SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7H_C_SAMC530_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bui STAPHYLOKINASE

(Staphylococcus
phage 42D.m)
PF02821
(Staphylokinase)
3 TYR C  44
GLU C  46
ASN C 122
None
0.96A 2y7hC-1buiC:
undetectable
2y7hC-1buiC:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans)
PF00722
(Glyco_hydro_16)
3 TYR A 166
GLU A 162
ASN A  10
None
0.97A 2y7hC-1cpnA:
0.0
2y7hC-1cpnA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4v TNF-RELATED
APOPTOSIS INDUCING
LIGAND


(Homo sapiens)
PF00229
(TNF)
3 TYR B 213
GLU B 173
ASN B 140
None
1.02A 2y7hC-1d4vB:
undetectable
2y7hC-1d4vB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF)
PF13091
(PLDc_2)
3 TYR A 218
GLU A 322
ASN A 465
None
None
PO4  A 600 (-3.1A)
0.74A 2y7hC-1f0iA:
0.9
2y7hC-1f0iA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkf NK CELL ACTIVATING
RECEPTOR


(Homo sapiens)
PF07686
(V-set)
3 TYR A  24
GLU A  32
ASN A  99
None
1.01A 2y7hC-1hkfA:
undetectable
2y7hC-1hkfA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN


(Mus musculus)
PF02816
(Alpha_kinase)
3 TYR A1552
GLU A1557
ASN A1559
None
1.03A 2y7hC-1iahA:
0.0
2y7hC-1iahA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
3 TYR A 540
GLU A 147
ASN A 150
None
1.02A 2y7hC-1ksiA:
0.0
2y7hC-1ksiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE


(Escherichia
coli)
PF02965
(Met_synt_B12)
3 TYR A1102
GLU A1105
ASN A1119
None
1.00A 2y7hC-1mskA:
0.0
2y7hC-1mskA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens)
PF00023
(Ank)
PF12796
(Ank_2)
3 TYR E 248
GLU E 213
ASN E 182
None
0.98A 2y7hC-1nfiE:
undetectable
2y7hC-1nfiE:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6r BETA-LACTAMASE

(Enterobacter
cloacae)
PF00144
(Beta-lactamase)
3 TYR A 112
GLU A 272
ASN A 346
None
1.04A 2y7hC-1s6rA:
0.0
2y7hC-1s6rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima)
PF00150
(Cellulase)
3 TYR A 200
GLU A 139
ASN A  94
None
0.86A 2y7hC-1vjzA:
0.0
2y7hC-1vjzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
3 TYR A 331
GLU A 249
ASN A 163
None
0.90A 2y7hC-1zl6A:
undetectable
2y7hC-1zl6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus)
PF01229
(Glyco_hydro_39)
3 TYR A 230
GLU A 160
ASN A 165
None
0.90A 2y7hC-2bs9A:
undetectable
2y7hC-2bs9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE


(Porphyromonas
gingivalis)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
3 TYR A 643
GLU A 564
ASN A 361
None
0.96A 2y7hC-2d5lA:
undetectable
2y7hC-2d5lA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9m ZINC FINGER
CCCH-TYPE DOMAIN
CONTAINING PROTEIN
7A


(Homo sapiens)
PF00642
(zf-CCCH)
3 TYR A 893
GLU A 932
ASN A 927
None
0.95A 2y7hC-2d9mA:
undetectable
2y7hC-2d9mA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
3 TYR A  80
GLU A 224
ASN A 165
None
None
EPE  A 501 ( 4.2A)
1.02A 2y7hC-2douA:
2.4
2y7hC-2douA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli)
PF00756
(Esterase)
3 TYR A 204
GLU A 173
ASN A 177
None
0.97A 2y7hC-2gzsA:
undetectable
2y7hC-2gzsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
PF04945
(YHS)
3 TYR A 362
GLU A 292
ASN A 287
None
1.02A 2y7hC-2incA:
0.7
2y7hC-2incA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes)
PF00534
(Glycos_transf_1)
3 TYR A 212
GLU A 189
ASN A 283
None
1.02A 2y7hC-2iuyA:
undetectable
2y7hC-2iuyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nra PI PROTEIN

(Escherichia
coli)
PF01051
(Rep_3)
3 TYR C 144
GLU C 102
ASN C 104
None
1.02A 2y7hC-2nraC:
undetectable
2y7hC-2nraC:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR


(Campylobacter
jejuni)
PF00497
(SBP_bac_3)
3 TYR A 198
GLU A  39
ASN A  20
None
0.92A 2y7hC-2v25A:
undetectable
2y7hC-2v25A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus)
PF13091
(PLDc_2)
3 TYR A 216
GLU A 317
ASN A 459
None
0.76A 2y7hC-2ze4A:
undetectable
2y7hC-2ze4A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajv PUTATIVE
UNCHARACTERIZED
PROTEIN


(Aeropyrum
pernix)
PF01974
(tRNA_int_endo)
3 TYR A  89
GLU A  51
ASN A  35
None
0.96A 2y7hC-3ajvA:
undetectable
2y7hC-3ajvA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu7 GENTISATE
1,2-DIOXYGENASE


(Ruegeria
pomeroyi)
PF07883
(Cupin_2)
3 TYR A 306
GLU A 331
ASN A 366
None
1.01A 2y7hC-3bu7A:
undetectable
2y7hC-3bu7A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 TYR A 241
GLU A  25
ASN A 206
None
None
DCS  A 372 ( 4.7A)
0.96A 2y7hC-3e6eA:
undetectable
2y7hC-3e6eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE


(Homo sapiens)
PF00566
(RabGAP-TBC)
3 TYR A 668
GLU A 671
ASN A 689
None
UNX  A 902 ( 4.4A)
None
0.97A 2y7hC-3hzjA:
undetectable
2y7hC-3hzjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE


(Colwellia
psychrerythraea)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 TYR A  62
GLU A 353
ASN A 397
None
1.02A 2y7hC-3ic9A:
2.5
2y7hC-3ic9A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE


(Pisum sativum)
PF00171
(Aldedh)
3 TYR A 419
GLU A 393
ASN A 162
None
NAD  A 505 (-2.9A)
NAD  A 505 ( 4.8A)
1.04A 2y7hC-3iwkA:
undetectable
2y7hC-3iwkA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE


(Pseudoalteromonas
atlantica)
PF00171
(Aldedh)
3 TYR A 416
GLU A 390
ASN A 157
None
1.04A 2y7hC-3k2wA:
undetectable
2y7hC-3k2wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN


(Bacteroides
vulgatus)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 TYR A 107
GLU A 467
ASN A 473
EDO  A  14 (-3.7A)
EDO  A  14 (-3.2A)
None
0.91A 2y7hC-3kezA:
undetectable
2y7hC-3kezA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN


(Bacteroides
vulgatus)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 TYR A 112
GLU A 497
ASN A 503
1PE  A   5 (-3.6A)
1PE  A   5 (-2.6A)
None
0.80A 2y7hC-3lewA:
undetectable
2y7hC-3lewA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1


(Saccharomyces
cerevisiae)
PF16499
(Melibiase_2)
3 TYR A 307
GLU A 276
ASN A 270
None
None
NAG  A3001 (-2.2A)
0.75A 2y7hC-3lrkA:
undetectable
2y7hC-3lrkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 TYR A 112
GLU A 485
ASN A 491
GOL  A  10 (-3.4A)
GOL  A  10 (-2.5A)
None
1.03A 2y7hC-3mcxA:
undetectable
2y7hC-3mcxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7o ENDOGLUCANASE

(Thermotoga
maritima)
PF01670
(Glyco_hydro_12)
3 TYR A 181
GLU A 117
ASN A  25
None
0.91A 2y7hC-3o7oA:
undetectable
2y7hC-3o7oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H


(Human
gammaherpesvirus
4)
no annotation 3 TYR A 261
GLU A 293
ASN A 245
None
1.01A 2y7hC-3phfA:
1.0
2y7hC-3phfA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis)
PF00150
(Cellulase)
3 TYR A 231
GLU A 169
ASN A 134
None
0.86A 2y7hC-3pzuA:
undetectable
2y7hC-3pzuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF00171
(Aldedh)
3 TYR A 393
GLU A 368
ASN A 141
None
0.94A 2y7hC-3rhdA:
3.3
2y7hC-3rhdA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE


(Plasmodium
falciparum)
PF00557
(Peptidase_M24)
3 TYR A 160
GLU A  92
ASN A 279
None
1.02A 2y7hC-3s6bA:
undetectable
2y7hC-3s6bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 TYR A 116
GLU A 486
ASN A 492
None
0.88A 2y7hC-3snxA:
undetectable
2y7hC-3snxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE


(Labrenzia
aggregata)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 TYR A 216
GLU A 266
ASN A 291
None
MG  A 391 (-2.6A)
None
1.01A 2y7hC-3stpA:
undetectable
2y7hC-3stpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3


(Deinococcus
radiodurans)
PF00933
(Glyco_hydro_3)
3 TYR A 226
GLU A 205
ASN A 136
None
1.00A 2y7hC-3tevA:
undetectable
2y7hC-3tevA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1


(Pseudomonas
syringae group
genomosp. 3)
no annotation 3 TYR B 186
GLU B 188
ASN B 116
None
1.01A 2y7hC-3u0jB:
undetectable
2y7hC-3u0jB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ


(Streptoalloteichus
tenebrarius)
PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C)
3 TYR A 230
GLU A 172
ASN A 184
None
CA0  A 602 (-3.3A)
None
0.97A 2y7hC-3vexA:
1.9
2y7hC-3vexA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh7 CP32M

(-)
no annotation 3 TYR B 638
GLU B 634
ASN B 624
None
0.91A 2y7hC-3vh7B:
undetectable
2y7hC-3vh7B:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE


(Ruminococcus
albus)
PF07221
(GlcNAc_2-epim)
3 TYR A 373
GLU A 308
ASN A 315
None
0.97A 2y7hC-3vw5A:
undetectable
2y7hC-3vw5A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win 17 KD HEMAGGLUTININ
COMPONENT
HA3


(Clostridium
botulinum;
Clostridium
botulinum)
PF05588
(Botulinum_HA-17)
PF03505
(Clenterotox)
3 TYR C  24
GLU C 144
ASN E 546
None
0.99A 2y7hC-3winC:
undetectable
2y7hC-3winC:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE


(Rhodothermus
marinus)
PF07221
(GlcNAc_2-epim)
3 TYR A 389
GLU A 326
ASN A 333
None
1.00A 2y7hC-3wkhA:
undetectable
2y7hC-3wkhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus)
PF01670
(Glyco_hydro_12)
3 TYR A 243
GLU A 178
ASN A  82
GOL  A 409 (-4.6A)
BGC  A 414 (-3.9A)
BGC  A 412 (-3.1A)
0.96A 2y7hC-3wq1A:
undetectable
2y7hC-3wq1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
3 TYR A  66
GLU A 102
ASN A  12
None
MG  A1253 ( 4.9A)
None
0.97A 2y7hC-3zdbA:
undetectable
2y7hC-3zdbA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as3 PHOSPHORYLCHOLINE
PHOSPHATASE


(Pseudomonas
aeruginosa)
no annotation 3 TYR A 249
GLU A 170
ASN A 223
None
0.75A 2y7hC-4as3A:
undetectable
2y7hC-4as3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi5 TRIOSEPHOSPHATE
ISOMERASE


(Giardia
intestinalis)
PF00121
(TIM)
3 TYR A 169
GLU A 130
ASN A 138
None
0.85A 2y7hC-4bi5A:
undetectable
2y7hC-4bi5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Bacillus cereus)
PF00268
(Ribonuc_red_sm)
3 TYR A 239
GLU A 236
ASN A 260
None
1.00A 2y7hC-4bmrA:
undetectable
2y7hC-4bmrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cd8 ENDO-BETA-1,4-MANNAN
ASE


(Alicyclobacillus
acidocaldarius)
no annotation 3 TYR A 203
GLU A 151
ASN A  97
MVL  A 400 (-3.8A)
MVL  A 400 (-2.6A)
BMA  A 401 (-3.2A)
0.95A 2y7hC-4cd8A:
undetectable
2y7hC-4cd8A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 TYR A  75
GLU A  48
ASN A 369
None
1.00A 2y7hC-4eclA:
undetectable
2y7hC-4eclA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe)
PF11715
(Nup160)
3 TYR B  57
GLU B 434
ASN B 101
None
0.97A 2y7hC-4fhnB:
2.1
2y7hC-4fhnB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF


(Thermococcus
kodakarensis)
PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF)
3 TYR A 174
GLU A  89
ASN A  36
None
0.91A 2y7hC-4g9iA:
undetectable
2y7hC-4g9iA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2


(Mus musculus)
PF00169
(PH)
PF00621
(RhoGEF)
3 TYR A1013
GLU A 545
ASN A 931
None
0.88A 2y7hC-4gzuA:
undetectable
2y7hC-4gzuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN


(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
3 TYR A 150
GLU A  77
ASN A  75
None
0.88A 2y7hC-4l37A:
undetectable
2y7hC-4l37A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5h VVTL1

(Vitis vinifera)
PF00314
(Thaumatin)
3 TYR A 197
GLU A 107
ASN A  65
None
0.72A 2y7hC-4l5hA:
undetectable
2y7hC-4l5hA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis)
no annotation 3 TYR C 149
GLU C 156
ASN C  90
0FX  C 301 (-4.0A)
None
None
0.99A 2y7hC-4nv1C:
undetectable
2y7hC-4nv1C:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE


(Streptococcus
pyogenes)
PF00171
(Aldedh)
3 TYR A 386
GLU A 360
ASN A 132
None
1.03A 2y7hC-4ohtA:
undetectable
2y7hC-4ohtA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Polaromonas sp.
JS666)
PF03480
(DctP)
3 TYR A  47
GLU A  79
ASN A 180
EAX  A 401 (-4.1A)
EAX  A 401 (-3.0A)
None
0.97A 2y7hC-4pddA:
undetectable
2y7hC-4pddA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV


(Bacteroides
ovatus)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
3 TYR A 643
GLU A 564
ASN A 340
None
0.98A 2y7hC-4q1vA:
undetectable
2y7hC-4q1vA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC


(Homo sapiens)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
3 TYR B 384
GLU B 335
ASN B 236
None
1.03A 2y7hC-4r3zB:
undetectable
2y7hC-4r3zB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica)
PF08543
(Phos_pyr_kin)
3 TYR B  47
GLU B 257
ASN B 259
None
0.89A 2y7hC-4s1iB:
undetectable
2y7hC-4s1iB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzo PROTEIN HTP-1

(Caenorhabditis
elegans)
PF02301
(HORMA)
3 TYR A 221
GLU A 107
ASN A 243
None
1.02A 2y7hC-4tzoA:
undetectable
2y7hC-4tzoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus)
no annotation 3 TYR B  53
GLU B  49
ASN B  80
None
0.98A 2y7hC-4w5uB:
undetectable
2y7hC-4w5uB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE


(Homo sapiens)
PF09764
(Nt_Gln_amidase)
3 TYR A  27
GLU A  29
ASN A 176
None
None
EDO  A 301 (-4.3A)
1.02A 2y7hC-4w79A:
undetectable
2y7hC-4w79A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53)
PF00150
(Cellulase)
3 TYR A 205
GLU A 142
ASN A 107
None
0.77A 2y7hC-4xzbA:
undetectable
2y7hC-4xzbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfv VIOF

(Providencia
alcalifaciens)
PF00551
(Formyl_trans_N)
3 TYR A 151
GLU A 158
ASN A  92
None
0.93A 2y7hC-4yfvA:
undetectable
2y7hC-4yfvA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE


(Aspergillus
flavus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 TYR A  53
GLU A 413
ASN A 319
LGC  A 602 ( 4.5A)
LGC  A 602 (-2.9A)
None
0.96A 2y7hC-4ynuA:
undetectable
2y7hC-4ynuA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE


(Caldicellulosiruptor
saccharolyticus)
PF07221
(GlcNAc_2-epim)
3 TYR A 376
GLU A 312
ASN A 319
None
0.98A 2y7hC-4z4lA:
undetectable
2y7hC-4z4lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
3 TYR A 222
GLU A 106
ASN A 474
None
1.00A 2y7hC-4zktA:
1.5
2y7hC-4zktA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
3 TYR A 332
GLU A 250
ASN A 164
None
0.88A 2y7hC-4zktA:
1.5
2y7hC-4zktA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Oceanimonas
doudoroffii)
PF00171
(Aldedh)
3 TYR A 408
GLU A 382
ASN A 149
None
NAD  A 501 (-3.0A)
NAD  A 501 (-3.1A)
0.97A 2y7hC-4zz7A:
undetectable
2y7hC-4zz7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
3 TYR A 511
GLU A 447
ASN A 392
None
0.84A 2y7hC-5dmyA:
undetectable
2y7hC-5dmyA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis)
PF05147
(LANC_like)
PF13575
(DUF4135)
3 TYR A 299
GLU A 313
ASN A 237
None
1.01A 2y7hC-5dztA:
undetectable
2y7hC-5dztA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE


(Homo sapiens)
PF03291
(Pox_MCEL)
3 TYR A 391
GLU A 401
ASN A 405
None
0.83A 2y7hC-5e9jA:
9.4
2y7hC-5e9jA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus)
PF00150
(Cellulase)
PF03424
(CBM_17_28)
3 TYR A 257
GLU A 188
ASN A 152
EDO  A 614 (-4.1A)
CA  A 643 (-2.5A)
None
0.88A 2y7hC-5ecuA:
undetectable
2y7hC-5ecuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE


(Caenorhabditis
elegans)
PF07910
(Peptidase_C78)
3 TYR A 207
GLU A 369
ASN A 387
None
0.73A 2y7hC-5ejjA:
undetectable
2y7hC-5ejjA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified)
PF00150
(Cellulase)
PF03424
(CBM_17_28)
3 TYR A 261
GLU A 192
ASN A 156
None
0.87A 2y7hC-5fipA:
undetectable
2y7hC-5fipA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1


(Thielavia
terrestris)
PF05183
(RdRP)
3 TYR A 987
GLU A 493
ASN A 470
None
0.95A 2y7hC-5fswA:
3.3
2y7hC-5fswA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum)
PF00232
(Glyco_hydro_1)
3 TYR A 316
GLU A 172
ASN A 186
None
0.88A 2y7hC-5jboA:
undetectable
2y7hC-5jboA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A


(Bacteroides
ovatus)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110)
3 TYR A 415
GLU A 716
ASN A 693
None
1.01A 2y7hC-5jouA:
undetectable
2y7hC-5jouA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
3 TYR A1789
GLU A1743
ASN A1517
None
1.00A 2y7hC-5m5pA:
undetectable
2y7hC-5m5pA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC


(Arabidopsis
thaliana;
Arabidopsis
thaliana)
PF00421
(PSII)
PF01716
(MSP)
3 TYR O 102
GLU C 367
ASN C 294
None
0.92A 2y7hC-5mdxO:
undetectable
2y7hC-5mdxO:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA
COATOMER SUBUNIT
DELTA-LIKE PROTEIN


(Chaetomium
thermophilum;
Chaetomium
thermophilum)
PF01602
(Adaptin_N)
PF01217
(Clat_adaptor_s)
3 TYR A 114
GLU B 115
ASN B 118
None
0.93A 2y7hC-5mu7A:
undetectable
2y7hC-5mu7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 3 TYR A 700
GLU A 704
ASN A 740
None
1.00A 2y7hC-5nfhA:
1.9
2y7hC-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obw CHAPERONE PROTEIN
DNAK


(Mycoplasma
genitalium)
no annotation 3 TYR A 128
GLU A 133
ASN A  79
GOL  A 412 ( 3.9A)
GOL  A 410 ( 4.9A)
None
1.01A 2y7hC-5obwA:
undetectable
2y7hC-5obwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME


(uncultured
organism)
no annotation 3 TYR A 258
GLU A 196
ASN A 159
EDO  A 411 (-4.0A)
EDO  A 411 ( 4.1A)
None
1.01A 2y7hC-5wh8A:
undetectable
2y7hC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF07942
(N2227)
3 TYR A 110
GLU A 120
ASN A 125
None
0.94A 2y7hC-5x62A:
7.9
2y7hC-5x62A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmg UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
no annotation 3 TYR A 213
GLU A  28
ASN A 240
None
0.99A 2y7hC-5xmgA:
undetectable
2y7hC-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus)
no annotation 3 TYR B 195
GLU B 143
ASN B  89
BMA  B 401 (-4.5A)
BMA  B 401 (-2.6A)
BMA  B 402 (-3.0A)
0.96A 2y7hC-5yllB:
undetectable
2y7hC-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhg OUTER CAPSID PROTEIN
VP8*


(Rotavirus C)
no annotation 3 TYR A 153
GLU A  50
ASN A  66
None
1.00A 2y7hC-5zhgA:
undetectable
2y7hC-5zhgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT A
ALTERNATIVE COMPLEX
III SUBUNIT B


(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae)
no annotation
no annotation
3 TYR A 424
GLU A 419
ASN B 982
None
0.79A 2y7hC-6btmA:
undetectable
2y7hC-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-)
no annotation 3 TYR A 809
GLU A 513
ASN A 827
MGD  A 903 (-4.1A)
None
MGD  A 903 (-2.2A)
0.97A 2y7hC-6czaA:
undetectable
2y7hC-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME RNA HELICASE
MTR4


(Homo sapiens;
Homo sapiens)
no annotation
no annotation
3 TYR H 163
GLU M 577
ASN M 580
None
1.00A 2y7hC-6d6qH:
undetectable
2y7hC-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2


(Moorea
bouillonii)
no annotation 3 TYR A 748
GLU A 659
ASN A 652
None
0.95A 2y7hC-6d6yA:
2.9
2y7hC-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3


(Saccharomyces
cerevisiae)
no annotation 3 TYR O  49
GLU O 582
ASN O 575
None
1.00A 2y7hC-6eu2O:
2.3
2y7hC-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2


(Saccharomyces
cerevisiae)
no annotation 3 TYR l 170
GLU l 190
ASN l 118
None
0.99A 2y7hC-6fail:
2.1
2y7hC-6fail:
undetectable