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 619
VAL A 627
ALA A 644
ILE A 676
MET A 695
GLY A 698
LEU A 746
 None
 0.61A 2y7jD-4p2kA:
26.7		 2y7jD-4p2kA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 ILE A  27
VAL A  35
ALA A  49
ILE A  83
MET A 107
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-4.8A)
None
ANP  A 402 (-4.6A)
 0.36A 2y7jD-4qnyA:
28.2		 2y7jD-4qnyA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  48
VAL A  56
ALA A  69
ILE A 101
LEU A 124
MET A 125
LEU A 173
 38Z  A 418 ( 4.4A)
None
38Z  A 418 (-3.4A)
38Z  A 418 ( 4.9A)
38Z  A 418 ( 4.8A)
None
38Z  A 418 (-4.4A)
 0.47A 2y7jD-4qtbA:
27.8		 2y7jD-4qtbA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
MET A  84
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.55A 2y7jD-4ueuA:
27.2		 2y7jD-4ueuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 VAL B 275
ALA B 288
MET B 337
GLY B 340
ASP B 344
LEU B 389
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
 0.66A 2y7jD-4xeyB:
25.8		 2y7jD-4xeyB:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  29
VAL A  37
ALA A  50
ILE A  82
LEU A 105
MET A 106
LEU A 154
 42A  A 402 ( 4.7A)
None
42A  A 402 (-3.2A)
None
42A  A 402 ( 4.9A)
None
42A  A 402 ( 4.9A)
 0.56A 2y7jD-4xrlA:
28.1		 2y7jD-4xrlA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 None
 0.61A 2y7jD-4zslA:
26.1		 2y7jD-4zslA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 ILE A  30
VAL A  38
ALA A  51
ILE A  84
LEU A 108
MET A 109
 ANP  A 401 (-4.9A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.5A)
None
ANP  A 401 ( 4.8A)
None
 0.42A 2y7jD-5awmA:
23.7		 2y7jD-5awmA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A  69
VAL A  77
ALA A  90
LEU A 146
MET A 147
LEU A 196
 None
 0.52A 2y7jD-5ci6A:
24.8		 2y7jD-5ci6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 ILE A  81
VAL A  89
ALA A 102
LEU A 152
ASP A 160
LEU A 211
 ANP  A 401 ( 4.1A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
None
 0.87A 2y7jD-5dbxA:
23.5		 2y7jD-5dbxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		6 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
 0.57A 2y7jD-5ezrA:
27.3		 2y7jD-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
ILE A 960
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.6A)
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.58A 2y7jD-5f1zA:
26.2		 2y7jD-5f1zA:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 VAL A  28
ALA A  41
PHE A  90
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.46A 2y7jD-5hu3A:
35.8		 2y7jD-5hu3A:
34.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 ILE A  24
VAL A  32
ALA A  45
PHE A  94
GLY A 100
LEU A 147
 None
 1.00A 2y7jD-5ig1A:
26.9		 2y7jD-5ig1A:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 726
ALA A 743
LEU A 792
MET A 793
GLY A 796
ASP A 800
LEU A 844
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.30A 2y7jD-5j9zA:
24.7		 2y7jD-5j9zA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.55A 2y7jD-5jznA:
34.9		 2y7jD-5jznA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 276
VAL A 284
ALA A 297
GLY A 350
ASP A 354
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
 0.73A 2y7jD-5kbrA:
16.2		 2y7jD-5kbrA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
VAL A 897
ALA A 909
GLY A 962
ASP A 966
LEU A1016
 None
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
 0.78A 2y7jD-5lpyA:
25.4		 2y7jD-5lpyA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A 897
ALA A 909
MET A 959
GLY A 962
ASP A 966
LEU A1016
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
 0.58A 2y7jD-5lpyA:
25.4		 2y7jD-5lpyA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
VAL A 897
ALA A 909
MET A 959
GLY A 962
ASP A 966
LEU A1016
 ADP  A1200 (-4.7A)
ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.2A)
ADP  A1200 (-4.7A)
 0.68A 2y7jD-5lpzA:
25.4		 2y7jD-5lpzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 155
VAL A 163
ALA A 176
PHE A 228
LEU A 230
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
None
7A7  A 501 (-4.9A)
 0.89A 2y7jD-5lxdA:
26.2		 2y7jD-5lxdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 163
ALA A 176
ILE A 212
PHE A 228
LEU A 230
LEU A 282
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
None
7A7  A 501 (-4.9A)
 0.69A 2y7jD-5lxdA:
26.2		 2y7jD-5lxdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  98
VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
 None
 0.63A 2y7jD-5u7qA:
28.4		 2y7jD-5u7qA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 ILE A 197
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
None
 1.02A 2y7jD-5uuuA:
30.4		 2y7jD-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
 0.57A 2y7jD-5uuuA:
30.4		 2y7jD-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 ILE A 197
VAL A 205
ALA A 218
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
MES  A 604 (-3.9A)
None
None
 0.74A 2y7jD-5uuuA:
30.4		 2y7jD-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 6 ILE A  75
VAL A  83
ALA A  95
GLY A 147
ASP A 151
LEU A 206
 ANP  A1000 (-4.2A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
None
ANP  A1000 ( 4.9A)
ANP  A1000 (-4.5A)
 0.82A 2y7jD-5xd6A:
14.6		 2y7jD-5xd6A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 ILE A 215
VAL A 223
ALA A 236
ILE A 272
PHE A 288
LEU A 290
LEU A 342
 None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.8A)
HRM  A 601 (-3.6A)
HRM  A 601 (-4.6A)
None
 0.50A 2y7jD-5y86A:
26.2		 2y7jD-5y86A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 ILE A 733
VAL A 741
ALA A 754
PHE A 813
MET A 816
LEU A 866
 CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
CJM  A1102 ( 4.4A)
None
CJM  A1102 (-4.4A)
 0.54A 2y7jD-6b3eA:
29.0		 2y7jD-6b3eA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 ILE A 218
VAL A 226
ALA A 237
GLY A 294
ASP A 298
LEU A 347
 DL1  A 601 (-4.0A)
None
DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 ( 4.9A)
DL1  A 601 (-3.9A)
 0.69A 2y7jD-6bfnA:
24.1		 2y7jD-6bfnA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ILE A 171
VAL A 179
ALA A 192
PHE A 267
LEU A 269
GLY A 273
LEU A 319
 BI9  A 501 (-4.0A)
BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
BI9  A 501 ( 4.2A)
BI9  A 501 (-4.4A)
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
 0.41A 2y7jD-6bqlA:
31.6		 2y7jD-6bqlA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 7 ILE A 134
VAL A 142
ALA A 155
PHE A 230
LEU A 232
GLY A 236
LEU A 282
 H1N  A 501 (-4.3A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-3.7A)
H1N  A 501 (-4.3A)
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
 0.43A 2y7jD-6ccfA:
31.0		 2y7jD-6ccfA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ILE A 171
VAL A 179
ALA A 192
PHE A 267
LEU A 269
GLY A 273
LEU A 319
 F6J  A 501 (-4.3A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-3.7A)
F6J  A 501 ( 4.4A)
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.5A)
 0.58A 2y7jD-6cmjA:
30.7		 2y7jD-6cmjA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 VAL A 205
ALA A 217
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.51A 2y7jD-6cz4A:
18.0		 2y7jD-6cz4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 VAL A 200
ALA A 211
MET A 265
GLY A 268
ASP A 272
LEU A 318
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-3.3A)
CJT  A 502 (-4.7A)
 0.45A 2y7jD-6f3dA:
24.7		 2y7jD-6f3dA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 VAL A 177
ALA A 191
PHE A 243
LEU A 245
ASP A 252
LEU A 297
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
None
 0.62A 2y7jD-6fylA:
28.2		 2y7jD-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 6 VAL A 175
ALA A 189
PHE A 241
LEU A 243
ASP A 250
LEU A 295
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.5A)
EAQ  A 501 ( 4.9A)
None
EAQ  A 501 (-4.9A)
 0.62A 2y7jD-6fyoA:
27.7		 2y7jD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 VAL A 175
ALA A 189
PHE A 241
LEU A 243
ASP A 250
LEU A 295
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
None
 0.63A 2y7jD-6fyvA:
28.2		 2y7jD-6fyvA:
undetectable