SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7J_A_B49A1294_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
ASP A 539
 None
 0.54A 2y7jA-1k2pA:
19.3		 2y7jA-1k2pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ILE A 201
VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
 None
 0.49A 2y7jA-1k9aA:
25.6		 2y7jA-1k9aA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 580
VAL A 588
ALA A 606
PHE A 654
MET A 657
GLY A 660
LEU A 731
 None
 0.84A 2y7jA-1lufA:
24.3		 2y7jA-1lufA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ILE A 211
VAL A 219
ALA A 230
GLY A 286
LEU A 340
ASP A 351
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.54A 2y7jA-1py5A:
19.4		 2y7jA-1py5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 369
VAL A 377
ALA A 389
PHE A 435
MET A 438
GLY A 441
LEU A 489
ASP A 500
 None
 0.83A 2y7jA-1snxA:
23.8		 2y7jA-1snxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
ALA A  55
ILE A  89
GLY A 110
LEU A 158
 None
 0.43A 2y7jA-1u5qA:
29.5		 2y7jA-1u5qA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
ALA A  55
ILE A  89
LEU A 158
ASP A 169
 None
 0.70A 2y7jA-1u5qA:
29.5		 2y7jA-1u5qA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  26
ALA A  39
ILE A  75
PHE A  91
MET A  94
LEU A 144
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
 0.61A 2y7jA-1ua2A:
23.0		 2y7jA-1ua2A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  98
ALA A 111
PHE A 159
MET A 162
GLY A 165
LEU A 212
 None
 0.59A 2y7jA-2ac5A:
27.0		 2y7jA-2ac5A:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
ILE A  72
LEU A  95
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.67A 2y7jA-2f9gA:
20.6		 2y7jA-2f9gA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
ILE A  72
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.31A 2y7jA-2f9gA:
20.6		 2y7jA-2f9gA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
ALA A  55
ILE A  89
GLY A 110
LEU A 158
 STU  A 400 (-4.2A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
 0.44A 2y7jA-2gcdA:
30.6		 2y7jA-2gcdA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 635
VAL A 643
ALA A 659
ILE A 691
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.74A 2y7jA-2henA:
20.3		 2y7jA-2henA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ILE A 428
VAL A 436
ALA A 452
LEU A 501
GLY A 505
GLU A 506
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-3.5A)
4ST  A1687 (-4.4A)
 0.87A 2y7jA-2j0jA:
24.3		 2y7jA-2j0jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
VAL A 436
ALA A 452
GLY A 505
GLU A 506
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-3.6A)
BII  A1687 (-4.1A)
BII  A1687 (-4.2A)
 0.71A 2y7jA-2jkmA:
23.9		 2y7jA-2jkmA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
VAL A 436
ALA A 452
LEU A 501
GLY A 505
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.4A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.60A 2y7jA-2jkmA:
23.9		 2y7jA-2jkmA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		9 VAL A  33
ALA A  46
ILE A  87
PHE A 103
LEU A 105
MET A 106
GLY A 109
GLU A 110
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
None
ATP  A 381 (-3.3A)
ATP  A 381 ( 4.8A)
 0.34A 2y7jA-2phkA:
38.0		 2y7jA-2phkA:
53.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
ILE A 548
GLY A 570
LEU A 633
ASP A 644
 None
 0.58A 2y7jA-2psqA:
22.0		 2y7jA-2psqA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
 None
 0.40A 2y7jA-2qkwB:
25.3		 2y7jA-2qkwB:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.66A 2y7jA-2qobA:
25.5		 2y7jA-2qobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 681
VAL A 689
ALA A 705
ILE A 737
MET A 756
GLY A 759
LEU A 807
 None
 0.81A 2y7jA-2r2pA:
23.0		 2y7jA-2r2pA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 732
ALA A 749
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.54A 2y7jA-2r4bA:
22.8		 2y7jA-2r4bA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 ILE A 490
VAL A 498
ALA A 509
ILE A 557
PHE A 605
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
5ID  A1800 (-4.5A)
 0.50A 2y7jA-2vuwA:
18.9		 2y7jA-2vuwA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 424
ALA A 445
ILE A 473
LEU A 491
MET A 492
GLY A 495
GLU A 496
 None
 0.97A 2y7jA-2wntA:
26.0		 2y7jA-2wntA:
32.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 424
ALA A 445
LEU A 491
MET A 492
GLY A 495
GLU A 496
LEU A 542
 None
 0.94A 2y7jA-2wntA:
26.0		 2y7jA-2wntA:
32.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
GLY A 307
GLU A 308
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.53A 2y7jA-2xk9A:
29.1		 2y7jA-2xk9A:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 627
VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.9A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.62A 2y7jA-2xyuA:
20.3		 2y7jA-2xyuA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1010
ALA A1028
LEU A1078
MET A1079
GLY A1082
ASP A1150
 S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 (-4.7A)
None
S91  A   1 (-3.3A)
None
 0.70A 2y7jA-2z8cA:
26.5		 2y7jA-2z8cA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
ILE A 548
GLY A 570
LEU A 633
ASP A 644
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.40A 2y7jA-3b2tA:
23.0		 2y7jA-3b2tA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
 3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
 0.66A 2y7jA-3c0iA:
33.0		 2y7jA-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 201
VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
 None
 0.49A 2y7jA-3d7uA:
26.4		 2y7jA-3d7uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 639
VAL A 647
ALA A 663
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.64A 2y7jA-3dkoA:
22.9		 2y7jA-3dkoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 150
VAL A 158
ALA A 169
ILE A 204
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.46A 2y7jA-3dtcA:
23.3		 2y7jA-3dtcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  32
VAL A  40
ALA A  53
ILE A  86
LEU A 110
MET A 111
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
35F  A   1 (-4.5A)
None
 0.36A 2y7jA-3e7oA:
24.2		 2y7jA-3e7oA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 ILE A  34
VAL A  42
ALA A  55
ILE A  86
LEU A 104
GLY A 108
GLU A 109
LEU A 155
 DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.6A)
 0.82A 2y7jA-3f3zA:
30.1		 2y7jA-3f3zA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 439
ALA A 455
LEU A 504
GLY A 508
GLU A 509
LEU A 556
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-3.8A)
AGS  A 999 (-4.5A)
 0.55A 2y7jA-3fzpA:
23.8		 2y7jA-3fzpA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 ALA A 247
ILE A 286
LEU A 303
MET A 304
GLY A 307
LEU A 354
ASP A 368
 None
 0.75A 2y7jA-3i6uA:
28.0		 2y7jA-3i6uA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 ALA A 247
ILE A 286
MET A 304
GLY A 307
GLU A 308
LEU A 354
ASP A 368
 None
 0.74A 2y7jA-3i6uA:
28.0		 2y7jA-3i6uA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
LEU A 354
ASP A 368
 None
 0.82A 2y7jA-3i6uA:
28.0		 2y7jA-3i6uA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 VAL A 234
ALA A 247
ILE A 286
MET A 304
GLU A 308
LEU A 354
ASP A 368
 None
 0.85A 2y7jA-3i6uA:
28.0		 2y7jA-3i6uA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
ILE A 697
MET A 716
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.92A 2y7jA-3kulA:
26.9		 2y7jA-3kulA:
26.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  47
ALA A  60
ILE A  94
GLY A 116
GLU A 117
LEU A 165
ASP A 179
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
None
None
None
QUE  A   1 (-2.9A)
 0.74A 2y7jA-3lm5A:
31.9		 2y7jA-3lm5A:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
ALA A  55
ILE A  88
LEU A 161
ASP A 172
 GOL  A 434 ( 4.5A)
None
GOL  A 434 ( 4.1A)
None
GOL  A 434 (-4.2A)
GOL  A 433 (-2.7A)
 0.64A 2y7jA-3n9xA:
23.8		 2y7jA-3n9xA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 VAL A 200
ALA A 213
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.32A 2y7jA-3nyoA:
29.9		 2y7jA-3nyoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 734
ALA A 751
LEU A 800
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.44A 2y7jA-3pp0A:
25.0		 2y7jA-3pp0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ILE A 557
VAL A 565
ALA A 576
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.69A 2y7jA-3ppzA:
29.0		 2y7jA-3ppzA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 552
ALA A 570
PHE A 617
MET A 620
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.40A 2y7jA-3v5qA:
23.1		 2y7jA-3v5qA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1978
LEU A2028
MET A2029
GLY A2032
LEU A2086
ASP A2102
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
 0.65A 2y7jA-3zbfA:
25.6		 2y7jA-3zbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1959
ALA A1978
LEU A2028
MET A2029
GLY A2032
LEU A2086
 None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.45A 2y7jA-3zbfA:
25.6		 2y7jA-3zbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 625
VAL A 633
ALA A 649
ILE A 681
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.70A 2y7jA-3zfxA:
26.1		 2y7jA-3zfxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 568
ALA A 586
PHE A 633
MET A 636
GLY A 639
LEU A 699
 None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.45A 2y7jA-4at3A:
23.2		 2y7jA-4at3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A  97
VAL A 105
ALA A 121
ILE A 153
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.58A 2y7jA-4aw5A:
20.4		 2y7jA-4aw5A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 105
ALA A 121
ILE A 153
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.65A 2y7jA-4aw5A:
20.4		 2y7jA-4aw5A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 (-4.0A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.64A 2y7jA-4b99A:
26.6		 2y7jA-4b99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 VAL A 254
ALA A 267
ILE A 302
GLY A 324
GLU A 325
LEU A 371
ASP A 382
 None
 0.79A 2y7jA-4c0tA:
29.4		 2y7jA-4c0tA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.73A 2y7jA-4e93A:
19.8		 2y7jA-4e93A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 523
ALA A 541
PHE A 588
MET A 591
GLY A 594
LEU A 656
 None
 0.43A 2y7jA-4f0iA:
17.2		 2y7jA-4f0iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.65A 2y7jA-4fodA:
23.9		 2y7jA-4fodA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1130
ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.29A 2y7jA-4fodA:
23.9		 2y7jA-4fodA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  29
VAL A  37
ALA A  50
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.46A 2y7jA-4fr4A:
29.8		 2y7jA-4fr4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 413
VAL A 421
ALA A 434
GLY A 487
LEU A 533
ASP A 544
 B49  A 701 (-4.2A)
None
B49  A 701 (-3.2A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.51A 2y7jA-4ks8A:
22.1		 2y7jA-4ks8A:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.55A 2y7jA-4lggA:
23.4		 2y7jA-4lggA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 ILE A 197
ARG A 199
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
 29X  A 702 (-4.7A)
None
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
 1.16A 2y7jA-4mk0A:
23.3		 2y7jA-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.78A 2y7jA-4mk0A:
23.3		 2y7jA-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.95A 2y7jA-4mk0A:
23.3		 2y7jA-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 644
ILE A 676
MET A 695
GLY A 698
LEU A 746
ASP A 757
 None
 0.58A 2y7jA-4p2kA:
26.3		 2y7jA-4p2kA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 619
VAL A 627
ALA A 644
ILE A 676
MET A 695
GLY A 698
LEU A 746
 None
 0.74A 2y7jA-4p2kA:
26.3		 2y7jA-4p2kA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 ILE A  27
VAL A  35
ALA A  49
ILE A  83
MET A 107
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-4.8A)
None
ANP  A 402 (-4.6A)
 0.38A 2y7jA-4qnyA:
28.1		 2y7jA-4qnyA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  48
VAL A  56
ALA A  69
ILE A 101
LEU A 124
MET A 125
LEU A 173
 38Z  A 418 ( 4.4A)
None
38Z  A 418 (-3.4A)
38Z  A 418 ( 4.9A)
38Z  A 418 ( 4.8A)
None
38Z  A 418 (-4.4A)
 0.44A 2y7jA-4qtbA:
27.9		 2y7jA-4qtbA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 150
VAL A 158
ALA A 169
ILE A 204
GLY A 226
LEU A 275
ASP A 294
 None
 0.88A 2y7jA-4uy9A:
22.5		 2y7jA-4uy9A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  29
VAL A  37
ALA A  50
ILE A  82
LEU A 105
MET A 106
LEU A 154
 42A  A 402 ( 4.7A)
None
42A  A 402 (-3.2A)
None
42A  A 402 ( 4.9A)
None
42A  A 402 ( 4.9A)
 0.61A 2y7jA-4xrlA:
28.1		 2y7jA-4xrlA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
VAL A 477
ALA A 488
ILE A 522
GLY A 545
LEU A 595
 4CV  A 801 (-4.3A)
None
4CV  A 801 (-3.5A)
4CV  A 801 ( 4.2A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
 0.62A 2y7jA-4yffA:
24.1		 2y7jA-4yffA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 None
 0.70A 2y7jA-4zslA:
26.1		 2y7jA-4zslA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
ALA A 512
ILE A 545
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.3A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.54A 2y7jA-5a46A:
23.5		 2y7jA-5a46A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 ILE A  30
VAL A  38
ALA A  51
ILE A  84
LEU A 108
MET A 109
 ANP  A 401 (-4.9A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.5A)
None
ANP  A 401 ( 4.8A)
None
 0.46A 2y7jA-5awmA:
23.3		 2y7jA-5awmA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A  69
VAL A  77
ALA A  90
LEU A 146
MET A 147
LEU A 196
 None
 0.61A 2y7jA-5ci6A:
24.5		 2y7jA-5ci6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
VAL A  30
ALA A  44
GLY A  98
LEU A 145
ASP A 165
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.69A 2y7jA-5ci7A:
30.8		 2y7jA-5ci7A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 ILE A  81
VAL A  89
ALA A 102
LEU A 152
GLY A 156
LEU A 211
 ANP  A 401 ( 4.1A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
None
 0.71A 2y7jA-5dbxA:
23.4		 2y7jA-5dbxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		7 ILE A 540
ARG A 542
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
 4ZS  A 901 (-4.2A)
None
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
 0.66A 2y7jA-5ezrA:
27.8		 2y7jA-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		7 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
GLU A 618
LEU A 664
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
 0.72A 2y7jA-5ezrA:
27.8		 2y7jA-5ezrA:
18.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 VAL A  28
ALA A  41
PHE A  90
LEU A  92
GLY A  96
GLU A  97
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-3.5A)
ADP  A 301 (-4.7A)
 0.35A 2y7jA-5hu3A:
35.8		 2y7jA-5hu3A:
34.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
ARG A  21
VAL A  30
ALA A  43
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 (-3.8A)
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.87A 2y7jA-5j5tA:
25.0		 2y7jA-5j5tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 726
ALA A 743
LEU A 792
MET A 793
GLY A 796
LEU A 844
ASP A 855
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.48A 2y7jA-5j9zA:
24.2		 2y7jA-5j9zA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.40A 2y7jA-5jznA:
31.7		 2y7jA-5jznA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
VAL A 897
ALA A 909
MET A 959
GLY A 962
LEU A1016
 ADP  A1200 (-4.7A)
ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
 0.68A 2y7jA-5lpzA:
24.9		 2y7jA-5lpzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 155
VAL A 163
ALA A 176
ILE A 212
PHE A 228
LEU A 230
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
None
7A7  A 501 (-4.9A)
 0.75A 2y7jA-5lxdA:
26.4		 2y7jA-5lxdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  98
VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
 None
 0.45A 2y7jA-5u7qA:
28.6		 2y7jA-5u7qA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 ILE A 197
ARG A 199
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
None
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
None
 1.14A 2y7jA-5uuuA:
30.6		 2y7jA-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 ILE A 197
ARG A 199
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
ASP A 335
 QRW  A 601 (-4.7A)
None
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
QRW  A 601 (-3.7A)
 1.28A 2y7jA-5uuuA:
30.6		 2y7jA-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 6 ILE A 327
VAL A 335
ALA A 348
GLY A 401
LEU A 447
ASP A 458
 M77  A 601 ( 4.8A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
 0.57A 2y7jA-5vefA:
30.2		 2y7jA-5vefA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 ILE A 215
VAL A 223
ALA A 236
ILE A 272
PHE A 288
LEU A 290
LEU A 342
 None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.8A)
HRM  A 601 (-3.6A)
HRM  A 601 (-4.6A)
None
 0.44A 2y7jA-5y86A:
26.1		 2y7jA-5y86A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 ILE A 733
VAL A 741
ALA A 754
PHE A 813
MET A 816
LEU A 866
 CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
CJM  A1102 ( 4.4A)
None
CJM  A1102 (-4.4A)
 0.52A 2y7jA-6b3eA:
29.0		 2y7jA-6b3eA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 ILE A 218
VAL A 226
ALA A 237
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 (-4.0A)
None
DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.70A 2y7jA-6bfnA:
23.3		 2y7jA-6bfnA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ILE A 171
VAL A 179
ALA A 192
PHE A 267
LEU A 269
GLY A 273
LEU A 319
 BI9  A 501 (-4.0A)
BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
BI9  A 501 ( 4.2A)
BI9  A 501 (-4.4A)
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
 0.43A 2y7jA-6bqlA:
31.7		 2y7jA-6bqlA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 7 ILE A 134
VAL A 142
ALA A 155
PHE A 230
LEU A 232
GLY A 236
LEU A 282
 H1N  A 501 (-4.3A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-3.7A)
H1N  A 501 (-4.3A)
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
 0.42A 2y7jA-6ccfA:
31.3		 2y7jA-6ccfA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 ILE A 171
VAL A 179
ALA A 192
PHE A 267
LEU A 269
ASP A 330
 F6J  A 501 (-4.3A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-3.7A)
F6J  A 501 ( 4.4A)
F6J  A 501 (-3.8A)
 0.67A 2y7jA-6cmjA:
31.1		 2y7jA-6cmjA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ILE A 171
VAL A 179
ALA A 192
PHE A 267
LEU A 269
GLY A 273
LEU A 319
 F6J  A 501 (-4.3A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-3.7A)
F6J  A 501 ( 4.4A)
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.5A)
 0.47A 2y7jA-6cmjA:
31.1		 2y7jA-6cmjA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 VAL A 205
ALA A 217
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.62A 2y7jA-6cz4A:
24.3		 2y7jA-6cz4A:
14.16